JP2010509309A - ３−ベンジル−２−メチル−２，３，３ａ，４，５，６，７，７ａ−オクタヒドロベンゾ［ｄ］イソオキサゾール−４−オンの塩 - Google Patents

３−ベンジル−２−メチル−２，３，３ａ，４，５，６，７，７ａ−オクタヒドロベンゾ［ｄ］イソオキサゾール−４−オンの塩 Download PDF

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Publication number
JP2010509309A
JP2010509309A JP2009535824A JP2009535824A JP2010509309A JP 2010509309 A JP2010509309 A JP 2010509309A JP 2009535824 A JP2009535824 A JP 2009535824A JP 2009535824 A JP2009535824 A JP 2009535824A JP 2010509309 A JP2010509309 A JP 2010509309A
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Japan
Prior art keywords
fumarate
compound
formula
medicament
salt
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JP2009535824A
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English (en)
Japanese (ja)
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JP2010509309A5 (enExample
Inventor
ネッギアニ・ファビオ
ディニ・ラウラ
Original Assignee
アビオゲン ファルマ ソシエタ ペル アチオニ
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Publication of JP2010509309A publication Critical patent/JP2010509309A/ja
Publication of JP2010509309A5 publication Critical patent/JP2010509309A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2009535824A 2006-11-02 2007-10-31 ３−ベンジル−２−メチル−２，３，３ａ，４，５，６，７，７ａ−オクタヒドロベンゾ［ｄ］イソオキサゾール−４−オンの塩 Pending JP2010509309A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002102A ITMI20062102A1 (it) 2006-11-02 2006-11-02 Nuovui sali di 3-benzil-2-metil-2,3,3a,4,5,6,7,7a-ottaidrobenzo-d-isossazol-4-one
PCT/IB2007/003291 WO2008053325A1 (en) 2006-11-02 2007-10-31 A salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one

Publications (2)

Publication Number Publication Date
JP2010509309A true JP2010509309A (ja) 2010-03-25
JP2010509309A5 JP2010509309A5 (enExample) 2010-12-24

Family

ID=39145485

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009535824A Pending JP2010509309A (ja) 2006-11-02 2007-10-31 ３−ベンジル−２−メチル−２，３，３ａ，４，５，６，７，７ａ−オクタヒドロベンゾ［ｄ］イソオキサゾール−４−オンの塩
JP2009535825A Pending JP2010509310A (ja) 2006-11-02 2007-10-31 ３−ベンジル−２−メチル−２，３，３ａ，４，５，６，７，７ａ−オクタヒドロベンゾ［ｄ］イソオキサゾール−４−オンの塩

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009535825A Pending JP2010509310A (ja) 2006-11-02 2007-10-31 ３−ベンジル−２−メチル−２，３，３ａ，４，５，６，７，７ａ−オクタヒドロベンゾ［ｄ］イソオキサゾール−４−オンの塩

Country Status (20)

Country Link
US (2) US20100069450A1 (enExample)
EP (2) EP2094674B1 (enExample)
JP (2) JP2010509309A (enExample)
KR (2) KR20090082452A (enExample)
CN (2) CN101535281A (enExample)
AT (2) ATE502021T1 (enExample)
AU (2) AU2007315832A1 (enExample)
BR (2) BRPI0718392A2 (enExample)
CA (2) CA2667515A1 (enExample)
DE (2) DE602007013278D1 (enExample)
HR (2) HRP20090477A2 (enExample)
IL (2) IL198443A0 (enExample)
IT (1) ITMI20062102A1 (enExample)
MX (2) MX2009004294A (enExample)
NO (2) NO20092115L (enExample)
NZ (2) NZ577978A (enExample)
RS (2) RS20090389A (enExample)
RU (2) RU2009120724A (enExample)
WO (2) WO2008053326A1 (enExample)
ZA (2) ZA200903618B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2112142A1 (en) * 2008-04-24 2009-10-28 Abiogen Pharma S.p.A. Process for preparing a crystalline form compound of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one
ITMI20080768A1 (it) * 2008-04-24 2009-10-25 Abiogen Pharma Spa Procedimento per la preparazione di un composto in forma cristallina di 3-benzil-2-metil-2,3,3a,4,5,6,7,7a-ottaidro-benzo[d]isossazol-4-one
EP2218721A1 (en) * 2009-02-11 2010-08-18 LEK Pharmaceuticals d.d. Novel salts of sitagliptin
WO2011010332A1 (en) * 2009-07-23 2011-01-27 Abiogen Pharma S.P.A. Process for preparing rel-(3r*,3as*,7as*)-3-benzyl-2-methyl-2,3, 3a,4,5,6,7,7a- octahydrobenzo[d]isoxazoi-4-one or a salt thereof
US10131642B1 (en) * 2015-01-30 2018-11-20 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07504181A (ja) * 1992-02-19 1995-05-11 ビーティージー・インターナショナル・リミテッド ベンズイソキサゾール誘導体及びそれらを含む医薬組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161595A (en) * 1978-10-02 1979-07-17 Bristol-Myers Company Levulinic acid salt
US4419358A (en) * 1981-11-12 1983-12-06 Mead Johnson & Company Isethionic acid salt of 9-cyclohexyl-2-propoxy-9H-purine-6-amine and compositions containing an effective bronchodilating concentration of it

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07504181A (ja) * 1992-02-19 1995-05-11 ビーティージー・インターナショナル・リミテッド ベンズイソキサゾール誘導体及びそれらを含む医薬組成物

Also Published As

Publication number Publication date
CN101535281A (zh) 2009-09-16
EP2094675A1 (en) 2009-09-02
RU2009120724A (ru) 2010-12-10
WO2008053325A1 (en) 2008-05-08
DE602007013801D1 (de) 2011-05-19
HRP20090477A2 (hr) 2009-11-30
CA2667513A1 (en) 2008-05-08
ZA200903618B (en) 2010-07-28
DE602007013278D1 (de) 2011-04-28
EP2094675B1 (en) 2011-04-06
NZ577978A (en) 2010-10-29
CA2667515A1 (en) 2008-05-08
ATE504578T1 (de) 2011-04-15
AU2007315832A1 (en) 2008-05-08
BRPI0718391A2 (pt) 2013-11-26
AU2007315833A1 (en) 2008-05-08
US20100069450A1 (en) 2010-03-18
US20100069451A1 (en) 2010-03-18
MX2009004294A (es) 2009-05-08
RS20090388A (sr) 2010-12-31
ITMI20062102A1 (it) 2008-05-03
KR20090077014A (ko) 2009-07-13
HRP20090470A2 (hr) 2009-11-30
JP2010509310A (ja) 2010-03-25
RS20090389A (sr) 2010-12-31
IL198444A0 (en) 2010-02-17
WO2008053326A1 (en) 2008-05-08
EP2094674B1 (en) 2011-03-16
NO20092114L (no) 2009-05-29
NO20092115L (no) 2009-05-29
IL198443A0 (en) 2010-02-17
RU2009120667A (ru) 2010-12-10
EP2094674A1 (en) 2009-09-02
CN101535282A (zh) 2009-09-16
ATE502021T1 (de) 2011-04-15
BRPI0718392A2 (pt) 2013-11-26
ZA200903810B (en) 2010-07-28
NZ577311A (en) 2010-10-29
MX2009004293A (es) 2009-05-08
KR20090082452A (ko) 2009-07-30

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