JP2010516239A5 - - Google Patents
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- Publication number
- JP2010516239A5 JP2010516239A5 JP2009545965A JP2009545965A JP2010516239A5 JP 2010516239 A5 JP2010516239 A5 JP 2010516239A5 JP 2009545965 A JP2009545965 A JP 2009545965A JP 2009545965 A JP2009545965 A JP 2009545965A JP 2010516239 A5 JP2010516239 A5 JP 2010516239A5
- Authority
- JP
- Japan
- Prior art keywords
- lectin
- glycan
- binding
- cell
- binding agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004856 Lectins Human genes 0.000 claims 23
- 108090001090 Lectins Proteins 0.000 claims 23
- 239000002523 lectin Substances 0.000 claims 23
- 239000011230 binding agent Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 17
- 150000004676 glycans Chemical group 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 6
- 210000001671 embryonic stem cell Anatomy 0.000 claims 6
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 4
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims 4
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 4
- 230000004988 N-glycosylation Effects 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 102000000795 Galectin 1 Human genes 0.000 claims 1
- 108010001498 Galectin 1 Proteins 0.000 claims 1
- 102000007563 Galectins Human genes 0.000 claims 1
- 108010046569 Galectins Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20075034A FI20075034A0 (fi) | 2007-01-18 | 2007-01-18 | Uudet menetelmät ja reagenssit solujen valmistamiseksi |
| FI20075033A FI20075033A0 (fi) | 2007-01-18 | 2007-01-18 | Uudet hiilihydraattiprofiilikoostumukset ihmisen soluista ja menetelmät niiden analysoimiseksi ja muuntamiseksi |
| PCT/FI2008/050016 WO2008087257A1 (en) | 2007-01-18 | 2008-01-18 | Novel methods and reagents directed to production of cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516239A JP2010516239A (ja) | 2010-05-20 |
| JP2010516239A5 true JP2010516239A5 (https=) | 2011-12-01 |
Family
ID=39635689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009545965A Pending JP2010516239A (ja) | 2007-01-18 | 2008-01-18 | 細胞の産生に対する新規方法および試薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100068806A1 (https=) |
| EP (1) | EP2108043A4 (https=) |
| JP (1) | JP2010516239A (https=) |
| AU (1) | AU2008206884B2 (https=) |
| CA (1) | CA2676323A1 (https=) |
| WO (1) | WO2008087257A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1962719A4 (en) | 2005-08-29 | 2011-05-04 | Technion Res And Dev Of Foundation Ltd | MEDIA FOR BREEDING STEM CELLS |
| DK3441459T3 (da) | 2006-08-02 | 2021-06-07 | Technion Res & Dev Foundation | Fremgangsmåder til ekspansion af embryonale stamceller i en suspensionskultur |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| US20100120142A1 (en) * | 2008-07-11 | 2010-05-13 | Suomen Punainen Risti Veripalvelu | Culture of human embryonic cells |
| AU2009267964A1 (en) * | 2008-07-11 | 2010-01-14 | Glykos Finland Oy | Culture of cells |
| ES2442024T3 (es) | 2008-07-15 | 2014-02-07 | Academia Sinica | Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados |
| US9018010B2 (en) | 2009-11-12 | 2015-04-28 | Technion Research & Development Foundation Limited | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| KR20130112028A (ko) * | 2010-06-17 | 2013-10-11 | 스템알디, 인크. | 무혈청 합성 세포배양 배지 |
| FI20106354A0 (fi) * | 2010-12-20 | 2010-12-20 | Suomen Punainen Risti Veripalvelu | Menetelmä ihmisen retinan pigmentti-epiteelisolujen valmistamiseksi |
