JP2010520856A5 - - Google Patents
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- Publication number
- JP2010520856A5 JP2010520856A5 JP2009548736A JP2009548736A JP2010520856A5 JP 2010520856 A5 JP2010520856 A5 JP 2010520856A5 JP 2009548736 A JP2009548736 A JP 2009548736A JP 2009548736 A JP2009548736 A JP 2009548736A JP 2010520856 A5 JP2010520856 A5 JP 2010520856A5
- Authority
- JP
- Japan
- Prior art keywords
- ligand
- metal ion
- polyoxohydroxy
- modified
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910021645 metal ion Inorganic materials 0.000 claims 43
- 238000000034 method Methods 0.000 claims 34
- 239000003446 ligand Substances 0.000 claims 31
- 239000000203 mixture Substances 0.000 claims 26
- 239000011343 solid material Substances 0.000 claims 25
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 12
- 239000000872 buffer Substances 0.000 claims 12
- 125000004043 oxo group Chemical group O=* 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
- 239000000126 substance Substances 0.000 claims 9
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 claims 8
- 239000001361 adipic acid Substances 0.000 claims 6
- 235000011037 adipic acid Nutrition 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 5
- 229910052751 metal Inorganic materials 0.000 claims 5
- 239000002184 metal Substances 0.000 claims 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 4
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 4
- 239000006172 buffering agent Substances 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- IHPYMWDTONKSCO-UHFFFAOYSA-N 2,2'-piperazine-1,4-diylbisethanesulfonic acid Chemical compound OS(=O)(=O)CCN1CCN(CCS(O)(=O)=O)CC1 IHPYMWDTONKSCO-UHFFFAOYSA-N 0.000 claims 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 3
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 claims 3
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 3
- 239000007995 HEPES buffer Substances 0.000 claims 3
- 239000007993 MOPS buffer Substances 0.000 claims 3
- 239000007990 PIPES buffer Substances 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000007983 Tris buffer Substances 0.000 claims 3
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 3
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 3
- 150000002500 ions Chemical class 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 3
- 238000006116 polymerization reaction Methods 0.000 claims 3
- 239000012429 reaction media Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 239000007790 solid phase Substances 0.000 claims 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 3
- 229940095064 tartrate Drugs 0.000 claims 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 2
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims 2
- 239000003513 alkali Substances 0.000 claims 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 230000003139 buffering effect Effects 0.000 claims 2
- 235000015165 citric acid Nutrition 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 235000013373 food additive Nutrition 0.000 claims 2
- 239000002778 food additive Substances 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 239000001630 malic acid Substances 0.000 claims 2
- 235000011090 malic acid Nutrition 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 235000016709 nutrition Nutrition 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 239000000376 reactant Substances 0.000 claims 2
- 238000001179 sorption measurement Methods 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 2
- 239000011975 tartaric acid Substances 0.000 claims 2
- 235000002906 tartaric acid Nutrition 0.000 claims 2
- 239000005711 Benzoic acid Substances 0.000 claims 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 1
- YIKYNHJUKRTCJL-UHFFFAOYSA-N Ethyl maltol Chemical compound CCC=1OC=CC(=O)C=1O YIKYNHJUKRTCJL-UHFFFAOYSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 claims 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229940072107 ascorbate Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000005611 electricity Effects 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- 238000005538 encapsulation Methods 0.000 claims 1
- 229940093503 ethyl maltol Drugs 0.000 claims 1
- 229940014144 folate Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 239000000174 gluconic acid Substances 0.000 claims 1
