JP2010505518A - メトトレキサートを送達する動電システムおよび方法 - Google Patents
メトトレキサートを送達する動電システムおよび方法 Download PDFInfo
- Publication number
- JP2010505518A JP2010505518A JP2009531436A JP2009531436A JP2010505518A JP 2010505518 A JP2010505518 A JP 2010505518A JP 2009531436 A JP2009531436 A JP 2009531436A JP 2009531436 A JP2009531436 A JP 2009531436A JP 2010505518 A JP2010505518 A JP 2010505518A
- Authority
- JP
- Japan
- Prior art keywords
- applicator
- skin
- electrode
- drug
- needle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 title claims abstract description 48
- 229960000485 methotrexate Drugs 0.000 title claims abstract description 48
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrotherapy Devices (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/538,249 US20070185432A1 (en) | 2005-09-19 | 2006-10-03 | Electrokinetic system and method for delivering methotrexate |
| PCT/US2007/021226 WO2008042404A2 (en) | 2006-10-03 | 2007-10-03 | Electrokinetic system and method for delivering methotrexate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010505518A true JP2010505518A (ja) | 2010-02-25 |
| JP2010505518A5 JP2010505518A5 (enExample) | 2011-12-08 |
Family
ID=39269032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531436A Pending JP2010505518A (ja) | 2006-10-03 | 2007-10-03 | メトトレキサートを送達する動電システムおよび方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20070185432A1 (enExample) |
| EP (1) | EP2079515A2 (enExample) |
| JP (1) | JP2010505518A (enExample) |
| WO (1) | WO2008042404A2 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013529100A (ja) * | 2010-04-28 | 2013-07-18 | キンバリー クラーク ワールドワイド インコーポレイテッド | 射出成形型マイクロニードルアレイ及びその製造方法 |
| WO2015129545A1 (ja) * | 2014-02-27 | 2015-09-03 | 久光製薬株式会社 | マイクロニードル・シート |
| JP2016005543A (ja) * | 2014-05-26 | 2016-01-14 | 株式会社スズキプレシオン | 注入針装置及び注入器具セット |
| JP2016036476A (ja) * | 2014-08-07 | 2016-03-22 | 典雄 宮城 | 注射針 |
| JP2017170161A (ja) * | 2011-06-28 | 2017-09-28 | イノビオ ファーマシューティカルズ,インコーポレイティド | 低侵襲表皮電気穿孔装置 |
| JP2018086071A (ja) * | 2016-11-28 | 2018-06-07 | 株式会社リコー | 経皮吸収デバイス及び経皮吸収パッチ |
| KR20190099479A (ko) * | 2016-12-22 | 2019-08-27 | 오하이오 스테이트 이노베이션 파운데이션 | 나노채널 기반 카고 전달을 위한 상호침투 마이크로구조물 |
| US12415058B2 (en) | 2016-12-22 | 2025-09-16 | Ohio State Innovation Foundation | Interpenetrating microstructures for nanochannel-based sampling and/or cargo delivery |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6835184B1 (en) * | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
| AU2003209095A1 (en) | 2002-02-11 | 2003-09-04 | Antares Pharma, Inc. | Intradermal injector |
| US8571648B2 (en) * | 2004-05-07 | 2013-10-29 | Aesthera | Apparatus and method to apply substances to tissue |
| US7842029B2 (en) * | 2004-05-07 | 2010-11-30 | Aesthera | Apparatus and method having a cooling material and reduced pressure to treat biological external tissue |
| DK1850892T4 (da) | 2005-01-24 | 2023-06-06 | Antares Pharma Inc | Forfyldt nål-assisteret sprøjtejetinjektor |
| US20090264809A1 (en) * | 2006-04-10 | 2009-10-22 | The Regents Of The University Of California | Method and apparatus of low strengh electric field network-mediated delnery of drug, gene, sirna, shrn, protein, peptide, antibody or other biomedical and therapeutic molecules and reagents in skin, soft tissue, joints and bone |
| US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
