JP2010516239A5 - - Google Patents
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- Publication number
- JP2010516239A5 JP2010516239A5 JP2009545965A JP2009545965A JP2010516239A5 JP 2010516239 A5 JP2010516239 A5 JP 2010516239A5 JP 2009545965 A JP2009545965 A JP 2009545965A JP 2009545965 A JP2009545965 A JP 2009545965A JP 2010516239 A5 JP2010516239 A5 JP 2010516239A5
- Authority
- JP
- Japan
- Prior art keywords
- lectin
- glycan
- binding
- cell
- binding agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004856 Lectins Human genes 0.000 claims 23
- 108090001090 Lectins Proteins 0.000 claims 23
- 239000002523 lectin Substances 0.000 claims 23
- 239000011230 binding agent Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 17
- 150000004676 glycans Chemical group 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 6
- 210000001671 embryonic stem cell Anatomy 0.000 claims 6
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 4
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims 4
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 4
- 230000004988 N-glycosylation Effects 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 102000000795 Galectin 1 Human genes 0.000 claims 1
- 108010001498 Galectin 1 Proteins 0.000 claims 1
- 102000007563 Galectins Human genes 0.000 claims 1
- 108010046569 Galectins Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20075033A FI20075033A0 (fi) | 2007-01-18 | 2007-01-18 | Uudet hiilihydraattiprofiilikoostumukset ihmisen soluista ja menetelmät niiden analysoimiseksi ja muuntamiseksi |
| FI20075034A FI20075034A0 (fi) | 2007-01-18 | 2007-01-18 | Uudet menetelmät ja reagenssit solujen valmistamiseksi |
| PCT/FI2008/050016 WO2008087257A1 (en) | 2007-01-18 | 2008-01-18 | Novel methods and reagents directed to production of cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516239A JP2010516239A (ja) | 2010-05-20 |
| JP2010516239A5 true JP2010516239A5 (https=) | 2011-12-01 |
Family
ID=39635689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009545965A Pending JP2010516239A (ja) | 2007-01-18 | 2008-01-18 | 細胞の産生に対する新規方法および試薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100068806A1 (https=) |
| EP (1) | EP2108043A4 (https=) |
| JP (1) | JP2010516239A (https=) |
| AU (1) | AU2008206884B2 (https=) |
| CA (1) | CA2676323A1 (https=) |
| WO (1) | WO2008087257A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007026353A2 (en) | 2005-08-29 | 2007-03-08 | Technion Research & Development Foundation Ltd. | Media for culturing stem cells |
| EP2059586B1 (en) | 2006-08-02 | 2016-07-20 | Technion Research & Development Foundation Ltd. | Methods of expanding embryonic stem cells in a suspension culture |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| EP2315828B1 (en) * | 2008-07-11 | 2015-07-01 | Glykos Finland Oy | Method for culturing induced pluripotent stem cells with a lectin |
| US20100120142A1 (en) * | 2008-07-11 | 2010-05-13 | Suomen Punainen Risti Veripalvelu | Culture of human embryonic cells |
| JP5986745B2 (ja) | 2008-07-15 | 2016-09-06 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | Ｐｔｆｅ様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法 |
| EP3633025B1 (en) | 2009-11-12 | 2022-09-14 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| CN103068969A (zh) * | 2010-06-17 | 2013-04-24 | 思迪公司 | 化学成分确定的无血清细胞培养基 |
| FI20106354A0 (fi) * | 2010-12-20 | 2010-12-20 | Suomen Punainen Risti Veripalvelu | Menetelmä ihmisen retinan pigmentti-epiteelisolujen valmistamiseksi |
| US10534931B2 (en) | 2011-03-17 | 2020-01-14 | Attachmate Corporation | Systems, devices and methods for automatic detection and masking of private data |
| US9557335B2 (en) * | 2011-08-01 | 2017-01-31 | Biologistics Llc | Method of isolating and identifying fruit oligosaccharides from ripe banana fruit |
