JP2010511709A5 - - Google Patents
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- Publication number
- JP2010511709A5 JP2010511709A5 JP2009540267A JP2009540267A JP2010511709A5 JP 2010511709 A5 JP2010511709 A5 JP 2010511709A5 JP 2009540267 A JP2009540267 A JP 2009540267A JP 2009540267 A JP2009540267 A JP 2009540267A JP 2010511709 A5 JP2010511709 A5 JP 2010511709A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- imidazo
- phenylmethyl
- aryl
- purine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 N-dialkylamino Inorganic materials 0.000 claims description 27
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 26
- 125000005843 halogen group Chemical group 0.000 claims description 24
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims description 20
- 125000001424 substituent group Chemical group 0.000 claims description 9
- 229920006395 saturated elastomer Polymers 0.000 claims description 8
- LMKPHJYTFHAGHK-UHFFFAOYSA-N cyclodrine Chemical compound C1CCCC1(O)C(C(=O)OCCN(CC)CC)C1=CC=CC=C1 LMKPHJYTFHAGHK-UHFFFAOYSA-N 0.000 claims description 7
- OSXKHFTZRHDUJN-UHFFFAOYSA-N N(2),3-ethenoguanine Chemical compound O=C1NC2=NC=CN2C2=C1NC=N2 OSXKHFTZRHDUJN-UHFFFAOYSA-N 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
- 125000003003 spiro group Chemical group 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 125000000623 heterocyclic group Chemical group 0.000 claims description 3
- 125000004043 oxo group Chemical group O=* 0.000 claims description 3
- LMKVVNSEQFWADD-IKLZKGPXSA-N (4S)-5-benzyl-4,8-dimethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-12,14-diene-7-thione Chemical compound C[C@H]1NC2N3C(N(C(C2N1CC1=CC=CC=C1)=S)C)NC1C3=CC=C1 LMKVVNSEQFWADD-IKLZKGPXSA-N 0.000 claims description 2
- HTTROEILAAXBHH-MRVPVSSYSA-N (7s)-2,5-dimethyl-7-propan-2-yl-7,8-dihydro-3h-imidazo[2,1-b]purin-4-one Chemical compound C([C@@H](N=1)C(C)C)N2C=1N(C)C(=O)C1=C2N=C(C)N1 HTTROEILAAXBHH-MRVPVSSYSA-N 0.000 claims description 2
- WRIUADNGMJXJRO-UHFFFAOYSA-N 3-benzyl-5,7,7-trimethyl-2-(trifluoromethyl)-8h-imidazo[2,1-b]purin-4-one Chemical compound C1=2C(=O)N(C)C3=NC(C)(C)CN3C=2N=C(C(F)(F)F)N1CC1=CC=CC=C1 WRIUADNGMJXJRO-UHFFFAOYSA-N 0.000 claims description 2
- BJFYUTNMJGGJOQ-UYLHMDRGSA-N C[C@@H]1NC2N3C(N(C(C2N1)=O)C)NC1C3=CC=CC1 Chemical compound C[C@@H]1NC2N3C(N(C(C2N1)=O)C)NC1C3=CC=CC1 BJFYUTNMJGGJOQ-UYLHMDRGSA-N 0.000 claims description 2
- RMXSRFARZCDMQL-OOHRUDITSA-N C[C@H]1NC2N3C(N(C(C2N1CC1=CC=C(C=C1)Br)=O)C)NC1C3=CC=C1 Chemical compound C[C@H]1NC2N3C(N(C(C2N1CC1=CC=C(C=C1)Br)=O)C)NC1C3=CC=C1 RMXSRFARZCDMQL-OOHRUDITSA-N 0.000 claims description 2
- CEVCYARBXMROHU-XVSUJQINSA-N C[C@H]1NC2N3C(N(C(C2N1CC1=CC=C(C=C1)OC)=O)C)NC1C3=CC=C1 Chemical compound C[C@H]1NC2N3C(N(C(C2N1CC1=CC=C(C=C1)OC)=O)C)NC1C3=CC=C1 CEVCYARBXMROHU-XVSUJQINSA-N 0.000 claims description 2
- NUBDLRGGGIDRCR-KOGDIJHLSA-N C[C@H]1NC2N3C(N(C(C2N1CC1=CC=NC=C1)=O)C)NC1C3=CC=C1 Chemical compound C[C@H]1NC2N3C(N(C(C2N1CC1=CC=NC=C1)=O)C)NC1C3=CC=C1 NUBDLRGGGIDRCR-KOGDIJHLSA-N 0.000 claims description 2
- VRZPGEFNPZRJIS-BDAKNGLRSA-N cis-5,6a,7,8,9,9a-hexahydro-2,3,5-trimethylcyclopent[4,5]imidazo[2,1-b]purin-4(3h)-one Chemical compound N12C=3N=C(C)N(C)C=3C(=O)N(C)C2=N[C@H]2[C@@H]1CCC2 VRZPGEFNPZRJIS-BDAKNGLRSA-N 0.000 claims description 2
