JP2019529481A5 - - Google Patents
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- Publication number
- JP2019529481A5 JP2019529481A5 JP2019516972A JP2019516972A JP2019529481A5 JP 2019529481 A5 JP2019529481 A5 JP 2019529481A5 JP 2019516972 A JP2019516972 A JP 2019516972A JP 2019516972 A JP2019516972 A JP 2019516972A JP 2019529481 A5 JP2019529481 A5 JP 2019529481A5
- Authority
- JP
- Japan
- Prior art keywords
- theta
- crystalline form
- compound
- crystal
- starting temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000013078 crystal Substances 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 18
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 18
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000003828 vacuum filtration Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402813P | 2016-09-30 | 2016-09-30 | |
| US62/402,813 | 2016-09-30 | ||
| PCT/US2017/054227 WO2018064441A1 (en) | 2016-09-30 | 2017-09-29 | Crystalline forms of a bile acid derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019529481A JP2019529481A (ja) | 2019-10-17 |
| JP2019529481A5 true JP2019529481A5 (https=) | 2020-09-17 |
Family
ID=61760943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019516972A Withdrawn JP2019529481A (ja) | 2016-09-30 | 2017-09-29 | 胆汁酸誘導体の結晶形態 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20200024299A1 (https=) |
| EP (1) | EP3518937A4 (https=) |
| JP (1) | JP2019529481A (https=) |
| KR (1) | KR20190057108A (https=) |
| CN (1) | CN109963567A (https=) |
| AU (1) | AU2017336803A1 (https=) |
| BR (1) | BR112019006242A2 (https=) |
| CA (1) | CA3038534A1 (https=) |
| IL (1) | IL265621A (https=) |
| MX (1) | MX2019003684A (https=) |
| WO (1) | WO2018064441A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| IL295825A (en) | 2020-02-28 | 2022-10-01 | Kallyope Inc | gpr40 agonists |
| WO2021236617A1 (en) | 2020-05-19 | 2021-11-25 | Kallyope, Inc. | Ampk activators |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7932244B2 (en) * | 2006-06-27 | 2011-04-26 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions |
| CN101528752A (zh) * | 2006-10-16 | 2009-09-09 | 辉瑞产品公司 | 治疗性吡唑基噻吩并吡啶 |
| JP5441705B2 (ja) * | 2007-10-15 | 2014-03-12 | 武田薬品工業株式会社 | アミド化合物およびその用途 |
| EP2468762A1 (en) * | 2010-11-30 | 2012-06-27 | Dr. Falk Pharma Gmbh | Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size |
| SI3336097T1 (sl) * | 2012-06-19 | 2021-07-30 | Intercept Pharmaceuticals, Inc. | Priprava nekristalinične oblike obetiholne kisline |
| SG11201503247UA (en) * | 2012-10-26 | 2015-06-29 | Intercept Pharmaceuticals Inc | Process for preparing bile acid derivatives |
| AU2013352288B2 (en) * | 2012-11-28 | 2017-11-23 | Intercept Pharmaceuticals, Inc. | Treatment of pulmonary disease |
| HUP1300504A2 (en) * | 2013-08-27 | 2015-03-30 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Sorafenib salts |
| US10604544B2 (en) * | 2015-08-07 | 2020-03-31 | Intercept Pharmaceuticals, Inc. | Methods for preparation of bile acids and derivatives thereof |
| AU2016325619A1 (en) * | 2015-09-24 | 2018-04-12 | Intercept Pharmaceuticals, Inc. | Methods and intermediates for the preparation bile acid derivatives |
-
2017
- 2017-09-29 KR KR1020197012131A patent/KR20190057108A/ko not_active Withdrawn
- 2017-09-29 CA CA3038534A patent/CA3038534A1/en not_active Abandoned
- 2017-09-29 WO PCT/US2017/054227 patent/WO2018064441A1/en not_active Ceased
- 2017-09-29 MX MX2019003684A patent/MX2019003684A/es unknown
- 2017-09-29 AU AU2017336803A patent/AU2017336803A1/en not_active Abandoned
- 2017-09-29 BR BR112019006242A patent/BR112019006242A2/pt not_active IP Right Cessation
- 2017-09-29 JP JP2019516972A patent/JP2019529481A/ja not_active Withdrawn
- 2017-09-29 EP EP17857474.5A patent/EP3518937A4/en not_active Withdrawn
- 2017-09-29 US US16/337,982 patent/US20200024299A1/en not_active Abandoned
- 2017-09-29 CN CN201780071347.7A patent/CN109963567A/zh active Pending
-
2019
- 2019-03-26 IL IL265621A patent/IL265621A/en unknown