JP2010514811A5 - - Google Patents
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- Publication number
- JP2010514811A5 JP2010514811A5 JP2009544316A JP2009544316A JP2010514811A5 JP 2010514811 A5 JP2010514811 A5 JP 2010514811A5 JP 2009544316 A JP2009544316 A JP 2009544316A JP 2009544316 A JP2009544316 A JP 2009544316A JP 2010514811 A5 JP2010514811 A5 JP 2010514811A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- benzo
- heteroaryl
- group
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88285006P | 2006-12-29 | 2006-12-29 | |
| US60/882,850 | 2006-12-29 | ||
| US89540007P | 2007-03-16 | 2007-03-16 | |
| US60/895,400 | 2007-03-16 | ||
| US97093107P | 2007-09-07 | 2007-09-07 | |
| US60/970,931 | 2007-09-07 | ||
| PCT/US2007/089177 WO2008083367A2 (en) | 2006-12-29 | 2007-12-29 | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014021926A Division JP5797792B2 (ja) | 2006-12-29 | 2014-02-07 | Axlインヒビターとして有用な多環式ヘテロアリール置換トリアゾール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514811A JP2010514811A (ja) | 2010-05-06 |
| JP2010514811A5 true JP2010514811A5 (enExample) | 2012-09-06 |
| JP5546250B2 JP5546250B2 (ja) | 2014-07-09 |
Family
ID=39387343
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544316A Active JP5546250B2 (ja) | 2006-12-29 | 2007-12-29 | Axlインヒビターとして有用な多環式ヘテロアリール置換トリアゾール |
| JP2014021926A Active JP5797792B2 (ja) | 2006-12-29 | 2014-02-07 | Axlインヒビターとして有用な多環式ヘテロアリール置換トリアゾール |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014021926A Active JP5797792B2 (ja) | 2006-12-29 | 2014-02-07 | Axlインヒビターとして有用な多環式ヘテロアリール置換トリアゾール |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7709482B2 (enExample) |
| EP (1) | EP2078010B1 (enExample) |
| JP (2) | JP5546250B2 (enExample) |
| CN (1) | CN101622246B (enExample) |
| AU (1) | AU2007341937B2 (enExample) |
| CA (1) | CA2710234C (enExample) |
| CY (1) | CY1115188T1 (enExample) |
| DK (1) | DK2078010T3 (enExample) |
| ES (1) | ES2460894T3 (enExample) |
| HR (1) | HRP20140378T1 (enExample) |
| ME (1) | ME01832B (enExample) |
| PL (1) | PL2078010T3 (enExample) |
| PT (1) | PT2078010E (enExample) |
| RS (1) | RS53281B (enExample) |
| SI (1) | SI2078010T1 (enExample) |
| WO (1) | WO2008083367A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008543888A (ja) * | 2005-06-24 | 2008-12-04 | ギリアード サイエンシーズ, インコーポレイテッド | ピリド(3,2−d)ピリミジン、およびC型肝炎を治療するのに有用な医薬組成物 |
| US7884119B2 (en) * | 2005-09-07 | 2011-02-08 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as Axl inhibitors |
| US8338435B2 (en) * | 2006-07-20 | 2012-12-25 | Gilead Sciences, Inc. | Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections |
| TW200840584A (en) * | 2006-12-26 | 2008-10-16 | Gilead Sciences Inc | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
| EP2114954B1 (en) | 2006-12-29 | 2013-02-13 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| AU2007342005A1 (en) * | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as Axl inhibitors |
| ES2404668T3 (es) | 2006-12-29 | 2013-05-28 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con arilo bicíclico puenteado y heteroarilo bicíclico puenteado, útiles como agentes inhibidores del axl |
| PT2078010E (pt) * | 2006-12-29 | 2014-05-07 | Rigel Pharmaceuticals Inc | Triazoles substituídos com heteroarilos policíclicos úteis como inibidores de axl |
| JP2010514810A (ja) | 2006-12-29 | 2010-05-06 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axlインヒビターとして有用な置換トリアゾール |
