JP2011525355A5 - - Google Patents
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- Publication number
- JP2011525355A5 JP2011525355A5 JP2011514618A JP2011514618A JP2011525355A5 JP 2011525355 A5 JP2011525355 A5 JP 2011525355A5 JP 2011514618 A JP2011514618 A JP 2011514618A JP 2011514618 A JP2011514618 A JP 2011514618A JP 2011525355 A5 JP2011525355 A5 JP 2011525355A5
- Authority
- JP
- Japan
- Prior art keywords
- population
- purified
- cells
- mscs
- mesenchymal stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 5
- 102100032807 Tumor necrosis factor-inducible gene 6 protein Human genes 0.000 claims 3
- 101710169430 Tumor necrosis factor-inducible gene 6 protein Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 claims 1
- 101000595198 Homo sapiens Podocalyxin Proteins 0.000 claims 1
- 102100032816 Integrin alpha-6 Human genes 0.000 claims 1
- 102100036031 Podocalyxin Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7373908P | 2008-06-18 | 2008-06-18 | |
| US61/073,739 | 2008-06-18 | ||
| PCT/US2009/003657 WO2009154770A2 (en) | 2008-06-18 | 2009-06-18 | Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015119567A Division JP2015199755A (ja) | 2008-06-18 | 2015-06-12 | 医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011525355A JP2011525355A (ja) | 2011-09-22 |
| JP2011525355A5 true JP2011525355A5 (https=) | 2012-08-02 |
| JP5866601B2 JP5866601B2 (ja) | 2016-02-17 |
Family
ID=41434601
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514618A Expired - Fee Related JP5866601B2 (ja) | 2008-06-18 | 2009-06-18 | 医薬組成物の製造方法 |
| JP2015119567A Pending JP2015199755A (ja) | 2008-06-18 | 2015-06-12 | 医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015119567A Pending JP2015199755A (ja) | 2008-06-18 | 2015-06-12 | 医薬組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10035834B2 (https=) |
| EP (2) | EP3029061B1 (https=) |
| JP (2) | JP5866601B2 (https=) |
| WO (1) | WO2009154770A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9878003B2 (en) | 2006-03-06 | 2018-01-30 | The University Of Manchester | Method of treating bone disorders using TSG-6 |
| EP2485741A4 (en) * | 2009-10-06 | 2013-07-24 | Cohen Mcniece Foundation | PREPARATION AND USE OF STROMAL CELLS FOR THE TREATMENT OF CARDIAC DISORDERS |
| KR20110095218A (ko) | 2010-02-18 | 2011-08-24 | 주식회사 강스템홀딩스 | ＰＩ３Ｋ／ＡＫＴ／ＧＳＫ３ 경로를 통해 성체줄기세포의 증식, 다분화능 및 재프로그래밍을 촉진하는 ＣＤ４９ｆ |
| EP2566566B1 (en) * | 2010-05-03 | 2017-09-06 | The Texas A&M University System | Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases |
| EP2741757B1 (en) | 2011-09-11 | 2018-05-16 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
| EP2626369A1 (en) * | 2011-11-24 | 2013-08-14 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Engineered mesenchymal stem cells and their therapeutic use |
| RU2482182C1 (ru) * | 2011-12-02 | 2013-05-20 | Государственное научное учреждение Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. Я.Р. Коваленко Российской академии сельскохозяйственных наук (ГНУ ВИЭВ Россельхозакадемии) | КУЛЬТУРА МУЛЬТИПОТЕНТНЫХ МЕЗЕНХИМНЫХ СТВОЛОВЫХ КЛЕТОК, ВЫДЕЛЕННЫХ ИЗ ЖИРОВОЙ ТКАНИ КРУПНОГО РОГАТОГО СКОТА (Textus adiposus Bos taurus), ДЛЯ ВЕТЕРИНАРИИ, КЛЕТОЧНОЙ И ТКАНЕВОЙ ИНЖЕНЕРИИ |
