JP2010525826A - 癌を治療するためのｍｉｒ３４治療剤を含む組成物 - Google Patents

癌を治療するためのｍｉｒ３４治療剤を含む組成物 Download PDF

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JP2010525826A
JP2010525826A JP2010506716A JP2010506716A JP2010525826A JP 2010525826 A JP2010525826 A JP 2010525826A JP 2010506716 A JP2010506716 A JP 2010506716A JP 2010506716 A JP2010506716 A JP 2010506716A JP 2010525826 A JP2010525826 A JP 2010525826A
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クレアリー，ミツシエル・エイ
ジヤクソン，エイミー・エル
リンズレイ，ピーター・エス
バーチヤード，ジユルジヤ
リム，リー・ピー
マグナス，ジル・エフ
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ロゼッタ インファーマティックス エルエルシー
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JP2010506716A 2007-05-03 2008-05-05 癌を治療するためのｍｉｒ３４治療剤を含む組成物 Pending JP2010525826A (ja)

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US92762107P 2007-05-03 2007-05-03
PCT/US2008/062689 WO2008137867A2 (en) 2007-05-03 2008-05-05 Compositions comprising mir34 therapeutic agents for treating cancer

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JP2010525826A5 JP2010525826A5 (enExample) 2011-06-23

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US (2) US8378088B2 (enExample)
EP (1) EP2152722B1 (enExample)
JP (1) JP2010525826A (enExample)
AU (1) AU2008247427A1 (enExample)
CA (1) CA2686165A1 (enExample)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014506791A (ja) * 2011-02-03 2014-03-20 マーナ セラピューティクス インコーポレイテッド ｍｉＲ−３４の合成模倣体
US9642872B2 (en) 2010-09-30 2017-05-09 University Of Zurich Treatment of B-cell lymphoma with microRNA
JP2019069971A (ja) * 2012-07-13 2019-05-09 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． キラル制御