| US10534931B2 (en) | 2011-03-17 | 2020-01-14 | Attachmate Corporation | Systems, devices and methods for automatic detection and masking of private data |
| US9557335B2 (en) * | 2011-08-01 | 2017-01-31 | Biologistics Llc | Method of isolating and identifying fruit oligosaccharides from ripe banana fruit |
| WO2013033513A1 (en) | 2011-08-31 | 2013-03-07 | University Of Georgia Research Foundation, Inc. | Apoptosis-targeting nanoparticles |
| JP6356614B2 (ja) | 2012-02-17 | 2018-07-11 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | 薬剤のミトコンドリア輸送のためのナノ粒子 |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| JP5979452B2 (ja) * | 2012-06-11 | 2016-08-24 | 国立大学法人北海道大学 | 多能性幹細胞の選別方法 |
| WO2014031498A1 (en) | 2012-08-18 | 2014-02-27 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| AU2013305827A1 (en) | 2012-08-21 | 2015-03-05 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
| JP5856029B2 (ja) | 2012-08-31 | 2016-02-09 | 阿部 博幸 | 間葉系幹細胞を未分化増殖させる方法、および間葉系幹細胞を濃縮する方法 |
| WO2014053709A1 (en) | 2012-10-05 | 2014-04-10 | Glykos Finland Oy | A method for culturing stem cells |
| CA2906643A1 (en) * | 2013-03-15 | 2014-09-25 | The Jackson Laboratory | Isolation of non-embryonic stem cells and uses thereof |
| WO2014170549A1 (en) | 2013-04-16 | 2014-10-23 | Glykos Finland Oy | A method for generating induced pluripotent stem cells |
| EP3013365B1 (en) | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2 antigens and use thereof |
| EP3013347B1 (en) | 2013-06-27 | 2019-12-11 | Academia Sinica | Glycan conjugates and use thereof |
| JP6486368B2 (ja) | 2013-09-06 | 2019-03-20 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 改変されたグリコシル基を含む糖脂質を用いたヒトｉＮＫＴ細胞の活性化 |
| WO2016114819A1 (en) * | 2015-01-16 | 2016-07-21 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| AU2015206370A1 (en) | 2014-01-16 | 2016-07-07 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| CN104862278B (zh) * | 2014-02-26 | 2018-07-10 | 苏州方舟基因药业有限公司 | 一种离体人造血干细胞扩增培养液配方 |
| US10398663B2 (en) | 2014-03-14 | 2019-09-03 | University Of Georgia Research Foundation, Inc. | Mitochondrial delivery of 3-bromopyruvate |
| CN106415244B (zh) | 2014-03-27 | 2020-04-24 | 中央研究院 | 反应性标记化合物及其用途 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| CA2950415A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
| CN106661099A (zh) | 2014-05-27 | 2017-05-10 | 中央研究院 | 抗her2醣抗体及其用途 |
| JP7093612B2 (ja) | 2014-05-27 | 2022-06-30 | アカデミア シニカ | Ｂａｃｔｅｒｏｉｄｅｓ由来のフコシダーゼおよびそれを使用する方法 |
| WO2015184001A1 (en) | 2014-05-28 | 2015-12-03 | Academia Sinica | Anti-tnf-alpha glycoantibodies and uses thereof |
| TWI745275B (zh) | 2014-09-08 | 2021-11-11 | 中央研究院 | 使用醣脂激活人類ｉＮＫＴ細胞 |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| JP6779887B2 (ja) | 2015-01-24 | 2020-11-04 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 新規なグリカンコンジュゲートおよびその使用方法 |
| WO2016205678A1 (en) | 2015-06-19 | 2016-12-22 | Emory University | Methods of measuring cell purity for making quality control determinations and related compositions |
| EP3426693A4 (en) | 2016-03-08 | 2019-11-13 | Academia Sinica | PROCESS FOR MODULAR SYNTHESIS OF N-GLYCANES AND ARRANGEMENTS THEREOF |
| CN107541790B (zh) * | 2016-06-24 | 2021-07-06 | 上海交通大学 | 一种糖基化检测的人凝集素/类人凝集素芯片及制备方法 |
| CA3034057A1 (en) | 2016-08-22 | 2018-03-01 | CHO Pharma Inc. | Antibodies, binding fragments, and methods of use |
