JP2010505444A - 軟骨にターゲティングするためのポリペプチドリガンド及びその使用方法 - Google Patents

軟骨にターゲティングするためのポリペプチドリガンド及びその使用方法 Download PDF

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JP2010505444A
JP2010505444A JP2009532369A JP2009532369A JP2010505444A JP 2010505444 A JP2010505444 A JP 2010505444A JP 2009532369 A JP2009532369 A JP 2009532369A JP 2009532369 A JP2009532369 A JP 2009532369A JP 2010505444 A JP2010505444 A JP 2010505444A
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polypeptide
seq
cartilage
therapeutic agent
delivery system
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JP2010505444A5 (OSRAM
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エー.フブベルル ジェフフレイ
エー.ロトヘンフルフ ドミニクエ
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エコレ ポルイテクフニクエ フェデラレ デ ラウサンネ
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Publication of JP2010505444A publication Critical patent/JP2010505444A/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009532369A 2006-10-10 2007-10-09 軟骨にターゲティングするためのポリペプチドリガンド及びその使用方法 Pending JP2010505444A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/545,819 US7592009B2 (en) 2006-10-10 2006-10-10 Polypeptide ligands for targeting cartilage and methods of use thereof
PCT/US2007/021529 WO2008063291A2 (en) 2006-10-10 2007-10-09 Polypeptide ligands for targeting cartilage and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2010505444A true JP2010505444A (ja) 2010-02-25
JP2010505444A5 JP2010505444A5 (OSRAM) 2010-12-02

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JP2009532369A Pending JP2010505444A (ja) 2006-10-10 2007-10-09 軟骨にターゲティングするためのポリペプチドリガンド及びその使用方法

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US (2) US7592009B2 (OSRAM)
EP (1) EP2084275A4 (OSRAM)
JP (1) JP2010505444A (OSRAM)
AU (1) AU2007322346A1 (OSRAM)
CA (1) CA2665839A1 (OSRAM)
IL (1) IL198120A0 (OSRAM)
WO (1) WO2008063291A2 (OSRAM)

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JP2016511747A (ja) * 2013-01-04 2016-04-21 マサチューセッツ インスティテュート オブ テクノロジー ナノ粒子表面結合に基づく薬物の組織への送達
JP2017501214A (ja) * 2013-11-25 2017-01-12 サノフイ 治療的な使用のためのdotam誘導体
JP2018527348A (ja) * 2015-09-09 2018-09-20 フレッド ハッチンソン キャンサー リサーチ センター 軟骨ホーミングペプチド
JP2020511459A (ja) * 2017-03-16 2020-04-16 ブレイズ バイオサイエンス, インコーポレイテッド 軟骨ホーミングペプチドコンジュゲート及びその使用方法
JP2021518357A (ja) * 2018-03-16 2021-08-02 ブレイズ バイオサイエンス, インコーポレイテッド 欠失した軟骨ホーミングペプチド、及び、ペプチド複合体、及び、それらの使用方法

