JP2010523726A5 - - Google Patents
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- Publication number
- JP2010523726A5 JP2010523726A5 JP2010503393A JP2010503393A JP2010523726A5 JP 2010523726 A5 JP2010523726 A5 JP 2010523726A5 JP 2010503393 A JP2010503393 A JP 2010503393A JP 2010503393 A JP2010503393 A JP 2010503393A JP 2010523726 A5 JP2010523726 A5 JP 2010523726A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- disease
- drug
- treatment
- addiction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000011117 substance-related disease Diseases 0.000 claims description 26
- 208000007848 Alcoholism Diseases 0.000 claims description 17
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 15
- 206010013663 drug dependence Diseases 0.000 claims description 14
- 206010061218 Inflammation Diseases 0.000 claims description 13
- 230000004054 inflammatory process Effects 0.000 claims description 13
- 206010013654 Drug abuse Diseases 0.000 claims description 12
- 206010020853 Hypertonic bladder Diseases 0.000 claims description 12
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 208000020629 overactive bladder Diseases 0.000 claims description 12
- 201000010099 disease Diseases 0.000 claims description 11
- 201000007930 alcohol dependence Diseases 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 208000018526 Narcotic-Related disease Diseases 0.000 claims description 8
- 108010025083 TRPV1 receptor Proteins 0.000 claims description 8
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims description 8
- 201000005040 opiate dependence Diseases 0.000 claims description 8
- 230000002265 prevention Effects 0.000 claims description 8
- 208000017520 skin disease Diseases 0.000 claims description 8
- 208000024827 Alzheimer disease Diseases 0.000 claims description 7
- 208000010877 cognitive disease Diseases 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 7
- 206010059866 Drug resistance Diseases 0.000 claims description 6
- 208000023105 Huntington disease Diseases 0.000 claims description 6
- 206010046543 Urinary incontinence Diseases 0.000 claims description 6
- 206010001584 alcohol abuse Diseases 0.000 claims description 6
- 208000025746 alcohol use disease Diseases 0.000 claims description 6
- 210000001508 eye Anatomy 0.000 claims description 6
- 210000000936 intestine Anatomy 0.000 claims description 6
- 206010027175 memory impairment Diseases 0.000 claims description 6
- 201000006417 multiple sclerosis Diseases 0.000 claims description 6
- 210000002850 nasal mucosa Anatomy 0.000 claims description 6
- 229940005483 opioid analgesics Drugs 0.000 claims description 6
- 210000003491 skin Anatomy 0.000 claims description 6
- 210000003932 urinary bladder Anatomy 0.000 claims description 6
- 208000018737 Parkinson disease Diseases 0.000 claims description 5
- 208000027418 Wounds and injury Diseases 0.000 claims description 5
- 230000007278 cognition impairment Effects 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- RLWGDRLXZSLGHV-UHFFFAOYSA-N 1-[[4-(2-aminoethoxy)-3-methoxyphenyl]methyl]-3-[(4-tert-butylphenyl)methyl]urea Chemical compound C1=C(OCCN)C(OC)=CC(CNC(=O)NCC=2C=CC(=CC=2)C(C)(C)C)=C1 RLWGDRLXZSLGHV-UHFFFAOYSA-N 0.000 claims description 4
- 208000032841 Bulimia Diseases 0.000 claims description 4
- 206010006550 Bulimia nervosa Diseases 0.000 claims description 4
- 206010006895 Cachexia Diseases 0.000 claims description 4
- 206010011224 Cough Diseases 0.000 claims description 4
- 206010012735 Diarrhoea Diseases 0.000 claims description 4
- 208000030814 Eating disease Diseases 0.000 claims description 4
- 208000019454 Feeding and Eating disease Diseases 0.000 claims description 4
- 208000009889 Herpes Simplex Diseases 0.000 claims description 4
- 206010035664 Pneumonia Diseases 0.000 claims description 4
