JP2010505518A - メトトレキサートを送達する動電システムおよび方法 - Google Patents

メトトレキサートを送達する動電システムおよび方法 Download PDF

Info

Publication number
JP2010505518A
JP2010505518A JP2009531436A JP2009531436A JP2010505518A JP 2010505518 A JP2010505518 A JP 2010505518A JP 2009531436 A JP2009531436 A JP 2009531436A JP 2009531436 A JP2009531436 A JP 2009531436A JP 2010505518 A JP2010505518 A JP 2010505518A
Authority
JP
Japan
Prior art keywords
applicator
skin
electrode
drug
needle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009531436A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010505518A5 (enExample
Inventor
ロバート・ダブリュー・イーサリッジ・ザ・サード
デニス・アイ・ゴールドバーグ
フィリップ・エム・フライデン
ジョン・エス・ピーターセン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transport Pharmaceuticals Inc
Original Assignee
Transport Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transport Pharmaceuticals Inc filed Critical Transport Pharmaceuticals Inc
Publication of JP2010505518A publication Critical patent/JP2010505518A/ja
Publication of JP2010505518A5 publication Critical patent/JP2010505518A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2009531436A 2006-10-03 2007-10-03 メトトレキサートを送達する動電システムおよび方法 Pending JP2010505518A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/538,249 US20070185432A1 (en) 2005-09-19 2006-10-03 Electrokinetic system and method for delivering methotrexate
PCT/US2007/021226 WO2008042404A2 (en) 2006-10-03 2007-10-03 Electrokinetic system and method for delivering methotrexate

Publications (2)

Publication Number Publication Date
JP2010505518A true JP2010505518A (ja) 2010-02-25
JP2010505518A5 JP2010505518A5 (enExample) 2011-12-08

Family

ID=39269032

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009531436A Pending JP2010505518A (ja) 2006-10-03 2007-10-03 メトトレキサートを送達する動電システムおよび方法

Country Status (4)

Country Link
US (1) US20070185432A1 (enExample)
EP (1) EP2079515A2 (enExample)
JP (1) JP2010505518A (enExample)
WO (1) WO2008042404A2 (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013529100A (ja) * 2010-04-28 2013-07-18 キンバリー クラーク ワールドワイド インコーポレイテッド 射出成形型マイクロニードルアレイ及びその製造方法
WO2015129545A1 (ja) * 2014-02-27 2015-09-03 久光製薬株式会社 マイクロニードル・シート
JP2016005543A (ja) * 2014-05-26 2016-01-14 株式会社スズキプレシオン 注入針装置及び注入器具セット
JP2016036476A (ja) * 2014-08-07 2016-03-22 典雄 宮城 注射針
JP2017170161A (ja) * 2011-06-28 2017-09-28 イノビオ ファーマシューティカルズ，インコーポレイティド 低侵襲表皮電気穿孔装置
JP2018086071A (ja) * 2016-11-28 2018-06-07 株式会社リコー 経皮吸収デバイス及び経皮吸収パッチ
KR20190099479A (ko) * 2016-12-22 2019-08-27 오하이오 스테이트 이노베이션 파운데이션 나노채널 기반 카고 전달을 위한 상호침투 마이크로구조물
US12415058B2 (en) 2016-12-22 2025-09-16 Ohio State Innovation Foundation Interpenetrating microstructures for nanochannel-based sampling and/or cargo delivery