- 125000002541 furyl group Chemical group 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 2
- 125000006261 methyl amino sulfonyl group Chemical group [H]N(C([H])([H])[H])S(*)(=O)=O 0.000 claims description 2
- 150000004702 methyl esters Chemical class 0.000 claims description 2
- 125000001544 thienyl group Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 74
- 125000003118 aryl group Chemical group 0.000 claims 38
- 125000000753 cycloalkyl group Chemical group 0.000 claims 36
- 125000001072 heteroaryl group Chemical group 0.000 claims 28
- 229910052799 carbon Inorganic materials 0.000 claims 25
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 125000003710 aryl alkyl group Chemical group 0.000 claims 19
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 19
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical group 0.000 claims 15
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 14
- 229940121836 Phosphodiesterase 1 inhibitor Drugs 0.000 claims 13
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 10
- 125000004663 dialkyl amino group Chemical group 0.000 claims 10
- 150000001721 carbon Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000004414 alkyl thio group Chemical group 0.000 claims 7
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 7
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims 5
- 125000004423 acyloxy group Chemical group 0.000 claims 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 4
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 125000006682 monohaloalkyl group Chemical group 0.000 claims 4
- 125000006684 polyhaloalkyl group Polymers 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 4
- 125000001769 aryl amino group Chemical group 0.000 claims 3
- 125000005110 aryl thio group Chemical group 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 3
- 229940011871 estrogen Drugs 0.000 claims 3
- 239000000262 estrogen Substances 0.000 claims 3
- 125000005241 heteroarylamino group Chemical group 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- VILOVKQUBCFZCP-UHFFFAOYSA-N 2,5,7,7,8-pentamethyl-3,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound N=1C(C)(C)C(C)N2C=1N(C)C(=O)C1=C2N=C(C)N1 VILOVKQUBCFZCP-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000005122 aminoalkylamino group Chemical group 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 2
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 125000005191 hydroxyalkylamino group Chemical group 0.000 claims 2
- 230000009245 menopause Effects 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 239000000186 progesterone Substances 0.000 claims 2
- 229960003387 progesterone Drugs 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 claims 1
- ZFIXLLHBDJAIIF-VAJTXYMYSA-N (4R)-5-benzyl-4,8-dimethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-12,14-dien-7-one Chemical compound C[C@@H]1NC2N3C(N(C(C2N1CC1=CC=CC=C1)=O)C)NC1C3=CC=C1 ZFIXLLHBDJAIIF-VAJTXYMYSA-N 0.000 claims 1
