JP2010506932A5 - - Google Patents
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- Publication number
- JP2010506932A5 JP2010506932A5 JP2009533389A JP2009533389A JP2010506932A5 JP 2010506932 A5 JP2010506932 A5 JP 2010506932A5 JP 2009533389 A JP2009533389 A JP 2009533389A JP 2009533389 A JP2009533389 A JP 2009533389A JP 2010506932 A5 JP2010506932 A5 JP 2010506932A5
- Authority
- JP
- Japan
- Prior art keywords
- debenzoyl
- butoxycarbonyl
- tert
- crystalline
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 10
- 238000000634 powder X-ray diffraction Methods 0.000 claims 8
- 229960003668 docetaxel Drugs 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- -1 Deacetyl taxol trihydrate Chemical class 0.000 claims 4
- 239000012296 anti-solvent Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical group CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 3
- 239000013078 crystal Substances 0.000 claims 3
- 150000005826 halohydrocarbons Chemical class 0.000 claims 3
- 238000002329 infrared spectrum Methods 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- XCDIRYDKECHIPE-QHEQPUDQSA-N docetaxel trihydrate Chemical compound O.O.O.O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 XCDIRYDKECHIPE-QHEQPUDQSA-N 0.000 claims 2
- 229950010692 docetaxel trihydrate Drugs 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000002002 slurry Substances 0.000 claims 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000011874 heated mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000003595 spectral effect Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85334106P | 2006-10-20 | 2006-10-20 | |
| PCT/US2007/022309 WO2008051465A2 (en) | 2006-10-20 | 2007-10-19 | Process for making crystalline anhydrous docetaxel |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013087629A Division JP2013155191A (ja) | 2006-10-20 | 2013-04-18 | 結晶性の無水ドセタキセルの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010506932A JP2010506932A (ja) | 2010-03-04 |
| JP2010506932A5 true JP2010506932A5 (https=) | 2010-11-25 |
Family
ID=39325127
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533389A Pending JP2010506932A (ja) | 2006-10-20 | 2007-10-19 | 結晶性の無水ドセタキセルの製造方法 |
| JP2013087629A Pending JP2013155191A (ja) | 2006-10-20 | 2013-04-18 | 結晶性の無水ドセタキセルの製造方法 |
| JP2014233275A Pending JP2015057423A (ja) | 2006-10-20 | 2014-11-18 | 無水ドセタキセルの製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013087629A Pending JP2013155191A (ja) | 2006-10-20 | 2013-04-18 | 結晶性の無水ドセタキセルの製造方法 |
| JP2014233275A Pending JP2015057423A (ja) | 2006-10-20 | 2014-11-18 | 無水ドセタキセルの製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7662980B2 (https=) |
| EP (2) | EP2094084A4 (https=) |
| JP (3) | JP2010506932A (https=) |
| KR (1) | KR101266549B1 (https=) |
| CN (1) | CN101534642A (https=) |
| AR (1) | AR063347A1 (https=) |
| AU (1) | AU2007309534B2 (https=) |
| CA (2) | CA2667416C (https=) |
| NZ (1) | NZ576355A (https=) |
| WO (1) | WO2008051465A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8703982B2 (en) | 2003-03-17 | 2014-04-22 | Phyton Holdings Llc | Purification of taxanes |
| CA2653541C (en) | 2005-06-06 | 2014-12-23 | The University Of British Columbia | Polymer-based serum albumin substitute |