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2290068A3 (en) 2004-05-28 2012-01-04 Asuragen, Inc. Methods and compositions involving microRNA
ES2503765T3 (es) 2004-11-12 2014-10-07 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
AU2008247427A1 (en) 2007-05-03 2008-11-13 Rosetta Inpharmatics Llc Compositions comprising miR34 therapeutic agents for treating cancer
CN101801419A (zh) * 2007-06-08 2010-08-11 米尔纳疗法公司 作为治疗干预的靶标的miR-34调控的基因和路径
WO2009036332A1 (en) 2007-09-14 2009-03-19 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US8188060B2 (en) * 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
US8841268B2 (en) * 2008-05-07 2014-09-23 Sapporo Medical University Method and kit for detection of cancer, and therapeutic agent for cancer
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US9217155B2 (en) 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
EP2191834A1 (en) * 2008-11-26 2010-06-02 Centre National De La Recherche Scientifique (Cnrs) Compositions and methods for treating retrovirus infections
LU91545B1 (en) 2009-03-27 2010-09-28 Univ Luxembourg Mirna as a prognostic diagnostic biomarker and therapeutic agent for breast cancer and other human associated pathologies
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
FR2948687B1 (fr) 2009-07-29 2015-09-04 Centre Nat Rech Scient Utilisation de microarn pour le traitement de pathologies respiratoires chroniques
EP2476758A4 (en) * 2009-09-07 2013-04-03 Yoshiki Murakami METHOD FOR PREDICTING THE THERAPEUTIC EFFECT ON CHRONIC HEPATITIS C
WO2011088309A1 (en) 2010-01-14 2011-07-21 Regulus Therapeutics Inc. Microrna compositions and methods
CA2833912C (en) 2010-04-23 2021-09-21 University Of Massachusetts Aav-based treatment of cholesterol-related disorders
WO2011133874A1 (en) 2010-04-23 2011-10-27 University Of Massachusetts Multicistronic expression constructs
US20130149320A1 (en) * 2010-05-31 2013-06-13 Centre National De La Recherche Scientifique Asf1b as a Prognosis Marker and Therapeutic Target in Human Cancer
CN102031309A (zh) * 2010-11-30 2011-04-27 华东师范大学 miRNA-34c化合物作为脑胶质瘤标志物的应用
US9222085B2 (en) 2011-02-03 2015-12-29 Mirna Therapeutics, Inc. Synthetic mimics of MIR-124
US9226976B2 (en) 2011-04-21 2016-01-05 University Of Massachusetts RAAV-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
US20130028956A1 (en) 2011-07-29 2013-01-31 Andre Fischer Method for preventing or treating memory impairment and pharmaceutical compositions useful therefore
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
EP2785872A4 (en) * 2011-12-01 2015-12-09 Univ Ohio State MATERIALS AND METHODS RELATED TO NSAID CHEMOPRVENTION IN COLORECTAL CANCER
WO2013170146A1 (en) 2012-05-10 2013-11-14 Uab Research Foundation Methods and compositions for modulating mir-204 activity
EP2857513A4 (en) 2012-05-26 2016-05-25 Bonac Corp Single-stranded nucleic acid molecule controlling the expression of a gene transporter
CN105324119A (zh) * 2013-06-16 2016-02-10 国立大学法人东京医科齿科大学 具有外显子跳跃效应的双链反义核酸
JP6486836B2 (ja) 2013-12-26 2019-03-20 学校法人東京医科大学 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途
RU2697094C2 (ru) 2013-12-27 2019-08-12 Бонак Корпорейшн ИСКУССТВЕННАЯ мкРНК С СООТВЕТСТВИЕМ ДЛЯ КОНТРОЛЯ ЭКСПРЕССИИ ГЕНОВ И ЕЕ ПРИМЕНЕНИЕ
WO2016054554A1 (en) 2014-10-03 2016-04-07 University Of Massachusetts Heterologous targeting peptide grafted aavs
WO2016065001A1 (en) 2014-10-21 2016-04-28 University Of Massachusetts Recombinant aav variants and uses thereof
AU2015368293B2 (en) 2014-12-27 2021-07-22 Bonac Corporation Naturally occuring miRNA for controlling gene expression, and use of same
EP3256170B1 (en) 2015-02-13 2020-09-23 University of Massachusetts Compositions and methods for transient delivery of nucleases
HK1244031A1 (en) 2015-03-27 2018-07-27 Bonac Corporation Single-chain nucleic acid molecule having delivery function and gene expression control ability
WO2016172008A1 (en) 2015-04-24 2016-10-27 University Of Massachusetts Modified aav constructions and uses thereof
EP3364996B1 (en) * 2015-10-22 2021-08-25 University of Massachusetts Prostate-targeting adeno-associated virus serotype vectors
US11060088B2 (en) 2016-02-12 2021-07-13 University Of Massachusetts Anti-angiogenic miRNA therapeutics for inhibiting corneal neovascularization
WO2017152182A1 (en) * 2016-03-04 2017-09-08 Rhode Island Hospital Targeting microrna for cancer treatment
EP3216869B1 (en) 2016-03-09 2019-09-18 Colizzi, Vittorio Nutraceutical plant derived microrna elements for treatment of leukemia
US10457940B2 (en) 2016-09-22 2019-10-29 University Of Massachusetts AAV treatment of Huntington's disease
