JP2010523700A - キナーゼインヒビターとして有用なアミノピリミジン - Google Patents

キナーゼインヒビターとして有用なアミノピリミジン Download PDF

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Publication number
JP2010523700A
JP2010523700A JP2010503221A JP2010503221A JP2010523700A JP 2010523700 A JP2010523700 A JP 2010523700A JP 2010503221 A JP2010503221 A JP 2010503221A JP 2010503221 A JP2010503221 A JP 2010503221A JP 2010523700 A JP2010523700 A JP 2010523700A
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JP
Japan
Prior art keywords
alkyl
compound
compound according
cancer
heteroatoms selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2010503221A
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English (en)
Japanese (ja)
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JP2010523700A5 (enExample
Inventor
ヘイリー ビンチ，
スティーブン ヤング，
クリストファー デイビス，
マイケル モーティモア，
ジュリアン ゴレック，
ジョン スタッドリー，
ダニエル ロビンソン，
ホアン−ミゲル ヒメネス，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2010523700A publication Critical patent/JP2010523700A/ja
Publication of JP2010523700A5 publication Critical patent/JP2010523700A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010503221A 2007-04-13 2008-04-11 キナーゼインヒビターとして有用なアミノピリミジン Pending JP2010523700A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92349507P 2007-04-13 2007-04-13
US94677607P 2007-06-28 2007-06-28
PCT/US2008/059975 WO2008128009A2 (en) 2007-04-13 2008-04-11 Aminopyrimidines useful as kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013191748A Division JP2013256532A (ja) 2007-04-13 2013-09-17 キナーゼインヒビターとして有用なアミノピリミジン

Publications (2)

Publication Number Publication Date
JP2010523700A true JP2010523700A (ja) 2010-07-15
JP2010523700A5 JP2010523700A5 (enExample) 2012-05-24

Family

ID=39764683

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010503221A Pending JP2010523700A (ja) 2007-04-13 2008-04-11 キナーゼインヒビターとして有用なアミノピリミジン
JP2013191748A Pending JP2013256532A (ja) 2007-04-13 2013-09-17 キナーゼインヒビターとして有用なアミノピリミジン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013191748A Pending JP2013256532A (ja) 2007-04-13 2013-09-17 キナーゼインヒビターとして有用なアミノピリミジン

Country Status (9)

Country Link
US (2) US8455507B2 (enExample)
EP (1) EP2146982A2 (enExample)
JP (2) JP2010523700A (enExample)
CN (1) CN101679386A (enExample)
AU (1) AU2008240313A1 (enExample)
CA (1) CA2683785A1 (enExample)
MX (1) MX2009011059A (enExample)
NZ (1) NZ580343A (enExample)
WO (1) WO2008128009A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ580343A (en) * 2007-04-13 2012-03-30 Vertex Pharma Aminopyrimidines useful as kinase inhibitors
JP2012521425A (ja) * 2009-03-23 2012-09-13 Ｍｓｄ株式会社 オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
EP2411011A4 (en) * 2009-03-24 2012-08-15 Msd Kk NEW AMINO-PYRIDINE DERIVATIVES WITH SELECTIVE AURORA A INHIBITION
SMT201800608T1 (it) 2012-04-24 2019-01-11 Vertex Pharma Inibitori di dna-pk
UA112897C2 (uk) 2012-05-09 2016-11-10 Байєр Фарма Акцієнгезелльшафт Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань
AU2014244555B2 (en) 2013-03-12 2018-06-28 Vertex Pharmaceuticals Incorporated DNA-PK inhibitors
HUE041877T2 (hu) 2013-10-17 2019-06-28 Vertex Pharma (S)-N-Metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propán-2-il)kinolin-4-karboxamid kokristályai és deuterált származékai DNS-PK inhibitorokként
US10752612B2 (en) 2015-04-17 2020-08-25 Ludwig Institute For Cancer Research Ltd PLK4 inhibitors
WO2017207340A1 (de) 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Neue substituierte benzimidazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
US11110108B2 (en) 2016-09-27 2021-09-07 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors
KR20200090198A (ko) * 2017-11-23 2020-07-28 바이오메드 엑스 게엠베하 트로포미오신 수용체 키나제 A(TrkA) 저해제로서의 피리미딘 유도체

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Also Published As

Publication number Publication date
JP2013256532A (ja) 2013-12-26
US20130324725A1 (en) 2013-12-05
NZ580343A (en) 2012-03-30
MX2009011059A (es) 2009-11-26
AU2008240313A1 (en) 2008-10-23
EP2146982A2 (en) 2010-01-27
US20120095014A1 (en) 2012-04-19
WO2008128009A3 (en) 2009-01-08
CN101679386A (zh) 2010-03-24
WO2008128009A2 (en) 2008-10-23
US8455507B2 (en) 2013-06-04
CA2683785A1 (en) 2008-10-23

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