- HTTROEILAAXBHH-QMMMGPOBSA-N (7r)-2,5-dimethyl-7-propan-2-yl-7,8-dihydro-3h-imidazo[2,1-b]purin-4-one Chemical compound C([C@H](N=1)C(C)C)N2C=1N(C)C(=O)C1=C2N=C(C)N1 HTTROEILAAXBHH-QMMMGPOBSA-N 0.000 claims 1
- NVRVNEBAXHEDFJ-LJQANCHMSA-N (7r)-3,7-dibenzyl-2,5-dimethyl-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound C([C@H]1N=C2N(C(C=3N(CC=4C=CC=CC=4)C(C)=NC=3N2C1)=O)C)C1=CC=CC=C1 NVRVNEBAXHEDFJ-LJQANCHMSA-N 0.000 claims 1
- IEPMPAZHBXLCOP-LLVKDONJSA-N (7r)-3-benzyl-2,5,7-trimethyl-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound C([C@H](N=1)C)N2C=1N(C)C(=O)C1=C2N=C(C)N1CC1=CC=CC=C1 IEPMPAZHBXLCOP-LLVKDONJSA-N 0.000 claims 1
- UGTHPHLZFMDADA-MRXNPFEDSA-N (7r)-3-benzyl-2,5-dimethyl-7-(2-methylpropyl)-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound C([C@H](N=1)CC(C)C)N2C=1N(C)C(=O)C1=C2N=C(C)N1CC1=CC=CC=C1 UGTHPHLZFMDADA-MRXNPFEDSA-N 0.000 claims 1
- UKYVGPSNGAZSMN-SFHVURJKSA-N (7r)-3-benzyl-2,5-dimethyl-7-phenyl-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound C([C@H](N=C1N(C(C=23)=O)C)C=4C=CC=CC=4)N1C=2N=C(C)N3CC1=CC=CC=C1 UKYVGPSNGAZSMN-SFHVURJKSA-N 0.000 claims 1
- LPWLBWDFJZDWEX-HNNXBMFYSA-N (7r)-3-benzyl-2,5-dimethyl-7-propan-2-yl-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound C([C@H](N=1)C(C)C)N2C=1N(C)C(=O)C1=C2N=C(C)N1CC1=CC=CC=C1 LPWLBWDFJZDWEX-HNNXBMFYSA-N 0.000 claims 1
- LPWLBWDFJZDWEX-OAHLLOKOSA-N (7s)-3-benzyl-2,5-dimethyl-7-propan-2-yl-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound C([C@@H](N=1)C(C)C)N2C=1N(C)C(=O)C1=C2N=C(C)N1CC1=CC=CC=C1 LPWLBWDFJZDWEX-OAHLLOKOSA-N 0.000 claims 1
- DOWZFRHFNTWIRI-FQNRMIAFSA-N (7s)-3-benzyl-7-butan-2-yl-2,5-dimethyl-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound C([C@@H](N=1)C(C)CC)N2C=1N(C)C(=O)C1=C2N=C(C)N1CC1=CC=CC=C1 DOWZFRHFNTWIRI-FQNRMIAFSA-N 0.000 claims 1
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- AVUXINBHZQJDEL-UHFFFAOYSA-N 2,5,7,7-tetramethyl-3,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound O=C1N(C)C2=NC(C)(C)CN2C2=C1NC(C)=N2 AVUXINBHZQJDEL-UHFFFAOYSA-N 0.000 claims 1
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 claims 1
- YYYNZFNCEJVVKL-UHFFFAOYSA-N 3-benzyl-2,5-dimethyl-7-propyl-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound N=1C(CCC)CN2C=1N(C)C(=O)C1=C2N=C(C)N1CC1=CC=CC=C1 YYYNZFNCEJVVKL-UHFFFAOYSA-N 0.000 claims 1
- WFJGMVOWVZKNLA-UHFFFAOYSA-N 3-benzyl-5-methyl-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound C1=2C(=O)N(C)C3=NCCN3C=2N=CN1CC1=CC=CC=C1 WFJGMVOWVZKNLA-UHFFFAOYSA-N 0.000 claims 1
- PAIMQQBUPHMLIS-UHFFFAOYSA-N 3-benzyl-5-methyl-8,9-dihydro-7h-pyrimido[2,1-b]purin-4-one Chemical compound N12CCCN=C2N(C)C(=O)C2=C1N=CN2CC1=CC=CC=C1 PAIMQQBUPHMLIS-UHFFFAOYSA-N 0.000 claims 1
- PNWOWTKHERLXTQ-UHFFFAOYSA-N 3-benzyl-5-methyl-8-phenyl-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound C1=2C(=O)N(C)C3=NCC(C=4C=CC=CC=4)N3C=2N=CN1CC1=CC=CC=C1 PNWOWTKHERLXTQ-UHFFFAOYSA-N 0.000 claims 1
- DCFKJGKOPGOTIK-UHFFFAOYSA-N 3-benzyl-5-methylspiro[7h-imidazo[2,1-b]purine-8,1'-cyclohexane]-4-one Chemical compound N12C=3N=CN(CC=4C=CC=CC=4)C=3C(=O)N(C)C2=NCC21CCCCC2 DCFKJGKOPGOTIK-UHFFFAOYSA-N 0.000 claims 1
- VPTYAXRMVTVLAL-UHFFFAOYSA-N 3-benzyl-7-ethyl-2,5-dimethyl-7,8-dihydroimidazo[2,1-b]purin-4-one Chemical compound N=1C(CC)CN2C=1N(C)C(=O)C1=C2N=C(C)N1CC1=CC=CC=C1 VPTYAXRMVTVLAL-UHFFFAOYSA-N 0.000 claims 1
