EA200970718A1 - Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения - Google Patents

Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения

Info

Publication number
EA200970718A1
EA200970718A1 EA200970718A EA200970718A EA200970718A1 EA 200970718 A1 EA200970718 A1 EA 200970718A1 EA 200970718 A EA200970718 A EA 200970718A EA 200970718 A EA200970718 A EA 200970718A EA 200970718 A1 EA200970718 A1 EA 200970718A1
Authority
EA
Eurasian Patent Office
Prior art keywords
materials
polyoxohydroxide
ligand
modified
methods
Prior art date
Application number
EA200970718A
Other languages
English (en)
Other versions
EA019635B1 (ru
Inventor
Джонатан Джозеф Паувэл
Сильван Франсуа Алин Браграбер
Нано Хорхе Родригес Фариа
Дора Исабэль Амараль Перейра
Original Assignee
Медикал Ресёрч Каунсил
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0702270.0A external-priority patent/GB0702270D0/en
Application filed by Медикал Ресёрч Каунсил filed Critical Медикал Ресёрч Каунсил
Publication of EA200970718A1 publication Critical patent/EA200970718A1/ru
Publication of EA019635B1 publication Critical patent/EA019635B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/295Iron group metal compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02Iron compounds
    • C07F15/025Iron compounds without a metal-carbon linkage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76Metal complexes of amino carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F11/00Compounds containing elements of Groups 6 or 16 of the Periodic Table
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02Iron compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07GCOMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G99/00Subject matter not provided for in other groups of this subclass

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Cosmetics (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)

Abstract

Описаны лиганд-модифицированные полиоксогидроксидные материалы с ионами металла и их применение, в частности, для пищевых, медицинских, косметических или биологических целей, например, для лечения состояния, связанного с недостаточностью одного из компонентов указанного материала, или для удаления эндогенного вещества, способного связываться с указанным материалом. Настоящее изобретение относится также к способам получения материалов, к оптимизации их физико-химических свойств и к их применению в медицинских целях.
EA200970718A 2007-02-06 2008-02-06 Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения EA019635B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88838607P 2007-02-06 2007-02-06
GBGB0702270.0A GB0702270D0 (en) 2007-02-06 2007-02-06 Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation
PCT/GB2008/000408 WO2008096130A1 (en) 2007-02-06 2008-02-06 Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation

Publications (2)

Publication Number Publication Date
EA200970718A1 true EA200970718A1 (ru) 2010-02-26
EA019635B1 EA019635B1 (ru) 2014-05-30

Family

ID=39204358

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970718A EA019635B1 (ru) 2007-02-06 2008-02-06 Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения

Country Status (16)

Country Link
US (1) US8058462B2 (ru)
EP (1) EP2125847B1 (ru)
JP (1) JP5756598B2 (ru)
KR (1) KR101514470B1 (ru)
AU (1) AU2008212653B2 (ru)
BR (1) BRPI0807212B1 (ru)
CA (1) CA2676146C (ru)
CY (1) CY1116590T1 (ru)
EA (1) EA019635B1 (ru)
GB (1) GB2451713B (ru)
HK (1) HK1138598A1 (ru)
HR (1) HRP20150944T1 (ru)
IL (1) IL199901A (ru)
MX (1) MX2009008281A (ru)
PL (1) PL2125847T3 (ru)
WO (1) WO2008096130A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0807212B1 (pt) 2007-02-06 2022-01-11 United Kingdom Research And Innovation Processos para produzir um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante, composições para uso em terapia que compreende o material sólido de íon metálico de poli oxohidróxi modificado por ligante e uso das composições e uso de uma composição compreendendo um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante
GB0814326D0 (en) * 2008-08-05 2008-09-10 Medical Res Council Phosphate binding materials and their uses
GB201101299D0 (en) 2011-01-25 2011-03-09 Medical Res Council Oxygen sensors and their uses
GB201507002D0 (en) * 2015-04-24 2015-06-10 Medical Res Council Copper Oxo-hydroxide nanoparticles and their uses as biocidal agents
GB201517893D0 (en) * 2015-10-09 2015-11-25 Medical Res Council Methods for producing carboxylate ligand modified ferric iron hydroxide colloids
WO2017167963A1 (en) * 2016-03-31 2017-10-05 Medical Research Council Methods for producing ferric maltol compositions from ligand modified and ligand coated ferric hydroxides
JP7033544B2 (ja) 2016-03-31 2022-03-10 シールド ティーエックス (ユーケー) リミテッド 水酸化第一鉄からマルトール第二鉄組成物を生成するための方法
EP3496728B1 (en) 2016-08-10 2021-05-26 United Kingdom Research and Innovation Compositions comprising nanosilica particles and their use in methods of activating t lymphocytes for therapy
MA50229A (fr) 2017-09-11 2020-07-22 Pharmacosmos Holding As Composés complexes de fer à usage thérapeutique
GB202005054D0 (en) 2020-04-06 2020-05-20 Nemysis Ltd Carboxylate Ligand Modified Ferric Iron Hydroxide Compositions for Use in the Treatment or Prevention of Iron Deficiency Associated with Liver Diseases
BR112024002150A2 (pt) 2021-08-03 2024-04-30 Pharmacosmos Holding As Compostos de complexo de ferro para uso subcutâneo na terapia de deficiência de ferro em animais de companhia