| WO2007109654A2 (en) * | 2006-03-21 | 2007-09-27 | Dr. Reddy's Laboratories Ltd. | Docetaxel polymorphs and processes |
| KR100878455B1 (ko) * | 2007-04-10 | 2009-01-13 | 한미약품 주식회사 | 안정한 무수결정형 도세탁셀 및 이의 제조방법 |
| WO2009006590A2 (en) * | 2007-07-04 | 2009-01-08 | Dr. Reddy's Laboratories Ltd. | Docetaxel process and polymorphs |
| WO2010059916A2 (en) * | 2008-11-20 | 2010-05-27 | Dr. Reddy's Laboratories Ltd. | Preparation of docetaxel |
| PL388144A1 (pl) | 2009-05-29 | 2010-12-06 | Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością | Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie |
| ES2621613T3 (es) * | 2009-11-04 | 2017-07-04 | Emcure Pharmaceuticals Limited | Un proceso mejorado para la preparación de derivados de taxano |
| KR101149600B1 (ko) * | 2009-12-31 | 2012-05-29 | 주식회사 삼양제넥스바이오 | 고순도 무수결정형 도세탁셀 제조방법 |
| CN102906157B (zh) | 2010-03-01 | 2016-08-24 | 不列颠哥伦比亚大学 | 衍生的超支化聚丙三醇 |
| EA027666B1 (ru) | 2010-05-03 | 2017-08-31 | ТЕИКОКУ ФАРМА ЮСЭй, ИНК. | Неводные лекарственные средства в форме проэмульсии на основе таксанов и способы их приготовления и использования |
| EP2447268A1 (en) | 2010-10-29 | 2012-05-02 | INDENA S.p.A. | Crystalline form of 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III |
| KR20120096200A (ko) * | 2011-02-22 | 2012-08-30 | 동아제약주식회사 | 결정형 도세탁셀 및 이의 제조방법 |
| WO2012131698A1 (en) * | 2011-04-01 | 2012-10-04 | Shilpa Medicare Limited | Process for preparing docetaxel and its hydrate |
| US8842114B1 (en) | 2011-04-29 | 2014-09-23 | Nvidia Corporation | System, method, and computer program product for adjusting a depth of displayed objects within a region of a display |
| WO2012160568A1 (en) * | 2011-05-23 | 2012-11-29 | Shilpa Medicare Limited | Process for preparing docetaxel trihydrate polymorph |
| JO3685B1 (ar) * | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| KR101508302B1 (ko) * | 2013-06-10 | 2015-04-06 | 숭실대학교산학협력단 | 초음파를 이용한 도세탁셀 수화물 제조방법 |
| EP2865675A1 (en) * | 2013-10-23 | 2015-04-29 | INDENA S.p.A. | A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof |
| JP2018527287A (ja) | 2015-05-15 | 2018-09-20 | アルブヴェックス エルエルシー | ドセタキセルおよびヒト血清アルブミンの複合体 |
| WO2018081520A1 (en) | 2016-10-27 | 2018-05-03 | Zhuhai Beihai Biotech Co., Ltd. | Neutral ph compositions of docetaxel and human serum albumin |
| CN109836401B (zh) * | 2017-11-28 | 2023-02-14 | 正大天晴药业集团股份有限公司 | 一种多西他赛的纯化方法 |
| CA3166973C (en) | 2020-02-04 | 2025-03-18 | Zhuhai Beihai Biotech Co., Ltd. | Formulations of docetaxel |
| CN111718316A (zh) * | 2020-07-02 | 2020-09-29 | 无锡紫杉药业有限公司 | 一种三水多西他赛生产工艺 |
| CN118510503A (zh) | 2022-02-25 | 2024-08-16 | 珠海贝海生物技术有限公司 | 多西他赛组合物和方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL63968A (en) * | 1980-10-01 | 1985-10-31 | Glaxo Group Ltd | Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it |
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
| MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
| FR2696459B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
| FR2696460B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
| DE4235133A1 (de) * | 1992-10-19 | 1994-04-21 | Bayer Ag | Kristallines (R)-(-)-2-Cycloheptyl-N-methylsulfonyl-[4-(2-chinolinyl-methoxy)-phenyl]-acetamid |
