JP2010509234A - 新生物疾患、自己免疫疾患および炎症性疾患を処置する方法 - Google Patents
新生物疾患、自己免疫疾患および炎症性疾患を処置する方法 Download PDFInfo
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| CN106794266A (zh) * | 2014-07-01 | 2017-05-31 | 安普希韦纳治疗公司 | 双特异性cd33和cd3结合蛋白 |
| JP2018533909A (ja) * | 2015-08-28 | 2018-11-22 | アムニクス オペレーティング インコーポレイテッド | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| US10738118B2 (en) | 2015-05-29 | 2020-08-11 | Amphivena Therapeutics, Inc. | Methods of using bispecific CD33 and CD3 binding proteins |
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| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| AU2007317333A1 (en) * | 2006-11-02 | 2008-05-15 | Seattle Genetics, Inc. | Methods of treating neoplastic, autoimmune and inflammatory diseases |
| CN104013956B (zh) | 2007-01-25 | 2018-12-18 | 达娜-法勃肿瘤研究所公司 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
| CA2680854C (en) | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| CN105001332B (zh) | 2007-05-21 | 2018-12-04 | 奥尔德生物控股有限责任公司 | 针对il-6的抗体及其用途 |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
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| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| WO2009131712A2 (en) | 2008-04-25 | 2009-10-29 | Duke University Medical Center | Regulatory b cells and their uses |
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| US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
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| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| EP2417975A4 (en) * | 2009-08-31 | 2012-11-14 | Xi An Libang Medical Technology Co Ltd | FULVESTRANT NANOPERLENES / MICROPERLES AND MANUFACTURING METHOD AND USE |
| AU2010293383B2 (en) | 2009-09-10 | 2014-12-18 | Kyowa Kirin Co., Ltd. | Medicament including antibody composition specifically bound to human CC chemokine receptor 4 (CCR4) |
| US20120294852A1 (en) | 2009-11-24 | 2012-11-22 | Smith Jeffrey T L | Antagonists of il-6 to raise albumin and/or lower crp |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
| US10131875B2 (en) | 2010-08-04 | 2018-11-20 | Duke University | Regulatory B cells and their uses |
| UA112062C2 (uk) | 2010-10-04 | 2016-07-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Cd33-зв'язувальний агент |
| GB201016864D0 (en) | 2010-10-06 | 2010-11-17 | Univ Aston | Therapeutic methods |
| CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
| WO2012088272A1 (en) * | 2010-12-21 | 2012-06-28 | Duke University | Methods and compositions combining immunotherapy with monocyte activation |
| US10017739B2 (en) | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
| JP6401702B2 (ja) | 2012-09-07 | 2018-10-10 | ザ・ガバナーズ・オブ・ザ・ユニバーシティー オブ・アルバータ | 炎症性肝疾患の診断のための方法および組成物 |
| MX376327B (es) | 2012-09-28 | 2025-03-07 | Ellis Kline | Regimen de glicosidasa para el tratamiento de enfermedades infecciosas. |
| AU2014207429B2 (en) * | 2013-01-18 | 2018-11-01 | Ellis KLINE | Selective glycosidase regimen for immune programming and treatment of cancer |
| CA2906597A1 (en) * | 2013-03-13 | 2014-10-02 | Health Research, Inc. | Enhancement of vaccines |
| TWI688401B (zh) * | 2013-09-13 | 2020-03-21 | 美商安進公司 | 用於治療骨髓性白血病的表觀遺傳因子與靶向cd33及cd3之雙特異性化合物的組合 |
| GB201319620D0 (en) * | 2013-11-06 | 2013-12-18 | Norwegian University Of Science And Technology | Immunosuppressive agents and their use in therapy |
