JP2010523805A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010523805A5 JP2010523805A5 JP2010503206A JP2010503206A JP2010523805A5 JP 2010523805 A5 JP2010523805 A5 JP 2010523805A5 JP 2010503206 A JP2010503206 A JP 2010503206A JP 2010503206 A JP2010503206 A JP 2010503206A JP 2010523805 A5 JP2010523805 A5 JP 2010523805A5
- Authority
- JP
- Japan
- Prior art keywords
- blend
- solidified
- solidified blend
- uhmwpe
- antioxidant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 32
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 claims 10
- 230000003078 antioxidant Effects 0.000 claims 8
- 239000003963 antioxidant agent Substances 0.000 claims 8
- 235000006708 antioxidants Nutrition 0.000 claims 8
- 230000001678 irradiating Effects 0.000 claims 7
- 238000002156 mixing Methods 0.000 claims 6
- 238000002844 melting Methods 0.000 claims 5
- 230000001954 sterilising Effects 0.000 claims 5
- 238000004132 cross linking Methods 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 238000004659 sterilization and disinfection Methods 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 229960001295 Tocopherol Drugs 0.000 claims 3
- 238000000748 compression moulding Methods 0.000 claims 3
- 235000010384 tocopherol Nutrition 0.000 claims 3
- 239000011732 tocopherol Substances 0.000 claims 3
- 229930003799 tocopherols Natural products 0.000 claims 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 3
- OAIJSZIZWZSQBC-LWRKPGOESA-N Lycopene Natural products CC(C)=CCC\C(C)=C/C=C/C(/C)=C\C=C\C(\C)=C/C=C/C=C(/C)\C=C\C=C(\C)/C=C/C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-LWRKPGOESA-N 0.000 claims 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N benzohydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000560 biocompatible material Substances 0.000 claims 2
- 239000000316 bone substitute Substances 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 238000000465 moulding Methods 0.000 claims 2
- 230000000278 osteoconductive Effects 0.000 claims 2
- 230000002138 osteoinductive Effects 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 210000001519 tissues Anatomy 0.000 claims 2
- 229960002747 Betacarotene Drugs 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 239000004594 Masterbatch (MB) Substances 0.000 claims 1
- 210000002381 Plasma Anatomy 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- OENHQHLEOONYIE-VYAWBVGESA-N beta-Carotene Natural products CC=1CCCC(C)(C)C=1\C=C\C(\C)=C/C=C/C(/C)=C\C=C\C=C(\C)/C=C/C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-VYAWBVGESA-N 0.000 claims 1
- 235000013734 beta-carotene Nutrition 0.000 claims 1
- 239000011648 beta-carotene Substances 0.000 claims 1
- 238000000071 blow moulding Methods 0.000 claims 1
- 238000007707 calorimetry Methods 0.000 claims 1
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000005712 crystallization Effects 0.000 claims 1
- 238000010894 electron beam technology Methods 0.000 claims 1
- 238000005367 electrostatic precipitation Methods 0.000 claims 1
- 238000007720 emulsion polymerization reaction Methods 0.000 claims 1
- 238000001125 extrusion Methods 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 235000012907 honey Nutrition 0.000 claims 1
- 238000001513 hot isostatic pressing Methods 0.000 claims 1
- 229960004337 hydroquinone Drugs 0.000 claims 1
- 238000001746 injection moulding Methods 0.000 claims 1
- 235000012661 lycopene Nutrition 0.000 claims 1
- 239000001751 lycopene Substances 0.000 claims 1
- 229960004999 lycopene Drugs 0.000 claims 1
- 238000003754 machining Methods 0.000 claims 1
- 238000002074 melt spinning Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000002530 phenolic antioxidant Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000009987 spinning Methods 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000010409 thin film Substances 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
- 150000003700 vitamin C derivatives Chemical class 0.000 claims 1
- 238000009736 wetting Methods 0.000 claims 1
- 239000002076 α-tocopherol Substances 0.000 claims 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims 1
