JP2010507577A - トリアゾロピリダジンタンパク質キナーゼモジュレーター - Google Patents

トリアゾロピリダジンタンパク質キナーゼモジュレーター Download PDF

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Publication number
JP2010507577A
JP2010507577A JP2009533536A JP2009533536A JP2010507577A JP 2010507577 A JP2010507577 A JP 2010507577A JP 2009533536 A JP2009533536 A JP 2009533536A JP 2009533536 A JP2009533536 A JP 2009533536A JP 2010507577 A JP2010507577 A JP 2010507577A
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substituted
unsubstituted
alkyl
pyridinyl
halogen
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Japanese (ja)
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JP2010507577A5 (enExample
Inventor
クリストファー・ロナルド・スミス
ピエール−イヴ・ブーノー
エリザベス・アン・ジェファーソン
パトリック・エス・リー
エドゥアルド・トレス
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エスジーエックス ファーマシューティカルズ、インコーポレイテッド
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Publication of JP2010507577A publication Critical patent/JP2010507577A/ja
Publication of JP2010507577A5 publication Critical patent/JP2010507577A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2009533536A 2006-10-23 2007-10-18 トリアゾロピリダジンタンパク質キナーゼモジュレーター Withdrawn JP2010507577A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86255206P 2006-10-23 2006-10-23
US87138406P 2006-12-21 2006-12-21
US91375207P 2007-04-24 2007-04-24
US95283307P 2007-07-30 2007-07-30
PCT/US2007/081832 WO2008051805A2 (en) 2006-10-23 2007-10-18 Triazolo-pyridazine protein kinase modulators

Publications (2)

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JP2010507577A true JP2010507577A (ja) 2010-03-11
JP2010507577A5 JP2010507577A5 (enExample) 2010-12-02

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JP2009533536A Withdrawn JP2010507577A (ja) 2006-10-23 2007-10-18 トリアゾロピリダジンタンパク質キナーゼモジュレーター

Country Status (16)

Country Link
US (1) US8071581B2 (enExample)
EP (1) EP2081937B1 (enExample)
JP (1) JP2010507577A (enExample)
KR (1) KR101083177B1 (enExample)
AU (1) AU2007309237B2 (enExample)
BR (1) BRPI0717317A2 (enExample)
CA (1) CA2667453A1 (enExample)
DK (1) DK2081937T3 (enExample)
EA (1) EA016527B1 (enExample)
ES (1) ES2393132T3 (enExample)
MX (1) MX2009004060A (enExample)
PE (1) PE20081256A1 (enExample)
PL (1) PL2081937T3 (enExample)
PT (1) PT2081937E (enExample)
TW (1) TW200833692A (enExample)
WO (1) WO2008051805A2 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011524385A (ja) * 2008-06-18 2011-09-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｍｅｔキナーゼ阻害剤としての３−（３−ピリミジン−２−イルベンジル）−１，２，４−トリアゾロ［４，３−ｂ］ピリダジン誘導体
JP2012512200A (ja) * 2008-12-18 2012-05-31 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ３−（３−ピリミジン−２−イルベンジル）−１，２，４−トリアゾロ［４，３−ｂ］ピリミジン誘導体
JP2013525371A (ja) * 2010-04-22 2013-06-20 バーテックス ファーマシューティカルズ インコーポレイテッド シクロアルキルカルボキサミド−インドール化合物の製造方法
JP2013527238A (ja) * 2010-06-01 2013-06-27 アンジオン バイオメディカ コーポレーション チトクロームｐ４５０阻害剤およびその使用
JP2015526486A (ja) * 2012-09-03 2015-09-10 クラウン バイオサイエンス インコーポレイテッド（台湾） 抗がん剤としての高選択性ｃ−Ｍｅｔ阻害剤
JP2016512209A (ja) * 2013-03-13 2016-04-25 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ベンゾオキサゼピン化合物の作製方法
JP2017503770A (ja) * 2013-12-09 2017-02-02 ユーシービー バイオファルマ エスピーアールエル Ｔｎｆ活性のモジュレーターとしてのトリアゾロピリダジン誘導体