| WO2013033513A1 (en) | 2011-08-31 | 2013-03-07 | University Of Georgia Research Foundation, Inc. | Apoptosis-targeting nanoparticles |
| EP2814496B1 (en) | 2012-02-17 | 2018-04-11 | University Of Georgia Research Foundation, Inc. | Nanoparticles for mitochondrial trafficking of agents |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| WO2013186946A1 (ja) * | 2012-06-11 | 2013-12-19 | 国立大学法人北海道大学 | 多能性幹細胞の選別方法 |
| WO2014031498A1 (en) | 2012-08-18 | 2014-02-27 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| WO2014031762A1 (en) | 2012-08-21 | 2014-02-27 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
| JP5856029B2 (ja) * | 2012-08-31 | 2016-02-09 | 阿部 博幸 | 間葉系幹細胞を未分化増殖させる方法、および間葉系幹細胞を濃縮する方法 |
| WO2014053709A1 (en) | 2012-10-05 | 2014-04-10 | Glykos Finland Oy | A method for culturing stem cells |
| TW201522637A (zh) * | 2013-03-15 | 2015-06-16 | Jackson Lab | 非胚胎幹細胞之單離及其用途 |
| EP2986713A1 (en) | 2013-04-16 | 2016-02-24 | Glykos Finland Oy | A method for generating induced pluripotent stem cells |
| EP3013365B1 (en) | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2 antigens and use thereof |
| WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
| US9782476B2 (en) | 2013-09-06 | 2017-10-10 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| CA2937123A1 (en) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| WO2016114819A1 (en) * | 2015-01-16 | 2016-07-21 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| CN104862278B (zh) * | 2014-02-26 | 2018-07-10 | 苏州方舟基因药业有限公司 | 一种离体人造血干细胞扩增培养液配方 |
| WO2015138992A1 (en) | 2014-03-14 | 2015-09-17 | University Of Georgia Research Foundation, Inc. | Mitochondrial delivery of 3-bromopyruvate |
| WO2015148915A1 (en) | 2014-03-27 | 2015-10-01 | Academia Sinica | Reactive labelling compounds and uses thereof |
| KR20170003720A (ko) | 2014-05-27 | 2017-01-09 | 아카데미아 시니카 | 항-ｃｄ20 글리코항체 및 이의 용도 |
| KR102512592B1 (ko) | 2014-05-27 | 2023-03-21 | 아카데미아 시니카 | 항-ｈｅｒ2 글리코항체 및 이의 용도 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| CA2950423A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| CN106714829A (zh) | 2014-05-28 | 2017-05-24 | 中央研究院 | 抗TNF‑α醣抗体及其用途 |
| CA2960712A1 (en) | 2014-09-08 | 2016-03-17 | Academia Sinica | Human inkt cell activation using glycolipids |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| AU2015378564A1 (en) | 2015-01-24 | 2017-07-13 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| WO2016205678A1 (en) | 2015-06-19 | 2016-12-22 | Emory University | Methods of measuring cell purity for making quality control determinations and related compositions |
| WO2017156192A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
| CN107541790B (zh) * | 2016-06-24 | 2021-07-06 | 上海交通大学 | 一种糖基化检测的人凝集素/类人凝集素芯片及制备方法 |
| EP3500594A4 (en) | 2016-08-22 | 2020-03-11 | Cho Pharma Inc. | ANTIBODIES, BINDING FRAGMENTS AND METHOD FOR USE |
| CN107909197B (zh) * | 2017-11-13 | 2021-08-31 | 国网福建省电力有限公司 | 一种基于馈线树的大支路运行方式统计分析方法 |
| CN109289087B (zh) * | 2018-10-09 | 2021-02-12 | 温州医科大学附属第一医院 | 一种用于治疗激素性股骨头坏死的复合支架及其制备方法 |
| JP7341031B2 (ja) * | 2018-10-31 | 2023-09-08 | ソマール株式会社 | 間葉系幹細胞の分離・選別方法、培養方法及びそれに用いる選別材料 |
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| IL54911A0 (en) | 1978-06-15 | 1978-08-31 | Yeda Res & Dev | Process for the fractionation of cells |
| US4493793A (en) | 1978-12-26 | 1985-01-15 | E-Y Laboratories | Soluble immunoassay reagent comprising lectin covalently bonded to reactive component |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE3724625A1 (de) * | 1987-07-24 | 1989-02-02 | Boehringer Mannheim Gmbh | Enzymatisch inaktive, immunologisch aktive ss-galactosidase-muteine |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
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| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