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL264270A (ru)
US2575347A (en) 1949-07-14 1951-11-20 Interchem Corp Metallo organic compounds
GB959282A (en) 1959-08-19 1964-05-27 Hardman & Holden Ltd Improvements relating to organic aluminium compounds
US3076798A (en) 1961-02-23 1963-02-05 Hausmann Lab Ltd Process for preparing a ferric hydroxide polymaltose complex
US3679377A (en) 1970-02-17 1972-07-25 Union Oil Co Iron complexes containing aquo,sulfate and hydroxyl ligands
US3821192A (en) 1971-08-18 1974-06-28 Central Pharmacal Co Process for preparing an iron-saccharide complex
US4162986A (en) * 1977-06-20 1979-07-31 Mooney Chemicals, Inc. Oil-soluble high metal content transitional metal organic oxy, hydroxy, complexes
US4137359A (en) 1977-10-31 1979-01-30 Mooney Chemicals, Inc. Elastomers with improved metal adhesion
DE4239442C2 (de) 1992-11-24 2001-09-13 Sebo Gmbh Verwendung eines mit polynuklearen Metalloxidhydroxiden modifizierten Adsorptionsmaterials zur selektiven Elimination von anorganischem Phosphat aus proteinhaltigen Flüssigkeiten
US6177581B1 (en) * 1999-10-12 2001-01-23 The Dow Chemical Company Mixed-metal chelates and process for the preparation thereof
US20030049284A1 (en) 2001-09-05 2003-03-13 Boccio Jose Ruben Method of increasing the solubility of alphahydrocarboxilic salts, and products obtained by the method
BR0212542B1 (pt) 2001-10-08 2014-04-08 Purac Biochem Bv Método para a preparação de gluconato de cálcio, mistura de sal de gluconato/sal de ácido orgânico, lactato/gluconato de cálcio, produto de alimento fortificado com cálcio, e, suco de laranja
WO2003062140A2 (en) * 2002-01-24 2003-07-31 William Marsh Rice University Organic acid-feooh (ferroxane) particles and ferroxane-derived ceramics and ceramic membranes
US7994217B2 (en) 2002-05-02 2011-08-09 Xanodyne Pharmaceuticals, Inc. Prenatal multivitamin/multimineral supplement
GB0211500D0 (en) 2002-05-18 2002-06-26 Vitra Pharmaceuticals Ltd Method of forming iron hydroxypyrone compounds
DE10249552A1 (de) 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
US6706904B1 (en) 2002-12-04 2004-03-16 Albion International, Inc. Dimetalhydroxy malates
TWI335218B (en) 2003-02-19 2011-01-01 Panion & Bf Biotech Inc Ferric organic compounds, uses thereof and methods of making same
US7964568B2 (en) 2003-05-30 2011-06-21 Chromaceutical Advanced Technologies, Inc. Synthesis of high molecular weight iron-saccharidic complexes
WO2005094203A2 (en) 2004-03-16 2005-10-13 Navinta, Llc Sodium ferric gluconate complexes and method of manufacture thereof
WO2005094202A2 (en) 2004-03-16 2005-10-13 Navinta, Llc Iron sucrose complexes and method of manufacture thereof
CN101043824A (zh) 2004-10-08 2007-09-26 荷兰联合利华有限公司 用于治疗和/或预防营养失调的铁络合物
DE202005014332U1 (de) 2005-09-09 2006-01-19 Institut für Oberflächenmodifizierung e.V. Metallorganisches Nanopulver
BRPI0807212B1 (pt) 2007-02-06 2022-01-11 United Kingdom Research And Innovation Processos para produzir um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante, composições para uso em terapia que compreende o material sólido de íon metálico de poli oxohidróxi modificado por ligante e uso das composições e uso de uma composição compreendendo um material sólido de íon metálico de poli oxo-hidróxi modificado por ligante
TWI468167B (zh) 2007-11-16 2015-01-11 威佛(國際)股份有限公司 藥學組成物
GB0814326D0 (en) 2008-08-05 2008-09-10 Medical Res Council Phosphate binding materials and their uses

