JP2007532548A5 - - Google Patents
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- Publication number
- JP2007532548A5 JP2007532548A5 JP2007507417A JP2007507417A JP2007532548A5 JP 2007532548 A5 JP2007532548 A5 JP 2007532548A5 JP 2007507417 A JP2007507417 A JP 2007507417A JP 2007507417 A JP2007507417 A JP 2007507417A JP 2007532548 A5 JP2007532548 A5 JP 2007532548A5
- Authority
- JP
- Japan
- Prior art keywords
- polymorph
- mammal
- pharmaceutical composition
- administering
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 241000124008 Mammalia Species 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 238000000113 differential scanning calorimetry Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 238000002329 infrared spectrum Methods 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 230000001457 vasomotor Effects 0.000 claims 2
- 206010065687 Bone loss Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000033830 Hot Flashes Diseases 0.000 claims 1
- 206010060800 Hot flush Diseases 0.000 claims 1
- 206010030247 Oestrogen deficiency Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- OMZAMQFQZMUNTP-UHFFFAOYSA-N acetic acid;1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol Chemical compound CC(O)=O.C=1C=C(OCCN2CCCCCC2)C=CC=1CN1C2=CC=C(O)C=C2C(C)=C1C1=CC=C(O)C=C1 OMZAMQFQZMUNTP-UHFFFAOYSA-N 0.000 claims 1
- 229960003713 bazedoxifene acetate Drugs 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002357 endometrial effect Effects 0.000 claims 1
- 201000006564 estrogen excess Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56058404P | 2004-04-07 | 2004-04-07 | |
| PCT/US2005/011423 WO2005100314A1 (en) | 2004-04-07 | 2005-04-06 | Crystalline polymorph of bazedoxifene acetate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008171116A Division JP2009007361A (ja) | 2004-04-07 | 2008-06-30 | バゼドキシフェンアセテートの結晶質多形体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532548A JP2007532548A (ja) | 2007-11-15 |
| JP2007532548A5 true JP2007532548A5 (https=) | 2008-08-14 |
Family
ID=34965585
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007507417A Abandoned JP2007532548A (ja) | 2004-04-07 | 2005-04-06 | バゼドキシフェンアセテートの結晶質多形体 |
| JP2008171116A Withdrawn JP2009007361A (ja) | 2004-04-07 | 2008-06-30 | バゼドキシフェンアセテートの結晶質多形体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008171116A Withdrawn JP2009007361A (ja) | 2004-04-07 | 2008-06-30 | バゼドキシフェンアセテートの結晶質多形体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7683052B2 (https=) |
| EP (1) | EP1732889A1 (https=) |
| JP (2) | JP2007532548A (https=) |
| KR (1) | KR20070004815A (https=) |
| CN (1) | CN1938271A (https=) |
| AR (1) | AR048683A1 (https=) |
| AU (1) | AU2005233114A1 (https=) |
| BR (1) | BRPI0509257A (https=) |
| CA (1) | CA2561296A1 (https=) |
| EC (1) | ECSP066910A (https=) |
| GT (1) | GT200500080A (https=) |
| IL (1) | IL178101A0 (https=) |
| NO (1) | NO20065046L (https=) |
| PA (1) | PA8629201A1 (https=) |
| PE (1) | PE20060173A1 (https=) |
| RU (1) | RU2006132352A (https=) |
| TW (1) | TW200536845A (https=) |
| UA (1) | UA86055C2 (https=) |
| WO (1) | WO2005100314A1 (https=) |
| ZA (1) | ZA200608361B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20070188A1 (es) * | 2005-06-29 | 2007-03-16 | Wyeth Corp | Formulaciones de estrogenos conjugados y bazedoxifeno |
| AU2006283121A1 (en) * | 2005-08-24 | 2007-03-01 | Wyeth | Bazedoxifene acetate formulations and manufacturing process thereof |
| PE20090100A1 (es) * | 2007-03-30 | 2009-02-26 | Wyeth Corp | Metodos de separacion y deteccion de acetato de bacedoxifeno en composiciones farmaceuticas |
| CZ302358B6 (cs) * | 2007-07-25 | 2011-03-30 | Zentiva, A. S. | Nové soli bazedoxifenu |
| CN101977897A (zh) * | 2008-02-11 | 2011-02-16 | 惠氏有限责任公司 | 制备乙酸巴多昔芬的多晶型a的方法 |
| WO2009102778A1 (en) * | 2008-02-11 | 2009-08-20 | Wyeth | Amorphous polymorph of bazedoxifene acetate |
| ITMI20091109A1 (it) * | 2009-06-23 | 2010-12-24 | Wyeth Corp | Forma polimorfa d di bazedoxifene acetato e metodi per la sua preparazione |