- 235000012208 gluconic acid Nutrition 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- 238000002173 high-resolution transmission electron microscopy Methods 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 239000012456 homogeneous solution Substances 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 238000002329 infrared spectrum Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- WKPSFPXMYGFAQW-UHFFFAOYSA-N iron;hydrate Chemical compound O.[Fe] WKPSFPXMYGFAQW-UHFFFAOYSA-N 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 229910021644 lanthanide ion Inorganic materials 0.000 claims 1
- 230000005389 magnetism Effects 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 229940043353 maltol Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- -1 oxo hydroxides Chemical class 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims 1
- 235000015497 potassium bicarbonate Nutrition 0.000 claims 1
- 239000011736 potassium bicarbonate Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 235000011044 succinic acid Nutrition 0.000 claims 1
- 229910001428 transition metal ion Inorganic materials 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88838607P | 2007-02-06 | 2007-02-06 | |
| US60/888,386 | 2007-02-06 | ||
| GB0702270.0 | 2007-02-06 | ||
| GBGB0702270.0A GB0702270D0 (en) | 2007-02-06 | 2007-02-06 | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| PCT/GB2008/000408 WO2008096130A1 (en) | 2007-02-06 | 2008-02-06 | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010520856A JP2010520856A (ja) | 2010-06-17 |
| JP2010520856A5 true JP2010520856A5 (enExample) | 2011-03-31 |
| JP5756598B2 JP5756598B2 (ja) | 2015-07-29 |
Family
ID=39204358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548736A Active JP5756598B2 (ja) | 2007-02-06 | 2008-02-06 | リガンド修飾ポリオキソヒドロキシ金属イオン物質、それらの使用およびそれらの調製方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8058462B2 (enExample) |
| EP (1) | EP2125847B1 (enExample) |
| JP (1) | JP5756598B2 (enExample) |
| KR (1) | KR101514470B1 (enExample) |
| AU (1) | AU2008212653B2 (enExample) |
| BR (1) | BRPI0807212B1 (enExample) |
| CA (1) | CA2676146C (enExample) |
| CY (1) | CY1116590T1 (enExample) |
| EA (1) | EA019635B1 (enExample) |
| GB (1) | GB2451713B (enExample) |
| HR (1) | HRP20150944T1 (enExample) |
| IL (1) | IL199901A (enExample) |
| MX (1) | MX2009008281A (enExample) |
| PL (1) | PL2125847T3 (enExample) |
| WO (1) | WO2008096130A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2451713B (en) | 2007-02-06 | 2009-12-16 | Medical Res Council | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| GB0814326D0 (en) * | 2008-08-05 | 2008-09-10 | Medical Res Council | Phosphate binding materials and their uses |
| GB201101299D0 (en) | 2011-01-25 | 2011-03-09 | Medical Res Council | Oxygen sensors and their uses |
| GB201507002D0 (en) * | 2015-04-24 | 2015-06-10 | Medical Res Council | Copper Oxo-hydroxide nanoparticles and their uses as biocidal agents |
| GB201517893D0 (en) | 2015-10-09 | 2015-11-25 | Medical Res Council | Methods for producing carboxylate ligand modified ferric iron hydroxide colloids |
| US11267836B2 (en) | 2016-03-31 | 2022-03-08 | Shield TX (UK) Limited | Methods for producing ferric maltol compositions from ligand modified and ligand coated ferric hydroxides |
| EP3436442B1 (en) | 2016-03-31 | 2020-10-28 | Shield TX (UK) Limited | Methods for producing ferric maltol compositions from ferrous hydroxides |
| SG11201901129XA (en) | 2016-08-10 | 2019-03-28 | Res & Innovation Uk | Compositions comprising nanosilica particles and their use in methods of activating t lymphocytes for therapy |
| KR20200044030A (ko) | 2017-09-11 | 2020-04-28 | 파르마코스모스 홀딩 에이/에스 | 치료용 철 착화합물 |
| GB202005054D0 (en) * | 2020-04-06 | 2020-05-20 | Nemysis Ltd | Carboxylate Ligand Modified Ferric Iron Hydroxide Compositions for Use in the Treatment or Prevention of Iron Deficiency Associated with Liver Diseases |
| WO2022061065A1 (en) * | 2020-09-17 | 2022-03-24 | Doyle Robert P | Complexes of magnesium maltol (3-hydroxy-2-methyl-4h-pyran-4-one) for oral supplementation |
| KR20240041957A (ko) | 2021-08-03 | 2024-04-01 | 파르마코스모스 홀딩 에이/에스 | 반려동물의 철 결핍증 치료방법에서 피하 사용을 위한 철 착화합물 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL264270A (enExample) * | ||||