- 208000004880 Polyuria Diseases 0.000 claims description 4
- 208000003251 Pruritus Diseases 0.000 claims description 4
- 201000004681 Psoriasis Diseases 0.000 claims description 4
- 208000025747 Rheumatic disease Diseases 0.000 claims description 4
- 208000007107 Stomach Ulcer Diseases 0.000 claims description 4
- 102100029613 Transient receptor potential cation channel subfamily V member 1 Human genes 0.000 claims description 4
- 108050004388 Transient receptor potential cation channel subfamily V member 1 Proteins 0.000 claims description 4
- 206010047642 Vitiligo Diseases 0.000 claims description 4
- 206010052428 Wound Diseases 0.000 claims description 4
- 239000000556 agonist Substances 0.000 claims description 4
- 230000000172 allergic effect Effects 0.000 claims description 4
- 208000022531 anorexia Diseases 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 4
- 208000010668 atopic eczema Diseases 0.000 claims description 4
- 229960002504 capsaicin Drugs 0.000 claims description 4
- 235000017663 capsaicin Nutrition 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 4
- 206010061428 decreased appetite Diseases 0.000 claims description 4
- 235000014632 disordered eating Nutrition 0.000 claims description 4
- 230000035619 diuresis Effects 0.000 claims description 4
- 208000000718 duodenal ulcer Diseases 0.000 claims description 4
- 206010015037 epilepsy Diseases 0.000 claims description 4
- 230000029142 excretion Effects 0.000 claims description 4
- 201000005917 gastric ulcer Diseases 0.000 claims description 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
- 230000037023 motor activity Effects 0.000 claims description 4
- 210000005036 nerve Anatomy 0.000 claims description 4
- 230000004770 neurodegeneration Effects 0.000 claims description 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 4
- 230000000926 neurological effect Effects 0.000 claims description 4
- 208000023504 respiratory system disease Diseases 0.000 claims description 4
- 206010015946 Eye irritation Diseases 0.000 claims description 3
- 208000001132 Osteoporosis Diseases 0.000 claims description 3
- 208000031481 Pathologic Constriction Diseases 0.000 claims description 3
- 230000036626 alertness Effects 0.000 claims description 3
- 206010006451 bronchitis Diseases 0.000 claims description 3
- 210000000748 cardiovascular system Anatomy 0.000 claims description 3
- 230000001054 cortical effect Effects 0.000 claims description 3
- 231100000013 eye irritation Toxicity 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 3
- 230000007794 irritation Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 201000008482 osteoarthritis Diseases 0.000 claims description 3
- 230000036262 stenosis Effects 0.000 claims description 3
- 208000037804 stenosis Diseases 0.000 claims description 3
- 230000001629 suppression Effects 0.000 claims description 3
- 208000028698 Cognitive impairment Diseases 0.000 claims description 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 206010029333 Neurosis Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 238000002690 local anesthesia Methods 0.000 claims 2
- 208000015238 neurotic disease Diseases 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 206010006487 Bronchostenosis Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 description 11
- 208000004454 Hyperalgesia Diseases 0.000 description 4
- 208000019695 Migraine disease Diseases 0.000 description 4
- 206010027599 migraine Diseases 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 3
- 208000000094 Chronic Pain Diseases 0.000 description 3
- 208000005298 acute pain Diseases 0.000 description 3
- 208000004296 neuralgia Diseases 0.000 description 3
- 208000021722 neuropathic pain Diseases 0.000 description 3
- 208000009935 visceral pain Diseases 0.000 description 3
