CN101534642A - 用于制备结晶无水多西紫杉醇的方法 - Google Patents

用于制备结晶无水多西紫杉醇的方法 Download PDF

Info

Publication number
CN101534642A
CN101534642A CNA2007800391041A CN200780039104A CN101534642A CN 101534642 A CN101534642 A CN 101534642A CN A2007800391041 A CNA2007800391041 A CN A2007800391041A CN 200780039104 A CN200780039104 A CN 200780039104A CN 101534642 A CN101534642 A CN 101534642A
Authority
CN
China
Prior art keywords
takes
tert
butoxycarbonyl
benzoyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800391041A
Other languages
English (en)
Chinese (zh)
Inventor
Y-X·廖
M-F·胡
S-P·陈
C-N·林
Y-L·林
T-Y·肖
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scinopharm Singapore Pte Ltd
Original Assignee
Scinopharm Singapore Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scinopharm Singapore Pte Ltd filed Critical Scinopharm Singapore Pte Ltd
Publication of CN101534642A publication Critical patent/CN101534642A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
CNA2007800391041A 2006-10-20 2007-10-19 用于制备结晶无水多西紫杉醇的方法 Pending CN101534642A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85334106P 2006-10-20 2006-10-20
US60/853,341 2006-10-20

Publications (1)

Publication Number Publication Date
CN101534642A true CN101534642A (zh) 2009-09-16

Family

ID=39325127

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800391041A Pending CN101534642A (zh) 2006-10-20 2007-10-19 用于制备结晶无水多西紫杉醇的方法

Country Status (10)

Country Link
US (2) US7662980B2 (https=)
EP (2) EP2094084A4 (https=)
JP (3) JP2010506932A (https=)
KR (1) KR101266549B1 (https=)
CN (1) CN101534642A (https=)
AR (1) AR063347A1 (https=)
AU (1) AU2007309534B2 (https=)
CA (2) CA2667416C (https=)
NZ (1) NZ576355A (https=)
WO (1) WO2008051465A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109836401A (zh) * 2017-11-28 2019-06-04 正大天晴药业集团股份有限公司 一种多西他赛的纯化方法
CN111718316A (zh) * 2020-07-02 2020-09-29 无锡紫杉药业有限公司 一种三水多西他赛生产工艺

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CA2653541C (en) 2005-06-06 2014-12-23 The University Of British Columbia Polymer-based serum albumin substitute
WO2007109654A2 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
WO2010059916A2 (en) * 2008-11-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Preparation of docetaxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
ES2621613T3 (es) * 2009-11-04 2017-07-04 Emcure Pharmaceuticals Limited Un proceso mejorado para la preparación de derivados de taxano
KR101149600B1 (ko) * 2009-12-31 2012-05-29 주식회사 삼양제넥스바이오 고순도 무수결정형 도세탁셀 제조방법
CN102906157B (zh) 2010-03-01 2016-08-24 不列颠哥伦比亚大学 衍生的超支化聚丙三醇
EA027666B1 (ru) 2010-05-03 2017-08-31 ТЕИКОКУ ФАРМА ЮСЭй, ИНК. Неводные лекарственные средства в форме проэмульсии на основе таксанов и способы их приготовления и использования
EP2447268A1 (en) 2010-10-29 2012-05-02 INDENA S.p.A. Crystalline form of 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III
KR20120096200A (ko) * 2011-02-22 2012-08-30 동아제약주식회사 결정형 도세탁셀 및 이의 제조방법
WO2012131698A1 (en) * 2011-04-01 2012-10-04 Shilpa Medicare Limited Process for preparing docetaxel and its hydrate
US8842114B1 (en) 2011-04-29 2014-09-23 Nvidia Corporation System, method, and computer program product for adjusting a depth of displayed objects within a region of a display
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
JO3685B1 (ar) * 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
KR101508302B1 (ko) * 2013-06-10 2015-04-06 숭실대학교산학협력단 초음파를 이용한 도세탁셀 수화물 제조방법
EP2865675A1 (en) * 2013-10-23 2015-04-29 INDENA S.p.A. A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
JP2018527287A (ja) 2015-05-15 2018-09-20 アルブヴェックス エルエルシー ドセタキセルおよびヒト血清アルブミンの複合体
WO2018081520A1 (en) 2016-10-27 2018-05-03 Zhuhai Beihai Biotech Co., Ltd. Neutral ph compositions of docetaxel and human serum albumin
CA3166973C (en) 2020-02-04 2025-03-18 Zhuhai Beihai Biotech Co., Ltd. Formulations of docetaxel
CN118510503A (zh) 2022-02-25 2024-08-16 珠海贝海生物技术有限公司 多西他赛组合物和方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
DE4235133A1 (de) * 1992-10-19 1994-04-21 Bayer Ag Kristallines (R)-(-)-2-Cycloheptyl-N-methylsulfonyl-[4-(2-chinolinyl-methoxy)-phenyl]-acetamid
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
JP3623531B2 (ja) * 1993-06-07 2005-02-23 ビーエーエスエフ アクチェンゲゼルシャフト 結晶質ｌ−アスコルビン酸−２−燐酸エステルマグネシウム塩の製造法
FR2722191B1 (fr) * 1994-07-08 1996-08-23 Rhone Poulenc Rorer Sa Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
US6531611B2 (en) * 2001-03-23 2003-03-11 Scinopharm Taiwan, Ltd. Process for making taxane derivatives
US6881852B2 (en) 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
ATE405556T1 (de) 2002-04-05 2008-09-15 Natural Pharmaceuticals Inc Umwandlung von taxanmolekülen
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US6956123B2 (en) 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
WO2005061474A1 (en) * 2003-12-12 2005-07-07 Quiral Química Do Brasil Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions
CN1878881A (zh) 2003-12-19 2006-12-13 大同特殊钢株式会社 耐熔化损失性优良的高温工具钢及模具构件
BRPI0606132A2 (pt) * 2005-10-12 2009-06-02 Sicor Inc formas cristalinas de docetaxel e processos para seu preparo
KR100995390B1 (ko) * 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
WO2007109654A2 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109836401A (zh) * 2017-11-28 2019-06-04 正大天晴药业集团股份有限公司 一种多西他赛的纯化方法
CN109836401B (zh) * 2017-11-28 2023-02-14 正大天晴药业集团股份有限公司 一种多西他赛的纯化方法
CN111718316A (zh) * 2020-07-02 2020-09-29 无锡紫杉药业有限公司 一种三水多西他赛生产工艺

