JP2010505741A - カチオン性のサブユニット間結合を有するオリゴヌクレオチドアナログ - Google Patents

カチオン性のサブユニット間結合を有するオリゴヌクレオチドアナログ Download PDF

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JP2010505741A
JP2010505741A JP2009509880A JP2009509880A JP2010505741A JP 2010505741 A JP2010505741 A JP 2010505741A JP 2009509880 A JP2009509880 A JP 2009509880A JP 2009509880 A JP2009509880 A JP 2009509880A JP 2010505741 A JP2010505741 A JP 2010505741A
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oligomer
cationic
seq
bond
sequence
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JP2010505741A5 (enExample
Inventor
ドワイト ディー． ウェラー，
ジェド エヌ． ハッシンガー，
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エイブイアイ バイオファーマ， インコーポレイテッド
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Priority claimed from US11/432,031 external-priority patent/US8084433B2/en
Priority claimed from US11/432,216 external-priority patent/US7625873B2/en
Priority claimed from US11/432,155 external-priority patent/US20070037763A1/en
Priority claimed from US11/431,968 external-priority patent/US8785407B2/en
Priority claimed from US11/433,724 external-priority patent/US7888012B2/en
Priority claimed from US11/433,214 external-priority patent/US8067569B2/en
Priority claimed from US11/433,213 external-priority patent/US20070004661A1/en
Priority claimed from US11/433,840 external-priority patent/US7507196B2/en
Priority claimed from US11/433,033 external-priority patent/US8415313B2/en
Priority claimed from US11/433,257 external-priority patent/US20070037764A1/en
Priority claimed from US11/518,058 external-priority patent/US8329668B2/en
Priority claimed from US11/517,757 external-priority patent/US8524676B2/en
Priority claimed from US11/595,161 external-priority patent/US20070111962A1/en
Priority claimed from US11/715,572 external-priority patent/US7582615B2/en
Application filed by エイブイアイ バイオファーマ， インコーポレイテッド filed Critical エイブイアイ バイオファーマ， インコーポレイテッド
Publication of JP2010505741A publication Critical patent/JP2010505741A/ja
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JP2009509880A 2006-05-10 2007-05-10 カチオン性のサブユニット間結合を有するオリゴヌクレオチドアナログ Pending JP2010505741A (ja)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US11/431,968 US8785407B2 (en) 2006-05-10 2006-05-10 Antisense antiviral agent and method for treating ssRNA viral infection
US11/432,031 US8084433B2 (en) 2004-09-16 2006-05-10 Antisense antiviral compound and method for treating ssRNA viral infection
US11/432,155 US20070037763A1 (en) 2003-12-24 2006-05-10 Oligonucleotide compound and method for treating nidovirus infections
US11/432,216 US7625873B2 (en) 2004-07-02 2006-05-10 Antisense antibacterial method and compound
US80014506P 2006-05-11 2006-05-11
US80007606P 2006-05-11 2006-05-11
US80012006P 2006-05-11 2006-05-11
US79997606P 2006-05-11 2006-05-11
US11/433,840 US7507196B2 (en) 2004-11-01 2006-05-11 Antisense antiviral compounds and methods for treating a filovirus infection
US11/433,724 US7888012B2 (en) 2005-02-09 2006-05-11 Antisense composition and method for treating muscle atrophy
US11/433,257 US20070037764A1 (en) 2003-10-23 2006-05-11 Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
US11/433,214 US8067569B2 (en) 2000-05-04 2006-05-11 Splice-region antisense composition and method
US11/433,033 US8415313B2 (en) 2004-01-23 2006-05-11 Antisense oligomers and methods for inducing immune tolerance and immunosuppression
US11/433,213 US20070004661A1 (en) 2004-10-26 2006-05-11 Antisense antiviral compound and method for treating influenza viral infection
US11/517,757 US8524676B2 (en) 2005-09-08 2006-09-08 Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds
US11/518,058 US8329668B2 (en) 2005-09-08 2006-09-08 Antisense antiviral compound and method for treating picornavirus infection
US11/595,161 US20070111962A1 (en) 2005-11-08 2006-11-08 Immunosuppression compound and treatment method
US11/715,572 US7582615B2 (en) 2006-03-07 2007-03-07 Antisense antiviral compound and method for treating arenavirus infection
PCT/US2007/011435 WO2008036127A2 (en) 2006-05-10 2007-05-10 Oligonucleotide analogs having cationic intersubunit linkages

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JP2010505741A true JP2010505741A (ja) 2010-02-25
JP2010505741A5 JP2010505741A5 (enExample) 2010-07-01

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US (1) US7943762B2 (enExample)
EP (2) EP2024499B1 (enExample)
JP (1) JP2010505741A (enExample)
AU (1) AU2007297861A1 (enExample)
CA (1) CA2651881A1 (enExample)
CY (2) CY1120409T1 (enExample)
DK (2) DK2735568T3 (enExample)
ES (2) ES2645410T3 (enExample)
HU (2) HUE035799T2 (enExample)
LT (2) LT2735568T (enExample)
PL (1) PL2735568T3 (enExample)
PT (1) PT2735568T (enExample)
SI (2) SI2024499T1 (enExample)
WO (1) WO2008036127A2 (enExample)