| US2575347A (en) * | 1949-07-14 | 1951-11-20 | Interchem Corp | Metallo organic compounds |
| GB959282A (en) * | 1959-08-19 | 1964-05-27 | Hardman & Holden Ltd | Improvements relating to organic aluminium compounds |
| US3076798A (en) | 1961-02-23 | 1963-02-05 | Hausmann Lab Ltd | Process for preparing a ferric hydroxide polymaltose complex |
| US3679377A (en) | 1970-02-17 | 1972-07-25 | Union Oil Co | Iron complexes containing aquo,sulfate and hydroxyl ligands |
| US3821192A (en) | 1971-08-18 | 1974-06-28 | Central Pharmacal Co | Process for preparing an iron-saccharide complex |
| US4162986A (en) * | 1977-06-20 | 1979-07-31 | Mooney Chemicals, Inc. | Oil-soluble high metal content transitional metal organic oxy, hydroxy, complexes |
| US4137359A (en) | 1977-10-31 | 1979-01-30 | Mooney Chemicals, Inc. | Elastomers with improved metal adhesion |
| DE4239442C2 (de) | 1992-11-24 | 2001-09-13 | Sebo Gmbh | Verwendung eines mit polynuklearen Metalloxidhydroxiden modifizierten Adsorptionsmaterials zur selektiven Elimination von anorganischem Phosphat aus proteinhaltigen Flüssigkeiten |
| US6177581B1 (en) | 1999-10-12 | 2001-01-23 | The Dow Chemical Company | Mixed-metal chelates and process for the preparation thereof |
| US20030049284A1 (en) | 2001-09-05 | 2003-03-13 | Boccio Jose Ruben | Method of increasing the solubility of alphahydrocarboxilic salts, and products obtained by the method |
| EP1434869B1 (en) | 2001-10-08 | 2010-12-15 | Purac Biochem N.V. | Method for preparing calcium gluconate |
| EP1476399B1 (en) * | 2002-01-24 | 2007-03-28 | William Marsh Rice University | Organic acid-feooh (ferroxane) particles and ferroxane-derived ceramics and ceramic membranes |
| US7994217B2 (en) | 2002-05-02 | 2011-08-09 | Xanodyne Pharmaceuticals, Inc. | Prenatal multivitamin/multimineral supplement |
| GB0211500D0 (en) | 2002-05-18 | 2002-06-26 | Vitra Pharmaceuticals Ltd | Method of forming iron hydroxypyrone compounds |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US6706904B1 (en) | 2002-12-04 | 2004-03-16 | Albion International, Inc. | Dimetalhydroxy malates |
| TWI335218B (en) | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| US7964568B2 (en) | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| EP1733058B8 (en) | 2004-03-16 | 2012-10-24 | Navinta LLC | Iron sucrose complexes and method of manufacture thereof |
| WO2005094203A2 (en) | 2004-03-16 | 2005-10-13 | Navinta, Llc | Sodium ferric gluconate complexes and method of manufacture thereof |
| BRPI0515847A (pt) | 2004-10-08 | 2008-08-12 | Unilever Nv | uso de um complexo de ferro, composição alimentìcia, gênero alimentìcio fortificado com ferro, composição de bebida, bebida fortificada com ferro, suplemento alimentar e composição farmacêutica |
| DE202005014332U1 (de) | 2005-09-09 | 2006-01-19 | Institut für Oberflächenmodifizierung e.V. | Metallorganisches Nanopulver |
| GB2451713B (en) | 2007-02-06 | 2009-12-16 | Medical Res Council | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| TWI592159B (zh) | 2007-11-16 | 2017-07-21 | 威佛（國際）股份有限公司 | 藥學組成物 |
| GB0814326D0 (en) | 2008-08-05 | 2008-09-10 | Medical Res Council | Phosphate binding materials and their uses |
-
2008
- 2008-02-06 GB GB0802214A patent/GB2451713B/en active Active
- 2008-02-06 US US12/026,861 patent/US8058462B2/en active Active
- 2008-02-06 WO PCT/GB2008/000408 patent/WO2008096130A1/en not_active Ceased
- 2008-02-06 JP JP2009548736A patent/JP5756598B2/ja active Active
- 2008-02-06 AU AU2008212653A patent/AU2008212653B2/en active Active
- 2008-02-06 KR KR1020097016904A patent/KR101514470B1/ko active Active
- 2008-02-06 CA CA2676146A patent/CA2676146C/en active Active
- 2008-02-06 BR BRPI0807212-4A patent/BRPI0807212B1/pt active IP Right Grant
- 2008-02-06 EA EA200970718A patent/EA019635B1/ru unknown
- 2008-02-06 PL PL08709331T patent/PL2125847T3/pl unknown
- 2008-02-06 HR HRP20150944TT patent/HRP20150944T1/hr unknown
- 2008-02-06 MX MX2009008281A patent/MX2009008281A/es active IP Right Grant
- 2008-02-06 EP EP08709331.6A patent/EP2125847B1/en active Active
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2009
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2015
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