- VMYIZJTYOYPOCT-UHFFFAOYSA-N 5-benzyl-4,8,11-trimethyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one Chemical compound C1=2C(=O)N(C)C3=NC4(C)CCCC4N3C=2N=C(C)N1CC1=CC=CC=C1 VMYIZJTYOYPOCT-UHFFFAOYSA-N 0.000 claims 1
- 208000037853 Abnormal uterine bleeding Diseases 0.000 claims 1
- 201000000736 Amenorrhea Diseases 0.000 claims 1
- 206010001928 Amenorrhoea Diseases 0.000 claims 1
- 201000005670 Anovulation Diseases 0.000 claims 1
- 206010002659 Anovulatory cycle Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
- STKXMYWTVCSRLS-UHFFFAOYSA-N CC1N=C2C(=CN(C3=NC4(CCCCC4)CN23)C)N1CC5=CC=CC=C5 Chemical compound CC1N=C2C(=CN(C3=NC4(CCCCC4)CN23)C)N1CC5=CC=CC=C5 STKXMYWTVCSRLS-UHFFFAOYSA-N 0.000 claims 1
- CNVAHKSOYWOKJP-UHFFFAOYSA-N CC1N=C2C(=CN(C3=NCC4(N23)CCCCC4)C)N1CC5=CC=CC=C5 Chemical compound CC1N=C2C(=CN(C3=NCC4(N23)CCCCC4)C)N1CC5=CC=CC=C5 CNVAHKSOYWOKJP-UHFFFAOYSA-N 0.000 claims 1
- UTECHGLOLWYNFQ-PUGIBVIZSA-N CN1[C@@H]2N(C3N(C(N([C@]3(C1=O)C)CC1=CC=CC=C1)(C)C)C)C=CC=N2 Chemical compound CN1[C@@H]2N(C3N(C(N([C@]3(C1=O)C)CC1=CC=CC=C1)(C)C)C)C=CC=N2 UTECHGLOLWYNFQ-PUGIBVIZSA-N 0.000 claims 1
- AKEVCIRHLZCMRV-LUJMMXPNSA-N C[C@@H]1NC2N3C(N(C(C2N1)=O)C)NC1C3=CC=C1 Chemical compound C[C@@H]1NC2N3C(N(C(C2N1)=O)C)NC1C3=CC=C1 AKEVCIRHLZCMRV-LUJMMXPNSA-N 0.000 claims 1
- GNDYBYRTZZQRFE-VCUXHZHDSA-N C[C@@H]1NC2N3C(N(C(C2N1CC1=CC=CC=C1)=O)C)NC1(C3=CCC1)C Chemical compound C[C@@H]1NC2N3C(N(C(C2N1CC1=CC=CC=C1)=O)C)NC1(C3=CCC1)C GNDYBYRTZZQRFE-VCUXHZHDSA-N 0.000 claims 1
- PVMDGNFIHHJTNP-KLUFDXJZSA-N C[C@@H]1NC2N3C(N(C(C2N1CC1=CC=CC=C1)=O)C)NC1C3=CC=CC1 Chemical compound C[C@@H]1NC2N3C(N(C(C2N1CC1=CC=CC=C1)=O)C)NC1C3=CC=CC1 PVMDGNFIHHJTNP-KLUFDXJZSA-N 0.000 claims 1
- GNDYBYRTZZQRFE-JYAUUPNBSA-N C[C@H]1NC2N3C(N(C(C2N1CC1=CC=CC=C1)=O)C)NC1(C3=CCC1)C Chemical compound C[C@H]1NC2N3C(N(C(C2N1CC1=CC=CC=C1)=O)C)NC1(C3=CCC1)C GNDYBYRTZZQRFE-JYAUUPNBSA-N 0.000 claims 1
- ZFIXLLHBDJAIIF-IKLZKGPXSA-N C[C@H]1NC2N3C(N(C(C2N1CC1=CC=CC=C1)=O)C)NC1C3=CC=C1 Chemical compound C[C@H]1NC2N3C(N(C(C2N1CC1=CC=CC=C1)=O)C)NC1C3=CC=C1 ZFIXLLHBDJAIIF-IKLZKGPXSA-N 0.000 claims 1
- FPRBSJYQXZQXMW-JBUCPIAYSA-N C[C@H]1NC2N3C(N(C(C2N1CCN1CCOCC1)=O)C)NC1C3=CC=C1 Chemical compound C[C@H]1NC2N3C(N(C(C2N1CCN1CCOCC1)=O)C)NC1C3=CC=C1 FPRBSJYQXZQXMW-JBUCPIAYSA-N 0.000 claims 1
- PTYRBCFRIXICEH-KZPUIKEJSA-N C[C@H]1NC2N3C(N(C(C2N1COC(C)=O)=O)C)NC1C3=CC=C1 Chemical compound C[C@H]1NC2N3C(N(C(C2N1COC(C)=O)=O)C)NC1C3=CC=C1 PTYRBCFRIXICEH-KZPUIKEJSA-N 0.000 claims 1
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| AR091507A1 (es) | 2012-06-21 | 2015-02-11 | Intra Cellular Therapies Inc | SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA |
-
2007
- 2007-12-05 US US12/517,945 patent/US9006258B2/en not_active Expired - Fee Related
- 2007-12-05 WO PCT/US2007/024866 patent/WO2008070095A1/en not_active Ceased
- 2007-12-05 EP EP07853247A patent/EP2089034A4/en not_active Withdrawn
- 2007-12-05 JP JP2009540267A patent/JP5837278B2/ja not_active Expired - Fee Related
-
2013
- 2013-07-18 JP JP2013149462A patent/JP2013231074A/ja active Pending
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