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JP2011503184A (ja) * 2007-11-15 2011-01-27 エイブイアイ バイオファーマ， インコーポレイテッド モルホリノオリゴマーの合成方法
JP2013530154A (ja) * 2010-05-28 2013-07-25 サレプタ セラピューティクス， インコーポレイテッド 修飾されたサブユニット間結合および／または末端基を有するオリゴヌクレオチドアナログ
JP2015500204A (ja) * 2011-11-18 2015-01-05 サレプタ セラピューティクス， インコーポレイテッド 機能的に修飾されたオリゴヌクレオチドおよびそのサブユニット
JP2015504650A (ja) * 2011-11-30 2015-02-16 サレプタ セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症における誘発されたエクソン包含
JP2015506669A (ja) * 2011-11-30 2015-03-05 サレプタ セラピューティクス， インコーポレイテッド 延長リピート病を処置するためのオリゴヌクレオチド
WO2016060135A1 (ja) * 2014-10-14 2016-04-21 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
US9920085B2 (en) 2012-03-20 2018-03-20 Sarepta Therapeutics, Inc. Boronic acid conjugates of oligonucleotide analogues
US10017763B2 (en) 2010-09-03 2018-07-10 Sarepta Therapeutics, Inc. dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
JP2018518148A (ja) * 2015-03-18 2018-07-12 サレプタ セラピューティクス，インコーポレイテッド ミオスタチンにおけるアンチセンスに誘導されるエクソンの排除
WO2019216433A1 (ja) * 2018-05-10 2019-11-14 日本新薬株式会社 オリゴ核酸化合物の製造方法
JP2020530981A (ja) * 2017-06-27 2020-11-05 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ Ｔ細胞の機能を調節するためのアンチセンスオリゴヌクレオチド
US10905709B2 (en) 2015-08-28 2021-02-02 Sarepta Therapeutics, Inc. Modified antisense oligomers for exon inclusion in spinal muscular atrophy
US10947536B2 (en) 2011-10-04 2021-03-16 Royal Holloway And Bedford New College Oligomers
US11020417B2 (en) 2015-06-04 2021-06-01 Sarepta Therapeutics, Inc Methods and compounds for treatment of lymphocyte-related diseases and conditions
JP2021518361A (ja) * 2018-03-16 2021-08-02 サレプタ セラピューティクス， インコーポレイテッド アンチセンス送達用キメラペプチド

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JP2003533986A (ja) 2000-05-04 2003-11-18 エイブイアイ バイオファーマ， インコーポレイテッド スプライス領域アンチセンス組成物および方法
EP2351844B1 (en) * 2003-04-29 2014-06-11 Sarepta Therapeutics, Inc. Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells
US20050222068A1 (en) * 2003-10-23 2005-10-06 Mourich Dan V Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
US20050171044A1 (en) * 2003-12-24 2005-08-04 Stein David A. Oligonucleotide compound and method for treating nidovirus infections
WO2005072527A2 (en) * 2004-01-23 2005-08-11 Avi Biopharma, Inc. Antisense oligomers and methods for inducing immune tolerance and immunosuppression
US20050288246A1 (en) 2004-05-24 2005-12-29 Iversen Patrick L Peptide conjugated, inosine-substituted antisense oligomer compound and method
ATE498685T1 (de) 2004-06-28 2011-03-15 Univ Western Australia Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon
CA2875436A1 (en) 2004-07-02 2006-08-17 Sarepta Therapeutics, Inc. Antisense antibacterial method and compound
US8129352B2 (en) 2004-09-16 2012-03-06 Avi Biopharma, Inc. Antisense antiviral compound and method for treating ssRNA viral infection
US7524829B2 (en) * 2004-11-01 2009-04-28 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
AU2006213686A1 (en) * 2005-02-09 2006-08-17 Avi Bio Pharma, Inc. Antisense composition and method for treating muscle atrophy
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
US8524676B2 (en) * 2005-09-08 2013-09-03 Sarepta Therapeutics, Inc. Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds
US8501704B2 (en) 2005-11-08 2013-08-06 Sarepta Therapeutics, Inc. Immunosuppression compound and treatment method
US8785407B2 (en) * 2006-05-10 2014-07-22 Sarepta Therapeutics, Inc. Antisense antiviral agent and method for treating ssRNA viral infection
US20070265215A1 (en) * 2006-05-11 2007-11-15 Iversen Patrick L Antisense restenosis composition and method
JP5864100B2 (ja) 2007-06-29 2016-02-17 サレプタ セラピューティクス インコーポレイテッド 組織特異的ペプチドコンジュゲートおよび方法
US20100016215A1 (en) 2007-06-29 2010-01-21 Avi Biopharma, Inc. Compound and method for treating myotonic dystrophy
AU2015200600B2 (en) * 2007-06-29 2017-04-20 Sarepta Therapeutics, Inc. Tissue specific peptide conjugates and methods
JP5515738B2 (ja) * 2007-07-25 2014-06-11 味の素株式会社 ジベンゾフルベン誘導体の淘汰方法
US8076476B2 (en) * 2007-11-15 2011-12-13 Avi Biopharma, Inc. Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits
US8299206B2 (en) 2007-11-15 2012-10-30 Avi Biopharma, Inc. Method of synthesis of morpholino oligomers
EP2235034B1 (en) * 2007-12-28 2016-11-23 Sarepta Therapeutics, Inc. Immunomodulatory agents and methods of use
TR201902952T4 (tr) 2008-10-24 2019-03-21 Sarepta Therapeutics Inc Dmd için ekson atlama bileşimleri.
WO2010080554A1 (en) * 2008-12-17 2010-07-15 Avi Biopharma, Inc. Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
WO2010141511A2 (en) 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
US20110269665A1 (en) 2009-06-26 2011-11-03 Avi Biopharma, Inc. Compound and method for treating myotonic dystrophy
WO2011018798A2 (en) * 2009-08-14 2011-02-17 Indian Association For The Cultivation Of Science Morpholino-based antisense agent
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