| WO2015085171A1 (en) * | 2013-12-06 | 2015-06-11 | Adventist Health Systems/Sunbelt, Inc. | Role of mcp-1 in relapse of acute myeloid leukemia after hematopoietic stem cell transplantation |
| HK1252675A1 (zh) | 2015-06-12 | 2019-05-31 | Alector Llc | 抗cd33抗体及其使用方法 |
| JP7376977B2 (ja) | 2015-06-12 | 2023-11-09 | アレクトル エルエルシー | 抗cd33抗体及びその使用方法 |
| WO2017160954A1 (en) | 2016-03-15 | 2017-09-21 | Seattle Genetics, Inc. | Combinations of pbd-based antibody drug conjugates with bcl-2 inhibitors |
| JOP20170091B1 (ar) * | 2016-04-19 | 2021-08-17 | Amgen Res Munich Gmbh | إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية |
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| EP3469001A4 (en) | 2016-06-09 | 2020-05-06 | Seattle Genetics, Inc. | COMBINATIONS OF PBD-BASED ANTIBODY CONJUGATES WITH FLT3 INHIBITORS |
| WO2018112407A1 (en) | 2016-12-15 | 2018-06-21 | Duke University | Antibodies and methods for depleting regulatory b10 cells and use in combination with immune checkpoint inhibitors |
| PE20200486A1 (es) | 2017-08-03 | 2020-03-03 | Alector Llc | Anticuerpos anti-cd33 y metodos para utilizarlos |
| WO2019094931A1 (en) * | 2017-11-10 | 2019-05-16 | Actinium Pharmaceuticals, Inc. | Combination therapy for treatment of a hematological disease |
| CN112912144A (zh) | 2018-08-31 | 2021-06-04 | 艾利妥 | 抗cd33抗体及其使用方法 |
| WO2020077258A1 (en) * | 2018-10-12 | 2020-04-16 | Jeanmarie Guenot | Cd33×cd3 binding proteins for treating inflammatory conditions and diseases |
| KR20220016083A (ko) | 2019-04-30 | 2022-02-08 | 센티 바이오사이언시스, 인코포레이티드 | 키메라 수용체 및 이의 사용 방법 |
| WO2021059133A1 (en) * | 2019-09-23 | 2021-04-01 | Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies A4Tec - Associação | Polymeric micelle, methods of production and uses thereof |
| CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
| EP4023220A4 (en) * | 2020-10-08 | 2024-02-14 | Curome Biosciences Co., Ltd. | Pharmaceutical composition for preventing or treating cholestatic liver disease, containing beta-lapachone as active ingredient |
| WO2023081898A1 (en) | 2021-11-08 | 2023-05-11 | Alector Llc | Soluble cd33 as a biomarker for anti-cd33 efficacy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001502888A (ja) * | 1996-08-09 | 2001-03-06 | ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド | Cd33様タンパク質をコードするヌクレオチド配列 |
| JP2004505994A (ja) * | 2000-08-08 | 2004-02-26 | イムノメディクス, インコーポレイテッド | 慢性骨髄性白血病の免疫療法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US20030229208A1 (en) * | 1988-12-28 | 2003-12-11 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JPH05503632A (ja) * | 1989-12-14 | 1993-06-17 | スローン ― ケターリング・インスティチュート・フォー・キャンサー・リサーチ | モノクローナル抗体m195の超可変領域の治療的使用およびその構築 |
| US6599505B1 (en) * | 1992-04-10 | 2003-07-29 | Research Development Foundation | Immunotoxins directed against CD33 related surface antigens |
| US6007814A (en) * | 1992-06-15 | 1999-12-28 | Sloan-Kettering Institute For Cancer Research | Therapeutic uses of the hypervariable region of monoclonal antibody M195 and constructs thereof |
| US6653104B2 (en) * | 1996-10-17 | 2003-11-25 | Immunomedics, Inc. | Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells |
| US7194554B1 (en) * | 1998-12-08 | 2007-03-20 | Nomadix, Inc. | Systems and methods for providing dynamic network authorization authentication and accounting |
