JP2010512324A5 - - Google Patents
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- Publication number
- JP2010512324A5 JP2010512324A5 JP2009540318A JP2009540318A JP2010512324A5 JP 2010512324 A5 JP2010512324 A5 JP 2010512324A5 JP 2009540318 A JP2009540318 A JP 2009540318A JP 2009540318 A JP2009540318 A JP 2009540318A JP 2010512324 A5 JP2010512324 A5 JP 2010512324A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- amino acid
- antibody
- fragment
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
- 101000760337 Homo sapiens Urokinase plasminogen activator surface receptor Proteins 0.000 claims description 30
- 239000012634 fragment Substances 0.000 claims description 30
- 150000001413 amino acids Chemical class 0.000 claims description 26
- 241000124008 Mammalia Species 0.000 claims description 22
- 210000004988 splenocyte Anatomy 0.000 claims description 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 210000004027 cell Anatomy 0.000 claims description 11
- 230000001419 dependent effect Effects 0.000 claims description 11
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 10
- 210000004408 hybridoma Anatomy 0.000 claims description 10
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 10
- 230000003053 immunization Effects 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 108040001269 urokinase plasminogen activator receptor activity proteins Proteins 0.000 description 24
- 102000009816 urokinase plasminogen activator receptor activity proteins Human genes 0.000 description 24
- 235000001014 amino acid Nutrition 0.000 description 17
- 239000000427 antigen Substances 0.000 description 9
- 102000036639 antigens Human genes 0.000 description 9
- 108091007433 antigens Proteins 0.000 description 9
- 238000000749 co-immunoprecipitation Methods 0.000 description 3
- 241000282693 Cercopithecidae Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012133 immunoprecipitate Substances 0.000 description 2
- 241000283707 Capra Species 0.000 description 1
- 241000867607 Chlorocebus sabaeus Species 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 101150038998 PLAUR gene Proteins 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical group 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000011490 co-immunoprecipitation assay Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87362706P | 2006-12-08 | 2006-12-08 | |
| US93003407P | 2007-05-11 | 2007-05-11 | |
| PCT/US2007/025105 WO2008073312A2 (en) | 2006-12-08 | 2007-12-07 | Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014154804A Division JP6019457B2 (ja) | 2006-12-08 | 2014-07-30 | ウロキナーゼ型プラスミノーゲン活性化因子受容体エピトープ、それに由来するモノクローナル抗体及びそれらの使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010512324A JP2010512324A (ja) | 2010-04-22 |
| JP2010512324A5 true JP2010512324A5 (enExample) | 2011-02-03 |
Family
ID=39512272
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540318A Pending JP2010512324A (ja) | 2006-12-08 | 2007-12-07 | ウロキナーゼ型プラスミノーゲン活性化因子受容体エピトープ、それに由来するモノクローナル抗体及びそれらの使用方法 |
| JP2014154804A Active JP6019457B2 (ja) | 2006-12-08 | 2014-07-30 | ウロキナーゼ型プラスミノーゲン活性化因子受容体エピトープ、それに由来するモノクローナル抗体及びそれらの使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014154804A Active JP6019457B2 (ja) | 2006-12-08 | 2014-07-30 | ウロキナーゼ型プラスミノーゲン活性化因子受容体エピトープ、それに由来するモノクローナル抗体及びそれらの使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8105602B2 (enExample) |
| EP (1) | EP2117571B1 (enExample) |
| JP (2) | JP2010512324A (enExample) |
| CA (1) | CA2671971C (enExample) |
| DK (1) | DK2117571T3 (enExample) |
| ES (1) | ES2636451T3 (enExample) |
| PL (1) | PL2117571T3 (enExample) |
| PT (1) | PT2117571T (enExample) |
| WO (1) | WO2008073312A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070047246A (ko) * | 2004-05-25 | 2007-05-04 | 아테뉴온, 엘엘씨 | 유로키나아제형 플라스미노겐 활성인자(ｕＰＡ)와 그의수용체(ｕＰＡＲ)의 복합체에 결합하여 하류 ｕＰＡＲ상호작용을 억제하는 리간드의 동정 및 진단 또는치료에서의 용도 |
| US8105602B2 (en) | 2006-12-08 | 2012-01-31 | Tactic Pharma, Llc | Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof |
| US8697081B2 (en) * | 2008-04-09 | 2014-04-15 | The Regents Of The University Of Michigan | Method of modulating neovascularization |
| WO2011028531A1 (en) | 2009-08-24 | 2011-03-10 | Baylor College Of Medicine | Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses |
| PT2510012T (pt) * | 2009-12-09 | 2017-07-13 | Bayer Pharma AG | Anticorpos anti-c4.4a e utilizações dos mesmos |
| EP2534179A4 (en) * | 2010-02-12 | 2013-07-17 | Univ California | UPAR BINDING AGENT AND METHOD FOR THEIR USE |
| BR112013016107A2 (pt) | 2010-12-22 | 2017-04-04 | Ifom Fond Inst Firc Di Oncologia Molecolare | molécula dimérica, método de tratamento de câncer, composição farmacêutica e kit para o diagnóstico de uma patologia ou tumor mediado(a) por upar |
| CN103930128A (zh) | 2011-08-05 | 2014-07-16 | 意大利癌症研究基金会分子肿瘤学研究所(Ifom) | 组成型活性uPAR变体及其在抑制性抗体的生成与分离中的应用 |
| GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
| PT2812431T (pt) | 2012-02-09 | 2019-10-18 | Baylor College Medicine | Pepmixes para gerar ctls multivirais com larga especifidade |
| WO2015004148A1 (en) | 2013-07-08 | 2015-01-15 | Ifom Fondazione Istituto Firc Di Oncologia Molecolare | Biomarker of plasminogen activation system and/or of upar/vn interaction and uses thereof |
| WO2015017386A1 (en) * | 2013-08-01 | 2015-02-05 | The General Hospital Corporation | NON-GLYCOSYLATED suPAR BIOMARKERS AND USES THEREOF |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| SG10202112047TA (en) | 2015-09-18 | 2021-12-30 | Baylor College Medicine | Immunogenic antigen identification from a pathogen and correlation to clinical efficacy |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP7140362B2 (ja) * | 2018-04-09 | 2022-09-21 | 国立大学法人東海国立大学機構 | 活性型組換えアクロシン |
| CN115867570A (zh) * | 2020-06-15 | 2023-03-28 | 莫诺帕医疗公司 | 精确放射免疫治疗靶向尿激酶纤溶酶原激活剂受体（uPAR）以治疗严重COVID-19疾病 |
| EP4341265A4 (en) * | 2021-05-21 | 2025-07-23 | Northstar Medical Tech Llc | TRIVALENT RADIOISTOPE BIO-TARGETED RADIOPHARMACEUTICAL, METHODS OF PREPARATION AND USE |
| CN116410312A (zh) * | 2021-12-29 | 2023-07-11 | 博生吉医药科技(苏州)有限公司 | 一种新型upar单域抗体的开发 |
| EP4490511A2 (en) * | 2022-03-07 | 2025-01-15 | Rush University Medical Center | Novel treatment of diabetes and kidney disease by inhibition of d2d3 a proteolytic upar protein |
| CN117264061B (zh) * | 2023-11-22 | 2024-03-01 | 中山大学附属第八医院（深圳福田） | 一种识别uPAR的纳米抗体及其应用 |
| WO2025207781A1 (en) | 2024-03-26 | 2025-10-02 | Monopar Therapeutics Inc. | Antibody radioisotope constructs |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US5057313A (en) * | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8721023D0 (en) | 1987-09-07 | 1987-10-14 | Lepetit Spa | Modified plasminogen activators |
| IT1228881B (it) | 1988-08-12 | 1991-07-09 | Lepetit Spa | Anticorpo monoclonale specifico per l'epitopo dell'urochinasi prourichinasi corrispondente alla regione denominata gfd |
| US5066789A (en) * | 1988-09-30 | 1991-11-19 | Neorx Corporation | Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages |
| US5519120A (en) * | 1989-04-07 | 1996-05-21 | Cancerforskningsfondet Af 1989 | Urokinase-type plasminogen activator receptor antibodies |
| DE69033653T2 (de) * | 1989-04-07 | 2001-06-07 | Cancerforskningsfonden Af 1989 (Fonden Til Fremme Af Eksperimental Cancerforskning), Kopenhagen | Plasminogen-aktivator-rezeptor vom urokinasetyp |
| US5891664A (en) * | 1989-04-07 | 1999-04-06 | Cancerforskningsfondet Af 1989 | Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR) |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| CA2094276C (en) | 1990-10-18 | 2005-08-23 | Keld Dano | Antibodies against the urokinase receptor and their use |
| US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| JPH07501524A (ja) | 1991-11-18 | 1995-02-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ｕＰＡ−Ｒの検出・分離方法及びｕＰＡのｕＰＡ−Ｒへの結合阻止方法 |
| US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