Also Published As

Publication number Publication date
IL199901A (en) 2014-11-30
EP2125847A1 (en) 2009-12-02
GB2451713A (en) 2009-02-11
AU2008212653B2 (en) 2012-05-24
EA019635B1 (ru) 2014-05-30
MX2009008281A (es) 2009-08-25
BRPI0807212B1 (pt) 2022-01-11
IL199901A0 (en) 2010-04-15
CA2676146C (en) 2016-08-09
EP2125847B1 (en) 2015-06-17
JP5756598B2 (ja) 2015-07-29
KR101514470B1 (ko) 2015-04-22
CA2676146A1 (en) 2008-08-14
HRP20150944T1 (hr) 2015-10-09
GB2451713B (en) 2009-12-16
GB0802214D0 (en) 2008-03-12
US20080188555A1 (en) 2008-08-07
BRPI0807212A2 (pt) 2014-06-17
KR20090121281A (ko) 2009-11-25
WO2008096130A1 (en) 2008-08-14
AU2008212653A1 (en) 2008-08-14
CY1116590T1 (el) 2017-03-15
JP2010520856A (ja) 2010-06-17
US8058462B2 (en) 2011-11-15
HK1138598A1 (en) 2010-08-27
PL2125847T3 (pl) 2015-12-31

Similar Documents

Publication Publication Date Title
EA200970718A1 (ru) Лиганд-модифицированные полиоксогидроксидные материалы с ионами металла, их применение и способы их получения
CY1118977T1 (el) Επιτοποι σκληροστινης
CY1124412T1 (el) Aνti-dkk-1 αντισωματα
CY1117655T1 (el) Παραγοντες οι οποιοι επαγουν αποπτωση για την αντιμετωπιση καρκινου και ανοσολογικων και αυτοανοσων νοσηματων
TW200740849A (en) Dual variable domain immunoglobulin and uses thereof
MX2010002716A (es) Uso de slit, nefrina, efrina o semaforina para el tratamiento de enfermedades de cartilago.
ECSP11011297A (es) Proteinas ligadoras il-17
EA201101521A1 (ru) Способы лечения онкологических заболеваний, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
EA201001639A1 (ru) Композиции и способы их получения и применения
MX2012005037A (es) Inmunoglobulinas de dominio variable doble y usos de las mismas.
MX2012004415A (es) Inmunoglobulinas de dominio variable doble y usos de las mismas.
MX2012001262A (es) Inmunoglobulinas de dominio variable doble y usos de las misma.
MX2011011669A (es) Inmunoglobulinas de dominio variable dual y usos de las misma.
MX2018015915A (es) Proteinas de enlace especifico y usos de las mismas.
UA101478C2 (ru) Соединения, полезные как ингибиторы raf-киназы
ATE526987T1 (de) Dr5-antikörper und deren verwendung
EA201071300A1 (ru) Антитела к cxcr4
MY166776A (en) Humanised anti-ctla4 antibodies
DE602006014843D1 (de) Verwendung von hif 1alfa modulatoren zur behandlung von krebs
EA201290836A1 (ru) Связанные бис-арильные арилтриазолоны и их применение
NI200900189A (es) Anticuerpos contra la il-25
WO2006015258A3 (en) Methods and compositions related to argonaute proteins
EP3453723A3 (en) Anti-asic1 antibodies and uses thereof
DE602006017367D1 (de) Amino-oxo-indolyliden-verbindungen zur verwendung in der behandlung von juckender kopfhaut
CY1116802T1 (el) Ετεροκυκλικες ενωσεις

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment