KR101266549B1 - 결정형 무수 도세탁셀을 제조하는 방법 - Google Patents

결정형 무수 도세탁셀을 제조하는 방법 Download PDF

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Publication number
KR101266549B1
KR101266549B1 KR1020097010170A KR20097010170A KR101266549B1 KR 101266549 B1 KR101266549 B1 KR 101266549B1 KR 1020097010170 A KR1020097010170 A KR 1020097010170A KR 20097010170 A KR20097010170 A KR 20097010170A KR 101266549 B1 KR101266549 B1 KR 101266549B1
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South Korea
Prior art keywords
debenzoyl
formula
docetaxel
butoxycarbonyl
tert
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Expired - Fee Related
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English (en)
Korean (ko)
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KR20090080986A (ko
Inventor
유안-시우 랴오
멩-펜 호
슈-핑 첸
치아-닝 린
유-리 린
쯩-유 샤오
Original Assignee
시노팜 싱가포르 피티이 리미티드
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Publication of KR20090080986A publication Critical patent/KR20090080986A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
KR1020097010170A 2006-10-20 2007-10-19 결정형 무수 도세탁셀을 제조하는 방법 Expired - Fee Related KR101266549B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85334106P 2006-10-20 2006-10-20
US60/853,341 2006-10-20

Publications (2)

Publication Number Publication Date
KR20090080986A KR20090080986A (ko) 2009-07-27
KR101266549B1 true KR101266549B1 (ko) 2013-05-24

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ID=39325127

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KR1020097010170A Expired - Fee Related KR101266549B1 (ko) 2006-10-20 2007-10-19 결정형 무수 도세탁셀을 제조하는 방법

Country Status (10)

Country Link
US (2) US7662980B2 (https=)
EP (2) EP2094084A4 (https=)
JP (3) JP2010506932A (https=)
KR (1) KR101266549B1 (https=)
CN (1) CN101534642A (https=)
AR (1) AR063347A1 (https=)
AU (1) AU2007309534B2 (https=)
CA (2) CA2667416C (https=)
NZ (1) NZ576355A (https=)
WO (1) WO2008051465A2 (https=)

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CA2653541C (en) 2005-06-06 2014-12-23 The University Of British Columbia Polymer-based serum albumin substitute
WO2007109654A2 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
WO2010059916A2 (en) * 2008-11-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Preparation of docetaxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
ES2621613T3 (es) * 2009-11-04 2017-07-04 Emcure Pharmaceuticals Limited Un proceso mejorado para la preparación de derivados de taxano
KR101149600B1 (ko) * 2009-12-31 2012-05-29 주식회사 삼양제넥스바이오 고순도 무수결정형 도세탁셀 제조방법
CN102906157B (zh) 2010-03-01 2016-08-24 不列颠哥伦比亚大学 衍生的超支化聚丙三醇
EA027666B1 (ru) 2010-05-03 2017-08-31 ТЕИКОКУ ФАРМА ЮСЭй, ИНК. Неводные лекарственные средства в форме проэмульсии на основе таксанов и способы их приготовления и использования
EP2447268A1 (en) 2010-10-29 2012-05-02 INDENA S.p.A. Crystalline form of 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III
KR20120096200A (ko) * 2011-02-22 2012-08-30 동아제약주식회사 결정형 도세탁셀 및 이의 제조방법
WO2012131698A1 (en) * 2011-04-01 2012-10-04 Shilpa Medicare Limited Process for preparing docetaxel and its hydrate
US8842114B1 (en) 2011-04-29 2014-09-23 Nvidia Corporation System, method, and computer program product for adjusting a depth of displayed objects within a region of a display
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
JO3685B1 (ar) * 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
KR101508302B1 (ko) * 2013-06-10 2015-04-06 숭실대학교산학협력단 초음파를 이용한 도세탁셀 수화물 제조방법
EP2865675A1 (en) * 2013-10-23 2015-04-29 INDENA S.p.A. A crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
JP2018527287A (ja) 2015-05-15 2018-09-20 アルブヴェックス エルエルシー ドセタキセルおよびヒト血清アルブミンの複合体
WO2018081520A1 (en) 2016-10-27 2018-05-03 Zhuhai Beihai Biotech Co., Ltd. Neutral ph compositions of docetaxel and human serum albumin
CN109836401B (zh) * 2017-11-28 2023-02-14 正大天晴药业集团股份有限公司 一种多西他赛的纯化方法
CA3166973C (en) 2020-02-04 2025-03-18 Zhuhai Beihai Biotech Co., Ltd. Formulations of docetaxel
CN111718316A (zh) * 2020-07-02 2020-09-29 无锡紫杉药业有限公司 一种三水多西他赛生产工艺
CN118510503A (zh) 2022-02-25 2024-08-16 珠海贝海生物技术有限公司 多西他赛组合物和方法

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IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
DE4235133A1 (de) * 1992-10-19 1994-04-21 Bayer Ag Kristallines (R)-(-)-2-Cycloheptyl-N-methylsulfonyl-[4-(2-chinolinyl-methoxy)-phenyl]-acetamid
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
JP3623531B2 (ja) * 1993-06-07 2005-02-23 ビーエーエスエフ アクチェンゲゼルシャフト 結晶質ｌ−アスコルビン酸−２−燐酸エステルマグネシウム塩の製造法
FR2722191B1 (fr) * 1994-07-08 1996-08-23 Rhone Poulenc Rorer Sa Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
US6531611B2 (en) * 2001-03-23 2003-03-11 Scinopharm Taiwan, Ltd. Process for making taxane derivatives
US6881852B2 (en) 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
ATE405556T1 (de) 2002-04-05 2008-09-15 Natural Pharmaceuticals Inc Umwandlung von taxanmolekülen
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US6956123B2 (en) 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
WO2005061474A1 (en) * 2003-12-12 2005-07-07 Quiral Química Do Brasil Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions
CN1878881A (zh) 2003-12-19 2006-12-13 大同特殊钢株式会社 耐熔化损失性优良的高温工具钢及模具构件
BRPI0606132A2 (pt) * 2005-10-12 2009-06-02 Sicor Inc formas cristalinas de docetaxel e processos para seu preparo
KR100995390B1 (ko) * 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
WO2007109654A2 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes

Also Published As

Publication number Publication date
NZ576355A (en) 2012-04-27
JP2010506932A (ja) 2010-03-04
JP2015057423A (ja) 2015-03-26
AR063347A1 (es) 2009-01-21
CA2756603A1 (en) 2008-05-02
AU2007309534A1 (en) 2008-05-02
AU2007309534B2 (en) 2012-08-16
WO2008051465A3 (en) 2009-04-16
EP2330101A1 (en) 2011-06-08
CA2756603C (en) 2013-05-28
CA2667416A1 (en) 2008-05-02
KR20090080986A (ko) 2009-07-27
US20080108693A1 (en) 2008-05-08
US8357811B2 (en) 2013-01-22
WO2008051465A2 (en) 2008-05-02
EP2094084A2 (en) 2009-09-02
JP2013155191A (ja) 2013-08-15
CA2667416C (en) 2013-12-17
US20090275762A1 (en) 2009-11-05
CN101534642A (zh) 2009-09-16
US7662980B2 (en) 2010-02-16
EP2094084A4 (en) 2010-01-13

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