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
ATE409057T1 (de) 2002-02-11 2008-10-15 Antares Pharma Inc Intradermales injektionsgerät
US8571648B2 (en) * 2004-05-07 2013-10-29 Aesthera Apparatus and method to apply substances to tissue
US7842029B2 (en) * 2004-05-07 2010-11-30 Aesthera Apparatus and method having a cooling material and reduced pressure to treat biological external tissue
WO2006079064A1 (en) 2005-01-24 2006-07-27 Antares Pharma, Inc. Prefilled needle assisted jet injector
EP2001519A2 (en) * 2006-04-10 2008-12-17 The Regents Of The University Of California Method and apparatus of low strengh electric field network-mediated delivery of drug, gene, sirna, shrn, protein, peptide, antibody or other biomedical and therapeutic molecules and reagents in skin, soft tissue, joints and bone
WO2007131025A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Injector with adjustable dosing
US8251947B2 (en) 2006-05-03 2012-08-28 Antares Pharma, Inc. Two-stage reconstituting injector
US20090012434A1 (en) * 2007-07-03 2009-01-08 Anderson Robert S Apparatus, method, and system to treat a volume of skin
US20090069795A1 (en) * 2007-09-10 2009-03-12 Anderson Robert S Apparatus and method for selective treatment of tissue
US20090082713A1 (en) * 2007-09-20 2009-03-26 Friden Phillip M Method of enhancing iontophoretic delivery of a peptide
US20090093864A1 (en) * 2007-10-08 2009-04-09 Anderson Robert S Methods and devices for applying energy to tissue
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
JP5731829B2 (ja) 2008-03-10 2015-06-10 アンタレス・ファーマ・インコーポレーテッド 注射器安全装置
EP3581224A1 (en) 2008-08-05 2019-12-18 Antares Pharma, Inc. Multiple dosage injector
KR20110086854A (ko) * 2008-11-18 2011-08-01 쓰리엠 이노베이티브 프로퍼티즈 컴파니 중공 마이크로니들 어레이 및 방법
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2010101621A1 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Devices and methods for the analysis of an extractable medium
AU2010226442A1 (en) 2009-03-20 2011-10-13 Antares Pharma, Inc. Hazardous agent injection system
CN101829396B (zh) * 2009-03-27 2013-01-30 清华大学 微针阵列芯片及利用其的经皮给药贴剂及其制备方法
FI20095433A0 (fi) * 2009-04-20 2009-04-20 Valtion Teknillinen Mikroneula
US10159825B2 (en) * 2009-09-17 2018-12-25 Zipline Medical, Inc. Rapid closing surgical closure device
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
AU2011267977B2 (en) 2010-06-14 2015-02-05 Zipline Medical, Inc. Methods and apparatus for inhibiting scar formation
JP2013538069A (ja) 2010-07-16 2013-10-10 セブンス センス バイオシステムズ，インコーポレーテッド 流体移動デバイスのための低圧環境
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
EP2954916A3 (en) * 2010-08-13 2016-04-20 Seventh Sense Biosystems, Inc. Clinical and/or consumer techniques and devices
EP2637562B1 (en) 2010-11-09 2016-01-27 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
JP2014516644A (ja) 2011-04-29 2014-07-17 セブンス センス バイオシステムズ，インコーポレーテッド 血斑または他の体液の収集および／または操作のためのデバイスおよび方法
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP2701600B1 (en) 2011-04-29 2016-06-08 Seventh Sense Biosystems, Inc. Delivering and/or receiving fluids
AU2015203882C1 (en) * 2011-06-28 2017-09-21 Inovio Pharmaceuticals, Inc. A minimally invasive dermal electroporation device
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US10123800B2 (en) 2011-11-01 2018-11-13 Zipline Medical, Inc. Surgical incision and closure apparatus with integrated force distribution
US10123801B2 (en) 2011-11-01 2018-11-13 Zipline Medical, Inc. Means to prevent wound dressings from adhering to closure device
US12171432B2 (en) 2011-11-01 2024-12-24 Zipline Medical, Inc. Closure apparatuses and methods for ulcers and irregular skin defects
US9561034B2 (en) 2011-11-01 2017-02-07 Zipline Medical, Inc. Surgical incision and closure apparatus
JP2015501844A (ja) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
PT2822618T (pt) 2012-03-06 2024-03-04 Antares Pharma Inc Seringa pré-cheia com característica de força de rutura
EP2833944A4 (en) 2012-04-06 2016-05-25 Antares Pharma Inc ADMINISTRATION OF TESTOSTERONE COMPOSITIONS BY NEEDLE-SUPPORTED NOZZLE INJECTION
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
WO2014093875A1 (en) * 2012-12-14 2014-06-19 The Trustees Of Columbia University In The City Of New York System and method to locally deliver therapeutic agent to inner ear
JP2016504050A (ja) 2013-01-17 2016-02-12 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 細胞表現型の改変のためのシグナルセンサーポリヌクレオチド
PT2953667T (pt) 2013-02-11 2020-01-28 Antares Pharma Inc Dispositivo de injeção a jato auxiliado por agulha tendo força de gatilho reduzida
JP6030803B2 (ja) 2013-03-11 2016-11-24 アンタレス・ファーマ・インコーポレーテッド ピニオンシステムを有する用量注射器
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
EP3089677B1 (en) 2014-01-05 2020-04-01 Zipline Medical, Inc. Instrumented wound closure device
BR112017001479B1 (pt) * 2014-07-24 2022-12-06 Synapstim Ltd Sistema para fornecer a penetração de energia elétrica para dentro de um tecido corporal
WO2018081795A1 (en) 2016-10-31 2018-05-03 Zipline Medical, Inc. Systems and methods for monitoring physical therapy of the knee and other joints
US11412986B2 (en) * 2017-10-06 2022-08-16 Medtronic Xomed, Inc. Methods of recording responses of and stimulating bioelectric tissue
GB2574074B (en) 2018-07-27 2020-05-20 Mclaren Applied Tech Ltd Time synchronisation
CN111544593A (zh) * 2019-03-26 2020-08-18 华中科技大学同济医学院附属协和医院 一种载抗银屑病系统药物的微针贴片及其制备方法
GB2588236B (en) 2019-10-18 2024-03-20 Mclaren Applied Ltd Gyroscope bias estimation
CA3223587A1 (en) * 2021-06-30 2023-01-05 Paul Fisher Side-port injection devices for use with electroporation, and related systems and methods
CN116570829A (zh) * 2023-05-25 2023-08-11 东华大学 一种透皮给药贴片、其制备方法及应用

