JP2010521983A5 - - Google Patents
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- Publication number
- JP2010521983A5 JP2010521983A5 JP2010500347A JP2010500347A JP2010521983A5 JP 2010521983 A5 JP2010521983 A5 JP 2010521983A5 JP 2010500347 A JP2010500347 A JP 2010500347A JP 2010500347 A JP2010500347 A JP 2010500347A JP 2010521983 A5 JP2010521983 A5 JP 2010521983A5
- Authority
- JP
- Japan
- Prior art keywords
- gpcr
- ligand
- variant
- agonist
- parent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 29
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 28
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 28
- 239000003446 ligand Substances 0.000 claims description 27
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims description 2
- 239000000556 agonist Substances 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 3
- 108091006027 G proteins Proteins 0.000 claims 2
- 102000030782 GTP binding Human genes 0.000 claims 2
- 108091000058 GTP-Binding Proteins 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000009346 Adenosine receptors Human genes 0.000 claims 1
- 108050000203 Adenosine receptors Proteins 0.000 claims 1
- 102000008102 Ankyrins Human genes 0.000 claims 1
- 108010049777 Ankyrins Proteins 0.000 claims 1
- 102000003916 Arrestin Human genes 0.000 claims 1
- 108090000328 Arrestin Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 102000008924 GPCR kinases Human genes 0.000 claims 1
- 108050000878 GPCR kinases Proteins 0.000 claims 1
- 101000596394 Homo sapiens Vesicle-fusing ATPase Proteins 0.000 claims 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 1
- 102000017922 Neurotensin receptor Human genes 0.000 claims 1
- 108060003370 Neurotensin receptor Proteins 0.000 claims 1
- -1 RAMP Proteins 0.000 claims 1
- 102000008944 RGS Proteins Human genes 0.000 claims 1
- 108010074020 RGS Proteins Proteins 0.000 claims 1
- 102100035054 Vesicle-fusing ATPase Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 1
- 230000003196 chaotropic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940125425 inverse agonist Drugs 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000004031 partial agonist Substances 0.000 claims 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0705450A GB0705450D0 (en) | 2007-03-22 | 2007-03-22 | Mutant proteins and method for selecting them |
| GB0705450.5 | 2007-03-22 | ||
| GB0724052A GB0724052D0 (en) | 2007-12-08 | 2007-12-08 | Mutant proteins and methods for selecting them |
| GB0724052.6 | 2007-12-08 | ||
| PCT/GB2008/000986 WO2008114020A2 (en) | 2007-03-22 | 2008-03-20 | Mutant g-protein coupled receptors and methods for selecting them |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011171887A Division JP2011224018A (ja) | 2007-03-22 | 2011-08-05 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010521983A JP2010521983A (ja) | 2010-07-01 |
| JP2010521983A5 true JP2010521983A5 (enExample) | 2010-09-24 |
| JP4842400B2 JP4842400B2 (ja) | 2011-12-21 |
Family
ID=39386585
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500347A Active JP4842400B2 (ja) | 2007-03-22 | 2008-03-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2011171887A Pending JP2011224018A (ja) | 2007-03-22 | 2011-08-05 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2014100213A Pending JP2014155502A (ja) | 2007-03-22 | 2014-05-14 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2016129938A Active JP6426661B2 (ja) | 2007-03-22 | 2016-06-30 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2018135756A Pending JP2018164456A (ja) | 2007-03-22 | 2018-07-19 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2020193343A Active JP7419217B2 (ja) | 2007-03-22 | 2020-11-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011171887A Pending JP2011224018A (ja) | 2007-03-22 | 2011-08-05 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2014100213A Pending JP2014155502A (ja) | 2007-03-22 | 2014-05-14 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2016129938A Active JP6426661B2 (ja) | 2007-03-22 | 2016-06-30 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2018135756A Pending JP2018164456A (ja) | 2007-03-22 | 2018-07-19 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2020193343A Active JP7419217B2 (ja) | 2007-03-22 | 2020-11-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US8785135B2 (enExample) |
| EP (4) | EP2121919B1 (enExample) |
| JP (6) | JP4842400B2 (enExample) |
| CN (2) | CN103641908A (enExample) |
| AT (1) | ATE544854T1 (enExample) |
| AU (1) | AU2008228085B2 (enExample) |
| CA (1) | CA2681415C (enExample) |
| DK (1) | DK2121919T3 (enExample) |
| ES (2) | ES3008359T3 (enExample) |
| GB (4) | GB2456237B8 (enExample) |