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HUE036165T2 (hu) 2006-04-07 2018-06-28 Vertex Pharma ATP-kötõ kazetta transzportereinek modulátorai
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US8217177B2 (en) * 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
PE20121506A1 (es) 2006-07-14 2012-11-26 Amgen Inc Compuestos triazolopiridinas como inhibidores de c-met
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
US7683060B2 (en) 2006-08-07 2010-03-23 Incyte Corporation Triazolotriazines as kinase inhibitors
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
MY188335A (en) 2006-11-22 2021-11-30 Incyte Holdings Corp Imidazotriazines and imidazopyrimidines as kinase inhibitors
CN102015716B (zh) 2008-02-28 2014-09-17 诺华股份有限公司 用于治疗C-Met酪氨酸激酶介导的疾病的咪唑并[1,2-b]哒嗪衍生物
BRPI0912882A2 (pt) * 2008-05-21 2017-05-16 Incyte Corp sais de 2-flúor-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida e processos relacionados à preparação dos mesmos
DE102008037790A1 (de) 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
DE102008038220A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh Oxadiazolderivate
DE102008038221A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh 7-Azaindolderivate
DE102008038222A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh Indazol-5-carbonsäurehydrazid-derivate
EP2356116A1 (en) 2008-11-20 2011-08-17 OSI Pharmaceuticals, Inc. Substituted pyrroloý2,3-b¨-pyridines and-pyrazines
JP2012511575A (ja) * 2008-12-12 2012-05-24 アリアド・ファーマシューティカルズ・インコーポレイテッド キナーゼ阻害剤としてのアザインドール誘導体
DE102008062825A1 (de) 2008-12-23 2010-06-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo [4,3-b]pyridazin-derivate
MX2011008452A (es) * 2009-02-10 2011-12-16 Astrazeneca Ab Derivados de triazolo [4,3-b] piridazina y sus usos para el cancer de prostata.
WO2010104843A2 (en) * 2009-03-09 2010-09-16 The Regents Of The University Of California Substituted heterocycles and their use as allosteric modulators of nicotinic and gabaa receptors
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
EP2464649A1 (en) 2009-08-12 2012-06-20 Novartis AG Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
BR112012008061A2 (pt) 2009-08-20 2016-03-01 Novartis Ag compostos de oxima heterocíclica
RS63612B1 (sr) * 2009-12-31 2022-10-31 Hutchison Medipharma Ltd Neki triazolopirazini, njihove kompozicije i postupci njihovog korišćenja
JP5714030B2 (ja) 2010-02-03 2015-05-07 インサイト コーポレーションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｃ−Ｍｅｔ阻害剤としてのイミダゾ［１，２−ｂ］［１，２，４］トリアジン
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
AR081039A1 (es) 2010-05-14 2012-05-30 Osi Pharmaceuticals Llc Inhibidores biciclicos fusionados de quinasa
EP2569315A1 (en) 2010-05-14 2013-03-20 OSI Pharmaceuticals, LLC Fused bicyclic kinase inhibitors
EA025281B9 (ru) 2010-05-17 2017-08-31 Инкозен Терапьютикс Пвт. Лтд. СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ ПРОТЕИНКИНАЗ
US10414760B2 (en) 2016-11-29 2019-09-17 Angion Biomedica Corp. Cytochrome P450 inhibitors and uses thereof
AR085183A1 (es) 2010-07-30 2013-09-18 Lilly Co Eli Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer
JP2014505088A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー Ｃ−ＭＥＴチロシンキナーゼ阻害剤としての［１，２，４］トリアゾロ［４，３−ｂ］ピリダジン化合物