| CN107909197B (zh) * | 2017-11-13 | 2021-08-31 | 国网福建省电力有限公司 | 一种基于馈线树的大支路运行方式统计分析方法 |
| CN109289087B (zh) * | 2018-10-09 | 2021-02-12 | 温州医科大学附属第一医院 | 一种用于治疗激素性股骨头坏死的复合支架及其制备方法 |
| JP7341031B2 (ja) * | 2018-10-31 | 2023-09-08 | ソマール株式会社 | 間葉系幹細胞の分離・選別方法、培養方法及びそれに用いる選別材料 |
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| IL54911A0 (en) | 1978-06-15 | 1978-08-31 | Yeda Res & Dev | Process for the fractionation of cells |
| US4493793A (en) | 1978-12-26 | 1985-01-15 | E-Y Laboratories | Soluble immunoassay reagent comprising lectin covalently bonded to reactive component |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE3724625A1 (de) * | 1987-07-24 | 1989-02-02 | Boehringer Mannheim Gmbh | Enzymatisch inaktive, immunologisch aktive ss-galactosidase-muteine |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
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| AU784361C (en) | 1999-12-30 | 2007-03-15 | Imclone Systems Incorporated | Progenitor cell preservation factors and related methods and products |
| JP4703943B2 (ja) * | 2000-11-15 | 2011-06-15 | 幸夫 加藤 | 外部刺激に対する抵抗性付与剤 |
| FI20011671A7 (fi) | 2001-08-20 | 2003-02-21 | Carbion Oy | Tuumorispesifiset oligosakkaridisekvenssit ja niiden käyttö |
| US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| JP2003189847A (ja) | 2001-12-26 | 2003-07-08 | Kainosu:Kk | 多分化能神経幹細胞の分取方法 |
| JP4437015B2 (ja) | 2003-05-21 | 2010-03-24 | タカラバイオ株式会社 | 肝幹細胞の分離方法 |
| BRPI0412671A (pt) | 2003-08-08 | 2006-10-03 | Fresenius Kabi De Gmbh | conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima |
| JP5099288B2 (ja) * | 2003-09-09 | 2012-12-19 | 学校法人慶應義塾 | 神経幹細胞の生存及び／又は増殖及び神経突起伸張を促進する方法並びに促進剤、神経幹細胞を含む医薬組成物、検定方法、スクリーニング方法 |
| WO2005051429A2 (en) | 2003-11-19 | 2005-06-09 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Targeted conjugates with a modified saccharide linker |
| ES2390885T3 (es) | 2004-03-11 | 2012-11-19 | Fresenius Kabi Deutschland Gmbh | Conjugados de hidroxialquilalmidón y una proteína |
| KR101178786B1 (ko) * | 2004-03-23 | 2012-09-07 | 다이이찌 산쿄 가부시키가이샤 | 다능성 줄기세포의 증식 방법 |
| US7858578B2 (en) * | 2004-12-10 | 2010-12-28 | California Institute Of Technology | Methods of inducing neuronal growth by a Fucose-α(1-2) galactose (fuc-α(1-2) gal) moiety and a lectin |
| JP4388483B2 (ja) | 2004-12-27 | 2009-12-24 | 株式会社ツーセル | 間葉系幹細胞の骨化及び／又は軟骨化促進剤と骨化及び／又は軟骨化促進方法 |
| DE102005021435A1 (de) | 2005-05-04 | 2006-11-09 | Universitätsklinikum Freiburg | Verfahren zur serum-/proteinfreien Kultur von Stamm- und Progenitorzellen |
| WO2007006870A2 (en) * | 2005-07-11 | 2007-01-18 | Suomen Punainen Risti, Veripalvelu | Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof |
| WO2007054622A1 (en) | 2005-11-08 | 2007-05-18 | Suomen Punainen Risti, Veripalvelu | Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof |
| WO2007066352A1 (en) | 2005-12-06 | 2007-06-14 | Department Of Biotechnology | A method for preservation of human hematopoietic stem or progenitor cells |
-
2008
- 2008-01-18 EP EP08701716A patent/EP2108043A4/en not_active Withdrawn
- 2008-01-18 US US12/522,801 patent/US20100068806A1/en not_active Abandoned
- 2008-01-18 WO PCT/FI2008/050016 patent/WO2008087257A1/en not_active Ceased
- 2008-01-18 JP JP2009545965A patent/JP2010516239A/ja active Pending
- 2008-01-18 CA CA002676323A patent/CA2676323A1/en not_active Abandoned
- 2008-01-18 AU AU2008206884A patent/AU2008206884B2/en not_active Ceased
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