Claims (24)
- 医療用途での使用のためのUHMWPEを処理する方法であり、その方法は次の段階を含む：UHMWPEを酸化防止剤と一緒にして酸化防止剤0.01〜3.0wt％を有するブレンドを形成すること；ブレンドを固化するように処理すること、ここで固化されたブレンドは融点を有する；固化されたブレンドの融点未満の予熱温度に、固化されたブレンドを予熱すること；ならびに固化されたブレンドの融点未満の温度に、固化されたブレンドを維持する間に、固化されたブレンドに照射すること。
- UHMWPEを酸化防止剤と一緒にする段階が、酸化防止剤0.01〜3.0wt％を有する実施的に均一なUHMWPEブレンドを形成することを含む請求項１に記載の方法。
- UHMWPEを酸化防止剤と一緒にする段階が、溶媒ブレンド、高せん断混合、精密コーティング、流動床、噴霧、エマルション重合、静電沈殿、粒子の濡れまたは被覆およびマスターバッチブレンドの少なくとも１つにより、UHMWPE粉末をトコフェロールと混合することをさらに含む請求項１に記載の方法。
- UHMWPEを酸化防止剤と一緒にする段階が、高せん断混合により、UHMWPE粉末をトコフェロールと混合することをさらに含む請求項１に記載の方法。
- UHMWPEを、トコフェロール、ビタミンC、リコピン、蜂蜜、フェノール性酸化防止剤、アミン酸化防止剤、ハイドロキノン、ベータカロチン、アスコルビン酸、CoQエンザイムおよびそれらの誘導体から選ばれる酸化防止剤と一緒にする請求項１に記載の方法。
- UHMWPEをｄ、ｌ-α-トコフェロールと一緒にする請求項１に記載の方法。
- ブレンドを固化するように処理することが、圧縮成形、ネットシェイプ成形、射出成形、押出し、モノブロック成形、繊維、溶融紡糸、ブロー成形、溶液紡糸、熱間等方加圧、高圧結晶化および薄膜の少なくとも１つにより行われる請求項１に記載の方法。
- ブレンドを固化するように処理することが、圧縮成形によりブレンドを多孔質基板中に少なくとも部分的に伸長させて行われる請求項１に記載の方法。
- 基板が、骨代用材、細胞受容材、組織受容材、骨伝導性材および骨誘導材の少なくとも１つとして有用な、高度に多孔質の生体適合性材料である請求項８に記載の方法。
- 基板が、骨代用材、細胞受容材、組織受容材、骨伝導性材および骨誘導材の少なくとも１つとして有用な、高度に多孔質の生体適合性材料であり、少なくとも５５％の気孔率を有する請求項８に記載の方法。
- ブレンドを固化するように処理することが、肉眼でみて機械的に組み合わせる特徴を持つ基板上の粗面化した表面にブレンドを圧縮成形することにより行われる請求項１に記載の方法。
- 固化されたブレンドの融点が示差熱量測定法で測定される請求項１に記載の方法。
- 固化されたブレンドを実質的に６０℃〜１３０℃の予熱温度に予熱する請求項１に記載の方法。
- 固化されたブレンドを機械加工して医療用製品を形成することをさらに含む請求項１に記載の方法。
- 固化されたブレンドにより受けられる合計架橋照射線量を同定すること；
固化されたブレンドにより受けられる最大の個別照射線量を同定するが、固化されたブレンドを固化されたブレンドの融点未満に維持すること；ならびに
固化されたブレンドを照射する段階が、最大の個別照射線量に等しいか、少ない、第１の照射線量で固化されたブレンドを照射することを含む；
をさらに含む請求項１に記載の方法。 - 最大の個別照射線量に等しいか、少ない、少なくとも１つの続く照射線量で固化されたブレンドをさらに照射することを含む請求項１５に記載の方法。
- 固化されたブレンドを照射することが、電子ビーム照射、ガンマ照射およびX線照射の少なくとも１つで、固化されたブレンドを照射する請求項１５に記載の方法。
- 合計架橋照射線量が実質的に５０ｋGy〜１０００ｋGyである請求項１５に記載の方法。
- 合計架橋照射線量が実質的に１００ｋGy〜２５０ｋGyである請求項１５に記載の方法。
- 第１の照射の後に、固化されたブレンドの温度を予熱温度に平衡にすること；ならびに合計架橋照射線量および第１の照射線量および固化されたブレンドのための最大の個別照射線量の間の差異の小さい方に等しいか、少ない、第２の照射線量で固化されたブレンドを照射すること、をさらに含む請求項１５に記載の方法。
- ガスプラズマ殺菌、エチレンオキシド殺菌、ガンマ線殺菌、電離放射線殺菌、オートクレーブ処理および超臨界流体法の少なくとも１つによりUHMWPEブレンドを殺菌することをさらに含む請求項１に記載の方法。
- 照射段階後に、固化されたブレンドを熱処理することをさらに含む請求項１に記載の方法。
- 照射段階前に、固化されたブレンドの少なくとも１部分をシールドすることをさらに含む請求項１に記載の方法。
- 請求項１〜２３のいずれか１項に記載の方法により製造された生成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92273807P | 2007-04-10 | 2007-04-10 | |
| PCT/US2008/059909 WO2008124825A2 (en) | 2007-04-10 | 2008-04-10 | An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523805A JP2010523805A (ja) | 2010-07-15 |
| JP2010523805A5 true JP2010523805A5 (ja) | 2011-05-26 |
Family
ID=39540499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503206A Pending JP2010523805A (ja) | 2007-04-10 | 2008-04-10 | 医療機器用途のための、酸化防止剤で安定化された架橋超高分子量ポリエチレン |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US20080319137A1 (ja) |
| EP (4) | EP2578248B1 (ja) |
| JP (1) | JP2010523805A (ja) |
| AT (1) | ATE544476T1 (ja) |
| AU (1) | AU2008236996B2 (ja) |
| CA (1) | CA2678459C (ja) |
| ES (2) | ES2378721T3 (ja) |
| WO (1) | WO2008124825A2 (ja) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563623B2 (en) | 1996-02-13 | 2013-10-22 | The General Hospital Corporation | Radiation melt treated ultra high molecular weight polyethylene prosthetic devices |
| US8865788B2 (en) * | 1996-02-13 | 2014-10-21 | The General Hospital Corporation | Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices |
| US7431874B2 (en) | 2003-01-16 | 2008-10-07 | Massachusetts General Hospital | Methods for making oxidation resistant polymeric material |
| EP1924299B1 (en) | 2005-08-18 | 2009-11-25 | Zimmer GmbH | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| EP2578248B1 (en) | 2007-04-10 | 2021-05-19 | Zimmer, Inc. | An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US8664290B2 (en) | 2007-04-10 | 2014-03-04 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| CA2698258C (en) | 2007-09-04 | 2016-05-17 | Smith & Nephew Orthopaedics Ag | Ultra high molecular weight polyethylene for bearing surfaces |
| JP5571580B2 (ja) * | 2008-01-30 | 2014-08-13 | ジンマー，インコーポレイティド | 低剛性の整形外科部品 |
| US8586667B2 (en) * | 2008-05-13 | 2013-11-19 | Smith & Nephew Orthopaedics Ag | Oxidation resistant highly-crosslinked UHMWPE |
| US8133436B2 (en) | 2008-08-05 | 2012-03-13 | Howmedica Osteonics Corp. | Polyethylene cross-linked with an anthocyanin |