| HR (1) | HRP20120336T1 (enExample) |
| PL (1) | PL2121919T3 (enExample) |
| PT (1) | PT2121919E (enExample) |
| WO (1) | WO2008114020A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2121919B1 (en) | 2007-03-22 | 2012-02-08 | Heptares Therapeutics Limited | Mutant g-protein coupled receptors and methods for selecting them |
| GB0724051D0 (en) | 2007-12-08 | 2008-01-16 | Medical Res Council | Mutant proteins and methods for producing them |
| GB0724860D0 (en) * | 2007-12-20 | 2008-01-30 | Heptares Therapeutics Ltd | Screening |
| GB0802474D0 (en) | 2008-02-11 | 2008-03-19 | Heptares Therapeutics Ltd | Mutant proteins and methods for selecting them |
| WO2008068534A2 (en) * | 2008-03-05 | 2008-06-12 | Heptares Therapeutics Limited | Crystal structure of a betal -adremergi c receptor and uses thereof |
| GB0910725D0 (en) * | 2009-06-22 | 2009-08-05 | Heptares Therapeutics Ltd | Mutant proteins and methods for producing them |
| GB201014715D0 (en) * | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| EP3333185A1 (en) | 2010-08-20 | 2018-06-13 | Heptares Therapeutics Limited | Mutant gpcrs |
| WO2012098413A1 (en) * | 2011-01-21 | 2012-07-26 | Heptares Therapeutics Limited | Mutant g-protein coupled receptor proteins and methods for producing them |
| JP6263773B2 (ja) | 2011-02-23 | 2018-01-24 | マサチューセッツ インスティテュート オブ テクノロジー | 水溶性膜タンパク質およびその調製および使用方法 |
| WO2012120315A2 (en) | 2011-03-10 | 2012-09-13 | Heptares Therapeutics Limited | Mutant proteins and methods for producing them |
| DK2742066T3 (en) * | 2011-08-10 | 2018-03-05 | Heptares Therapeutics Ltd | STABLE PROTEINS |
| JP6251252B2 (ja) * | 2012-06-01 | 2017-12-20 | ヘプタレス セラピューティックス リミテッド | アッセイ |
| PT2951201T (pt) | 2013-01-30 | 2018-01-09 | Univ Brussel Vrije | Novos polipéptidos quiméricos para rastreamento e fins de descoberta de fármacos |
| US9932385B2 (en) | 2013-03-15 | 2018-04-03 | Medical Research Council | Mutant proteins and methods for their production |
| US9670264B2 (en) | 2013-04-25 | 2017-06-06 | The Trustees Of The University Of Pennsylvania | Water soluble G-protein coupled receptor |
| WO2014176524A2 (en) | 2013-04-25 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Opioid detection based on high quality graphene transistor arrays and a synthetic mu receptor |
| ES2900571T3 (es) | 2013-06-11 | 2022-03-17 | Scherrer Inst Paul | Método para determinar la unión de un ligando-GPCR mutante a resolución de un único aminoácido y parejas de ligando mutado y GPCR |
| US10373702B2 (en) | 2014-03-27 | 2019-08-06 | Massachusetts Institute Of Technology | Water-soluble trans-membrane proteins and methods for the preparation and use thereof |
| CN104151401A (zh) * | 2014-06-05 | 2014-11-19 | 维亚生物科技(上海)有限公司 | 融合表达离子通道蛋白及运输蛋白的方法及其使用的蛋白片断 |
| GB2527286A (en) * | 2014-06-11 | 2015-12-23 | Rsr Ltd | Glycoprotein hormone receptor mutations |
| WO2016070022A1 (en) | 2014-10-31 | 2016-05-06 | Abilita Bio, Inc. | Modified membrane spanning proteins and methods for the preparation and use thereof |
| US11618777B2 (en) | 2015-07-31 | 2023-04-04 | Shigeyuki Yokoyama | Method of manufacturing membrane protein and utilization thereof |
| GB201601690D0 (en) | 2016-01-29 | 2016-03-16 | Heptares Therapeutics Ltd | G proteins |
| EP3205450A1 (de) * | 2016-02-09 | 2017-08-16 | Hermes Schleifkörper GmbH | Verfahren zur herstellung eines keramischen formkörpers |
| AU2017259821B2 (en) | 2016-05-04 | 2024-07-18 | Abilita Bio, Inc. | Methods and platform for preparing multispanning membrane proteins |
| CN109553687B (zh) * | 2017-09-27 | 2021-07-06 | 北京大学 | 基于g蛋白偶联受体构建的荧光探针 |
| US12123814B1 (en) * | 2019-06-14 | 2024-10-22 | Pierce Biotechnology, Inc. | G- protein coupled receptor extraction formulations |
| US12371487B2 (en) | 2020-12-23 | 2025-07-29 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| CN114038498B (zh) * | 2022-01-06 | 2022-03-18 | 北京晶泰科技有限公司 | Gpcr的热稳定性突变预测方法、结构筛选方法及其装置 |
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-
2008
- 2008-03-20 EP EP08718823A patent/EP2121919B1/en active Active
- 2008-03-20 PT PT08718823T patent/PT2121919E/pt unknown
- 2008-03-20 ES ES21171713T patent/ES3008359T3/es active Active
- 2008-03-20 AU AU2008228085A patent/AU2008228085B2/en active Active
- 2008-03-20 CN CN201310556727.3A patent/CN103641908A/zh active Pending
- 2008-03-20 JP JP2010500347A patent/JP4842400B2/ja active Active
- 2008-03-20 EP EP12153522A patent/EP2450445A1/en not_active Ceased
- 2008-03-20 EP EP21171713.7A patent/EP3926045B1/en active Active
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2012
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2015
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