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EP2459213A1 (en) 2009-07-31 2012-06-06 Amgen Inc. Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
US20160208011A1 (en) 2010-01-28 2016-07-21 The Board Of Trustees Of The Leland Stanford Junior University Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same
US10487148B2 (en) 2010-01-28 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated impairments
US10626399B2 (en) 2010-01-28 2020-04-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating cognitive symptoms of an aging-associated impairment by modulating C-C chemokine receptor type 3 (CCR3)
WO2011097342A1 (en) * 2010-02-04 2011-08-11 University Of Utah Research Foundation Hydrophobically-modified hyaluronan and methods of making and using thereof
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US9173919B2 (en) 2011-02-16 2015-11-03 Purdue Research Foundation Collagen-targeted nanoparticles
US9161968B2 (en) 2011-04-08 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
PT2714718T (pt) 2011-05-24 2017-04-19 Symic Ip Llc Preparação e métodos de utilização de peptidoglicanas sintéticas que se ligam a ácido hialurónico
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
CN104870020A (zh) * 2012-10-19 2015-08-26 康奈尔大学 用于关节软骨的仿生型界面润滑剂
JP6603650B2 (ja) 2013-03-15 2019-11-06 パーデュー・リサーチ・ファウンデーション 細胞外マトリックス結合性合成ペプチドグリカン
US10231991B2 (en) 2013-07-19 2019-03-19 The Johns Hopkins University Biomaterials comprising hyaluronic acid binding peptides and extracellular matrix binding peptides for hyaluronic acid retention and tissue engineering applications
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
WO2015088915A1 (en) 2013-12-09 2015-06-18 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated conditions
US10905779B2 (en) 2013-12-09 2021-02-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening human blood products comprising plasma using immunocompromised rodent models
US10772931B2 (en) 2014-04-25 2020-09-15 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
MX382490B (es) 2014-08-27 2025-03-13 Amgen Inc Variantes de inhibidor de tejido de metaloproteinasa tipo tres (timp-3), composiciones y metodos
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
ES2902467T3 (es) * 2015-06-15 2022-03-28 Univ Leland Stanford Junior TIMP2 para su uso en el tratamiento de afecciones asociadas al envejecimiento
EP3995141B1 (en) 2016-04-28 2024-01-03 Alkahest, Inc. Plasma fractions as therapy for thymic cancer
US10525107B2 (en) 2016-08-18 2020-01-07 Alkahest, Inc. Blood plasma fractions as a treatment for aging-associated cognitive disorders
JP7191025B2 (ja) 2017-01-18 2022-12-16 フレッド ハッチンソン キャンサー センター Tead相互作用を妨害するためのペプチド組成物およびその使用方法
AU2018257921B2 (en) 2017-04-26 2024-06-06 Alkahest, Inc. Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products
US11040068B2 (en) 2017-04-26 2021-06-22 Alkahest, Inc. Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products
US11331393B2 (en) 2017-06-15 2022-05-17 Blaze Bioscience, Inc. Renal-homing peptide conjugates and methods of use thereof
EP3648774A4 (en) 2017-07-07 2021-04-21 Symic IP, LLC SYNTHETIC BIOCONJUGATES
US11866466B2 (en) 2017-12-19 2024-01-09 Blaze Bioscience, Inc. Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof
EP4420723A3 (en) 2018-10-12 2024-12-04 Theradaptive, Inc. Polypeptides including a beta-tricalcium phosphate-binding sequence and uses thereof
MX2021004755A (es) 2018-10-26 2021-06-08 Alkahest Inc Uso de plasma y fracciones de plasma para mejorar el dolor, la cicatrizacion de heridas y la recuperacion posoperatoria.
KR20220122648A (ko) * 2019-12-03 2022-09-02 차이나 메디칼 유니버시티 올리고펩티드, 이의 테스트 키트, 및 이의 의약 조성물
AU2021254751B2 (en) 2020-04-15 2025-01-30 Theradaptive, Inc. Compositions and methods for targeted therapeutic delivery to bone

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JP2006515985A (ja) * 2002-10-23 2006-06-15 エクセリクシス, インク. 分枝形態形成のモディファイヤーとしてのmbm及び使用方法

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016511747A (ja) * 2013-01-04 2016-04-21 マサチューセッツ インスティテュート オブ テクノロジー ナノ粒子表面結合に基づく薬物の組織への送達
US10226427B2 (en) 2013-01-04 2019-03-12 Massachusetts Institute Of Technology Surface binding of nanoparticle based drug delivery to tissue
JP2017501214A (ja) * 2013-11-25 2017-01-12 サノフイ 治療的な使用のためのdotam誘導体
JP2018527348A (ja) * 2015-09-09 2018-09-20 フレッド ハッチンソン キャンサー リサーチ センター 軟骨ホーミングペプチド
JP2022009342A (ja) * 2015-09-09 2022-01-14 フレッド ハッチンソン キャンサー リサーチ センター 軟骨ホーミングペプチド
JP7378449B2 (ja) 2015-09-09 2023-11-13 フレッド ハッチンソン キャンサー センター 軟骨ホーミングペプチド
JP2020511459A (ja) * 2017-03-16 2020-04-16 ブレイズ バイオサイエンス, インコーポレイテッド 軟骨ホーミングペプチドコンジュゲート及びその使用方法
JP7280193B2 (ja) 2017-03-16 2023-05-23 ブレイズ バイオサイエンス, インコーポレイテッド 軟骨ホーミングペプチドコンジュゲート及びその使用方法
JP2021518357A (ja) * 2018-03-16 2021-08-02 ブレイズ バイオサイエンス, インコーポレイテッド 欠失した軟骨ホーミングペプチド、及び、ペプチド複合体、及び、それらの使用方法

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Publication number Publication date
CA2665839A1 (en) 2008-05-29
WO2008063291A2 (en) 2008-05-29
US20100080850A1 (en) 2010-04-01
US20080118523A1 (en) 2008-05-22
IL198120A0 (en) 2011-08-01
AU2007322346A1 (en) 2008-05-29
US7592009B2 (en) 2009-09-22
EP2084275A2 (en) 2009-08-05
EP2084275A4 (en) 2012-01-04
WO2008063291A3 (en) 2008-10-02

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