| CN102307945B (zh) | 2008-11-20 | 2015-07-01 | 捷迈有限责任公司 | 聚乙烯材料 |
| US8933145B2 (en) | 2009-02-20 | 2015-01-13 | The General Hospital Corporation | High temperature melting |
| WO2010117752A1 (en) * | 2009-03-31 | 2010-10-14 | Zimmer, Inc. | Surface modification of ultrahigh molecular weight polyethylene |
| US20120070600A1 (en) * | 2009-05-20 | 2012-03-22 | Muratoglu Orhun K | Metods of preventing oxidation |
| DE102009023651B4 (de) * | 2009-05-26 | 2021-07-01 | Aesculap Ag | Verfahren zur Herstellung eines mit einem Stabilisator dotierten Polyethylens und Verwendung eines nach diesem Verfahren hergestellten Polyethylens |
| EA022361B1 (ru) * | 2009-11-11 | 2015-12-30 | Бореалис Аг | Сшитая полимерная композиция, кабель с улучшенными электрическими свойствами и способ его получения |
| GB0922339D0 (en) | 2009-12-21 | 2010-02-03 | Mcminn Derek J W | Acetabular cup prothesis and introducer thereof |
| WO2011128147A1 (en) * | 2010-04-14 | 2011-10-20 | Borealis Ag | Crosslinkable polymer composition and cable with advantageous electrical properties |
| US8399535B2 (en) | 2010-06-10 | 2013-03-19 | Zimmer, Inc. | Polymer [[s]] compositions including an antioxidant |
| US20140024736A1 (en) | 2010-11-03 | 2014-01-23 | Zimmer, Inc. | Polymer articles having chemically bonded agents and methods of making the same |
| US20120109301A1 (en) | 2010-11-03 | 2012-05-03 | Zimmer, Inc. | Modified Polymeric Materials And Methods Of Modifying Polymeric Materials |
| ES2807882T3 (es) | 2010-12-13 | 2021-02-24 | Cytec Tech Corp | Aditivos de procesamiento y usos de los mismos en moldeo rotacional |
| US11267951B2 (en) | 2010-12-13 | 2022-03-08 | Cytec Technology Corp. | Stabilizer compositions containing substituted chroman compounds and methods of use |
| EP2578606B2 (en) * | 2011-10-04 | 2019-08-28 | Borealis AG | Process for the production of polyolefins wherein an antioxidant is fed to the reaction mixture during the process |
| UA119740C2 (uk) * | 2012-06-13 | 2019-08-12 | Сайтек Текнолоджи Корп. | Композиції стабілізатора, що містять заміщені хроманові сполуки, і способи застосування |
| DE102013100529A1 (de) * | 2013-01-18 | 2014-07-24 | Bredent Gmbh & Co. Kg | Verankerungselement und Verfahren zur Herstellung |
| WO2015050851A1 (en) | 2013-10-01 | 2015-04-09 | Zimmer, Inc. | Polymer compositions comprising one or more protected antioxidants |
| EP3058017A4 (en) | 2013-10-17 | 2017-10-04 | The General Hospital Corporation | Peroxide cross-linking and high temperature melting |
| WO2015095790A1 (en) * | 2013-12-20 | 2015-06-25 | The Brigham And Women's Hospital, Inc. | Ductile crosslinked polymers and methods of making the same |
| EP3116941A1 (en) | 2014-03-12 | 2017-01-18 | Zimmer, Inc. | Melt-stabilized ultra high molecular weight polyethylene and method of making the same |
| US20150266210A1 (en) * | 2014-03-21 | 2015-09-24 | Howmedica Osteonics Corp. | Annealing method for cross-linked polyethylene |
| CN107207741B (zh) * | 2014-12-03 | 2021-05-11 | 捷迈有限公司 | 注入抗氧剂的超高分子量聚乙烯 |
| US20160280863A1 (en) * | 2015-03-25 | 2016-09-29 | Zimmer, Inc. | Melt-stabilized ultra high molecular weight antioxidant |
| CN105173970B (zh) * | 2015-09-29 | 2017-11-28 | 上海化工研究院有限公司 | 一种超高分子量聚乙烯电梯滑动导靴靴衬及其制备方法 |
| WO2018098376A1 (en) | 2016-11-22 | 2018-05-31 | Elektrofi, Inc. | Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof |
| JP2018131533A (ja) * | 2017-02-15 | 2018-08-23 | オリンパス株式会社 | 医療機器用塗料および医療機器 |
| JP6340448B1 (ja) * | 2017-03-21 | 2018-06-06 | 旭化成株式会社 | ポリエチレン系重合体パウダー及びその製造方法 |
| WO2019023392A1 (en) * | 2017-07-25 | 2019-01-31 | Elektrofi, Inc. | FORMATION OF PARTICLES COMPRISING AGENTS |
| WO2019046243A2 (en) | 2017-08-29 | 2019-03-07 | The General Hospital Corporation | UV-INITIATED REACTIONS IN POLYMERIC MATERIALS |
| CN108411495B (zh) * | 2018-02-07 | 2020-08-11 | 清华大学 | 骨诱导膜及其制备方法 |
| JP7131931B2 (ja) * | 2018-03-15 | 2022-09-06 | 三井化学株式会社 | オレフィン重合体の製造方法 |
| CN113365609A (zh) | 2019-01-31 | 2021-09-07 | 伊勒卓菲公司 | 颗粒形成和形态 |
