NO20092115L - Salt av 3-benzyl-2-metyl-2,3,3a,4,5,6,7,7a-oktahydrobenzo[d]isoksazol-4-on - Google Patents

Salt av 3-benzyl-2-metyl-2,3,3a,4,5,6,7,7a-oktahydrobenzo[d]isoksazol-4-on

Info

Publication number
NO20092115L
NO20092115L NO20092115A NO20092115A NO20092115L NO 20092115 L NO20092115 L NO 20092115L NO 20092115 A NO20092115 A NO 20092115A NO 20092115 A NO20092115 A NO 20092115A NO 20092115 L NO20092115 L NO 20092115L
Authority
NO
Norway
Prior art keywords
octahydrobenzo
isoxazol
benzyl
methyl
salt
Prior art date
Application number
NO20092115A
Other languages
English (en)
Inventor
Fabio Neggiani
Laura Dini
Original Assignee
Abiogen Pharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abiogen Pharma Spa filed Critical Abiogen Pharma Spa
Publication of NO20092115L publication Critical patent/NO20092115L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Den foreliggende oppfinnelse vedrører oksalatsaltet av forbindelsen med formel 1 i alle dets stereokjemiske konfigurasjoner, en fremgangsmåte for dets fremstilling og dets anvendelse ved behandling av sinnstemningsforstyrrelser, angstforstyrrelser, depresjon og krampetilstander, ved forbedring av læreevne, ved reversering av amnesi, ved å løse abstinenssyndrom fra droger og drogemisbruk. Fortrinnsvis vedrører oppfinnelsen oksalatsaltet av rel-(3R,3aS,7aS)-3-benzyl-2-metyl-2,3,3a,4,5,6,7,7a-oktahydrobenzo[d]isoksazol-4-on.
NO20092115A 2006-11-02 2009-05-29 Salt av 3-benzyl-2-metyl-2,3,3a,4,5,6,7,7a-oktahydrobenzo[d]isoksazol-4-on NO20092115L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002102A ITMI20062102A1 (it) 2006-11-02 2006-11-02 Nuovui sali di 3-benzil-2-metil-2,3,3a,4,5,6,7,7a-ottaidrobenzo-d-isossazol-4-one
PCT/IB2007/003292 WO2008053326A1 (en) 2006-11-02 2007-10-31 A salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one

Publications (1)

Publication Number Publication Date
NO20092115L true NO20092115L (no) 2009-05-29

Family

ID=39145485

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20092115A NO20092115L (no) 2006-11-02 2009-05-29 Salt av 3-benzyl-2-metyl-2,3,3a,4,5,6,7,7a-oktahydrobenzo[d]isoksazol-4-on
NO20092114A NO20092114L (no) 2006-11-02 2009-05-29 Salt av 3-benzyl-2-metyl-2,3,3a,4,5,6,7,7a-oktahydrobenzo[d]isoksazol-4-on

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20092114A NO20092114L (no) 2006-11-02 2009-05-29 Salt av 3-benzyl-2-metyl-2,3,3a,4,5,6,7,7a-oktahydrobenzo[d]isoksazol-4-on

Country Status (20)

Country Link
US (2) US20100069451A1 (no)
EP (2) EP2094675B1 (no)
JP (2) JP2010509310A (no)
KR (2) KR20090077014A (no)
CN (2) CN101535281A (no)
AT (2) ATE502021T1 (no)
AU (2) AU2007315832A1 (no)
BR (2) BRPI0718392A2 (no)
CA (2) CA2667513A1 (no)
DE (2) DE602007013278D1 (no)
HR (2) HRP20090470A2 (no)
IL (2) IL198444A0 (no)
IT (1) ITMI20062102A1 (no)
MX (2) MX2009004293A (no)
NO (2) NO20092115L (no)
NZ (2) NZ577978A (no)
RS (2) RS20090388A (no)
RU (2) RU2009120724A (no)
WO (2) WO2008053326A1 (no)
ZA (2) ZA200903618B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20080768A1 (it) * 2008-04-24 2009-10-25 Abiogen Pharma Spa Procedimento per la preparazione di un composto in forma cristallina di 3-benzil-2-metil-2,3,3a,4,5,6,7,7a-ottaidro-benzo[d]isossazol-4-one
EP2112142A1 (en) * 2008-04-24 2009-10-28 Abiogen Pharma S.p.A. Process for preparing a crystalline form compound of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one
EP2218721A1 (en) * 2009-02-11 2010-08-18 LEK Pharmaceuticals d.d. Novel salts of sitagliptin
WO2011010332A1 (en) * 2009-07-23 2011-01-27 Abiogen Pharma S.P.A. Process for preparing rel-(3r*,3as*,7as*)-3-benzyl-2-methyl-2,3, 3a,4,5,6,7,7a- octahydrobenzo[d]isoxazoi-4-one or a salt thereof
JP6615896B2 (ja) * 2015-01-30 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アルドステロン合成酵素阻害剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161595A (en) * 1978-10-02 1979-07-17 Bristol-Myers Company Levulinic acid salt
US4419358A (en) * 1981-11-12 1983-12-06 Mead Johnson & Company Isethionic acid salt of 9-cyclohexyl-2-propoxy-9H-purine-6-amine and compositions containing an effective bronchodilating concentration of it
GB2264299B (en) * 1992-02-19 1995-07-26 British Tech Group Iso-oxazolidine derivatives

Also Published As

Publication number Publication date
CA2667515A1 (en) 2008-05-08
RS20090388A (en) 2010-12-31
NZ577978A (en) 2010-10-29
KR20090082452A (ko) 2009-07-30
RU2009120724A (ru) 2010-12-10
JP2010509309A (ja) 2010-03-25
ZA200903618B (en) 2010-07-28
US20100069450A1 (en) 2010-03-18
JP2010509310A (ja) 2010-03-25
WO2008053326A1 (en) 2008-05-08
MX2009004293A (es) 2009-05-08
US20100069451A1 (en) 2010-03-18
BRPI0718392A2 (pt) 2013-11-26
ATE504578T1 (de) 2011-04-15
CN101535281A (zh) 2009-09-16
AU2007315833A1 (en) 2008-05-08
RU2009120667A (ru) 2010-12-10
ZA200903810B (en) 2010-07-28
ITMI20062102A1 (it) 2008-05-03
BRPI0718391A2 (pt) 2013-11-26
EP2094675B1 (en) 2011-04-06
WO2008053325A1 (en) 2008-05-08
KR20090077014A (ko) 2009-07-13
DE602007013278D1 (de) 2011-04-28
IL198443A0 (en) 2010-02-17
EP2094675A1 (en) 2009-09-02
DE602007013801D1 (de) 2011-05-19
NZ577311A (en) 2010-10-29
MX2009004294A (es) 2009-05-08
NO20092114L (no) 2009-05-29
ATE502021T1 (de) 2011-04-15
EP2094674B1 (en) 2011-03-16
HRP20090477A2 (hr) 2009-11-30
HRP20090470A2 (hr) 2009-11-30
CA2667513A1 (en) 2008-05-08
CN101535282A (zh) 2009-09-16
AU2007315832A1 (en) 2008-05-08
IL198444A0 (en) 2010-02-17
EP2094674A1 (en) 2009-09-02
RS20090389A (en) 2010-12-31

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