JP2020515248A5 - - Google Patents
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- Publication number
- JP2020515248A5 JP2020515248A5 JP2019552004A JP2019552004A JP2020515248A5 JP 2020515248 A5 JP2020515248 A5 JP 2020515248A5 JP 2019552004 A JP2019552004 A JP 2019552004A JP 2019552004 A JP2019552004 A JP 2019552004A JP 2020515248 A5 JP2020515248 A5 JP 2020515248A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- trem2p
- apoe4p
- genetically modified
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 63
- 150000001875 compounds Chemical class 0.000 claims description 32
- 208000024827 Alzheimer disease Diseases 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 19
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 14
- 238000012216 screening Methods 0.000 claims description 12
- 241000699670 Mus sp. Species 0.000 claims description 9
- 102200034293 rs17121818 Human genes 0.000 claims description 9
- 230000035772 mutation Effects 0.000 claims description 8
- 208000022099 Alzheimer disease 2 Diseases 0.000 claims description 7
- 208000024891 symptom Diseases 0.000 claims description 7
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 101100426015 Mus musculus Trem2 gene Proteins 0.000 claims description 5
- 101150037123 APOE gene Proteins 0.000 claims description 4
- 102100029470 Apolipoprotein E Human genes 0.000 claims description 4
- 238000011746 C57BL/6J (JAX™ mouse strain) Methods 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 4
- 238000009396 hybridization Methods 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 238000009399 inbreeding Methods 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023023328A JP2023056032A (ja) | 2017-03-21 | 2023-02-17 | ヒトＡＰＯＥ４およびマウスＴｒｅｍ２ ｐ．Ｒ４７Ｈを発現する遺伝子改変されたマウス、ならびにその使用の方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762474358P | 2017-03-21 | 2017-03-21 | |
| US62/474,358 | 2017-03-21 | ||
| PCT/US2018/023565 WO2018175581A1 (en) | 2017-03-21 | 2018-03-21 | A GENETICALLY MODIFIED MOUSE EXPRESSING HUMAN APOE4 MOUSE Trem2.p.R47H AND METHODS OF USE THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023023328A Division JP2023056032A (ja) | 2017-03-21 | 2023-02-17 | ヒトＡＰＯＥ４およびマウスＴｒｅｍ２ ｐ．Ｒ４７Ｈを発現する遺伝子改変されたマウス、ならびにその使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515248A JP2020515248A (ja) | 2020-05-28 |
| JP2020515248A5 true JP2020515248A5 (enExample) | 2021-04-22 |
| JP7623785B2 JP7623785B2 (ja) | 2025-01-29 |
Family
ID=63586166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019552004A Active JP7623785B2 (ja) | 2017-03-21 | 2018-03-21 | ヒトＡＰＯＥ４およびマウスＴｒｅｍ２ ｐ．Ｒ４７Ｈを発現する遺伝子改変されたマウス、ならびにその使用の方法 |
| JP2023023328A Ceased JP2023056032A (ja) | 2017-03-21 | 2023-02-17 | ヒトＡＰＯＥ４およびマウスＴｒｅｍ２ ｐ．Ｒ４７Ｈを発現する遺伝子改変されたマウス、ならびにその使用の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023023328A Ceased JP2023056032A (ja) | 2017-03-21 | 2023-02-17 | ヒトＡＰＯＥ４およびマウスＴｒｅｍ２ ｐ．Ｒ４７Ｈを発現する遺伝子改変されたマウス、ならびにその使用の方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11957115B2 (enExample) |
| EP (1) | EP3599842B1 (enExample) |
| JP (2) | JP7623785B2 (enExample) |
| CN (1) | CN110891417B (enExample) |
| AU (1) | AU2018239433B2 (enExample) |
| CA (1) | CA3057289A1 (enExample) |
| WO (1) | WO2018175581A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| WO2019246483A1 (en) * | 2018-06-21 | 2019-12-26 | The Jackson Laboratory | Genetically modified mouse models of alzheimer's disease |
| WO2023015153A2 (en) * | 2021-08-02 | 2023-02-09 | President And Fellows Of Harvard College | ANTISENSE OLIGONUCLEOTIDE TARGETING APOE ε4 AND USES THEREOF |
| CN114731987B (zh) * | 2022-05-19 | 2023-06-23 | 华芯微鱼(苏州)生物科技有限公司 | 颅缝早闭症小鼠模型、其构建方法及应用 |
| CN115536734B (zh) * | 2022-11-24 | 2024-04-30 | 安徽农业大学 | 具有肝癌细胞毒性和α-葡萄糖苷酶抑制活性的环色-丙-缬-亮-亮肽及制备方法 |
| CN116103292B (zh) * | 2022-11-25 | 2024-01-30 | 首都医科大学宣武医院 | Zdhhc21基因突变动物模型的构建方法及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356802A (en) | 1992-04-03 | 1994-10-18 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease |
| US5487994A (en) | 1992-04-03 | 1996-01-30 | The Johns Hopkins University | Insertion and deletion mutants of FokI restriction endonuclease |