| CA2704052C (en) * | 2007-10-26 | 2015-04-21 | Rigel Pharmaceuticals, Inc. | Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| JP5592884B2 (ja) * | 2008-07-09 | 2014-09-17 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axl阻害剤として有用な多環式ヘテロアリール置換トリアゾール |
| US8431594B2 (en) * | 2008-07-09 | 2013-04-30 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic heteroaryl substituted triazoles useful as AXL inhibitors |
| JP4644273B2 (ja) * | 2008-07-15 | 2011-03-02 | 本田技研工業株式会社 | 車両周辺監視装置 |
| RU2555326C2 (ru) * | 2009-01-16 | 2015-07-10 | Риджел Фармасьютикалз, Инк. | ИНГИБИТОРЫ Axl ДЛЯ ПРИМЕНЕНИЯ В КОМБИНИРОВАННОЙ ТЕРАПИИ ДЛЯ ПРЕДОТВРАЩЕНИЯ, УСТРАНЕНИЯ ИЛИ ЛЕЧЕНИЯ МЕТАСТAЗИРУЮЩЕГО РАКА |
| US9074192B2 (en) | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| PT3241840T (pt) | 2010-01-22 | 2022-10-13 | Univ Leland Stanford Junior | Inibição da sinalização de axl em terapêutica anti-metastática |
| US9879061B2 (en) | 2011-12-15 | 2018-01-30 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL/GAS6 signaling in the treatment of liver fibrosis |
| MY165215A (en) | 2012-01-31 | 2018-03-09 | Daiichi Sankyo Co Ltd | Pyridone derivatives |
| WO2014018535A1 (en) | 2012-07-25 | 2014-01-30 | Salk Institute For Biological Studies | Regulating the interaction between tam ligands and lipid membranes with exposed phosphatidylserine |
| AR096654A1 (es) * | 2013-06-20 | 2016-01-27 | Ab Science | Derivados de benzimidazol como inhibidores selectivos de proteína quinasa |
| CN105916506B (zh) | 2013-11-20 | 2020-01-07 | 圣诺康生命科学公司 | 作为tam家族激酶抑制剂的喹唑啉衍生物 |
| CN105764514B (zh) | 2013-11-27 | 2019-07-12 | 圣诺康生命科学公司 | 作为tam族激酶抑制剂的氨基吡啶衍生物 |
| EP3076966A2 (en) * | 2013-12-02 | 2016-10-12 | BerGenBio AS | Use of kinase inhibitors |
| TWI690525B (zh) | 2014-07-07 | 2020-04-11 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
| US10137173B2 (en) | 2014-10-20 | 2018-11-27 | Aravive Biologics, Inc. | Antiviral activity of Gas6 inhibitor |
| GB201420285D0 (en) * | 2014-11-14 | 2014-12-31 | Bergenbio As | Process |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| GB201509338D0 (en) | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
| WO2017027717A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Bicyclic fused pyrimidine compounds as tam inhibitors |
| US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
| ES2896079T3 (es) | 2016-02-26 | 2022-02-23 | Ono Pharmaceutical Co | Fármaco para la terapia del cáncer, caracterizado por la administración de la combinación entre un inhibidor de Axl y un inhibidor del punto de control inmunitario |
| CN114456176B (zh) | 2016-03-28 | 2024-08-30 | 因赛特公司 | 作为tam抑制剂的吡咯并三嗪化合物 |
| CN106083764B (zh) * | 2016-07-11 | 2018-09-18 | 上海皓元生物医药科技有限公司 | 一种用于制备axl抑制剂的高纯度中间体的手性拆分方法 |
| EP3673907A4 (en) | 2017-08-23 | 2020-08-19 | ONO Pharmaceutical Co., Ltd. | CANCER TREATMENT PHARMACEUTICAL INCLUDING AX1 INHIBITOR AS AN EFFECTIVE INGREDIENT |
| KR102739325B1 (ko) | 2017-09-27 | 2024-12-09 | 인사이트 코포레이션 | Tam 억제제로서 유용한 피롤로트리아진 유도체의 염 |
| US11826363B2 (en) | 2017-10-13 | 2023-11-28 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for solid cancers, which comprises Axl inhibitor as active ingredient |
| US11241438B2 (en) | 2018-06-29 | 2022-02-08 | Incyte Corporation | Formulations of an AXL/MER inhibitor |
| EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| PH12022552347A1 (en) | 2020-03-06 | 2024-01-29 | Incyte Corp | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
| IL297132A (en) | 2020-04-08 | 2022-12-01 | Bergenbio Asa | axl inhibitors for antiviral therapy |
| GB202006072D0 (en) | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
| GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
| TW202304908A (zh) * | 2021-04-14 | 2023-02-01 | 日商衛材R&D企管股份有限公司 | 四氫吡啶并嘧啶化合物 |
| CN115504967A (zh) * | 2021-06-23 | 2022-12-23 | 南京正大天晴制药有限公司 | 作为axl抑制剂的1,2,4-三唑化合物 |
| KR20240115979A (ko) | 2021-11-08 | 2024-07-26 | 프로젠토스 테라퓨틱스, 인크. | 혈소판-유래 성장 인자 수용체(pdgfr) 알파 억제제 및 이의 용도 |
| GB202209285D0 (en) | 2022-06-24 | 2022-08-10 | Bergenbio Asa | Dosage regimen for AXL inhibitor |
| AR129722A1 (es) | 2022-06-28 | 2024-09-18 | Arcus Biosciences Inc | Compuestos inhibidores de axl |
| WO2024051667A1 (zh) * | 2022-09-05 | 2024-03-14 | 南京正大天晴制药有限公司 | 具有axl抑制活性的取代三唑化合物 |
| WO2024054793A1 (en) * | 2022-09-09 | 2024-03-14 | University Of Rochester | Inhibition of efferocytosis as a treatment to prevent bone loss and increase bone density and strength |
| TW202542115A (zh) * | 2023-12-13 | 2025-11-01 | 美商艾可瑞克斯生物科學公司 | 稠合醌化合物 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1403866A (en) * | 1971-12-06 | 1975-08-28 | Wyeth John & Brother Ltd | Derivatives of 3-amino-1,2,4-triazoles |
| WO1995003286A1 (en) | 1993-07-23 | 1995-02-02 | The Green Cross Corporation | Triazole derivative and pharmaceutical use thereof |
| GB9918180D0 (en) | 1999-08-02 | 1999-10-06 | Smithkline Beecham Plc | Novel compositions |
| CA2432870A1 (en) | 2000-12-22 | 2002-07-25 | Ronghui Lin | Substituted triazole diamine derivatives as kinase inhibitors |
| TWI335221B (en) | 2001-09-27 | 2011-01-01 | Alcon Inc | Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma |
| PL220850B1 (pl) | 2002-05-03 | 2016-01-29 | Janssen Pharmaceutica Nv | Kopolimer dwublokowy, kompozycja zawierająca składnik aktywny i jej zastosowanie oraz sposób jej wytwarzania |
| JP4483581B2 (ja) | 2002-08-06 | 2010-06-16 | 東レ株式会社 | 腎疾患治療又は予防剤及び腎疾患の診断方法 |
| AU2003286746A1 (en) * | 2002-10-29 | 2004-05-25 | Rigel Pharmaceuticals, Inc. | Modulators of angiogenesis and tumorigenesis |
| AR042052A1 (es) * | 2002-11-15 | 2005-06-08 | Vertex Pharma | Diaminotriazoles utiles como inhibidores de proteinquinasas |
| CN1738615A (zh) * | 2002-11-15 | 2006-02-22 | 沃泰克斯药物股份有限公司 | 用作蛋白质激酶的抑制剂的二氨基三唑类 |
| AU2004263148B2 (en) | 2003-08-06 | 2008-08-21 | Vertex Pharmaceuticals, Incorporated | Aminotriazole compounds useful as inhibitors of protein kinases |
| BRPI0507634A (pt) | 2004-02-11 | 2007-07-03 | Janssen Pharmaceutica Nv | processo para preparação de compostos triazóis substituìdos |
| GB2415863A (en) | 2004-07-01 | 2006-01-04 | British Sky Broadcasting Ltd | Wireless network system and devices with redundancy between orthogonally polarised beams |
| RU2007109073A (ru) * | 2004-08-13 | 2008-09-20 | Дженентек, Инк. (Us) | Ингибиторы для атф-зависимого фермента на основе тиазола |
| MX2007003154A (es) * | 2004-09-17 | 2007-05-15 | Vertex Pharma | Compuestos de diaminotriazol de utilidad como inhibidores de proteina quinasa. |
| WO2006079921A2 (en) * | 2005-01-28 | 2006-08-03 | Pfizer Products Inc. | Drying of drug-containing particles |
| US7884119B2 (en) * | 2005-09-07 | 2011-02-08 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as Axl inhibitors |