| WO2021050953A1 (en) | 2019-09-13 | 2021-03-18 | Elektrofi, Inc. | Compositions and methods for the delivery of therapeutic biologics for treatment of disease |
| DE102021103016A1 (de) * | 2021-02-09 | 2022-08-11 | Aesculap Ag | Verfahren zur Herstellung eines Gleitflächenelements, Gleitflächenelement und Kniegelenkendoprothese |
| US11970600B2 (en) | 2021-03-31 | 2024-04-30 | The General Hospital Corporation | Di-cumyl peroxide crosslinking of UHMWPE |
| CN114437381B (zh) * | 2022-02-21 | 2024-04-26 | 中国科学院上海应用物理研究所 | 一种改性交联聚乙烯及其制备方法和应用、成型的聚乙烯 |
Family Cites Families (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS221403B1 (cs) | 1981-12-23 | 1983-04-29 | Bretislav Dolezel | Způsob zdravotně nezávadné stabilizace polyolefinů proti termooxidační a fotooxidační degradaci |
| CS221405B1 (cs) | 1981-12-23 | 1983-04-29 | Ludmila Adamirova | Způsob zdravotně nezávadné stabilizace polyolefinů proti degradaci ionizujícím zářením |
| EP0371059A1 (en) | 1986-01-14 | 1990-06-06 | Raychem Corporation | Conductive polymer composition |
| US5308549A (en) | 1991-11-12 | 1994-05-03 | Hoffmann-La Roche Inc. | Stabilizers for thermo plastic materials |
| US5282861A (en) | 1992-03-11 | 1994-02-01 | Ultramet | Open cell tantalum structures for cancellous bone implants and cell and tissue receptors |
| US5414049A (en) * | 1993-06-01 | 1995-05-09 | Howmedica Inc. | Non-oxidizing polymeric medical implant |
| US5559167A (en) | 1993-07-22 | 1996-09-24 | General Electric Company | Gamma irradiated thermoplastics and articles |
| WO1995006148A1 (en) | 1993-08-20 | 1995-03-02 | Smith & Nephew Richards, Inc. | Self-reinforced ultra-high molecular weight polyethylene composites |
| DE69423661T2 (de) | 1993-12-28 | 2000-11-23 | Dainippon Printing Co Ltd | Thermische Übertragungsaufzeichnungsschicht, die einen bestimmten Farbstoff verwendet |
| TW317568B (ja) | 1994-04-13 | 1997-10-11 | Ciba Sc Holding Ag | |
| WO1998001085A1 (en) | 1996-07-09 | 1998-01-15 | The Orthopaedic Hospital | Crosslinking of polyethylene for low wear using radiation and thermal treatments |
| US20050125074A1 (en) * | 1995-01-20 | 2005-06-09 | Ronald Salovey | Crosslinking of polyethylene for low wear using radiation and thermal treatments |
| CA2166450C (en) * | 1995-01-20 | 2008-03-25 | Ronald Salovey | Chemically crosslinked ultrahigh molecular weight polyethylene for artificial human joints |
| US5879398A (en) | 1995-02-14 | 1999-03-09 | Zimmer, Inc. | Acetabular cup |
| US5577368A (en) * | 1995-04-03 | 1996-11-26 | Johnson & Johnson Professional, Inc. | Method for improving wear resistance of polymeric bioimplantable components |
| US6087559A (en) | 1995-06-07 | 2000-07-11 | Pioneer Hi-Bred International, Inc. | Plant cells and plants transformed with Streptococcus mutans genes encoding wild-type or mutant glucosyltransferase B enzymes |
| JP3176932B2 (ja) * | 1995-10-18 | 2001-06-18 | チッソ株式会社 | オレフィン（共）重合体組成物とその製造方法及びオレフィン（共）重合用触媒とその製造方法 |
| WO1997020869A1 (fr) * | 1995-12-01 | 1997-06-12 | Chisso Corporation | Articles en resine moulee |
| US8563623B2 (en) * | 1996-02-13 | 2013-10-22 | The General Hospital Corporation | Radiation melt treated ultra high molecular weight polyethylene prosthetic devices |
| US5879400A (en) * | 1996-02-13 | 1999-03-09 | Massachusetts Institute Of Technology | Melt-irradiated ultra high molecular weight polyethylene prosthetic devices |
| PL189272B1 (pl) | 1996-02-13 | 2005-07-29 | Gen Hospital Corp | Proteza medyczna do stosowania wewnątrz ciała, zastosowanie poddanego działaniu promieniowania polietylenu o ultrawysokim ciężarze cząsteczkowym, sposób jego otrzymywania, oraz sposób wytwarzania protezy medycznej |
| US20020156536A1 (en) * | 1996-02-13 | 2002-10-24 | Harris William H. | Polyethylene hip joint prosthesis with extended range of motion |
| US8865788B2 (en) * | 1996-02-13 | 2014-10-21 | The General Hospital Corporation | Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices |
| US5753182A (en) * | 1996-02-14 | 1998-05-19 | Biomet, Inc. | Method for reducing the number of free radicals present in ultrahigh molecular weight polyethylene orthopedic components |