| US20090012434A1 (en) * | 2007-07-03 | 2009-01-08 | Anderson Robert S | Apparatus, method, and system to treat a volume of skin |
| US20090069795A1 (en) * | 2007-09-10 | 2009-03-12 | Anderson Robert S | Apparatus and method for selective treatment of tissue |
| EP2197541A4 (en) * | 2007-09-20 | 2011-06-01 | Nitric Biotherapeutics Inc | METHOD FOR REINFORCING IOPOPHORETIC DELIVERY OF A PEPTIDE |
| US20090093864A1 (en) * | 2007-10-08 | 2009-04-09 | Anderson Robert S | Methods and devices for applying energy to tissue |
| US20090099427A1 (en) * | 2007-10-12 | 2009-04-16 | Arkal Medical, Inc. | Microneedle array with diverse needle configurations |
| US8814834B2 (en) | 2008-03-10 | 2014-08-26 | Antares Pharma, Inc. | Injector safety device |
| EP3581224A1 (en) | 2008-08-05 | 2019-12-18 | Antares Pharma, Inc. | Multiple dosage injector |
| CN105999538A (zh) * | 2008-11-18 | 2016-10-12 | 3M创新有限公司 | 空心微针阵列和方法 |
| US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
| EP2408372B1 (en) | 2009-03-02 | 2019-01-09 | Seventh Sense Biosystems, Inc. | Devices associated with blood sampling |
| US9041541B2 (en) | 2010-01-28 | 2015-05-26 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
| US9033898B2 (en) | 2010-06-23 | 2015-05-19 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
| EP2408493B1 (en) | 2009-03-20 | 2024-07-24 | Antares Pharma, Inc. | Hazardous agent injection system |
| CN101829396B (zh) * | 2009-03-27 | 2013-01-30 | 清华大学 | 微针阵列芯片及利用其的经皮给药贴剂及其制备方法 |
| FI20095433A0 (fi) | 2009-04-20 | 2009-04-20 | Valtion Teknillinen | Mikroneula |
| US10159825B2 (en) * | 2009-09-17 | 2018-12-25 | Zipline Medical, Inc. | Rapid closing surgical closure device |
| JP6030551B2 (ja) | 2010-06-14 | 2016-11-24 | ジップライン メディカル, インコーポレイテッド | 瘢痕形成を阻止する方法および装置 |
| ES2561824T3 (es) | 2010-07-16 | 2016-03-01 | Seventh Sense Biosystems, Inc. | Ambiente a baja presión para dispositivos de transferencia de fluidos |
| US20130158482A1 (en) | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
| EP2954916A3 (en) * | 2010-08-13 | 2016-04-20 | Seventh Sense Biosystems, Inc. | Clinical and/or consumer techniques and devices |
| US20120039809A1 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
| ES2565805T3 (es) | 2010-11-09 | 2016-04-07 | Seventh Sense Biosystems, Inc. | Sistemas e interfaces para el muestreo de sangre |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| AU2012249683A1 (en) | 2011-04-29 | 2013-11-14 | Seventh Sense Biosystems, Inc. | Devices and methods for collection and/or manipulation of blood spots or other bodily fluids |
| KR102237667B1 (ko) | 2011-04-29 | 2021-04-12 | 세븐쓰 센스 바이오시스템즈, 인크. | 유체들의 전달 및/또는 수용 |
| US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
| AU2015203882C1 (en) * | 2011-06-28 | 2017-09-21 | Inovio Pharmaceuticals, Inc. | A minimally invasive dermal electroporation device |
| US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
| US9561034B2 (en) | 2011-11-01 | 2017-02-07 | Zipline Medical, Inc. | Surgical incision and closure apparatus |
| US10123800B2 (en) | 2011-11-01 | 2018-11-13 | Zipline Medical, Inc. | Surgical incision and closure apparatus with integrated force distribution |
| US10123801B2 (en) | 2011-11-01 | 2018-11-13 | Zipline Medical, Inc. | Means to prevent wound dressings from adhering to closure device |