| AR078785A1 (es) | 2009-10-27 | 2011-11-30 | Wyeth Llc | Formulaciones de bazedoxifeno con antioxidantes |
| EP2407467A1 (de) | 2010-07-14 | 2012-01-18 | Sandoz Ag | Kristalline Verbindung von 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol und Milchsäure |
| WO2012007453A1 (en) | 2010-07-14 | 2012-01-19 | Sandoz Ag | Crystalline compound of 1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1h-indol-5-ol |
| EP2616463A4 (en) | 2010-09-14 | 2014-01-08 | Reddys Lab Ltd Dr | PREPARATION OF CRYSTALLINE BAZEDOXIFES AND THEIR SALTS |
| EP2471770A1 (en) | 2010-12-28 | 2012-07-04 | Sandoz Ag | Method of preparing polymorphic pure form A of bazedoxifene acetate |
| CN103864664A (zh) * | 2012-12-18 | 2014-06-18 | 江苏柯菲平医药有限公司 | 巴多昔芬乙酸盐新晶型及其制备方法 |
| US9751835B2 (en) | 2013-05-15 | 2017-09-05 | Indiana University Research And Technology Corporation | Processes and intermediates for preparing indole pharmaceuticals |
| CN103864665B (zh) * | 2014-03-04 | 2016-03-02 | 苏州特瑞药业有限公司 | 醋酸巴多昔芬的制备方法 |
| CN104030963A (zh) * | 2014-06-30 | 2014-09-10 | 四川大学 | 一种巴多昔芬醋酸盐晶型a的制备方法 |
| CN111004165A (zh) * | 2019-12-03 | 2020-04-14 | 南京正济医药研究有限公司 | 一种醋酸巴多昔芬晶型a的制备方法 |
| US11246874B1 (en) | 2021-04-20 | 2022-02-15 | Oxygen Biotech LLC | Treatment of COVID-19 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880137A (en) | 1996-04-19 | 1999-03-09 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| DE69707189T2 (de) | 1996-04-19 | 2002-06-20 | American Home Products Corp., Madison | Östrogene Verbindungen |
| TW397821B (en) | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
| US5780497A (en) | 1996-04-19 | 1998-07-14 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| US5998402A (en) | 1996-04-19 | 1999-12-07 | American Home Products Corporation | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents |
| NZ503793A (en) * | 1997-10-15 | 2002-10-25 | Wyeth Corp | Novel aryloxy-alkyl-dialkylamines and processes for preparing these compounds |
| US6005102A (en) | 1997-10-15 | 1999-12-21 | American Home Products Corporation | Aryloxy-alkyl-dialkylamines |
| US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| AR029538A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
| EP1336602A1 (en) | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| IL165395A0 (en) | 2002-06-25 | 2006-01-15 | Wyeth Corp | Use of thio-oxubdile derivatives in treatment of hormone-related conditions |
| PE20060676A1 (es) | 2004-04-07 | 2006-07-24 | Wyeth Corp | Polimorfo cristalino de acetato de bazedoxifeno |
-
2005
- 2005-04-06 GT GT200500080A patent/GT200500080A/es unknown
- 2005-04-06 CA CA002561296A patent/CA2561296A1/en not_active Abandoned
- 2005-04-06 CN CNA2005800103454A patent/CN1938271A/zh not_active Withdrawn
- 2005-04-06 WO PCT/US2005/011423 patent/WO2005100314A1/en not_active Ceased
- 2005-04-06 BR BRPI0509257-4A patent/BRPI0509257A/pt not_active IP Right Cessation
- 2005-04-06 US US11/100,998 patent/US7683052B2/en active Active
- 2005-04-06 AR ARP050101366A patent/AR048683A1/es unknown
- 2005-04-06 TW TW094110849A patent/TW200536845A/zh unknown
- 2005-04-06 AU AU2005233114A patent/AU2005233114A1/en not_active Withdrawn
- 2005-04-06 JP JP2007507417A patent/JP2007532548A/ja not_active Abandoned
- 2005-04-06 PE PE2005000385A patent/PE20060173A1/es not_active Application Discontinuation
- 2005-04-06 EP EP05735042A patent/EP1732889A1/en not_active Withdrawn
- 2005-04-06 RU RU2006132352/04A patent/RU2006132352A/ru not_active Application Discontinuation
- 2005-04-06 UA UAA200610608A patent/UA86055C2/ru unknown
- 2005-04-06 KR KR1020067020645A patent/KR20070004815A/ko not_active Withdrawn
- 2005-04-06 PA PA20058629201A patent/PA8629201A1/es unknown
-
2006
- 2006-09-14 IL IL178101A patent/IL178101A0/en unknown
- 2006-10-06 ZA ZA200608361A patent/ZA200608361B/xx unknown
- 2006-10-06 EC EC2006006910A patent/ECSP066910A/es unknown
- 2006-11-02 NO NO20065046A patent/NO20065046L/no not_active Application Discontinuation
-
2008
- 2008-06-30 JP JP2008171116A patent/JP2009007361A/ja not_active Withdrawn
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