- 206010012335 Dependence Diseases 0.000 description 2
- IKYCZSUNGFRBJS-UHFFFAOYSA-N Euphorbia factor RL9 = U(1) = Resiniferatoxin Natural products COC1=CC(O)=CC(CC(=O)OCC=2CC3(O)C(=O)C(C)=CC3C34C(C)CC5(OC(O4)(CC=4C=CC=CC=4)OC5C3C=2)C(C)=C)=C1 IKYCZSUNGFRBJS-UHFFFAOYSA-N 0.000 description 2
- 208000035154 Hyperesthesia Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 206010020843 Hyperthermia Diseases 0.000 description 2
- 206010053552 allodynia Diseases 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 230000036031 hyperthermia Effects 0.000 description 2
- 239000003589 local anesthetic agent Substances 0.000 description 2
- DSDNAKHZNJAGHN-UHFFFAOYSA-N resinferatoxin Natural products C1=C(O)C(OC)=CC(CC(=O)OCC=2CC3(O)C(=O)C(C)=CC3C34C(C)CC5(OC(O4)(CC=4C=CC=CC=4)OC5C3C=2)C(C)=C)=C1 DSDNAKHZNJAGHN-UHFFFAOYSA-N 0.000 description 2
- DSDNAKHZNJAGHN-MXTYGGKSSA-N resiniferatoxin Chemical compound C1=C(O)C(OC)=CC(CC(=O)OCC=2C[C@]3(O)C(=O)C(C)=C[C@H]3[C@@]34[C@H](C)C[C@@]5(O[C@@](O4)(CC=4C=CC=CC=4)O[C@@H]5[C@@H]3C=2)C(C)=C)=C1 DSDNAKHZNJAGHN-MXTYGGKSSA-N 0.000 description 2
- 229940073454 resiniferatoxin Drugs 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 206010024421 Libido increased Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 208000029650 alcohol withdrawal Diseases 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 230000000949 anxiolytic effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000003920 cognitive function Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000004081 narcotic agent Substances 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007018151A DE102007018151A1 (de) | 2007-04-16 | 2007-04-16 | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| DE102007018151.7 | 2007-04-16 | ||
| PCT/EP2008/002994 WO2008125337A2 (de) | 2007-04-16 | 2008-04-15 | Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523726A JP2010523726A (ja) | 2010-07-15 |
| JP2010523726A5 true JP2010523726A5 (enExample) | 2013-12-12 |
| JP5557734B2 JP5557734B2 (ja) | 2014-07-23 |
Family
ID=39540731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503393A Expired - Fee Related JP5557734B2 (ja) | 2007-04-16 | 2008-04-15 | 新規バニロイド受容体リガンド及び医薬の製造におけるその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8642775B2 (enExample) |
| EP (1) | EP2146962A2 (enExample) |
| JP (1) | JP5557734B2 (enExample) |
| KR (1) | KR101497357B1 (enExample) |
| CN (1) | CN101687799B (enExample) |
| BR (1) | BRPI0810031A2 (enExample) |
| CA (1) | CA2683910A1 (enExample) |
| CO (1) | CO6220938A2 (enExample) |
| DE (1) | DE102007018151A1 (enExample) |
| EC (1) | ECSP099693A (enExample) |
| IL (1) | IL201506A0 (enExample) |
| MX (1) | MX2009011139A (enExample) |
| NZ (2) | NZ599254A (enExample) |
| RU (1) | RU2487120C2 (enExample) |
| WO (1) | WO2008125337A2 (enExample) |
| ZA (1) | ZA200907096B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090275515A1 (en) * | 2006-10-18 | 2009-11-05 | Yuntae Kim | 2-hydroxy-2-phenylthiophenylpropionamides as androgen receptor modulators |
| WO2008110351A2 (en) * | 2007-03-15 | 2008-09-18 | Dompe' Pha.R.Ma S.P.A. | Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents |
| DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| JP6130827B2 (ja) * | 2011-05-17 | 2017-05-17 | 塩野義製薬株式会社 | ヘテロ環化合物 |
| JP2013014534A (ja) * | 2011-07-04 | 2013-01-24 | Daicel Corp | ベンゾイルギ酸化合物、及びその製造方法 |
| BR112014001714A2 (pt) | 2011-07-26 | 2017-02-14 | Gruenenthal Gmbh | derivados de carboxamida e ureia aromáticos bicíclicos substituídos como ligantes de receptor vaniloide |
| WO2013013817A1 (en) | 2011-07-26 | 2013-01-31 | Grünenthal GmbH | Substituted heterocyclic aza derivatives |
| CN103889961A (zh) * | 2011-11-09 | 2014-06-25 | 格吕伦塔尔有限公司 | 作为辣椒素类似物受体配体的携带被含氧基团取代的苯基的被取代的基于吡唑基的甲酰胺及脲衍生物 |