| US12171432B2 (en) | 2011-11-01 | 2024-12-24 | Zipline Medical, Inc. | Closure apparatuses and methods for ulcers and irregular skin defects |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| KR20150003179A (ko) | 2012-03-06 | 2015-01-08 | 안타레스 팔마, 인코퍼레이티드 | 분리력 특징을 가진 사전충전형 주사기 |
| US9950125B2 (en) | 2012-04-06 | 2018-04-24 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
| WO2013169804A1 (en) | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| CA2932540A1 (en) * | 2012-12-14 | 2014-06-19 | The Trustees Of Columbia University In The City Of New York | System and method to locally deliver therapeutic agent to inner ear |
| HK1217215A1 (zh) | 2013-01-17 | 2016-12-30 | Modernatx, Inc. | 用於改变细胞表型的信号传感器多核苷酸 |
| US9744302B2 (en) | 2013-02-11 | 2017-08-29 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
| EP3572108A1 (en) | 2013-03-11 | 2019-11-27 | Antares Pharma, Inc. | Dosage injector with pinion system |
| WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| CN105873525A (zh) | 2014-01-05 | 2016-08-17 | 奇普林医药公司 | 仪表化伤口闭合装置 |
| CA2991689C (en) * | 2014-07-24 | 2023-06-20 | Sasi Solomon | Device and methods for delivery of stimulation to a body tissue |
| WO2018081795A1 (en) | 2016-10-31 | 2018-05-03 | Zipline Medical, Inc. | Systems and methods for monitoring physical therapy of the knee and other joints |
| CA3073215A1 (en) * | 2017-10-06 | 2019-04-11 | Medtronic Xomed, Inc. | Pledget stimulation and recording electrode assemblies |
| GB2574074B (en) | 2018-07-27 | 2020-05-20 | Mclaren Applied Tech Ltd | Time synchronisation |
| CN111544593A (zh) * | 2019-03-26 | 2020-08-18 | 华中科技大学同济医学院附属协和医院 | 一种载抗银屑病系统药物的微针贴片及其制备方法 |
| GB2588236B (en) | 2019-10-18 | 2024-03-20 | Mclaren Applied Ltd | Gyroscope bias estimation |
| CN116570829A (zh) * | 2023-05-25 | 2023-08-11 | 东华大学 | 一种透皮给药贴片、其制备方法及应用 |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US4378806A (en) * | 1980-08-12 | 1983-04-05 | Henley Cohn Julian L | Gapped resonant microwave apparatus for producing hyperthermia therapy of tumors |
| US4543088A (en) * | 1983-11-07 | 1985-09-24 | American Hospital Supply Corporation | Self-sealing subcutaneous injection site |
| US5163899A (en) * | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
| US5078700A (en) * | 1990-03-19 | 1992-01-07 | Becton, Dickinson And Company | Liquid crystalline catheter |
| US5160316A (en) * | 1990-09-10 | 1992-11-03 | Henley Julian L | Iontophoretic drug delivery apparatus |
| US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| US5331979A (en) * | 1992-07-27 | 1994-07-26 | Henley Julian L | Iontophoretic cigarette substitute |
| US5534023A (en) * | 1992-12-29 | 1996-07-09 | Henley; Julian L. | Fluid filled prosthesis excluding gas-filled beads |
| US5545143A (en) * | 1993-01-21 | 1996-08-13 | T. S. I. Medical | Device for subcutaneous medication delivery |
| US5667487A (en) * | 1993-04-07 | 1997-09-16 | Henley; Julian L. | Ionosonic drug delivery apparatus |
| US5415629A (en) * | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
| KR100370728B1 (ko) * | 1994-10-27 | 2003-04-07 | 실리콘 밸리 그룹, 인크. | 기판을균일하게코팅하는방법및장치 |
| US5908401A (en) * | 1996-05-08 | 1999-06-01 | The Aps Organization, Llp | Method for iontophoretic delivery of antiviral agents |
| US5676648A (en) * | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
| US6385487B1 (en) * | 1996-05-08 | 2002-05-07 | Biophoretic Therapeutic Systems, Llc | Methods for electrokinetic delivery of medicaments |