| US5721334A (en) | 1996-02-16 | 1998-02-24 | Newyork Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Process for producing ultra-high molecular weight low modulus polyethylene shaped articles via controlled pressure and temperature and compositions and articles produced therefrom |
| US6087553A (en) | 1996-02-26 | 2000-07-11 | Implex Corporation | Implantable metallic open-celled lattice/polyethylene composite material and devices |
| US6228900B1 (en) * | 1996-07-09 | 2001-05-08 | The Orthopaedic Hospital And University Of Southern California | Crosslinking of polyethylene for low wear using radiation and thermal treatments |
| US5827904A (en) * | 1996-09-27 | 1998-10-27 | Hahn; David | Medical implant composition |
| US6017975A (en) | 1996-10-02 | 2000-01-25 | Saum; Kenneth Ashley | Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance |
| US6231804B1 (en) * | 1997-04-02 | 2001-05-15 | Chisso Corporation | Modified olefin (co)polymer composition, process for preparing the same, and modified olefin (co)polymer composition molding |
| JP4315261B2 (ja) | 1998-02-25 | 2009-08-19 | ナカシマメディカル株式会社 | 人工関節用摺動部材および製造方法 |
| US6692679B1 (en) * | 1998-06-10 | 2004-02-17 | Depuy Orthopaedics, Inc. | Cross-linked molded plastic bearings |
| BR9911873A (pt) | 1998-07-06 | 2001-03-27 | Eastman Chem Co | Processo para produzir fitol, um derivado de fiteno, isofitol, um derivado de isofiteno, ou uma mistura dos mesmos, composto de epoxifitila substituìdo, composto de fiteno substituìdo, processo para produzir o mesmo, processo para produzir alfa-tocoferol, e, processo para coverter geranilgeraniol a alfa-tocoferol |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| EP0995449A1 (de) * | 1998-10-21 | 2000-04-26 | Sulzer Orthopädie AG | UHMW-Polyethylen für Implantate |
| SE9900519D0 (sv) | 1999-02-17 | 1999-02-17 | Lars Lidgren | A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof |
| WO2000072893A2 (en) * | 1999-05-27 | 2000-12-07 | Monsanto Company | Biomaterials modified with superoxide dismutase mimics |
| US6245276B1 (en) * | 1999-06-08 | 2001-06-12 | Depuy Orthopaedics, Inc. | Method for molding a cross-linked preform |
| US6627141B2 (en) * | 1999-06-08 | 2003-09-30 | Depuy Orthopaedics, Inc. | Method for molding a cross-linked preform |
| US6432349B1 (en) * | 1999-06-29 | 2002-08-13 | Zimmer, Inc. | Process of making an articulating bearing surface |
| US6184265B1 (en) * | 1999-07-29 | 2001-02-06 | Depuy Orthopaedics, Inc. | Low temperature pressure stabilization of implant component |
| US6365089B1 (en) | 1999-09-24 | 2002-04-02 | Zimmer, Inc. | Method for crosslinking UHMWPE in an orthopaedic implant |
| US6620198B2 (en) * | 1999-10-07 | 2003-09-16 | Exactech, Inc. | Composite bearing inserts for total knee joints |
| US6664317B2 (en) * | 2000-02-18 | 2003-12-16 | Ciba Specialty Chemicals Corporation | Stabilized gamma irradiated polyolefins |
| US6391390B1 (en) | 2000-03-22 | 2002-05-21 | Basf Corporation | Curable coating composition with improved durability |
| EP1276436B1 (en) * | 2000-04-27 | 2008-12-31 | Orthopaedic Hospital | Oxidation-resistant and wear-resistant polyethylenes for human joint replacements and methods for making them |
| US6503439B1 (en) * | 2000-06-15 | 2003-01-07 | Albert H. Burstein | Process for forming shaped articles of ultra high molecular weight polyethylene suitable for use as a prosthetic device or a component thereof |
| US6558794B1 (en) * | 2000-06-26 | 2003-05-06 | Technology Assessment & Transfer, Inc. | Ceramic particulate reinforced orthopedic implants |
| AU2001287574A1 (en) | 2000-06-30 | 2002-01-08 | Ingenium Pharmaceuticals Ag | Human g protein-coupled receptor igpcr20, and uses thereof |
| US6818172B2 (en) * | 2000-09-29 | 2004-11-16 | Depuy Products, Inc. | Oriented, cross-linked UHMWPE molding for orthopaedic applications |
| WO2002048259A2 (en) * | 2000-12-12 | 2002-06-20 | Massachusetts General Hospital | Selective, controlled manipulation of polymers |
| US6547828B2 (en) * | 2001-02-23 | 2003-04-15 | Smith & Nephew, Inc. | Cross-linked ultra-high molecular weight polyethylene for medical implant use |
