JP2010511667A5 - - Google Patents
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- Publication number
- JP2010511667A5 JP2010511667A5 JP2009539737A JP2009539737A JP2010511667A5 JP 2010511667 A5 JP2010511667 A5 JP 2010511667A5 JP 2009539737 A JP2009539737 A JP 2009539737A JP 2009539737 A JP2009539737 A JP 2009539737A JP 2010511667 A5 JP2010511667 A5 JP 2010511667A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- het
- compound according
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 cyano, formyl Chemical group 0.000 claims 50
- 125000000217 alkyl group Chemical group 0.000 claims 43
- 150000001875 compounds Chemical class 0.000 claims 29
- 125000003118 aryl group Chemical group 0.000 claims 28
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 125000001475 halogen functional group Chemical group 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 8
- 125000004663 dialkyl amino group Chemical group 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 7
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000005984 hexahydro-1H-1,4-diazepinyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000005943 1,2,3,6-tetrahydropyridyl group Chemical group 0.000 claims 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 4
- 239000002585 base Substances 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000002883 imidazolyl group Chemical group 0.000 claims 4
- 125000003373 pyrazinyl group Chemical group 0.000 claims 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims 4
- 125000002098 pyridazinyl group Chemical group 0.000 claims 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims 4
- 125000001425 triazolyl group Chemical group 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000000815 N-oxide group Chemical group 0.000 claims 3
- 241000191967 Staphylococcus aureus Species 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004103 aminoalkyl group Chemical group 0.000 claims 3
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 3
- 125000001422 pyrrolinyl group Chemical group 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 3
- 125000004306 triazinyl group Chemical group 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 125000005418 aryl aryl group Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000001288 lysyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 229910000104 sodium hydride Inorganic materials 0.000 claims 1
- 239000012312 sodium hydride Substances 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 238000000844 transformation Methods 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 0 *C1c2ccccc2N=C(*)[C@@]1C(*)=C(*)C*C=C Chemical compound *C1c2ccccc2N=C(*)[C@@]1C(*)=C(*)C*C=C 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125546 | 2006-12-06 | ||
| EP06125546.9 | 2006-12-06 | ||
| PCT/EP2007/063312 WO2008068266A1 (en) | 2006-12-06 | 2007-12-04 | Antibacterial quinoline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010511667A JP2010511667A (ja) | 2010-04-15 |
| JP2010511667A5 true JP2010511667A5 (cg-RX-API-DMAC7.html) | 2010-11-18 |
| JP5356244B2 JP5356244B2 (ja) | 2013-12-04 |
Family
ID=38038656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539737A Expired - Fee Related JP5356244B2 (ja) | 2006-12-06 | 2007-12-04 | 抗菌性キノリン誘導体 |
Country Status (33)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5857511B2 (ja) * | 2010-08-10 | 2016-02-10 | 住友化学株式会社 | 植物病害防除組成物およびその用途 |
| MX358506B (es) | 2012-04-27 | 2018-08-22 | Janssen Pharmaceutica Nv | Derivados de quinolina antibacterianos. |
| EP2841425B1 (en) | 2012-04-27 | 2016-03-23 | Janssen Pharmaceutica, N.V. | Antibacterial quinoline derivatives |
| CN105017147B (zh) * | 2014-04-30 | 2019-02-01 | 中国医学科学院药物研究所 | 一种回收和利用Bedaquiline立体化学异构体的方法 |
| CN105330595B (zh) * | 2014-07-14 | 2019-12-10 | 上海嘉坦医药科技有限公司 | 吡啶衍生物及其作为抗分支杆菌的应用 |
| EP3170810B1 (en) * | 2014-07-14 | 2018-09-19 | Cisen Pharmaceutical Co., Ltd. | Pyridine derivatives and anti-mycobacterial use thereof |
