BRPI0807212B1 - Processos para produzir um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante, composições para uso em terapia que compreende o material sólido de íon metálico de poli oxohidróxi modificado por ligante e uso das composições e uso de uma composição compreendendo um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante - Google Patents
Processos para produzir um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante, composições para uso em terapia que compreende o material sólido de íon metálico de poli oxohidróxi modificado por ligante e uso das composições e uso de uma composição compreendendo um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante Download PDFInfo
- Publication number
- BRPI0807212B1 BRPI0807212B1 BRPI0807212-4A BRPI0807212A BRPI0807212B1 BR PI0807212 B1 BRPI0807212 B1 BR PI0807212B1 BR PI0807212 A BRPI0807212 A BR PI0807212A BR PI0807212 B1 BRPI0807212 B1 BR PI0807212B1
- Authority
- BR
- Brazil
- Prior art keywords
- ligand
- hydroxy
- oxo
- metal ion
- iron
- Prior art date
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- 239000000463 material Substances 0.000 title claims abstract description 226
- 238000000034 method Methods 0.000 title claims abstract description 103
- 230000008569 process Effects 0.000 title claims abstract description 67
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- 238000002560 therapeutic procedure Methods 0.000 title claims description 8
- 150000001455 metallic ions Chemical class 0.000 title description 4
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 294
- 229910052742 iron Inorganic materials 0.000 claims description 145
- 239000003446 ligand Substances 0.000 claims description 139
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 76
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- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims description 47
- 238000004458 analytical method Methods 0.000 claims description 47
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- 238000004090 dissolution Methods 0.000 claims description 38
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- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 claims description 28
- 125000004043 oxo group Chemical group O=* 0.000 claims description 28
- 238000010521 absorption reaction Methods 0.000 claims description 25
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 22
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
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- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 15
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- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 14
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- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 11
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 6
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- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
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Images
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G99/00—Subject matter not provided for in other groups of this subclass
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Polyesters Or Polycarbonates (AREA)
- Catalysts (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
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| US88838607P | 2007-02-06 | 2007-02-06 | |
| US60/888,386 | 2007-02-06 | ||
| GB0702270.0 | 2007-02-06 | ||
| GBGB0702270.0A GB0702270D0 (en) | 2007-02-06 | 2007-02-06 | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
| PCT/GB2008/000408 WO2008096130A1 (en) | 2007-02-06 | 2008-02-06 | Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation |
Publications (2)
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| BRPI0807212A2 BRPI0807212A2 (pt) | 2014-06-17 |
| BRPI0807212B1 true BRPI0807212B1 (pt) | 2022-01-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| BRPI0807212-4A BRPI0807212B1 (pt) | 2007-02-06 | 2008-02-06 | Processos para produzir um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante, composições para uso em terapia que compreende o material sólido de íon metálico de poli oxohidróxi modificado por ligante e uso das composições e uso de uma composição compreendendo um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante |
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| EP (1) | EP2125847B1 (enExample) |
| JP (1) | JP5756598B2 (enExample) |
| KR (1) | KR101514470B1 (enExample) |
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| BR (1) | BRPI0807212B1 (enExample) |
| CA (1) | CA2676146C (enExample) |
| CY (1) | CY1116590T1 (enExample) |
| EA (1) | EA019635B1 (enExample) |
| GB (1) | GB2451713B (enExample) |
| HR (1) | HRP20150944T1 (enExample) |
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| MX (1) | MX2009008281A (enExample) |
| PL (1) | PL2125847T3 (enExample) |
| WO (1) | WO2008096130A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EA019635B1 (ru) | 2007-02-06 | 2014-05-30 | Медикал Ресёрч Каунсил | Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения |
| GB0814326D0 (en) * | 2008-08-05 | 2008-09-10 | Medical Res Council | Phosphate binding materials and their uses |
| GB201101299D0 (en) | 2011-01-25 | 2011-03-09 | Medical Res Council | Oxygen sensors and their uses |
| GB201507002D0 (en) * | 2015-04-24 | 2015-06-10 | Medical Res Council | Copper Oxo-hydroxide nanoparticles and their uses as biocidal agents |