Also Published As

Publication number Publication date
NZ576355A (en) 2012-04-27
JP2010506932A (ja) 2010-03-04
JP2015057423A (ja) 2015-03-26
AR063347A1 (es) 2009-01-21
CA2756603A1 (en) 2008-05-02
AU2007309534A1 (en) 2008-05-02
AU2007309534B2 (en) 2012-08-16
WO2008051465A3 (en) 2009-04-16
EP2330101A1 (en) 2011-06-08
CA2756603C (en) 2013-05-28
CA2667416A1 (en) 2008-05-02
KR20090080986A (ko) 2009-07-27
US20080108693A1 (en) 2008-05-08
US8357811B2 (en) 2013-01-22
WO2008051465A2 (en) 2008-05-02
EP2094084A2 (en) 2009-09-02
JP2013155191A (ja) 2013-08-15
CA2667416C (en) 2013-12-17
US20090275762A1 (en) 2009-11-05
US7662980B2 (en) 2010-02-16
KR101266549B1 (ko) 2013-05-24
EP2094084A4 (en) 2010-01-13

Similar Documents

Publication Publication Date Title
CN101534642A (zh) 用于制备结晶无水多西紫杉醇的方法
JP5593342B2 (ja) ドセタキセルの製造方法
JP7548814B2 (ja) Ｉｄｏ阻害剤および／またはｉｄｏ－ｈｄａｃ二重阻害剤としての多環式化合物
JP2009533330A (ja) ドセタキセルの多形体およびプロセス
JP2014524920A5 (https=)
KR20200108828A (ko) 발베나진의 고상 형태
DE69503213T2 (de) Baccatin-Derivate und Verfahren zu deren Herstellung
CN110143934B (zh) 一种含氟紫杉烷类化合物及其制备方法与应用
KR100921036B1 (ko) 탁산유도체의 제조방법 및 이에 사용되는 중간체
AU2012203862B2 (en) Process for making docetaxel trihydrate
JP2024516199A (ja) バルベナジンの合成方法
KR100847331B1 (ko) 도세탁셀의 제조방법 및 이에 사용되는 중간체
CN107778271B (zh) 抗癌化合物cx1409的合成方法
WO2013162922A1 (en) Taxane compounds, compositions and methods
TW202508579A (zh) 一種連接子-藥物的製備方法
CN110746382A (zh) 一种卡巴他赛前体衍生物及其合成方法与应用
JPH08291156A (ja) デアセトキシタキソール誘導体
HK1135104A (en) Method of preparing taxane derivatives and intermediates used therein

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20090916