| RU2482183C1 (ru) * | 2011-12-02 | 2013-05-20 | Государственное научное учреждение Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. Я.Р. Коваленко Российской академии сельскохозяйственных наук (ГНУ ВИЭВ Россельхозакадемии) | КУЛЬТУРА МУЛЬТИПОТЕНТНЫХ МЕЗЕНХИМНЫХ СТВОЛОВЫХ КЛЕТОК, ВЫДЕЛЕННЫХ ИЗ КОСТНОГО МОЗГА КРУПНОГО РОГАТОГО СКОТА (Medulla ossium Bos taurus), ДЛЯ ВЕТЕРИНАРИИ, КЛЕТОЧНОЙ И ТКАНЕВОЙ ИНЖЕНЕРИИ |
| US10702556B2 (en) | 2012-05-16 | 2020-07-07 | Minovia Therpautices Ltd. | Compositions and methods for inducing angiogenesis |
| EP2908910A4 (en) * | 2012-10-17 | 2016-06-29 | Texas A & M Univ Sys | TREATMENT OF BRAIN DAMAGE OR TRAUMA WITH TSG-6 PROTEIN |
| US10351825B2 (en) * | 2014-07-11 | 2019-07-16 | The Texas A&M University System | Mesenchymal stem cells derived from induced pluripotent stem cells |
| WO2016018761A1 (en) * | 2014-07-28 | 2016-02-04 | The Texas A&M University System | Mesenchymal stem cells expressing biomarkers that predict the effectiveness of the mesenchymal stem cells for treating diseases and disorders |
| IL299482B2 (en) | 2015-02-26 | 2025-02-01 | Minovia Therapeutics Ltd | Mammalian cells are enriched with active mitochondria |
| KR101816246B1 (ko) | 2016-09-07 | 2018-01-08 | 에스씨엠생명과학 주식회사 | 염증 자극된 중간엽 줄기세포를 포함하는 면역질환 또는 염증 질환의 예방 또는 치료용 약학적 조성물 |
| EP3551748B1 (en) * | 2016-12-12 | 2022-07-13 | Health and Biotech France (H&B France) | Perinatal tissue derived mesenchymal stem cells: method of preparation and uses thereof |
| EP3560527B1 (en) * | 2016-12-16 | 2024-01-31 | Regene Pharm Co., Ltd. | Tissue healing agent |
| CN110177560A (zh) * | 2016-12-28 | 2019-08-27 | 智再如股份有限公司 | 活体组织损伤的修复剂以及该修复剂的制造方法 |
| CN110423721B (zh) * | 2018-05-01 | 2024-02-27 | 云南济慈再生医学研究院有限公司 | 一种年轻化的修复型成纤维细胞的制备方法及其应用 |
| JP7458368B2 (ja) | 2018-07-22 | 2024-03-29 | ミノヴィア セラピューティクス リミテッド | 筋疾患のミトコンドリア増強療法 |
| US12329781B2 (en) | 2018-07-22 | 2025-06-17 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of renal diseases |
| US12551504B2 (en) | 2018-07-22 | 2026-02-17 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of pancreatic diseases |
| JP2021531288A (ja) | 2018-07-22 | 2021-11-18 | ミノヴィア セラピューティクス リミテッド | 眼疾患のミトコンドリア増強療法 |
| WO2020021536A1 (en) | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy for primary mitochondrial diseases |
| JP7524157B2 (ja) | 2018-07-22 | 2024-07-29 | ミノヴィア セラピューティクス リミテッド | 脳疾患のミトコンドリア増強療法 |
| US20220348880A1 (en) * | 2019-08-30 | 2022-11-03 | The Texas A&M University System | Xenogen-Free Mesenchymal Stem Cell Compositions and Methods of Use |
| CA3172402A1 (en) | 2020-03-31 | 2021-10-07 | Minovia Therapeutics Ltd. | Mitochondria-enriched genetically engineered cells and uses thereof |
| KR20220010461A (ko) * | 2020-07-17 | 2022-01-25 | 주식회사 엘지화학 | 종양괴사인자-자극된 유전자 6을 발현하는 중간엽 줄기세포를 포함하는 골관절염의 예방 또는 치료용 조성물 |
| KR20250085398A (ko) * | 2023-12-05 | 2025-06-12 | 재단법인 아산사회복지재단 | 턱관절 질환의 예방 또는 치료용 줄기세포 치료제 및 이의 제조방법 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5272065A (en) | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US4978745A (en) | 1987-11-23 | 1990-12-18 | Centocor, Inc. | Immunoreactive heterochain antibodies |