| CN108473428B (zh) * | 2016-01-13 | 2021-07-23 | 上海嘉坦医药科技有限公司 | 一种吡啶衍生物类化合物的制备方法及其中间体和晶型 |
| ES2934785T3 (es) * | 2016-03-07 | 2023-02-27 | Global Alliance For Tb Drug Development Inc | Compuestos antibacterianos y usos de los mismos |
| CN109384716B (zh) * | 2017-08-11 | 2021-06-29 | 海创药业股份有限公司 | 一种氘代喹啉化合物及其制备和用途 |
| US20250214980A1 (en) | 2022-03-14 | 2025-07-03 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| CN116925723B (zh) * | 2022-03-30 | 2025-04-01 | 中国石油天然气股份有限公司 | 油气田用杂环有机硅季铵盐与活性炭共混杀菌剂及制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2270123A1 (en) * | 1996-10-28 | 1998-05-07 | Department Of The Army, U.S. Government | Compounds, compositions and methods for treating antibiotic-resistant infections |
| JP4484703B2 (ja) * | 2002-07-25 | 2010-06-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キノリン誘導体およびミコバクテリア抑制剤としてのそれらの使用 |
| PL1711181T3 (pl) * | 2004-01-23 | 2010-02-26 | Janssen Pharmaceutica Nv | Pochodne chinoliny i ich zastosowanie jako inhibitorów mykobakteryjnych |
| US7338949B2 (en) * | 2004-01-23 | 2008-03-04 | Janssen Pharmaceutica N.V. | Mycobacterial inhibitors |
| EA011572B9 (ru) * | 2004-01-29 | 2018-01-31 | Янссен Фармацевтика Н.В. | Производные хинолина для применения в качестве микобактериальных ингибиторов |
| AU2005249231B2 (en) * | 2004-05-28 | 2010-11-11 | Janssen Pharmaceutica N.V. | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases |
| EP1677083A1 (fr) * | 2004-12-22 | 2006-07-05 | Roxer Industries S.A. | Capteur de niveau d'un liquide. |
| CA2528849C (en) * | 2005-06-08 | 2014-01-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
-
2007
- 2007-11-29 JO JO2007503A patent/JO2684B1/en active
- 2007-12-04 MX MX2009005982A patent/MX2009005982A/es active IP Right Grant
- 2007-12-04 UA UAA200904216A patent/UA101305C2/ru unknown
- 2007-12-04 KR KR1020097013405A patent/KR101514992B1/ko not_active Expired - Fee Related
- 2007-12-04 NZ NZ576863A patent/NZ576863A/en not_active IP Right Cessation
- 2007-12-04 DE DE602007006553T patent/DE602007006553D1/de active Active
- 2007-12-04 PL PL07857252T patent/PL2099762T3/pl unknown
- 2007-12-04 JP JP2009539737A patent/JP5356244B2/ja not_active Expired - Fee Related
- 2007-12-04 PT PT07857252T patent/PT2099762E/pt unknown
- 2007-12-04 AT AT07857252T patent/ATE467619T1/de active
- 2007-12-04 SI SI200730306T patent/SI2099762T1/sl unknown
- 2007-12-04 RS RSP-2010/0351A patent/RS51382B/sr unknown
- 2007-12-04 HR HR20100428T patent/HRP20100428T1/hr unknown
- 2007-12-04 EP EP07857252A patent/EP2099762B1/en active Active
- 2007-12-04 CN CN200780044917XA patent/CN101547907B/zh not_active Expired - Fee Related
- 2007-12-04 AP AP2009004872A patent/AP2478A/xx active
- 2007-12-04 AU AU2007328980A patent/AU2007328980B2/en not_active Ceased
- 2007-12-04 US US12/515,593 patent/US20100069366A1/en not_active Abandoned
- 2007-12-04 MY MYPI20092285A patent/MY145924A/en unknown
- 2007-12-04 ES ES07857252T patent/ES2345463T3/es active Active
- 2007-12-04 WO PCT/EP2007/063312 patent/WO2008068266A1/en not_active Ceased
- 2007-12-04 CA CA2668515A patent/CA2668515C/en active Active
- 2007-12-04 DK DK07857252.6T patent/DK2099762T3/da active
- 2007-12-04 ME MEP-2010-128A patent/ME01127B/me unknown
- 2007-12-04 BR BRPI0719920A patent/BRPI0719920B8/pt not_active IP Right Cessation
- 2007-12-04 EA EA200970534A patent/EA200970534A1/ru unknown
- 2007-12-05 AR ARP070105446A patent/AR064153A1/es unknown
- 2007-12-05 CL CL200703519A patent/CL2007003519A1/es unknown
- 2007-12-05 TW TW096146219A patent/TWI484959B/zh not_active IP Right Cessation
-
2009
- 2009-06-02 IL IL199079A patent/IL199079A/en active IP Right Grant
- 2009-06-05 ZA ZA200903947A patent/ZA200903947B/xx unknown
- 2009-07-06 NO NO20092539A patent/NO341996B1/no unknown
-
2010
- 2010-08-09 CY CY20101100742T patent/CY1111188T1/el unknown
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