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| AU6223296A (en) | 1995-06-07 | 1996-12-30 | Novartis Ag | Methods for obtaining compositions enriched for hematopoieti c stem cells and antibodies for use therein |
| US6084060A (en) | 1996-12-09 | 2000-07-04 | Imclone Systems Incorporated | Composition and method for preserving progenitor cells |
| US5935804A (en) | 1997-03-21 | 1999-08-10 | Laine; Roger A. | Method for detecting eubacteria in biological samples with catalytically inactive murein binding enzymes |
| US6331406B1 (en) | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
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| WO2000027995A1 (en) * | 1998-11-09 | 2000-05-18 | Monash University | Embryonic stem cells |
| IN191359B (https=) * | 1999-04-20 | 2003-11-29 | Nat Inst Immunology | |
| AUPQ319199A0 (en) * | 1999-09-30 | 1999-10-28 | Unisearch Limited | Method and apparatus for culturing cells |
| DE69926920T2 (de) | 1999-12-30 | 2006-06-29 | Imclone Systems, Inc. | Konservierungsfaktoren von Vorläuferzellen und damit verbundene Verfahren und Produkte |
| US6992178B2 (en) * | 2000-11-15 | 2006-01-31 | Two Cells Co., Ltd. | Agent imparting resistance to external stimuli |
| FI20011671A7 (fi) | 2001-08-20 | 2003-02-21 | Carbion Oy | Tuumorispesifiset oligosakkaridisekvenssit ja niiden käyttö |
| US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| JP2003189847A (ja) | 2001-12-26 | 2003-07-08 | Kainosu:Kk | 多分化能神経幹細胞の分取方法 |
| JP4437015B2 (ja) | 2003-05-21 | 2010-03-24 | タカラバイオ株式会社 | 肝幹細胞の分離方法 |
| EP1653991A2 (en) | 2003-08-08 | 2006-05-10 | Fresenius Kabi Deutschland GmbH | Conjugates of a polymer and a protein linked by an oxime linking group |
| EP1674566B1 (en) * | 2003-09-09 | 2011-04-13 | Keio University | Method of promoting subsistence and/or proliferation of neural stem cell and promoting extension of neurite, promoter therefor, pharmaceutical composition containing neural stem cell, method of assay and method of screening |
| US20070258986A1 (en) | 2003-11-19 | 2007-11-08 | Govt of the US as represented by the secretary, | Targeted Delivery System for Bioactive Agents |
| ES2390885T3 (es) | 2004-03-11 | 2012-11-19 | Fresenius Kabi Deutschland Gmbh | Conjugados de hidroxialquilalmidón y una proteína |
| CA2560581C (en) * | 2004-03-23 | 2013-06-11 | Toshihiro Akaike | Pluripotent stem cell growing method |
| US7858578B2 (en) * | 2004-12-10 | 2010-12-28 | California Institute Of Technology | Methods of inducing neuronal growth by a Fucose-α(1-2) galactose (fuc-α(1-2) gal) moiety and a lectin |
| JP4388483B2 (ja) | 2004-12-27 | 2009-12-24 | 株式会社ツーセル | 間葉系幹細胞の骨化及び／又は軟骨化促進剤と骨化及び／又は軟骨化促進方法 |
| DE102005021435A1 (de) | 2005-05-04 | 2006-11-09 | Universitätsklinikum Freiburg | Verfahren zur serum-/proteinfreien Kultur von Stamm- und Progenitorzellen |
| CA2652232A1 (en) * | 2005-07-11 | 2007-01-18 | Suomen Punainen Risti, Veripalvelu | Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof |
| EP1945676A4 (en) | 2005-11-08 | 2012-06-27 | Suomen Punainen Risti Veripalvelu | NEW CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR THEIR ANALYSIS AND MODIFICATION |
| WO2007066352A1 (en) | 2005-12-06 | 2007-06-14 | Department Of Biotechnology | A method for preservation of human hematopoietic stem or progenitor cells |
-
2008
- 2008-01-18 AU AU2008206884A patent/AU2008206884B2/en not_active Ceased
- 2008-01-18 JP JP2009545965A patent/JP2010516239A/ja active Pending
- 2008-01-18 CA CA002676323A patent/CA2676323A1/en not_active Abandoned
- 2008-01-18 WO PCT/FI2008/050016 patent/WO2008087257A1/en not_active Ceased
- 2008-01-18 EP EP08701716A patent/EP2108043A4/en not_active Withdrawn
- 2008-01-18 US US12/522,801 patent/US20100068806A1/en not_active Abandoned
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