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MX339302B (es) 2011-09-15 2016-05-19 Novartis Ag 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina.
WO2013045519A1 (en) 2011-09-27 2013-04-04 Genfit Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
KR101869534B1 (ko) * 2012-03-05 2018-06-20 한국화학연구원 신규한 트리아졸로 피리다진 유도체 및 그의 용도
NZ629499A (en) 2012-03-30 2016-05-27 Rhizen Pharmaceuticals Sa Novel 3,5-disubstituted-3h-imidazo[4,5-b]pyridine and 3,5- disubstituted -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases
AR092857A1 (es) 2012-07-16 2015-05-06 Vertex Pharma Composiciones farmaceuticas de (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)-n-(1-(2,3-dihidroxipropil)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-il)-1h-indol-5-il)ciclopropancarboxamida y administracion de las mismas
CN105209453B (zh) 2012-10-16 2017-06-20 詹森药业有限公司 ROR‑γ‑T的亚甲基连接的喹啉基调节剂
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US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
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US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9624225B2 (en) 2013-10-15 2017-04-18 Janssen Pharmaceutica Nv Quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
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WO2015134854A2 (en) * 2014-03-06 2015-09-11 Oyagen, Inc. Small molecule vif dimerization antagonists as anti-hiv agents and for use as hiv/aids therapeutics
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JP2018501279A (ja) 2014-12-31 2018-01-18 アンギオン バイオメディカ コーポレイション 疾患を治療するための方法及び薬剤
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011524385A (ja) * 2008-06-18 2011-09-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｍｅｔキナーゼ阻害剤としての３−（３−ピリミジン−２−イルベンジル）−１，２，４−トリアゾロ［４，３−ｂ］ピリダジン誘導体
JP2012512200A (ja) * 2008-12-18 2012-05-31 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ３−（３−ピリミジン−２−イルベンジル）−１，２，４−トリアゾロ［４，３−ｂ］ピリミジン誘導体
JP2013525371A (ja) * 2010-04-22 2013-06-20 バーテックス ファーマシューティカルズ インコーポレイテッド シクロアルキルカルボキサミド−インドール化合物の製造方法
JP2013527238A (ja) * 2010-06-01 2013-06-27 アンジオン バイオメディカ コーポレーション チトクロームｐ４５０阻害剤およびその使用
JP2015526486A (ja) * 2012-09-03 2015-09-10 クラウン バイオサイエンス インコーポレイテッド（台湾） 抗がん剤としての高選択性ｃ−Ｍｅｔ阻害剤
JP2016512209A (ja) * 2013-03-13 2016-04-25 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ベンゾオキサゼピン化合物の作製方法
JP2018008959A (ja) * 2013-03-13 2018-01-18 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ベンゾオキサゼピン化合物の作製方法
KR101871133B1 (ko) 2013-03-13 2018-06-25 에프. 호프만-라 로슈 아게 벤즈옥사제핀 화합물의 제조 방법
JP2017503770A (ja) * 2013-12-09 2017-02-02 ユーシービー バイオファルマ エスピーアールエル Ｔｎｆ活性のモジュレーターとしてのトリアゾロピリダジン誘導体

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Publication number Publication date
AU2007309237A1 (en) 2008-05-02
MX2009004060A (es) 2009-06-19
BRPI0717317A2 (pt) 2013-10-22
DK2081937T3 (da) 2012-10-01
US20100120739A1 (en) 2010-05-13
PL2081937T3 (pl) 2013-01-31
US8071581B2 (en) 2011-12-06
KR20090069303A (ko) 2009-06-30
KR101083177B1 (ko) 2011-11-11
TW200833692A (en) 2008-08-16
EA016527B1 (ru) 2012-05-30
EP2081937A2 (en) 2009-07-29
PT2081937E (pt) 2012-10-15
EA200970402A1 (ru) 2009-10-30
AU2007309237B2 (en) 2012-03-22
CA2667453A1 (en) 2008-05-02
EP2081937B1 (en) 2012-09-12
PE20081256A1 (es) 2008-10-13
ES2393132T3 (es) 2012-12-18
WO2008051805A2 (en) 2008-05-02
WO2008051805A3 (en) 2008-07-10

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