JP2010511672A5 - - Google Patents
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- Publication number
- JP2010511672A5 JP2010511672A5 JP2009539742A JP2009539742A JP2010511672A5 JP 2010511672 A5 JP2010511672 A5 JP 2010511672A5 JP 2009539742 A JP2009539742 A JP 2009539742A JP 2009539742 A JP2009539742 A JP 2009539742A JP 2010511672 A5 JP2010511672 A5 JP 2010511672A5
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- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- het
- group
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 49
- -1 cyano, formyl Chemical group 0.000 claims 46
- 150000001875 compounds Chemical class 0.000 claims 33
- 125000003118 aryl group Chemical group 0.000 claims 30
- 125000001475 halogen functional group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000001424 substituent group Chemical group 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 11
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 125000003386 piperidinyl group Chemical group 0.000 claims 10
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 125000004663 dialkyl amino group Chemical group 0.000 claims 7
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000005984 hexahydro-1H-1,4-diazepinyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 6
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 125000002393 azetidinyl group Chemical group 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 239000002585 base Substances 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
- 125000005943 1,2,3,6-tetrahydropyridyl group Chemical group 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 3
- 150000001204 N-oxides Chemical class 0.000 claims 3
- 241000191967 Staphylococcus aureus Species 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000004193 piperazinyl group Chemical group 0.000 claims 3
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000005418 aryl aryl group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004604 benzisothiazolyl group Chemical group S1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000002576 diazepinyl group Chemical group N1N=C(C=CC=C1)* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- UCQFSGCWHRTMGG-UHFFFAOYSA-N pyrazole-1-carboximidamide Chemical compound NC(=N)N1C=CC=N1 UCQFSGCWHRTMGG-UHFFFAOYSA-N 0.000 claims 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 1
- 125000001422 pyrrolinyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- UXAWXZDXVOYLII-UHFFFAOYSA-N tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate Chemical compound C1C2N(C(=O)OC(C)(C)C)CC1NC2 UXAWXZDXVOYLII-UHFFFAOYSA-N 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 238000000844 transformation Methods 0.000 claims 1
- 125000004306 triazinyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 0 *Cc1c(*)c2ccccc2nc1* Chemical compound *Cc1c(*)c2ccccc2nc1* 0.000 description 6
- BIWPGLUVRQJKPV-UHFFFAOYSA-N CNc1c(C(C(CCCCN2C(C3)CN(C)C3C2)(c2ccc(cccc3)c3c2)O)c2ccccc2)cc(cccc2)c2n1 Chemical compound CNc1c(C(C(CCCCN2C(C3)CN(C)C3C2)(c2ccc(cccc3)c3c2)O)c2ccccc2)cc(cccc2)c2n1 BIWPGLUVRQJKPV-UHFFFAOYSA-N 0.000 description 1
- PJHLPOYVJJRCRB-UHFFFAOYSA-N COc(c(C(C(CCCCN1CCNCCC1)(c1ccc(cccc2)c2c1)O)c1ccccc1)c1)nc(cc2)c1cc2Br Chemical compound COc(c(C(C(CCCCN1CCNCCC1)(c1ccc(cccc2)c2c1)O)c1ccccc1)c1)nc(cc2)c1cc2Br PJHLPOYVJJRCRB-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125545.1 | 2006-12-06 | ||
| EP06125545 | 2006-12-06 | ||
| PCT/EP2007/063319 WO2008068272A2 (en) | 2006-12-06 | 2007-12-04 | Antibacterial quinoline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010511672A JP2010511672A (ja) | 2010-04-15 |
| JP2010511672A5 true JP2010511672A5 (cg-RX-API-DMAC7.html) | 2010-11-11 |
| JP5466013B2 JP5466013B2 (ja) | 2014-04-09 |
Family
ID=38048032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539742A Expired - Fee Related JP5466013B2 (ja) | 2006-12-06 | 2007-12-04 | 抗菌性キノリン誘導体 |