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4378806A (en) * 1980-08-12 1983-04-05 Henley Cohn Julian L Gapped resonant microwave apparatus for producing hyperthermia therapy of tumors
US4543088A (en) * 1983-11-07 1985-09-24 American Hospital Supply Corporation Self-sealing subcutaneous injection site
US5163899A (en) * 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5078700A (en) * 1990-03-19 1992-01-07 Becton, Dickinson And Company Liquid crystalline catheter
US5160316A (en) * 1990-09-10 1992-11-03 Henley Julian L Iontophoretic drug delivery apparatus
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5331979A (en) * 1992-07-27 1994-07-26 Henley Julian L Iontophoretic cigarette substitute
US5534023A (en) * 1992-12-29 1996-07-09 Henley; Julian L. Fluid filled prosthesis excluding gas-filled beads
US5545143A (en) * 1993-01-21 1996-08-13 T. S. I. Medical Device for subcutaneous medication delivery
US5667487A (en) * 1993-04-07 1997-09-16 Henley; Julian L. Ionosonic drug delivery apparatus
US5415629A (en) * 1993-09-15 1995-05-16 Henley; Julian L. Programmable apparatus for the transdermal delivery of drugs and method
KR100370728B1 (ko) * 1994-10-27 2003-04-07 실리콘 밸리 그룹, 인크. 기판을균일하게코팅하는방법및장치
US6385487B1 (en) * 1996-05-08 2002-05-07 Biophoretic Therapeutic Systems, Llc Methods for electrokinetic delivery of medicaments
US5676648A (en) * 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
US5908401A (en) * 1996-05-08 1999-06-01 The Aps Organization, Llp Method for iontophoretic delivery of antiviral agents
US7184826B2 (en) * 1996-06-18 2007-02-27 Alza Corporation Device and method for enhancing transdermal flux of agents being delivered or sampled
US5911223A (en) * 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US6078842A (en) * 1997-04-08 2000-06-20 Elan Corporation, Plc Electrode and iontophoretic device and method
ATE499045T1 (de) * 1997-06-05 2011-03-15 Adiana Inc Vorrichtung zur weiblichen sterilisation
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB9817662D0 (en) * 1998-08-13 1998-10-07 Crocker Peter J Substance delivery
US6148231A (en) * 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US6328735B1 (en) * 1998-10-30 2001-12-11 E.P., Limited Thermal ablation system
US6148232A (en) * 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6597946B2 (en) * 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
JP4499295B2 (ja) * 1999-01-28 2010-07-07 サイト パルス サイエンシズ、インコーポレイテッド 細胞内への巨大分子の送達
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6792306B2 (en) * 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
AU4239300A (en) * 1999-04-16 2000-11-02 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US6511463B1 (en) * 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6656147B1 (en) * 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
US6939568B2 (en) * 2001-04-23 2005-09-06 Nucryst Pharmaceuticals Corp. Treatment of inflammatory skin conditions
US6690959B2 (en) * 2000-09-01 2004-02-10 Medtronic, Inc. Skin-mounted electrodes with nano spikes
US6591133B1 (en) * 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US20020099356A1 (en) * 2001-01-19 2002-07-25 Unger Evan C. Transmembrane transport apparatus and method
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7643874B2 (en) * 2001-10-24 2010-01-05 Power Paper Ltd. Dermal patch