| ES2143504T3 (es) | 1992-05-28 | 2000-05-16 | Univ Toledo | Uso de un material citotoxico acoplado a un material inhibidor del activador plasminogeno para la produccion de un medicamento para el tratamiento de celulas cancerigenas. |
| US5608110A (en) * | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
| WO1995004281A1 (en) * | 1993-07-27 | 1995-02-09 | THE UNITED STATES GOVERNMENT, represented by THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION | Quantitative method of measuring cancer cell urokinase and metastatic potential |
| US5532132A (en) * | 1993-09-28 | 1996-07-02 | President And Fellows Of Harvard University | Method for regulating formation of a complex of plasminogen activator, its receptor and inhibitor |
| JP2852192B2 (ja) * | 1994-07-08 | 1999-01-27 | カンセアフォースクニングスフォンデン・アフ・１９８９（フォンデン・チル・フレメ・アフ・エクスペリメンテル・カンセアフォースクニング） | ｕＰＡＲのドメイン２＋３のｕＰＡ結合部位および抗体 |
| US5618513A (en) * | 1995-06-07 | 1997-04-08 | Mallinckrodt Medical, Inc. | Method for preparing radiolabeled peptides |
| WO1997033899A1 (en) | 1996-03-14 | 1997-09-18 | Human Genome Sciences, Inc. | Apoptosis inducing molecule i |
| KR100497017B1 (ko) | 1996-03-22 | 2005-11-29 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 고사유도분자ii |
| EP1042343B1 (en) | 1997-11-03 | 2008-01-23 | Human Genome Sciences, Inc. | Vegi, an inhibitor of angiogenesis and tumor growth |
| US6077508A (en) | 1998-03-23 | 2000-06-20 | American Diagnostica Inc. | Urokinase plasminogen activator receptor as a target for diagnosis of metastases |
| DE50015293D1 (de) | 1999-04-13 | 2008-09-11 | Wilex Ag | Diagnostischer und therapeutischer Einsatz von Antikörpern gegen den Urokinase-Rezeptor |
| DE60219888T2 (de) | 2001-01-25 | 2008-01-17 | Fondazione Centro San Raffaele Del Monte Tabor | Antikörper zur modulierung der upa/upar interaktion und deren verwendungen |
| US6846484B2 (en) | 2001-12-28 | 2005-01-25 | Regents Of The University Of Minnesota | DTAT fusion toxin |
| ATE524739T1 (de) | 2002-02-13 | 2011-09-15 | American Diagnostica Inc | Verfahren zur auswahl von behandlungsschemata und vorhersage von behandlungsresultaten bei krebspatienten |
| WO2003079974A2 (en) * | 2002-03-18 | 2003-10-02 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Integrin ligand |
| KR100470535B1 (ko) | 2002-06-27 | 2005-02-22 | 재단법인서울대학교산학협력재단 | 유피에이 항체 부착 이뮤노리포좀 |
| WO2004099780A1 (en) | 2003-05-06 | 2004-11-18 | Rigshospitalet | Immunoassays for the detection of urokinase receptor forms |
| CA2546237A1 (en) | 2003-11-18 | 2005-06-02 | Attenuon Llc | Antibodies and/or conjugates thereof which bind to the amino terminal fragment of urokinase, compositions and uses thereof |
| US7541159B2 (en) * | 2004-04-14 | 2009-06-02 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Molecular-specific urokinase antibodies |
| KR20070047246A (ko) | 2004-05-25 | 2007-05-04 | 아테뉴온, 엘엘씨 | 유로키나아제형 플라스미노겐 활성인자(ｕＰＡ)와 그의수용체(ｕＰＡＲ)의 복합체에 결합하여 하류 ｕＰＡＲ상호작용을 억제하는 리간드의 동정 및 진단 또는치료에서의 용도 |
| WO2006090389A2 (en) * | 2005-02-24 | 2006-08-31 | Compugen Ltd. | Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof |
| US8105602B2 (en) | 2006-12-08 | 2012-01-31 | Tactic Pharma, Llc | Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof |
-
2007
- 2007-12-07 US US12/001,037 patent/US8105602B2/en active Active
- 2007-12-07 PL PL07862653T patent/PL2117571T3/pl unknown
- 2007-12-07 CA CA2671971A patent/CA2671971C/en active Active
- 2007-12-07 JP JP2009540318A patent/JP2010512324A/ja active Pending
- 2007-12-07 EP EP07862653.8A patent/EP2117571B1/en active Active
- 2007-12-07 ES ES07862653.8T patent/ES2636451T3/es active Active
- 2007-12-07 DK DK07862653.8T patent/DK2117571T3/en active
- 2007-12-07 PT PT78626538T patent/PT2117571T/pt unknown
- 2007-12-07 WO PCT/US2007/025105 patent/WO2008073312A2/en not_active Ceased
-
2014
- 2014-07-30 JP JP2014154804A patent/JP6019457B2/ja active Active
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