| US5436150A (en) | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| EP0788546B9 (en) | 1994-10-18 | 2007-06-13 | Dendreon Corporation | Nematode-extracted serine protease inhibitors and anticoagulant proteins |
| CN1206421A (zh) | 1995-11-01 | 1999-01-27 | 科斯药品公司 | 载脂蛋白e2和阿尔采默氏病的治疗 |
| US6175057B1 (en) * | 1997-10-08 | 2001-01-16 | The Regents Of The University Of California | Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy |
| US6046381A (en) * | 1998-04-30 | 2000-04-04 | The Regents Of The University Of California | Apolipoprotein E transgenic mice and assay methods |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| JP2001017028A (ja) | 1999-05-06 | 2001-01-23 | Mitsubishi Chemicals Corp | アポｅヒト化哺乳動物 |
| EP1063298A3 (en) | 1999-06-04 | 2001-03-28 | Glaxo Group Limited | Transgenic Animal Model for Alzheimer Disease |
| US6830910B1 (en) | 1999-07-21 | 2004-12-14 | Albert Einstein College Of Medicine Of Yeshiva University | Drosophila recombination-associated protein and methods for use |
| CN1230540C (zh) | 1999-07-21 | 2005-12-07 | 犹太大学阿尔伯特爱因斯坦医学院 | 果蝇重组相关蛋白质及其使用方法 |
| DE60320258T2 (de) * | 2002-07-12 | 2009-06-25 | Axon Neuroscience Forschungs- Und Entwicklungs Gmbh | Transgenes tier welches das trunkierte alzheimer tau protein exprimiert |
| AU2003266967B2 (en) | 2002-08-07 | 2006-11-16 | Novartis Ag | Methods for the treatment of dementia based on Apo E genotype |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| DK1802193T3 (da) | 2004-10-19 | 2014-06-10 | Regeneron Pharma | Fremgangsmåde til frembringelse af en homozygot mus til genetisk modifikation |
| EP1907566A4 (en) | 2005-05-27 | 2008-12-10 | Memory Pharm Corp | ALZHEIMER TRANSGENIC MOUSE MODEL VECTORS AND USES THEREOF |
| KR101419729B1 (ko) | 2005-07-26 | 2014-07-17 | 상가모 바이오사이언스 인코포레이티드 | 외래 핵산 서열의 표적화된 통합 및 발현 |
| CA2651494C (en) | 2006-05-25 | 2015-09-29 | Sangamo Biosciences, Inc. | Engineered cleavage half-domains |
| JP4942081B2 (ja) | 2006-06-20 | 2012-05-30 | 独立行政法人理化学研究所 | アルツハイマー病モデル動物およびその用途 |
| US20110166079A1 (en) | 2008-07-01 | 2011-07-07 | Cognosci, Inc. | Methods of treating cancer with apoe peptides |
| PE20150362A1 (es) | 2008-08-12 | 2015-03-20 | Zinfandel Pharmaceuticals Inc | Metodo de identificacion de factores de riesgo de la enfermedad |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| CN106834320B (zh) | 2009-12-10 | 2021-05-25 | 明尼苏达大学董事会 | Tal效应子介导的dna修饰 |
| US8450107B1 (en) | 2011-11-30 | 2013-05-28 | The Broad Institute Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| WO2013181618A2 (en) * | 2012-05-31 | 2013-12-05 | The Trustees Of Columbia University In The City Of New York | Methods to treat alzheimer's disease using apoe inhibitors |
| WO2014074942A1 (en) * | 2012-11-08 | 2014-05-15 | Illumina, Inc. | Risk variants of alzheimer's disease |
| US10941200B2 (en) * | 2016-07-22 | 2021-03-09 | Deutsches Zentrum Für Neurodegenerative Erkrankungen Ev | TREM2 cleavage modulators and uses thereof |
| WO2019246483A1 (en) | 2018-06-21 | 2019-12-26 | The Jackson Laboratory | Genetically modified mouse models of alzheimer's disease |
| WO2020154348A1 (en) | 2019-01-23 | 2020-07-30 | The Regents Of The University Of California | Human genomic construct reporter cells and mouse models to screen therapeutics against microglia-expressed disease associated genes |
| CA3205386A1 (en) | 2020-12-16 | 2022-06-23 | The Jackson Laboratory | A genetically modified immunodeficient mouse expressing human or humanized app and mutated human psen1 |
-
2018
- 2018-03-21 US US16/496,261 patent/US11957115B2/en active Active
- 2018-03-21 CN CN201880031011.2A patent/CN110891417B/zh active Active
- 2018-03-21 AU AU2018239433A patent/AU2018239433B2/en not_active Ceased
- 2018-03-21 CA CA3057289A patent/CA3057289A1/en active Pending
- 2018-03-21 WO PCT/US2018/023565 patent/WO2018175581A1/en not_active Ceased
- 2018-03-21 EP EP18770741.9A patent/EP3599842B1/en active Active
- 2018-03-21 JP JP2019552004A patent/JP7623785B2/ja active Active
-
2023
- 2023-02-17 JP JP2023023328A patent/JP2023056032A/ja not_active Ceased
-
2024
- 2024-03-14 US US18/605,786 patent/US20240315220A1/en active Pending
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