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20030144625A1 (en) * 2002-01-28 2003-07-31 Garry Sherman Method and apparatus for the treatment of infections of the nail matrix and nail plate
US6780171B2 (en) * 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115881B2 (en) * 2002-06-04 2006-10-03 Mario Rabinowitz Positioning and motion control by electrons, ions, and neutrals in electric fields
WO2004024224A1 (en) * 2002-09-16 2004-03-25 Sung-Yun Kwon Solid micro-perforators and methods of use
IL152271A (en) * 2002-10-13 2006-04-10 Meir Hefetz Structures of micro needles and manufacturing methods
US6923791B2 (en) * 2003-03-31 2005-08-02 Sterling Medivations, Inc. Infusion device having offset flow path
JP2006526454A (ja) * 2003-06-02 2006-11-24 パワー ペーパー リミティド 皮膚内へ酸化剤を制御デリバリーするためのキット、装置及び方法
KR20060033795A (ko) * 2003-07-14 2006-04-19 파워 페이퍼 리미티드 물질의 동전기적 운반을 이용한 손발톱진균증 치료를 위한방법, 기구 및 키트
KR20140134338A (ko) * 2003-09-11 2014-11-21 테라노스, 인코포레이티드 피분석물의 모니터링 및 약물 전달을 위한 의료 기기
JP2007509704A (ja) * 2003-10-31 2007-04-19 アルザ・コーポレーシヨン 経皮的ワクチン送達のための系および方法
US6834206B1 (en) * 2003-12-23 2004-12-21 Sono-Therapy Institute, Inc. Method for the electrical stimulation of human tissue to encourage hair growth
US7315758B2 (en) * 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
US20060275228A1 (en) * 2005-05-09 2006-12-07 Bissett Donald L Skin care compositions containing idebenone
US20060275237A1 (en) * 2005-05-09 2006-12-07 Bissett Donald L Skin care compositions containing idebenone
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9545507B2 (en) 2010-04-28 2017-01-17 Kimberly-Clark Worldwide, Inc. Injection molded microneedle array and method for forming the microneedle array
JP2013529100A (ja) * 2010-04-28 2013-07-18 キンバリー クラーク ワールドワイド インコーポレイテッド 射出成形型マイクロニードルアレイ及びその製造方法
US11291836B2 (en) 2011-06-28 2022-04-05 Inovio Pharmaceuticals, Inc. Minimally invasive dermal electroporation device
US10668279B2 (en) 2011-06-28 2020-06-02 Inovio Pharmaceuticals, Inc. Miniminally invasive dermal electroporation device
US12251561B2 (en) 2011-06-28 2025-03-18 Inovio Pharmaceuticals, Inc. Minimally invasive dermal electroporation device
JP2021037322A (ja) * 2011-06-28 2021-03-11 イノビオ ファーマシューティカルズ，インコーポレイティド 低侵襲表皮電気穿孔装置
JP2017170161A (ja) * 2011-06-28 2017-09-28 イノビオ ファーマシューティカルズ，インコーポレイティド 低侵襲表皮電気穿孔装置
WO2015129545A1 (ja) * 2014-02-27 2015-09-03 久光製薬株式会社 マイクロニードル・シート
JPWO2015129545A1 (ja) * 2014-02-27 2017-03-30 久光製薬株式会社 マイクロニードル・シート
JP2016005543A (ja) * 2014-05-26 2016-01-14 株式会社スズキプレシオン 注入針装置及び注入器具セット
JP2016036476A (ja) * 2014-08-07 2016-03-22 典雄 宮城 注射針
JP2018086071A (ja) * 2016-11-28 2018-06-07 株式会社リコー 経皮吸収デバイス及び経皮吸収パッチ
KR20190099479A (ko) * 2016-12-22 2019-08-27 오하이오 스테이트 이노베이션 파운데이션 나노채널 기반 카고 전달을 위한 상호침투 마이크로구조물
JP2020513900A (ja) * 2016-12-22 2020-05-21 オハイオ・ステイト・イノベーション・ファウンデーション ナノチャネルに基づくカーゴ送達のための相互貫入マイクロ構造体
JP7114094B2 (ja) 2016-12-22 2022-08-08 オハイオ・ステイト・イノベーション・ファウンデーション ナノチャネルに基づくカーゴ送達のための相互貫入マイクロ構造体
KR102539625B1 (ko) * 2016-12-22 2023-06-05 오하이오 스테이트 이노베이션 파운데이션 나노채널 기반 카고 전달을 위한 상호침투 마이크로구조물
US12415058B2 (en) 2016-12-22 2025-09-16 Ohio State Innovation Foundation Interpenetrating microstructures for nanochannel-based sampling and/or cargo delivery

