JP2010514811A5 - - Google Patents

Download PDF

Info

Publication number
JP2010514811A5
JP2010514811A5 JP2009544316A JP2009544316A JP2010514811A5 JP 2010514811 A5 JP2010514811 A5 JP 2010514811A5 JP 2009544316 A JP2009544316 A JP 2009544316A JP 2009544316 A JP2009544316 A JP 2009544316A JP 2010514811 A5 JP2010514811 A5 JP 2010514811A5
Authority
JP
Japan
Prior art keywords
optionally substituted
benzo
heteroaryl
group
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009544316A
Other languages
English (en)
Japanese (ja)
Other versions
JP5546250B2 (ja
JP2010514811A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/089177 external-priority patent/WO2008083367A2/en
Publication of JP2010514811A publication Critical patent/JP2010514811A/ja
Publication of JP2010514811A5 publication Critical patent/JP2010514811A5/ja
Application granted granted Critical
Publication of JP5546250B2 publication Critical patent/JP5546250B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009544316A 2006-12-29 2007-12-29 Ａｘｌインヒビターとして有用な多環式ヘテロアリール置換トリアゾール Active JP5546250B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US88285006P 2006-12-29 2006-12-29
US60/882,850 2006-12-29
US89540007P 2007-03-16 2007-03-16
US60/895,400 2007-03-16
US97093107P 2007-09-07 2007-09-07
US60/970,931 2007-09-07
PCT/US2007/089177 WO2008083367A2 (en) 2006-12-29 2007-12-29 Polycyclic heteroaryl substituted triazoles useful as axl inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014021926A Division JP5797792B2 (ja) 2006-12-29 2014-02-07 Ａｘｌインヒビターとして有用な多環式ヘテロアリール置換トリアゾール

Publications (3)

Publication Number Publication Date
JP2010514811A JP2010514811A (ja) 2010-05-06
JP2010514811A5 true JP2010514811A5 (enExample) 2012-09-06
JP5546250B2 JP5546250B2 (ja) 2014-07-09

Family

ID=39387343

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009544316A Active JP5546250B2 (ja) 2006-12-29 2007-12-29 Ａｘｌインヒビターとして有用な多環式ヘテロアリール置換トリアゾール
JP2014021926A Active JP5797792B2 (ja) 2006-12-29 2014-02-07 Ａｘｌインヒビターとして有用な多環式ヘテロアリール置換トリアゾール

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014021926A Active JP5797792B2 (ja) 2006-12-29 2014-02-07 Ａｘｌインヒビターとして有用な多環式ヘテロアリール置換トリアゾール

Country Status (16)