Country Status (33)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2970B1 (en) * | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| MX358506B (es) | 2012-04-27 | 2018-08-22 | Janssen Pharmaceutica Nv | Derivados de quinolina antibacterianos. |
| EP2841425B1 (en) * | 2012-04-27 | 2016-03-23 | Janssen Pharmaceutica, N.V. | Antibacterial quinoline derivatives |
| US20250214980A1 (en) | 2022-03-14 | 2025-07-03 | Slap Pharmaceuticals Llc | Multicyclic compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2270123A1 (en) * | 1996-10-28 | 1998-05-07 | Department Of The Army, U.S. Government | Compounds, compositions and methods for treating antibiotic-resistant infections |
| JP4484703B2 (ja) * | 2002-07-25 | 2010-06-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キノリン誘導体およびミコバクテリア抑制剤としてのそれらの使用 |
| PL1711181T3 (pl) * | 2004-01-23 | 2010-02-26 | Janssen Pharmaceutica Nv | Pochodne chinoliny i ich zastosowanie jako inhibitorów mykobakteryjnych |
| EA011572B9 (ru) * | 2004-01-29 | 2018-01-31 | Янссен Фармацевтика Н.В. | Производные хинолина для применения в качестве микобактериальных ингибиторов |
| AU2005249231B2 (en) * | 2004-05-28 | 2010-11-11 | Janssen Pharmaceutica N.V. | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| CA2528849C (en) * | 2005-06-08 | 2014-01-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
| HRP20170044T1 (hr) * | 2005-06-28 | 2017-03-10 | Janssen Pharmaceutica Nv | Derivati kinolina kao antibakterijska sredstva |
| JO2752B1 (en) * | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2855B1 (en) * | 2005-08-03 | 2015-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2837B1 (en) * | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | Quinoline derivatives acting as antibacterial agents |
| JO2952B1 (en) * | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
-
2007
- 2007-12-02 JO JO2007510A patent/JO2683B1/en active
- 2007-12-04 MX MX2009005906A patent/MX2009005906A/es active IP Right Grant
- 2007-12-04 DE DE602007010182T patent/DE602007010182D1/de active Active
- 2007-12-04 AU AU2007328892A patent/AU2007328892B2/en not_active Ceased
- 2007-12-04 CN CN200780045128.8A patent/CN101547906B/zh not_active Expired - Fee Related
- 2007-12-04 EA EA200970537A patent/EA016760B1/ru unknown
- 2007-12-04 KR KR1020097013568A patent/KR101553600B1/ko not_active Expired - Fee Related
- 2007-12-04 PT PT07847817T patent/PT2099761E/pt unknown
- 2007-12-04 HR HR20110024T patent/HRP20110024T1/hr unknown
- 2007-12-04 AP AP2009004873A patent/AP2477A/xx active
- 2007-12-04 WO PCT/EP2007/063319 patent/WO2008068272A2/en not_active Ceased
- 2007-12-04 DK DK07847817.9T patent/DK2099761T3/da active
- 2007-12-04 JP JP2009539742A patent/JP5466013B2/ja not_active Expired - Fee Related
- 2007-12-04 AT AT07847817T patent/ATE486061T1/de active
- 2007-12-04 PL PL07847817T patent/PL2099761T3/pl unknown
- 2007-12-04 CA CA2668558A patent/CA2668558C/en active Active
- 2007-12-04 RS RS20110019A patent/RS51582B/sr unknown
- 2007-12-04 MY MYPI20092287A patent/MY145940A/en unknown
- 2007-12-04 US US12/516,420 patent/US20100063026A1/en not_active Abandoned
- 2007-12-04 BR BRPI0719915-5A2A patent/BRPI0719915A2/pt not_active Application Discontinuation
- 2007-12-04 UA UAA200904443A patent/UA101307C2/ru unknown
- 2007-12-04 ES ES07847817T patent/ES2354755T3/es active Active
- 2007-12-04 ME MEP-2011-10A patent/ME01230B/me unknown
- 2007-12-04 EP EP07847817A patent/EP2099761B1/en active Active
- 2007-12-04 SI SI200730471T patent/SI2099761T1/sl unknown
- 2007-12-04 NZ NZ576862A patent/NZ576862A/en not_active IP Right Cessation
- 2007-12-05 TW TW096146212A patent/TWI487526B/zh not_active IP Right Cessation
- 2007-12-05 CL CL200703518A patent/CL2007003518A1/es unknown
- 2007-12-05 AR ARP070105441A patent/AR064148A1/es unknown
-
2009
- 2009-06-02 IL IL199082A patent/IL199082A/en active IP Right Grant
- 2009-06-05 ZA ZA200903949A patent/ZA200903949B/xx unknown
- 2009-07-06 NO NO20092541A patent/NO341984B1/no unknown
-
2011
- 2011-01-27 CY CY20111100087T patent/CY1112027T1/el unknown
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