| US20040152632A1 (en) * | 2002-11-06 | 2004-08-05 | Wyeth | Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome |
| JP2006508119A (ja) * | 2002-11-06 | 2006-03-09 | ワイス | 急性白血病および骨髄異形成症候群の治療のための組み合わせ療法 |
| CA2504818C (en) * | 2002-11-07 | 2013-04-23 | Immunogen, Inc. | Anti-cd33 antibodies and method for treatment of acute myeloid leukemia using the same |
| CN101083998A (zh) * | 2004-11-22 | 2007-12-05 | 王者制药研究发展有限公司 | 用腺苷a3受体激动剂强化治疗hif-1介导的病症 |
| JP2008523083A (ja) * | 2004-12-08 | 2008-07-03 | イムノメディクス, インコーポレイテッド | 炎症性疾患および免疫調節不全疾患、感染性疾患、病的血管新生およびがんの免疫療法および検出のための方法および組成物 |
| AU2007317333A1 (en) * | 2006-11-02 | 2008-05-15 | Seattle Genetics, Inc. | Methods of treating neoplastic, autoimmune and inflammatory diseases |
-
2007
- 2007-11-02 AU AU2007317333A patent/AU2007317333A1/en not_active Abandoned
- 2007-11-02 EP EP07863851A patent/EP2084527A4/en not_active Withdrawn
- 2007-11-02 CA CA002667808A patent/CA2667808A1/en not_active Abandoned
- 2007-11-02 US US12/513,313 patent/US20110038856A1/en not_active Abandoned
- 2007-11-02 JP JP2009535486A patent/JP2010509234A/ja active Pending
- 2007-11-02 WO PCT/US2007/083508 patent/WO2008058021A2/en not_active Ceased
-
2008
- 2008-04-11 US US12/101,785 patent/US7695716B2/en active Active
-
2010
- 2010-02-26 US US12/714,235 patent/US20100215653A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001502888A (ja) * | 1996-08-09 | 2001-03-06 | ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド | Cd33様タンパク質をコードするヌクレオチド配列 |
| JP2004505994A (ja) * | 2000-08-08 | 2004-02-26 | イムノメディクス, インコーポレイテッド | 慢性骨髄性白血病の免疫療法 |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106794266A (zh) * | 2014-07-01 | 2017-05-31 | 安普希韦纳治疗公司 | 双特异性cd33和cd3结合蛋白 |
| JP2017521415A (ja) * | 2014-07-01 | 2017-08-03 | アンフィヴェナ セラピューティクス,インク. | 二重特異性cd33およびcd3結合タンパク質 |
| US10626190B2 (en) | 2014-07-01 | 2020-04-21 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
| CN106794266B (zh) * | 2014-07-01 | 2021-02-23 | 安普希韦纳治疗公司 | 双特异性cd33和cd3结合蛋白 |
| CN112851820A (zh) * | 2014-07-01 | 2021-05-28 | 安普希韦纳治疗公司 | 双特异性cd33和cd3结合蛋白 |
| JP2022068346A (ja) * | 2014-07-01 | 2022-05-09 | アンフィヴェナ セラピューティクス,インク. | 二重特異性cd33およびcd3結合タンパク質 |
| CN112851820B (zh) * | 2014-07-01 | 2023-11-28 | 安普希韦纳治疗公司 | 双特异性cd33和cd3结合蛋白 |
| US10738118B2 (en) | 2015-05-29 | 2020-08-11 | Amphivena Therapeutics, Inc. | Methods of using bispecific CD33 and CD3 binding proteins |
| US11753469B2 (en) | 2015-05-29 | 2023-09-12 | Anji Bruno, Llc | Methods of using bispecific CD33 and CD3 binding proteins |
| JP2018533909A (ja) * | 2015-08-28 | 2018-11-22 | アムニクス オペレーティング インコーポレイテッド | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| JP2021178831A (ja) * | 2015-08-28 | 2021-11-18 | アムニクス ファーマシューティカルズ, インコーポレイテッド | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| JP2024105275A (ja) * | 2015-08-28 | 2024-08-06 | アムニクス ファーマシューティカルズ, インコーポレイテッド | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
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|---|---|
| CA2667808A1 (en) | 2008-05-15 |
| AU2007317333A1 (en) | 2008-05-15 |
| EP2084527A4 (en) | 2011-07-27 |
| US20110038856A1 (en) | 2011-02-17 |
| WO2008058021A3 (en) | 2008-07-03 |
| WO2008058021A2 (en) | 2008-05-15 |
| US7695716B2 (en) | 2010-04-13 |
| US20100215653A1 (en) | 2010-08-26 |
| EP2084527A2 (en) | 2009-08-05 |
| US20080267960A1 (en) | 2008-10-30 |
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