| GB201517893D0 (en) | 2015-10-09 | 2015-11-25 | Medical Res Council | Methods for producing carboxylate ligand modified ferric iron hydroxide colloids |
| CN109790138B (zh) * | 2016-03-31 | 2023-08-18 | 英国神盾Tx股份有限公司 | 由配体修饰的和配体涂覆的氢氧化铁生产麦芽酚铁组合物的方法 |
| CN109311837B (zh) | 2016-03-31 | 2022-09-30 | 英国神盾Tx股份有限公司 | 用于由氢氧化亚铁产生麦芽酚铁组合物的方法 |
| JP7510254B2 (ja) | 2016-08-10 | 2024-07-03 | ユナイテッド キングダム リサーチ アンド イノベーション | ナノシリカ粒子を含む組成物および療法のためにｔリンパ球を活性化する方法におけるそれらの使用 |
| MA50229A (fr) | 2017-09-11 | 2020-07-22 | Pharmacosmos Holding As | Composés complexes de fer à usage thérapeutique |
| GB202005054D0 (en) | 2020-04-06 | 2020-05-20 | Nemysis Ltd | Carboxylate Ligand Modified Ferric Iron Hydroxide Compositions for Use in the Treatment or Prevention of Iron Deficiency Associated with Liver Diseases |
| EP4213643A4 (en) * | 2020-09-17 | 2024-10-02 | Doyle, Robert, P. | Complexes of magnesium maltol (3-hydroxy-2-methyl-4h-pyran-4-one) for oral supplementation |
| JP2024529536A (ja) | 2021-08-03 | 2024-08-06 | ファーマコスモス ホールディング エー／エス | コンパニオンアニマルの鉄欠乏症の治療における皮下使用のための鉄錯体化合物 |
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| US2575347A (en) | 1949-07-14 | 1951-11-20 | Interchem Corp | Metallo organic compounds |
| GB959282A (en) | 1959-08-19 | 1964-05-27 | Hardman & Holden Ltd | Improvements relating to organic aluminium compounds |
| US3076798A (en) | 1961-02-23 | 1963-02-05 | Hausmann Lab Ltd | Process for preparing a ferric hydroxide polymaltose complex |
| US3679377A (en) | 1970-02-17 | 1972-07-25 | Union Oil Co | Iron complexes containing aquo,sulfate and hydroxyl ligands |
| US3821192A (en) | 1971-08-18 | 1974-06-28 | Central Pharmacal Co | Process for preparing an iron-saccharide complex |
| US4162986A (en) * | 1977-06-20 | 1979-07-31 | Mooney Chemicals, Inc. | Oil-soluble high metal content transitional metal organic oxy, hydroxy, complexes |
| US4137359A (en) | 1977-10-31 | 1979-01-30 | Mooney Chemicals, Inc. | Elastomers with improved metal adhesion |
| DE4239442C2 (de) | 1992-11-24 | 2001-09-13 | Sebo Gmbh | Verwendung eines mit polynuklearen Metalloxidhydroxiden modifizierten Adsorptionsmaterials zur selektiven Elimination von anorganischem Phosphat aus proteinhaltigen Flüssigkeiten |
| US6177581B1 (en) | 1999-10-12 | 2001-01-23 | The Dow Chemical Company | Mixed-metal chelates and process for the preparation thereof |
| US20030049284A1 (en) | 2001-09-05 | 2003-03-13 | Boccio Jose Ruben | Method of increasing the solubility of alphahydrocarboxilic salts, and products obtained by the method |
| US7618664B2 (en) | 2001-10-08 | 2009-11-17 | Cooperatieve Verkoop-En Productievereniging Van Aardappelmeel En Derivaten Avebe B.A. | Method for preparing calcium gluconate |
| AU2003237552A1 (en) * | 2002-01-24 | 2003-09-02 | William Marsh Rice University | Organic acid-feooh (ferroxane) particles and ferroxane-derived ceramics and ceramic membranes |
| US7994217B2 (en) | 2002-05-02 | 2011-08-09 | Xanodyne Pharmaceuticals, Inc. | Prenatal multivitamin/multimineral supplement |
| GB0211500D0 (en) | 2002-05-18 | 2002-06-26 | Vitra Pharmaceuticals Ltd | Method of forming iron hydroxypyrone compounds |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US6706904B1 (en) | 2002-12-04 | 2004-03-16 | Albion International, Inc. | Dimetalhydroxy malates |
| TWI335218B (en) | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
| US7964568B2 (en) | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| US7179939B2 (en) | 2004-03-16 | 2007-02-20 | Navinta Llc | Sodium ferric gluconate complexes and method of manufacture thereof |
| US7674780B2 (en) | 2004-03-16 | 2010-03-09 | Navinta Llc | Iron sucrose complexes and method of manufacture thereof |
| ZA200702421B (en) | 2004-10-08 | 2008-09-25 | Unilever Plc | Iron complex for use in the treatment and/or prevention of nutritional disorders |
| DE202005014332U1 (de) | 2005-09-09 | 2006-01-19 | Institut für Oberflächenmodifizierung e.V. | Metallorganisches Nanopulver |
| EA019635B1 (ru) | 2007-02-06 | 2014-05-30 | Медикал Ресёрч Каунсил | Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения |
| TWI592159B (zh) | 2007-11-16 | 2017-07-21 | 威佛（國際）股份有限公司 | 藥學組成物 |
| GB0814326D0 (en) | 2008-08-05 | 2008-09-10 | Medical Res Council | Phosphate binding materials and their uses |
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- 2008-02-06 PL PL08709331T patent/PL2125847T3/pl unknown
- 2008-02-06 BR BRPI0807212-4A patent/BRPI0807212B1/pt active IP Right Grant
- 2008-02-06 WO PCT/GB2008/000408 patent/WO2008096130A1/en not_active Ceased
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| GB2451713B (en) | 2009-12-16 |
| MX2009008281A (es) | 2009-08-25 |
| EP2125847A1 (en) | 2009-12-02 |
| AU2008212653A1 (en) | 2008-08-14 |
| PL2125847T3 (pl) | 2015-12-31 |
| HRP20150944T1 (hr) | 2015-10-09 |
| EP2125847B1 (en) | 2015-06-17 |
| CA2676146C (en) | 2016-08-09 |
| GB2451713A (en) | 2009-02-11 |
| HK1138598A1 (en) | 2010-08-27 |
| KR101514470B1 (ko) | 2015-04-22 |
| IL199901A0 (en) | 2010-04-15 |
| JP2010520856A (ja) | 2010-06-17 |
| AU2008212653B2 (en) | 2012-05-24 |
| BRPI0807212A2 (pt) | 2014-06-17 |
| US20080188555A1 (en) | 2008-08-07 |
| KR20090121281A (ko) | 2009-11-25 |
| IL199901A (en) | 2014-11-30 |
| CY1116590T1 (el) | 2017-03-15 |
| GB0802214D0 (en) | 2008-03-12 |
| EA200970718A1 (ru) | 2010-02-26 |
| US8058462B2 (en) | 2011-11-15 |
| JP5756598B2 (ja) | 2015-07-29 |
| EA019635B1 (ru) | 2014-05-30 |
| CA2676146A1 (en) | 2008-08-14 |
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