| FR2703049B1 (fr) * | 1993-03-22 | 1995-04-21 | Rhone Poulenc Rorer Sa | Procédé de purification des taxoïdes. |
| JP3623531B2 (ja) * | 1993-06-07 | 2005-02-23 | ビーエーエスエフ アクチェンゲゼルシャフト | 結晶質ｌ−アスコルビン酸−２−燐酸エステルマグネシウム塩の製造法 |
| FR2722191B1 (fr) * | 1994-07-08 | 1996-08-23 | Rhone Poulenc Rorer Sa | Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle |
| US5688977A (en) * | 1996-02-29 | 1997-11-18 | Napro Biotherapeutics, Inc. | Method for docetaxel synthesis |
| US5917062A (en) * | 1997-11-21 | 1999-06-29 | Indena S.P.A | Intermediates and methods useful in the semisynthesis of paclitaxel and analogs |
| US6531611B2 (en) * | 2001-03-23 | 2003-03-11 | Scinopharm Taiwan, Ltd. | Process for making taxane derivatives |
| US6881852B2 (en) | 2002-02-05 | 2005-04-19 | Dabur India Limited | Process of purification of paclitaxel and docetaxel |
| ATE405556T1 (de) | 2002-04-05 | 2008-09-15 | Natural Pharmaceuticals Inc | Umwandlung von taxanmolekülen |
| US6838569B2 (en) * | 2002-12-16 | 2005-01-04 | Dabur India Limited | Process for preparation of paclitaxel trihydrate and docetaxel trihydrate |
| US6956123B2 (en) | 2003-03-17 | 2005-10-18 | Natural Pharmaccuticals, Inc. | Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins |
| CN1268619C (zh) * | 2003-05-08 | 2006-08-09 | 上海迪赛诺化学制药有限公司 | 多烯紫杉醇三水化合物的制备方法 |
| WO2005061474A1 (en) * | 2003-12-12 | 2005-07-07 | Quiral Química Do Brasil | Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions |
| CN1878881A (zh) | 2003-12-19 | 2006-12-13 | 大同特殊钢株式会社 | 耐熔化损失性优良的高温工具钢及模具构件 |
| BRPI0606132A2 (pt) * | 2005-10-12 | 2009-06-02 | Sicor Inc | formas cristalinas de docetaxel e processos para seu preparo |
| KR100995390B1 (ko) * | 2006-01-02 | 2010-11-19 | 주식회사 삼양제넥스 | 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법 |
| WO2007109654A2 (en) * | 2006-03-21 | 2007-09-27 | Dr. Reddy's Laboratories Ltd. | Docetaxel polymorphs and processes |
-
2007
- 2007-10-19 AU AU2007309534A patent/AU2007309534B2/en not_active Ceased
- 2007-10-19 JP JP2009533389A patent/JP2010506932A/ja active Pending
- 2007-10-19 EP EP07861453A patent/EP2094084A4/en not_active Ceased
- 2007-10-19 AR ARP070104643A patent/AR063347A1/es unknown
- 2007-10-19 CA CA2667416A patent/CA2667416C/en not_active Expired - Fee Related
- 2007-10-19 US US11/975,511 patent/US7662980B2/en not_active Expired - Fee Related
- 2007-10-19 KR KR1020097010170A patent/KR101266549B1/ko not_active Expired - Fee Related
- 2007-10-19 CN CNA2007800391041A patent/CN101534642A/zh active Pending
- 2007-10-19 WO PCT/US2007/022309 patent/WO2008051465A2/en not_active Ceased
- 2007-10-19 CA CA2756603A patent/CA2756603C/en not_active Expired - Fee Related
- 2007-10-19 EP EP10170486A patent/EP2330101A1/en not_active Withdrawn
- 2007-10-19 NZ NZ576355A patent/NZ576355A/en not_active IP Right Cessation
-
2009
- 2009-07-13 US US12/501,883 patent/US8357811B2/en not_active Expired - Fee Related
-
2013
- 2013-04-18 JP JP2013087629A patent/JP2013155191A/ja active Pending
-
2014
- 2014-11-18 JP JP2014233275A patent/JP2015057423A/ja active Pending
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