| DE69719761T2 (de) * | 1996-06-18 | 2003-12-18 | Alza Corp., Palo Alto | Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten |
| US5911223A (en) * | 1996-08-09 | 1999-06-15 | Massachusetts Institute Of Technology | Introduction of modifying agents into skin by electroporation |
| US6078842A (en) * | 1997-04-08 | 2000-06-20 | Elan Corporation, Plc | Electrode and iontophoretic device and method |
| EP1005296B8 (en) * | 1997-06-05 | 2005-06-08 | Adiana, Inc. | Apparatus for tubal occlusion |
| US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| GB9815819D0 (en) * | 1998-07-22 | 1998-09-16 | Secr Defence | Transferring materials into cells and a microneedle array |
| GB9817662D0 (en) * | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
| US6148231A (en) * | 1998-09-15 | 2000-11-14 | Biophoretic Therapeutic Systems, Llc | Iontophoretic drug delivery electrodes and method |
| US6328735B1 (en) * | 1998-10-30 | 2001-12-11 | E.P., Limited | Thermal ablation system |
| US6148232A (en) * | 1998-11-09 | 2000-11-14 | Elecsys Ltd. | Transdermal drug delivery and analyte extraction |
| US6597946B2 (en) * | 1998-11-09 | 2003-07-22 | Transpharma Ltd. | Electronic card for transdermal drug delivery and analyte extraction |
| WO2000044438A1 (en) * | 1999-01-28 | 2000-08-03 | Cyto Pulse Sciences, Inc. | Delivery of macromolecules into cells |
| US6477410B1 (en) * | 2000-05-31 | 2002-11-05 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
| US6792306B2 (en) * | 2000-03-10 | 2004-09-14 | Biophoretic Therapeutic Systems, Llc | Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor |
| DE60018726T2 (de) * | 1999-04-16 | 2006-04-13 | Johnson & Johnson Consumer Companies, Inc. | Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren |
| US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6379324B1 (en) * | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| US6312612B1 (en) * | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US7133717B2 (en) * | 1999-08-25 | 2006-11-07 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery and diagnostic sampling |
| US6511463B1 (en) * | 1999-11-18 | 2003-01-28 | Jds Uniphase Corporation | Methods of fabricating microneedle arrays using sacrificial molds |
| US6565532B1 (en) * | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
| US6656147B1 (en) * | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
| US6989156B2 (en) * | 2001-04-23 | 2006-01-24 | Nucryst Pharmaceuticals Corp. | Therapeutic treatments using the direct application of antimicrobial metal compositions |
| US6690959B2 (en) * | 2000-09-01 | 2004-02-10 | Medtronic, Inc. | Skin-mounted electrodes with nano spikes |
| US6591133B1 (en) * | 2000-11-27 | 2003-07-08 | Microlin Llc | Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices |
| US20020099356A1 (en) * | 2001-01-19 | 2002-07-25 | Unger Evan C. | Transmembrane transport apparatus and method |
| US6881203B2 (en) * | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
| US6689100B2 (en) * | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
| US7643874B2 (en) * | 2001-10-24 | 2010-01-05 | Power Paper Ltd. | Dermal patch |
| US7429258B2 (en) * | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
| US20030144625A1 (en) * | 2002-01-28 | 2003-07-31 | Garry Sherman | Method and apparatus for the treatment of infections of the nail matrix and nail plate |
| US6780171B2 (en) * | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