Country Link
US (5) US7709482B2 (enExample)
EP (1) EP2078010B1 (enExample)
JP (2) JP5546250B2 (enExample)
CN (1) CN101622246B (enExample)
AU (1) AU2007341937B2 (enExample)
CA (1) CA2710234C (enExample)
CY (1) CY1115188T1 (enExample)
DK (1) DK2078010T3 (enExample)
ES (1) ES2460894T3 (enExample)
HR (1) HRP20140378T1 (enExample)
ME (1) ME01832B (enExample)
PL (1) PL2078010T3 (enExample)
PT (1) PT2078010E (enExample)
RS (1) RS53281B (enExample)
SI (1) SI2078010T1 (enExample)
WO (1) WO2008083367A2 (enExample)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006135993A1 (en) * 2005-06-24 2006-12-28 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis c.
CA2621503C (en) * 2005-09-07 2014-05-20 Rigel Pharmaceuticals, Inc. Triazole derivatives useful as axl inhibitors
US8338435B2 (en) * 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections
TW200840584A (en) * 2006-12-26 2008-10-16 Gilead Sciences Inc Pyrido(3,2-d)pyrimidines useful for treating viral infections
RS53281B (sr) 2006-12-29 2014-08-29 Rigel Pharmaceuticals Inc. Policiklični heteroaril supstituisani triazoli koji su korisni kao axl inhibitori
CA2710051C (en) 2006-12-29 2017-05-16 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as axl inhibitors
CA2710230C (en) 2006-12-29 2016-02-23 Rigel Pharmaceuticals, Inc. Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
CN101622248B (zh) 2006-12-29 2013-04-17 里格尔制药公司 用作axl抑制剂的n3-杂芳基取代的三唑和n5-杂芳基取代的三唑
ES2406930T3 (es) * 2006-12-29 2013-06-10 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con arilo bicíclico y heteroarilo bicíclico útiles como inhibidores de AXL
CA2704052C (en) * 2007-10-26 2015-04-21 Rigel Pharmaceuticals, Inc. Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors
HRP20170317T1 (hr) 2008-02-15 2017-04-21 Rigel Pharmaceuticals, Inc. Spojevi pirimidin-2-amina i njihova uporaba kao inhibitora jak kinaza
CA2730251C (en) 2008-07-09 2016-08-09 Rigel Pharmaceuticals, Inc. Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
CA2730231C (en) 2008-07-09 2016-10-18 Rigel Pharmaceuticals, Inc. Polycyclic heteroaryl substituted triazoles useful as axl inhibitors
JP4644273B2 (ja) * 2008-07-15 2011-03-02 本田技研工業株式会社 車両周辺監視装置
BRPI1007046B1 (pt) 2009-01-16 2019-07-16 Rigel Pharmaceuticals, Inc. Inibidores axl para uso em terapia de combinação para evitar, tratar ou controlar o câncer metastático.
CA3056999A1 (en) 2010-01-22 2011-07-28 Amato J. Giaccia Inhibition of axl signaling in anti-metastatic therapy
US9074192B2 (en) 2010-01-22 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of AXL signaling in anti-metastatic therapy
US9879061B2 (en) 2011-12-15 2018-01-30 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of AXL/GAS6 signaling in the treatment of liver fibrosis
SG11201404505PA (en) 2012-01-31 2014-10-30 Daiichi Sankyo Co Ltd Pyridone derivative
WO2014018535A1 (en) 2012-07-25 2014-01-30 Salk Institute For Biological Studies Regulating the interaction between tam ligands and lipid membranes with exposed phosphatidylserine
AR096654A1 (es) 2013-06-20 2016-01-27 Ab Science Derivados de benzimidazol como inhibidores selectivos de proteína quinasa
AU2014353006B2 (en) 2013-11-20 2019-04-04 Signalchem Life Sciences Corp. Quinazoline derivatives as TAM family kinase inhibitors
JP6496731B2 (ja) 2013-11-27 2019-04-03 シグナルケム・ライフサイエンシーズ・コーポレイションＳｉｇｎａｌｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｔａｍファミリーキナーゼ阻害剤としてのアミノピリジン誘導体
US9801880B2 (en) 2013-12-02 2017-10-31 Bergenbio As Use of kinase inhibitors
TWI723572B (zh) 2014-07-07 2021-04-01 日商第一三共股份有限公司 具有四氫吡喃基甲基之吡啶酮衍生物及其用途
CA2909669C (en) 2014-10-20 2023-12-12 Ruga Corporation Antiviral activity of gas6 inhibitor
GB201420285D0 (en) 2014-11-14 2014-12-31 Bergenbio As Process
US9840503B2 (en) 2015-05-11 2017-12-12 Incyte Corporation Heterocyclic compounds and uses thereof
GB201509338D0 (en) 2015-05-29 2015-07-15 Bergenbio As Combination therapy
WO2017027717A1 (en) 2015-08-12 2017-02-16 Incyte Corporation Bicyclic fused pyrimidine compounds as tam inhibitors
WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
ES2896079T3 (es) 2016-02-26 2022-02-23 Ono Pharmaceutical Co Fármaco para la terapia del cáncer, caracterizado por la administración de la combinación entre un inhibidor de Axl y un inhibidor del punto de control inmunitario
TWI828027B (zh) 2016-03-28 2024-01-01 美商英塞特公司 作為tam抑制劑之吡咯并三嗪化合物
CN106083764B (zh) * 2016-07-11 2018-09-18 上海皓元生物医药科技有限公司 一种用于制备axl抑制剂的高纯度中间体的手性拆分方法
EP3673907A4 (en) 2017-08-23 2020-08-19 ONO Pharmaceutical Co., Ltd. CANCER TREATMENT PHARMACEUTICAL INCLUDING AX1 INHIBITOR AS AN EFFECTIVE INGREDIENT
US10633387B2 (en) 2017-09-27 2020-04-28 Incyte Corporation Salts of TAM inhibitors
US11826363B2 (en) 2017-10-13 2023-11-28 Ono Pharmaceutical Co., Ltd. Therapeutic agent for solid cancers, which comprises Axl inhibitor as active ingredient
ES3031110T3 (en) 2018-06-29 2025-07-04 Incyte Corp Formulations of an axl/mer inhibitor
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
GB201912059D0 (en) 2019-08-22 2019-10-09 Bergenbio As Combaination therapy of a patient subgroup
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
PH12022552347A1 (en) 2020-03-06 2024-01-29 Incyte Corp Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors
GB202004189D0 (en) 2020-03-23 2020-05-06 Bergenbio As Combination therapy
WO2021204713A1 (en) 2020-04-08 2021-10-14 Bergenbio Asa Axl inhibitors for antiviral therapy
GB202006072D0 (en) 2020-04-24 2020-06-10 Bergenbio Asa Method of selecting patients for treatment with cmbination therapy
GB202104037D0 (en) 2021-03-23 2021-05-05 Bergenbio Asa Combination therapy
WO2022220227A1 (ja) * 2021-04-14 2022-10-20 エーザイ・アール・アンド・ディー・マネジメント株式会社 テトラヒドロピリドピリミジン化合物
CN115504967A (zh) * 2021-06-23 2022-12-23 南京正大天晴制药有限公司 作为axl抑制剂的1,2,4-三唑化合物
US20250129067A1 (en) 2021-11-08 2025-04-24 Progentos Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
GB202209285D0 (en) 2022-06-24 2022-08-10 Bergenbio Asa Dosage regimen for AXL inhibitor
AR129722A1 (es) 2022-06-28 2024-09-18 Arcus Biosciences Inc Compuestos inhibidores de axl
WO2024051667A1 (zh) * 2022-09-05 2024-03-14 南京正大天晴制药有限公司 具有axl抑制活性的取代三唑化合物
US20260069610A1 (en) * 2022-09-09 2026-03-12 University Of Rochester Inhibition of efferocytosis as a treatment to prevent bone loss and increase bone density and strength
AU2024399575A1 (en) * 2023-12-13 2026-06-25 Acurex Biosciences Corporation Fused quinone compounds