AU2017341849B2 (en) 2016-10-13 2024-03-21 University Of Massachusetts AAV capsid designs
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
JP6651061B2 (ja) 2017-11-09 2020-02-19 国立大学法人広島大学 ｍｉＲＮＡを含むがん治療用医薬組成物
CN107699565B (zh) * 2017-11-24 2020-05-22 苏州大学 微小rna及其在制备抗肿瘤药物中的应用
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WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070050146A1 (en) * 2004-05-14 2007-03-01 Itzhak Bentwich Micrornas and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020177568A1 (en) 1992-12-07 2002-11-28 Stinchcomb Dan T. Enzymatic nucleic acid treatment of diseases or conditions related to levels of NF-kappa B
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US5753613A (en) 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
WO2003070918A2 (en) 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Incorporated Rna interference by modified short interfering nucleic acid
US20070032441A1 (en) * 2001-05-18 2007-02-08 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
US20060009409A1 (en) * 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US7655785B1 (en) * 2002-11-14 2010-02-02 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
US7250496B2 (en) 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
WO2005018534A2 (en) 2003-05-16 2005-03-03 Rosetta Inpharmatics, Llc Methods and compositions for rna interference
US6882555B2 (en) 2003-06-18 2005-04-19 Lattice Semiconductor Corporation Bi-directional buffering for memory data lines
WO2005031002A2 (en) 2003-09-22 2005-04-07 Rosetta Inpharmatics Llc Synthetic lethal screen using rna interference
ATE452188T1 (de) 2004-02-10 2010-01-15 Sirna Therapeutics Inc Rna-interferenz-vermittelte hemmung der genexpression unter verwendung multifunktioneller sina (short interfering nucleic acid)
US20050182005A1 (en) 2004-02-13 2005-08-18 Tuschl Thomas H. Anti-microRNA oligonucleotide molecules
EP2290068A3 (en) * 2004-05-28 2012-01-04 Asuragen, Inc. Methods and compositions involving microRNA
WO2007056829A1 (en) 2005-11-21 2007-05-24 Johnson & Johnson Research Pty Limited Multitargeting interfering rnas having two active strands and methods for their design and use
US7893975B2 (en) * 2006-10-13 2011-02-22 Apple Inc. System and method for processing images using predetermined tone reproduction curves
EP2087301B1 (en) * 2006-11-07 2018-11-14 Tiax LLC dehumidification system and method for dehumidification
EP2111408A4 (en) 2007-01-17 2010-02-03 Univ Johns Hopkins COMPOSITIONS AND METHODS OF microRNA FOR THE TREATMENT OF NEOPLASIA
AU2008220438A1 (en) 2007-02-27 2008-09-04 Rosetta Genomics Ltd. Composition and methods for modulating cell proliferation and cell death
AU2008247427A1 (en) 2007-05-03 2008-11-13 Rosetta Inpharmatics Llc Compositions comprising miR34 therapeutic agents for treating cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070050146A1 (en) * 2004-05-14 2007-03-01 Itzhak Bentwich Micrornas and uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN5009002735; ＬＩＭ　Ｌ．Ｐ．: ＮＡＴＵＲＥ Ｖ４３３　Ｎ７０２７, 20050217, Ｐ７６９-７７３, ＮＡＴＵＲＥ　ＰＵＢＬＩＳＨＩＮＧ　ＧＲＯＵＰ *
JPN6013012167; Ｄｅｖ　Ｃｅｌｌ Ｖｏｌ．５, 2003, ｐ．３５１-３５８ *
JPN6013012169; Ｃｅｌｌ Ｖｏｌ．１１５, 2003, ｐ．２０９-２１６ *
JPN6013012171; Ｃｅｌｌ Ｖｏｌ．１１５, 2003, ｐ．１９９-２０８ *
JPN6013012174; ＲＮＡ Ｖｏｌ．９, 2003, ｐ．１０３４-１０４８ *
JPN6013012178; Ｇｅｎｅｓ　Ｄｅｖ Ｖｏｌ．２０, 2006, ｐ．１７３２-１７４３，　Ｓｕｐｐｌｅｍｅｎｔａｌ　Ｒｅｓｅａｒｃｈ　Ｄａｔａ *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9642872B2 (en) 2010-09-30 2017-05-09 University Of Zurich Treatment of B-cell lymphoma with microRNA
JP2014506791A (ja) * 2011-02-03 2014-03-20 マーナ セラピューティクス インコーポレイテッド ｍｉＲ−３４の合成模倣体
US9371526B2 (en) 2011-02-03 2016-06-21 Mirna Therapeutics, Inc. Synthetic mimics of miR-34
JP2016152804A (ja) * 2011-02-03 2016-08-25 マーナ セラピューティクス インコーポレイテッド ｍｉＲ−３４の合成模倣体
JP2019069971A (ja) * 2012-07-13 2019-05-09 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． キラル制御
JP7004637B2 (ja) 2012-07-13 2022-02-04 ウェイブ ライフ サイエンシズ リミテッド キラル制御
US11643657B2 (en) 2012-07-13 2023-05-09 Wave Life Sciences Ltd. Chiral control

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US20100227909A1 (en) 2010-09-09
WO2008137867A3 (en) 2009-04-16
EP2152722A4 (en) 2011-12-28
AU2008247427A1 (en) 2008-11-13
CA2686165A1 (en) 2008-11-13
EP2152722B1 (en) 2016-04-27
WO2008137862A3 (en) 2009-02-19
WO2008137862A2 (en) 2008-11-13
US20110105583A1 (en) 2011-05-05
WO2008137867A2 (en) 2008-11-13
US8399248B2 (en) 2013-03-19
EP2152722A2 (en) 2010-02-17
US8378088B2 (en) 2013-02-19

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