| CN1558927A (zh) * | 2001-09-25 | 2004-12-29 | ����ɭ���ڻ�ѧר����˾ | 增塑聚氯乙烯 |
| US8524884B2 (en) * | 2001-10-30 | 2013-09-03 | Colorado State University Research Foundation | Outer layer material having entanglement of hydrophobic polymer hostblended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest |
| WO2003049930A1 (en) | 2001-12-12 | 2003-06-19 | Depuy Products, Inc. | Orthopaedic device and method for making same |
| WO2003059200A1 (en) * | 2002-01-04 | 2003-07-24 | Massachusetts General Hospital | A high modulus crosslinked polyethylene with reduced residual free radical concentration prepared below the melt |
| US7595074B2 (en) | 2002-04-05 | 2009-09-29 | University Of Massachusetts Lowell | Polymeric antioxidants |
| AU2003262390A1 (en) * | 2002-04-19 | 2003-11-03 | Gammatron (Pty) Ltd | Method of increasing the hydrostatic stress strength of a polymer |
| US20050146070A1 (en) * | 2002-06-21 | 2005-07-07 | Massachusetts General Hospital | Meta lback or mesh crosslinking |
| WO2004009690A2 (en) * | 2002-07-18 | 2004-01-29 | Exxonmobil Chemical Patents Inc. | Ultraviolet radiation stabilized polyolefins |
| US8337968B2 (en) | 2002-09-11 | 2012-12-25 | Boston Scientific Scimed, Inc. | Radiation sterilized medical devices comprising radiation sensitive polymers |
| US6976999B2 (en) | 2002-11-19 | 2005-12-20 | Zimmer Technology, Inc. | Prosthetic device and method of making the same |
| US7431874B2 (en) * | 2003-01-16 | 2008-10-07 | Massachusetts General Hospital | Methods for making oxidation resistant polymeric material |
| US6933026B2 (en) * | 2003-02-06 | 2005-08-23 | Aradgim Corporation | Method to reduce damage caused by irradiation of halogenated polymers |
| US6853772B2 (en) * | 2003-05-13 | 2005-02-08 | 3M Innovative Properties Company | Fiber grating writing interferometer with continuous wavelength tuning and chirp capability |
| AT412969B (de) * | 2003-05-19 | 2005-09-26 | Klaus Dr Lederer | Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe) |
| US7214764B2 (en) * | 2003-06-30 | 2007-05-08 | Depuy Products, Inc. | Free radical quench process for irradiated ultrahigh molecular weight polyethylene |
| US20040265165A1 (en) | 2003-06-30 | 2004-12-30 | Depuy Products, Inc. | Free radical quench process for irradiated ultrahigh molecular weight polyethylene |
| JP2005054145A (ja) | 2003-08-07 | 2005-03-03 | Mitsubishi Gas Chem Co Inc | ガスバリア性（メタ）アクリレート樹脂硬化物および塗料、接着剤、フィルム |
| US7205051B2 (en) * | 2003-09-30 | 2007-04-17 | Depuy Products, Inc. | Medical implant or medical implant part |
| US7034097B2 (en) * | 2004-01-13 | 2006-04-25 | Lexmark International, Inc. | Polyurethane elastomers with combination of curatives |
| JP4813377B2 (ja) * | 2004-02-03 | 2011-11-09 | ザ・ジェネラル・ホスピタル・コーポレイション | 耐酸化性の高結晶性架橋ポリエチレン |
| JP5248107B2 (ja) * | 2004-05-11 | 2013-07-31 | ザ、ジェネラル、ホスピタル、コーポレイション | 耐酸化性重合体状材料の製造方法 |
| US7384430B2 (en) * | 2004-06-30 | 2008-06-10 | Depuy Products, Inc. | Low crystalline polymeric material for orthopaedic implants and an associated method |
| US7344672B2 (en) * | 2004-10-07 | 2008-03-18 | Biomet Manufacturing Corp. | Solid state deformation processing of crosslinked high molecular weight polymeric materials |
| GB0422666D0 (en) | 2004-10-12 | 2004-11-10 | Benoist Girard Sas | Prosthetic acetabular cups |
| US7235592B2 (en) * | 2004-10-12 | 2007-06-26 | Zimmer Gmbh | PVA hydrogel |
| US7335697B2 (en) * | 2004-12-23 | 2008-02-26 | Depuy Products, Inc. | Polymer composition comprising cross-linked polyethylene and methods for making the same |
| US7435372B2 (en) * | 2005-03-31 | 2008-10-14 | Zimmer, Inc. | Liquid bath annealing of polymers for orthopaedic implants |
| US20080274161A1 (en) * | 2005-05-18 | 2008-11-06 | Muratoglu Orhun K | Hydrogels and hydrogel particles |
| AU2012203503B2 (en) | 2005-08-18 | 2014-01-30 | Zimmer Gmbh | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| EP1924299B1 (en) | 2005-08-18 | 2009-11-25 | Zimmer GmbH | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
| US8461225B2 (en) * | 2005-08-22 | 2013-06-11 | The General Hospital Corporation | Oxidation resistant homogenized polymeric material |