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1403866A (en) * 1971-12-06 1975-08-28 Wyeth John & Brother Ltd Derivatives of 3-amino-1,2,4-triazoles
EP0710654A4 (en) 1993-07-23 1996-08-28 Green Cross Corp TRIAZOLE DERIVATIVE AND ITS PHARMACEUTICAL USE
GB9918180D0 (en) 1999-08-02 1999-10-06 Smithkline Beecham Plc Novel compositions
NZ526624A (en) * 2000-12-22 2005-07-29 Ortho Mcneil Pharm Inc Substituted triazole diamine derivatives as kinase inhibitors
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
MXPA04010778A (es) 2002-05-03 2005-03-07 Janssen Pharmaceutica Nv Microemulsiones polimericas.
US20060293256A1 (en) * 2002-08-06 2006-12-28 Masateru Yamada Remedy or preventive for kidney disease and method of diagnosing kidney disease
EP1563094A4 (en) * 2002-10-29 2007-04-25 Rigel Pharmaceuticals Inc MODULATORS OF ANGIOGENESIS AND TUMORIGENESIS
CN1738615A (zh) * 2002-11-15 2006-02-22 沃泰克斯药物股份有限公司 用作蛋白质激酶的抑制剂的二氨基三唑类
AR042052A1 (es) * 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
ATE455546T1 (de) 2003-08-06 2010-02-15 Vertex Pharma Aminotriazol-verbindungen als proteinkinase- hemmer
WO2005077922A2 (en) 2004-02-11 2005-08-25 Janssen Pharmaceutica, N.V. Process for the preparation of substituted triazole compounds
GB2415863A (en) 2004-07-01 2006-01-04 British Sky Broadcasting Ltd Wireless network system and devices with redundancy between orthogonally polarised beams
BRPI0515012A (pt) * 2004-08-13 2008-07-01 Genentech Inc substáncia quìmica, composição e formulação farmacêutica, método de tratamento, método de inibição de pelo menos uma enzima que utiliza atp e uso
PT1791830E (pt) * 2004-09-17 2011-04-04 Vertex Pharma Compostos de diaminotriazole úteis como inibidores de proteína-quinase
WO2006079921A2 (en) * 2005-01-28 2006-08-03 Pfizer Products Inc. Drying of drug-containing particles
CA2621503C (en) * 2005-09-07 2014-05-20 Rigel Pharmaceuticals, Inc. Triazole derivatives useful as axl inhibitors
US8097630B2 (en) 2006-10-10 2012-01-17 Rigel Pharmaceuticals, Inc. Pinane-substituted pyrimidinediamine derivatives useful as Axl inhibitors
FR2908131B1 (fr) 2006-11-03 2009-01-09 Univ Haute Alsace Etablissemen Derives d'aminobenzocycloheptene,leurs procedes de preparation et leur utilisation en therapeutique
WO2008080134A2 (en) 2006-12-22 2008-07-03 Rigel Pharmaceuticals, Inc. 4-amin0-2- (hetero) arylamino-5- (hetero) arylthiazoles useful as axl inhibitors
CA2710051C (en) 2006-12-29 2017-05-16 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as axl inhibitors
CN101622248B (zh) 2006-12-29 2013-04-17 里格尔制药公司 用作axl抑制剂的n3-杂芳基取代的三唑和n5-杂芳基取代的三唑
ES2406930T3 (es) * 2006-12-29 2013-06-10 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con arilo bicíclico y heteroarilo bicíclico útiles como inhibidores de AXL
CA2710230C (en) 2006-12-29 2016-02-23 Rigel Pharmaceuticals, Inc. Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
RS53281B (sr) 2006-12-29 2014-08-29 Rigel Pharmaceuticals Inc. Policiklični heteroaril supstituisani triazoli koji su korisni kao axl inhibitori
BRPI0813356A2 (pt) 2007-06-15 2014-12-30 Irm Llc Inibidores de proteína quinase e métodos para uso dos mesmos
CA2704052C (en) 2007-10-26 2015-04-21 Rigel Pharmaceuticals, Inc. Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors
HRP20170317T1 (hr) 2008-02-15 2017-04-21 Rigel Pharmaceuticals, Inc. Spojevi pirimidin-2-amina i njihova uporaba kao inhibitora jak kinaza
CA2730231C (en) 2008-07-09 2016-10-18 Rigel Pharmaceuticals, Inc. Polycyclic heteroaryl substituted triazoles useful as axl inhibitors
CA2730251C (en) 2008-07-09 2016-08-09 Rigel Pharmaceuticals, Inc. Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
BRPI1007046B1 (pt) 2009-01-16 2019-07-16 Rigel Pharmaceuticals, Inc. Inibidores axl para uso em terapia de combinação para evitar, tratar ou controlar o câncer metastático.
CA2766735C (en) 2011-02-07 2020-06-02 Ortho-Clinical Diagnostics, Inc. Determining conditions in centrifuged blood using measured pressure