| US4975369A (en) | 1988-04-21 | 1990-12-04 | Eli Lilly And Company | Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen |
| US5087617A (en) | 1989-02-15 | 1992-02-11 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
| DE69230136T2 (de) * | 1991-01-14 | 2000-05-25 | New York University, New York | Cytokin-induziertes protein, tsg-6, seine dna und verwendung |
| EP0593663A4 (en) | 1991-07-03 | 1996-10-30 | Regeneron Pharma | Method and assay system for neurotrophin activity |
| WO1995021381A1 (en) | 1994-02-01 | 1995-08-10 | The Rockefeller University | Methods and agents for measuring and controlling multidrug resistance |
| US6313091B1 (en) * | 1995-07-20 | 2001-11-06 | New York University | Pharmaceutical compositions containing TSG-6 for treating inflammatory diseases and cancer-related pathologies and method |
| CA2282729A1 (en) | 1997-02-26 | 1998-09-03 | The General Hospital Corporation | Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of alzheimer's disease |
| CA2296704C (en) * | 1997-07-14 | 2010-10-19 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| JP5030329B2 (ja) * | 1998-04-02 | 2012-09-19 | ジェネンテック， インコーポレイテッド | 心臓肥大の処置 |
| US20040214836A1 (en) * | 1998-05-29 | 2004-10-28 | Cheresh David A. | Method of treatment of myocardial infarction |
| CN1318105A (zh) * | 1998-09-15 | 2001-10-17 | M&E生物技术公司 | 负调节Osteoprotegerin配体活性的方法 |
| US6872546B1 (en) * | 1998-12-23 | 2005-03-29 | Human Genome Sciences, Inc. | Hyaluronan-binding proteins and encoding genes |
| US6610503B1 (en) | 1999-03-17 | 2003-08-26 | Xenogen Corporation | Animal models for predicting sepsis mortality |
| AU5062100A (en) | 1999-06-14 | 2001-01-02 | Novo Nordisk A/S | Fviia/tf activity inhibiting compounds |
| US6632979B2 (en) | 2000-03-16 | 2003-10-14 | Genentech, Inc. | Rodent HER2 tumor model |
| US20020045589A1 (en) * | 2000-03-30 | 2002-04-18 | Gary Shen | Hirulog-like peptide and gene therapy |
| US6905839B2 (en) | 2002-07-31 | 2005-06-14 | Takashi Furuta | In vivo phenotyping for human cytochrome P450 3A activity |
| US20070010008A1 (en) * | 2005-06-29 | 2007-01-11 | Tissuetech, Inc. | Ex vivo expansion of primary animal cells |
| AU2004278634B2 (en) * | 2003-10-03 | 2009-10-01 | Keiichi Fukuda | Method of inducing the differentiation of stem cells into cardiomyocytes |
| US9002545B2 (en) | 2011-01-07 | 2015-04-07 | Wabtec Holding Corp. | Data improvement system and method |
-
2009
- 2009-06-18 EP EP15200119.4A patent/EP3029061B1/en not_active Not-in-force
- 2009-06-18 JP JP2011514618A patent/JP5866601B2/ja not_active Expired - Fee Related
- 2009-06-18 EP EP09767083.0A patent/EP2294183B1/en not_active Not-in-force
- 2009-06-18 WO PCT/US2009/003657 patent/WO2009154770A2/en not_active Ceased
- 2009-06-18 US US12/487,373 patent/US10035834B2/en active Active
-
2015
- 2015-06-12 JP JP2015119567A patent/JP2015199755A/ja active Pending
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