| EP2016118A4 (en) * | 2005-08-22 | 2009-05-06 | Gen Hospital Corp | HIGH-NETWORK AND WEAR-RESISTANT POLYETHYLENE MANUFACTURED UNDER THE MELT |
| CA2619937C (en) * | 2005-08-22 | 2014-10-14 | Orhun K. Muratoglu | Highly crystalline polyethylene |
| US20070077268A1 (en) * | 2005-09-30 | 2007-04-05 | Depuy Products, Inc. | Hydrophobic carrier modified implants for beneficial agent delivery |
| WO2007050991A1 (en) * | 2005-10-27 | 2007-05-03 | Polnox Corporation | Stabilized polyolefin compositions |
| US7705176B2 (en) | 2005-10-27 | 2010-04-27 | Polnox Corporation | Macromolecular antioxidants based on sterically hindered phenols and phosphites |
| US7615075B2 (en) * | 2005-11-04 | 2009-11-10 | Rush University Medical Center | Plastic implant impregnated with a degradation protector |
| WO2007056561A2 (en) | 2005-11-09 | 2007-05-18 | Liquidia Technologies, Inc. | Medical device, materials, and methods |
| US7635725B2 (en) | 2006-02-21 | 2009-12-22 | The Brigham And Women's Hospital, Inc. | Crosslinked polymers |
| US20070232762A1 (en) * | 2006-03-31 | 2007-10-04 | Depuy Products, Inc. | Bearing material of medical implant having reduced wear rate and method for reducing wear rate |
| US20070239283A1 (en) | 2006-04-11 | 2007-10-11 | Berger Richard A | Acetabular cup conversion ring |
| AU2007267550A1 (en) * | 2006-05-25 | 2007-12-06 | The General Hospital Corporation | Anti-cross-linking agents and methods for inhibiting cross-linking of injectable hydrogel formulations |
| ITMI20061375A1 (it) * | 2006-07-14 | 2008-01-15 | Fabio Conteduca | Maeriale protesico sintetico a ridotta ossidabilita' e relativo processo di preparazione |
| JP4902455B2 (ja) | 2006-08-01 | 2012-03-21 | 東レ東燃機能膜合同会社 | ポリオレフィン多層微多孔膜、その製造方法、電池用セパレータ及び電池 |
| DK1891987T3 (da) | 2006-08-25 | 2010-12-13 | Depuy Products Inc | Bæremateriale for medicinsk implantat |
| US8871131B2 (en) | 2006-10-30 | 2014-10-28 | Smith And Nephew Orthopaedics Ag | Processes comprising crosslinking polyethylene or using crosslinked polyethylene |
| US7966043B2 (en) | 2006-12-09 | 2011-06-21 | Cisco Technology, Inc. | Method for creating multiple-input-multiple-output channel with beamforming using signals transmitted from single transmit antenna |
| EP2456283B1 (en) | 2007-01-25 | 2015-12-16 | The General Hospital Corporation | Methods for making oxidation-resistant cross-linked polymeric materials |
| US20100190920A1 (en) | 2007-02-14 | 2010-07-29 | Anuj Bellare | Crosslinked polymers and methods of making the same |
| WO2008109515A1 (en) * | 2007-03-02 | 2008-09-12 | The General Hospital Corporation | Cross-linking of antioxidant-containing polymers |
| US20100144930A1 (en) * | 2007-03-20 | 2010-06-10 | Smith & Nephew Orthopaedics Ag | Oxidation resistant highly-crosslinked uhmwpe |
| EP2578248B1 (en) | 2007-04-10 | 2021-05-19 | Zimmer, Inc. | An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US8664290B2 (en) | 2007-04-10 | 2014-03-04 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
| US8641959B2 (en) * | 2007-07-27 | 2014-02-04 | Biomet Manufacturing, Llc | Antioxidant doping of crosslinked polymers to form non-eluting bearing components |
| CA2698258C (en) | 2007-09-04 | 2016-05-17 | Smith & Nephew Orthopaedics Ag | Ultra high molecular weight polyethylene for bearing surfaces |
| WO2009045658A1 (en) | 2007-10-05 | 2009-04-09 | The Brigham And Women's Hospital, Inc. | Crosslinked polymers and methods of making the same |
| CN101848968B (zh) | 2007-11-06 | 2013-04-17 | 帝斯曼知识产权资产管理有限公司 | 用于生产高分子量聚乙烯的方法 |
| JP5571580B2 (ja) * | 2008-01-30 | 2014-08-13 | ジンマー，インコーポレイティド | 低剛性の整形外科部品 |
| US7806064B2 (en) | 2008-03-12 | 2010-10-05 | Wellman John G | Friction reducing pollution control system for marine vehicles |
| GB0812890D0 (en) | 2008-07-11 | 2008-08-20 | Smith & Nephew Orthopaedics Ag | Compositions and methods of making compositions |
| CN102307945B (zh) * | 2008-11-20 | 2015-07-01 | 捷迈有限责任公司 | 聚乙烯材料 |
| EP2427225B8 (en) | 2009-05-04 | 2017-03-22 | Smith & Nephew, Inc | Synergistic effects of blending multiple additives in uhmwpe |
| US20120070600A1 (en) | 2009-05-20 | 2012-03-22 | Muratoglu Orhun K | Metods of preventing oxidation |