| KR20140096351A (ko) * | 2011-11-09 | 2014-08-05 | 그뤼넨탈 게엠베하 | 바닐로이드 수용체 리간드로서의 ｎ함유 그룹으로 치환된 페닐 모이어티를 갖는 치환된 피라졸릴계 카복스아미드 및 우레아 유도체들 |
| WO2020017569A1 (ja) | 2018-07-17 | 2020-01-23 | 日本ケミファ株式会社 | Ｔ型カルシウムチャネル阻害剤 |
| AU2020250468A1 (en) | 2019-03-29 | 2021-11-04 | Kinki University | Use of T-type calcium channel blocker for treating pruritus |
| RU2755206C1 (ru) | 2020-05-20 | 2021-09-14 | Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) | Средство пролонгированного анальгетического действия и лекарственный препарат на его основе |
| CN115417809A (zh) * | 2022-09-05 | 2022-12-02 | 天津药明康德新药开发有限公司 | 一种4,4-二吡咯-2,2-联吡啶的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9919588D0 (en) * | 1999-08-18 | 1999-10-20 | Hoechst Schering Agrevo Gmbh | Fungicidal compounds |
| PT1204323E (pt) * | 1999-08-18 | 2004-11-30 | Aventis Cropscience Gmbh | Fungicidas |
| JP2004506714A (ja) * | 2000-08-21 | 2004-03-04 | パシフィック コーポレーション | 新規チオ尿素化合物及びこれを含有する薬学的組成物 |
| TWI239942B (en) | 2001-06-11 | 2005-09-21 | Dainippon Pharmaceutical Co | N-arylphenylacetamide derivative and pharmaceutical composition containing the same |
| US20030083345A1 (en) * | 2001-07-10 | 2003-05-01 | Torsten Hoffmann | Method of treatment and/or prevention of brain, spinal or nerve injury |
| FR2836917B1 (fr) | 2002-03-11 | 2006-02-24 | Lipha | Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif |
| JP2005527517A (ja) | 2002-03-14 | 2005-09-15 | ビーエーエスエフ アクチェンゲゼルシャフト | Ｚ置換アクリルアミド、それらの調製、およびそれらを含む組成物 |
| US7135493B2 (en) | 2003-01-13 | 2006-11-14 | Astellas Pharma Inc. | HDAC inhibitor |
| US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| EP1628661A2 (en) * | 2003-06-05 | 2006-03-01 | Vertex Pharmaceuticals Incorporated | Modulators of vr1 receptor |
| KR100707123B1 (ko) | 2003-07-02 | 2007-04-16 | 그뤼넨탈 게엠베하 | 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물 |
| WO2005080324A1 (en) * | 2004-01-22 | 2005-09-01 | Pfizer Limited | Sulfonamide derivatives for the treatment of diseases |
| US20050165015A1 (en) * | 2004-01-23 | 2005-07-28 | Ncube Mghele V. | Vanilloid receptor ligands and their use in treatments |
| EP1764095A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| WO2007045462A2 (de) * | 2005-10-19 | 2007-04-26 | Grünenthal GmbH | Neue vanilloid-rezeptor liganden und ihre verwendung zur herstellung von arzneimitteln |
| DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
-
2007
- 2007-04-16 DE DE102007018151A patent/DE102007018151A1/de not_active Withdrawn
-
2008
- 2008-04-15 MX MX2009011139A patent/MX2009011139A/es active IP Right Grant
- 2008-04-15 NZ NZ599254A patent/NZ599254A/xx not_active IP Right Cessation
- 2008-04-15 RU RU2009142024/04A patent/RU2487120C2/ru not_active IP Right Cessation
- 2008-04-15 JP JP2010503393A patent/JP5557734B2/ja not_active Expired - Fee Related
- 2008-04-15 KR KR1020097023888A patent/KR101497357B1/ko not_active Expired - Fee Related
- 2008-04-15 NZ NZ580381A patent/NZ580381A/en not_active IP Right Cessation
- 2008-04-15 US US12/103,198 patent/US8642775B2/en not_active Expired - Fee Related
- 2008-04-15 CA CA002683910A patent/CA2683910A1/en not_active Abandoned
- 2008-04-15 BR BRPI0810031-4A2A patent/BRPI0810031A2/pt not_active IP Right Cessation
- 2008-04-15 EP EP08735252A patent/EP2146962A2/de not_active Withdrawn
- 2008-04-15 WO PCT/EP2008/002994 patent/WO2008125337A2/de not_active Ceased
- 2008-04-15 CN CN200880020516.5A patent/CN101687799B/zh not_active Expired - Fee Related
-
2009
- 2009-10-12 ZA ZA2009/07096A patent/ZA200907096B/en unknown
- 2009-10-14 IL IL201506A patent/IL201506A0/en unknown
- 2009-10-16 CO CO09115659A patent/CO6220938A2/es active IP Right Grant
- 2009-10-16 EC EC2009009693A patent/ECSP099693A/es unknown
-
2011
- 2011-03-31 US US13/077,452 patent/US8791268B2/en not_active Expired - Fee Related
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