| WO2008045978A1 (en) | 2006-10-10 | 2008-04-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors |
| FR2908131B1 (fr) | 2006-11-03 | 2009-01-09 | Univ Haute Alsace Etablissemen | Derives d'aminobenzocycloheptene,leurs procedes de preparation et leur utilisation en therapeutique |
| US7879856B2 (en) | 2006-12-22 | 2011-02-01 | Rigel Pharmaceuticals, Inc. | Diaminothiazoles useful as Axl inhibitors |
| EP2114954B1 (en) | 2006-12-29 | 2013-02-13 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| AU2007342005A1 (en) * | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as Axl inhibitors |
| ES2404668T3 (es) | 2006-12-29 | 2013-05-28 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con arilo bicíclico puenteado y heteroarilo bicíclico puenteado, útiles como agentes inhibidores del axl |
| PT2078010E (pt) | 2006-12-29 | 2014-05-07 | Rigel Pharmaceuticals Inc | Triazoles substituídos com heteroarilos policíclicos úteis como inibidores de axl |
| JP2010514810A (ja) | 2006-12-29 | 2010-05-06 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axlインヒビターとして有用な置換トリアゾール |
| AU2008266290A1 (en) | 2007-06-15 | 2008-12-24 | Irm Llc | Protein kinase inhibitors and methods for using thereof |
| CA2704052C (en) | 2007-10-26 | 2015-04-21 | Rigel Pharmaceuticals, Inc. | Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| US8431594B2 (en) | 2008-07-09 | 2013-04-30 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic heteroaryl substituted triazoles useful as AXL inhibitors |
| JP5592884B2 (ja) | 2008-07-09 | 2014-09-17 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Axl阻害剤として有用な多環式ヘテロアリール置換トリアゾール |
| RU2555326C2 (ru) | 2009-01-16 | 2015-07-10 | Риджел Фармасьютикалз, Инк. | ИНГИБИТОРЫ Axl ДЛЯ ПРИМЕНЕНИЯ В КОМБИНИРОВАННОЙ ТЕРАПИИ ДЛЯ ПРЕДОТВРАЩЕНИЯ, УСТРАНЕНИЯ ИЛИ ЛЕЧЕНИЯ МЕТАСТAЗИРУЮЩЕГО РАКА |
| CA2766735C (en) | 2011-02-07 | 2020-06-02 | Ortho-Clinical Diagnostics, Inc. | Determining conditions in centrifuged blood using measured pressure |
-
2007
- 2007-12-29 PT PT78701075T patent/PT2078010E/pt unknown
- 2007-12-29 JP JP2009544316A patent/JP5546250B2/ja active Active
- 2007-12-29 AU AU2007341937A patent/AU2007341937B2/en active Active
- 2007-12-29 US US11/967,172 patent/US7709482B2/en active Active
- 2007-12-29 WO PCT/US2007/089177 patent/WO2008083367A2/en not_active Ceased
- 2007-12-29 RS RS20140215A patent/RS53281B/sr unknown
- 2007-12-29 PL PL07870107T patent/PL2078010T3/pl unknown
- 2007-12-29 DK DK07870107.5T patent/DK2078010T3/da active
- 2007-12-29 CA CA2710234A patent/CA2710234C/en active Active
- 2007-12-29 ES ES07870107.5T patent/ES2460894T3/es active Active
- 2007-12-29 HR HRP20140378TT patent/HRP20140378T1/hr unknown
- 2007-12-29 EP EP07870107.5A patent/EP2078010B1/en active Active
- 2007-12-29 SI SI200731449T patent/SI2078010T1/sl unknown
- 2007-12-29 CN CN200780048656.9A patent/CN101622246B/zh active Active
- 2007-12-29 ME MEP-2014-47A patent/ME01832B/me unknown
-
2010
- 2010-03-09 US US12/720,448 patent/US8618331B2/en active Active
-
2011
- 2011-01-07 US US12/986,951 patent/US8168636B2/en active Active
-
2012
- 2012-03-19 US US13/423,924 patent/US8741898B2/en active Active
-
2014
- 2014-02-07 JP JP2014021926A patent/JP5797792B2/ja active Active
- 2014-04-24 US US14/261,094 patent/US9156820B2/en active Active
- 2014-04-28 CY CY20141100312T patent/CY1115188T1/el unknown
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