| US8399535B2 (en) | 2010-06-10 | 2013-03-19 | Zimmer, Inc. | Polymer [[s]] compositions including an antioxidant |
| US9370602B2 (en) | 2010-12-06 | 2016-06-21 | Zimmer, Inc. | Crosslinked polymers including one or more antioxidants, methods for making same and methods for selecting antioxidants |
| JP5735443B2 (ja) | 2012-03-06 | 2015-06-17 | ジンマー ゲーエムベーハー | 超高分子量ポリエチレン物品および超高分子量ポリエチレン物品を形成する方法 |
| EP3116941A1 (en) | 2014-03-12 | 2017-01-18 | Zimmer, Inc. | Melt-stabilized ultra high molecular weight polyethylene and method of making the same |
| CN107207741B (zh) | 2014-12-03 | 2021-05-11 | 捷迈有限公司 | 注入抗氧剂的超高分子量聚乙烯 |
| JP5969637B2 (ja) | 2015-01-30 | 2016-08-17 | ジンマー ゲーエムベーハー | 超高分子量ポリエチレン物品および超高分子量ポリエチレン物品を形成する方法 |
-
2008
- 2008-04-10 EP EP12167581.3A patent/EP2578248B1/en active Active
- 2008-04-10 JP JP2010503206A patent/JP2010523805A/ja active Pending
- 2008-04-10 ES ES08745507T patent/ES2378721T3/es active Active
- 2008-04-10 EP EP12154330.0A patent/EP2486948B1/en active Active
- 2008-04-10 AT AT08745507T patent/ATE544476T1/de active
- 2008-04-10 US US12/100,894 patent/US20080319137A1/en not_active Abandoned
- 2008-04-10 WO PCT/US2008/059909 patent/WO2008124825A2/en active Application Filing
- 2008-04-10 CA CA2678459A patent/CA2678459C/en active Active
- 2008-04-10 EP EP12167580.5A patent/EP2564882B1/en active Active
- 2008-04-10 ES ES12154330.0T patent/ES2662102T3/es active Active
- 2008-04-10 AU AU2008236996A patent/AU2008236996B2/en active Active
- 2008-04-10 EP EP08745507A patent/EP2150285B1/en active Active
-
2009
- 2009-10-14 US US12/579,094 patent/US8129440B2/en active Active
-
2010
- 2010-12-14 US US12/967,581 patent/US8178594B2/en active Active
-
2012
- 2012-02-23 US US13/403,040 patent/US8669299B2/en active Active
-
2014
- 2014-01-17 US US14/157,708 patent/US9265545B2/en active Active
-
2015
- 2015-12-29 US US14/983,006 patent/US9926432B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010523805A5 (ja) | ||
| CA2739065C (en) | Surface crosslinked polyethylene | |
| JP5452920B2 (ja) | 高結晶性ポリエチレン | |
| JP5535650B2 (ja) | 耐酸化性架橋重合体状材料の製造方法 | |
| US9889224B2 (en) | Spatial control of additives by high temperature | |
| US10981302B2 (en) | Peroxide cross-linking and high temperature melting | |
| JP2009504899A (ja) | 耐酸化性の均質化した重合体状材料 | |
| JP2010516517A5 (ja) | ||
| Llorens et al. | Polylactide nanofibers loaded with vitamin B 6 and polyphenols as bioactive platform for tissue engineering | |
| JP2010529213A (ja) | 酸化防止剤含有ポリマーの架橋 | |
| Szustakiewicz et al. | Femtosecond laser-induced modification of PLLA/hydroxyapatite composite | |
| AU2017200223A1 (en) | Peroxide cross-linking of polymeric materials in the presence of antioxidants | |
| US20190218355A1 (en) | Method for producing a cross-linked moulded body from uhmwpe | |
| Larrañaga et al. | Improvement of thermal stability and mechanical properties of medical polyester composites by plasma surface modification of the bioactive glass particles | |
| CN111494724A (zh) | 复合可吸收界面螺钉及其制备方法 | |
| JP6016282B2 (ja) | 溶融加工のための生体再吸収性ポリマーの水分の制御及び可塑化 | |
| KR20180078429A (ko) | 농업 부산물을 이용한 바이오필라멘트 제조 방법 및 그 방법에 의하여 제조된 필라멘트 | |
| Verano-Naranjo et al. | Effect of 3D-printing conditions of polylactic acid filaments impregnated by supercritical fluids with a natural extract | |
| JP2001079081A (ja) | プロテーゼ部品および製造方法 | |
| Fernandes et al. | Development of 70/30 Poly-l-dl-Lactic Acid Filaments for 3D Printers (Part 1): Filament Manufacturing and Characterization of Printed Samples for Use as Bioabsorbable Products | |
| Neimash et al. | Physical properties of radiation-crosslinked polyvinyl alcohol–polyethylene glycol hydrogels from the viewpoint of their application as medical dressings | |
| Dunaev et al. | Phase transitions and structural formation of PEG-PCL-PEG copolymer in the processes of fused deposition 3D printing | |
| Yingsukwattana et al. | Development of a Protein-Filled Conduit for Peripheral Nerve Regeneration | |
| Strange | An Investigation into the Effects of Sterilisation on Poly (caprolactone) for In Vitro and In Vivo Medical Use |