| US7115881B2 (en) * | 2002-06-04 | 2006-10-03 | Mario Rabinowitz | Positioning and motion control by electrons, ions, and neutrals in electric fields |
| US8062573B2 (en) * | 2002-09-16 | 2011-11-22 | Theraject, Inc. | Solid micro-perforators and methods of use |
| IL152271A (en) * | 2002-10-13 | 2006-04-10 | Meir Hefetz | Structures of micro needles and manufacturing methods |
| US6923791B2 (en) * | 2003-03-31 | 2005-08-02 | Sterling Medivations, Inc. | Infusion device having offset flow path |
| EP1633431B1 (en) * | 2003-06-02 | 2008-11-12 | Power Paper Ltd. | Kit, device and method for controlled delivery of oxidizing agent into the skin |
| US7647100B2 (en) * | 2003-07-14 | 2010-01-12 | Power Paper Ltd. | Method, apparatus, and kit for onychomycosis treatment |
| EP1662987B1 (en) * | 2003-09-11 | 2011-11-09 | Theranos, Inc. | Medical device for analyte monitoring and drug delivery |
| US20050123565A1 (en) * | 2003-10-31 | 2005-06-09 | Janardhanan Subramony | System and method for transdermal vaccine delivery |
| US6834206B1 (en) * | 2003-12-23 | 2004-12-21 | Sono-Therapy Institute, Inc. | Method for the electrical stimulation of human tissue to encourage hair growth |
| US7315758B2 (en) * | 2004-06-03 | 2008-01-01 | Lynntech, Inc. | Transdermal delivery of therapeutic agent |
| US20060275228A1 (en) * | 2005-05-09 | 2006-12-07 | Bissett Donald L | Skin care compositions containing idebenone |
| US20060275237A1 (en) * | 2005-05-09 | 2006-12-07 | Bissett Donald L | Skin care compositions containing idebenone |
| US20070066934A1 (en) * | 2005-09-19 | 2007-03-22 | Transport Pharmaceuticals, Inc. | Electrokinetic delivery system and methods therefor |
| US20070276318A1 (en) * | 2006-05-26 | 2007-11-29 | Mit, Llp | Iontosonic-microneedle applicator apparatus and methods |
-
2006
- 2006-10-03 US US11/538,249 patent/US20070185432A1/en not_active Abandoned
-
2007
- 2007-10-03 JP JP2009531436A patent/JP2010505518A/ja active Pending
- 2007-10-03 WO PCT/US2007/021226 patent/WO2008042404A2/en not_active Ceased
- 2007-10-03 EP EP07852505A patent/EP2079515A2/en not_active Withdrawn
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| WO2015129545A1 (ja) * | 2014-02-27 | 2015-09-03 | 久光製薬株式会社 | マイクロニードル・シート |
| JPWO2015129545A1 (ja) * | 2014-02-27 | 2017-03-30 | 久光製薬株式会社 | マイクロニードル・シート |
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| JP2016036476A (ja) * | 2014-08-07 | 2016-03-22 | 典雄 宮城 | 注射針 |
| JP2018086071A (ja) * | 2016-11-28 | 2018-06-07 | 株式会社リコー | 経皮吸収デバイス及び経皮吸収パッチ |
| KR20190099479A (ko) * | 2016-12-22 | 2019-08-27 | 오하이오 스테이트 이노베이션 파운데이션 | 나노채널 기반 카고 전달을 위한 상호침투 마이크로구조물 |
| JP2020513900A (ja) * | 2016-12-22 | 2020-05-21 | オハイオ・ステイト・イノベーション・ファウンデーション | ナノチャネルに基づくカーゴ送達のための相互貫入マイクロ構造体 |
| JP7114094B2 (ja) | 2016-12-22 | 2022-08-08 | オハイオ・ステイト・イノベーション・ファウンデーション | ナノチャネルに基づくカーゴ送達のための相互貫入マイクロ構造体 |
| KR102539625B1 (ko) * | 2016-12-22 | 2023-06-05 | 오하이오 스테이트 이노베이션 파운데이션 | 나노채널 기반 카고 전달을 위한 상호침투 마이크로구조물 |
| US12415058B2 (en) | 2016-12-22 | 2025-09-16 | Ohio State Innovation Foundation | Interpenetrating microstructures for nanochannel-based sampling and/or cargo delivery |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008042404A2 (en) | 2008-04-10 |
| US20070185432A1 (en) | 2007-08-09 |
| EP2079515A2 (en) | 2009-07-22 |
| WO2008042404A3 (en) | 2008-08-07 |
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