Similar Documents

Publication Publication Date Title
JP2014080439A5 (enExample)
KR101428346B1 (ko) 벤즈옥사제핀 ｐｉ3ｋ 억제 화합물 및 사용 방법
AU2020274083B9 (en) FGFR inhibitors and methods of use thereof
CA3210224A1 (en) Cdk inhibitors and methods of use thereof
AU2019245403B2 (en) Imidazopiperazine inhibitors of transcription activating proteins
KR101449217B1 (ko) 벤즈옥세핀 ｐｉ3ｋ 억제제 화합물 및 사용 방법
TW202136255A (zh) 用於治療與ｓｔｉｎｇ活性相關之病狀的化合物及組合物
EP3670506B1 (en) Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
AU2007341937B2 (en) Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
TW202012409A (zh) 作為a2a/a2b 抑制劑之稠合吡嗪衍生物
AU2012302011A1 (en) Antibacterial compounds and methods for use
US10899769B2 (en) Imidazopiperazinone inhibitors of transcription activating proteins
JP2020514267A5 (enExample)
UA125503C2 (uk) Заміщені трициклічні сполуки як інгібітори fgfr
AU2007342005A1 (en) N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as Axl inhibitors
AU2010341573A1 (en) Isoindolinone inhibitors of phosphatidylinositol 3-kinase
CA2989499A1 (en) Pyridinyl/pyrimidinyl amide derivatives as cdk9 inhibitors
CN112218631B (zh) Atr激酶的杂环抑制剂
EP4100381A1 (en) Substituted 1,1'-biphenyl compounds and methods using same
JP6110787B2 (ja) ピリミドジアゼピノン化合物
CN114761404B (zh) 经取代的双环杂芳基化合物
EP4313983B1 (en) (s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo[1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
TW200819437A (en) Chemical compounds
US20190367536A1 (en) TETRAHYDROPYRIDO[4,3-d]PYRIMIDINE INHIBITORS OF ATR KINASE
KR20210046739A (ko) 고 활성 sting 단백질 작용제