Also Published As

Publication number Publication date
US20070185432A1 (en) 2007-08-09
WO2008042404A2 (en) 2008-04-10
WO2008042404A3 (en) 2008-08-07
EP2079515A2 (en) 2009-07-22

Similar Documents

Publication Publication Date Title
US20070185432A1 (en) Electrokinetic system and method for delivering methotrexate
JP2009508595A (ja) 界面動電送出システム及びその方法
US6591133B1 (en) Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
Banga et al. Iontophoresis and electroporation: comparisons and contrasts
ES2260021T3 (es) Aparatos para la microporacion de membranas biologicas utilizando dispositivos de interfaz de tejido de pelicula delgada, y su metodo.
Brown et al. Dermal and transdermal drug delivery systems: current and future prospects
JP4216073B2 (ja) 改善された薬物配給および診断用サンプリングのための組織電気穿孔法
US7315758B2 (en) Transdermal delivery of therapeutic agent
EP1590034B1 (en) Microneedle array patch
US8920375B2 (en) Gas pressure actuated microneedle arrays, and systems and methods relating to same
JP2006512164A (ja) 複合部材を有する有効成分送達装置
KR101175326B1 (ko) 생리 활성 물질의 경피 전달을 위한 마이크로 니들 장치 및 그 제조 방법
JP4647863B2 (ja) 薬剤投与具及び薬剤投与装置
CN110997058A (zh) 用于活性剂的受控制的和受监视的经皮给药的装置和方法及其用途
US20060264805A1 (en) Permeabilization of biological membranes
Swain et al. Advanced techniques for penetration enhancement in transdermal drug delivery system
KR20200086695A (ko) 활성 제제의 경피 전달 장치 및 방법
EP1355697A1 (en) Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
Banga New technologies to allow transdermal delivery of therapeutic proteins and small water-soluble drugs
Jain Transdermal drug delivery
Hui et al. Enhancing transdermal drug delivery with electroporation
EP4048373B1 (en) Continuous or periodical transdermal delivery of exogenous molecule
Levin Advances in radio-frequency transdermal drug delivery
Jatav et al. Recent advances in development of transdermal patches
MX2008003830A (es) Sistema de suministro electrocinetico y metodos para el mismo

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101004

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101004

A072 Dismissal of procedure [no reply to invitation to correct request for examination]

Free format text: JAPANESE INTERMEDIATE CODE: A073

Effective date: 20120207