JP2010504088A5 - - Google Patents

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Publication number
JP2010504088A5
JP2010504088A5 JP2009528732A JP2009528732A JP2010504088A5 JP 2010504088 A5 JP2010504088 A5 JP 2010504088A5 JP 2009528732 A JP2009528732 A JP 2009528732A JP 2009528732 A JP2009528732 A JP 2009528732A JP 2010504088 A5 JP2010504088 A5 JP 2010504088A5
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JP
Japan
Prior art keywords
seq
mature protein
nucleic acid
disease
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009528732A
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English (en)
Japanese (ja)
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JP2010504088A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/060013 external-priority patent/WO2008034891A2/en
Publication of JP2010504088A publication Critical patent/JP2010504088A/ja
Publication of JP2010504088A5 publication Critical patent/JP2010504088A5/ja
Pending legal-status Critical Current

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JP2009528732A 2006-09-21 2007-09-21 グルタミニルシクラーゼに関連した新規遺伝子 Pending JP2010504088A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84624406P 2006-09-21 2006-09-21
US94778007P 2007-07-03 2007-07-03
PCT/EP2007/060013 WO2008034891A2 (en) 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase

Publications (2)

Publication Number Publication Date
JP2010504088A JP2010504088A (ja) 2010-02-12
JP2010504088A5 true JP2010504088A5 (OSRAM) 2010-11-11

Family

ID=38779576

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009528732A Pending JP2010504088A (ja) 2006-09-21 2007-09-21 グルタミニルシクラーゼに関連した新規遺伝子

Country Status (12)

Country Link
US (3) US20080249083A1 (OSRAM)
EP (2) EP2082041B1 (OSRAM)
JP (1) JP2010504088A (OSRAM)
KR (1) KR101432848B1 (OSRAM)
AU (1) AU2007298929B2 (OSRAM)
BR (1) BRPI0718507A2 (OSRAM)
CA (1) CA2663635A1 (OSRAM)
EA (1) EA016584B1 (OSRAM)
IL (2) IL197090A (OSRAM)
MX (1) MX2009003090A (OSRAM)
NZ (2) NZ575727A (OSRAM)
WO (1) WO2008034891A2 (OSRAM)

Families Citing this family (34)

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CN101837127A (zh) * 2003-05-05 2010-09-22 前体生物药物股份公司 谷氨酰胺酰基和谷氨酸环化酶效应物的应用
US9277737B2 (en) 2006-09-21 2016-03-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
US8889709B2 (en) 2006-09-21 2014-11-18 Probiodrug Ag Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
JP2010504088A (ja) 2006-09-21 2010-02-12 プロビオドルグ エージー グルタミニルシクラーゼに関連した新規遺伝子
US8420684B2 (en) * 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5379692B2 (ja) * 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
DK2086960T3 (da) * 2006-11-09 2014-06-10 Probiodrug Ag Nye inhibitorer af glutaminylcyclase.
SI2091948T1 (sl) * 2006-11-30 2012-07-31 Probiodrug Ag Novi inhibitorji glutaminil ciklaze
EP2121944B1 (en) * 2007-01-19 2011-08-24 Probiodrug AG In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders
JP5612860B2 (ja) * 2007-03-09 2014-10-22 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのイミダゾ［１，５−ａ］ピリジン誘導体
WO2008128986A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Urea derivatives as glutaminyl cyclase inhibitors
EP2142515B1 (en) * 2007-04-18 2014-03-26 Probiodrug AG Nitrovinyl-diamine derivatives as glutaminyl cyclase inhibitors
DK2160380T3 (da) * 2007-04-18 2014-06-30 Probiodrug Ag Cyano-guanidin derivater som glutaminyl cyclase inhibitorer
WO2008128982A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Thioxoquinazolinone derivatives as glutaminyl cyclase inhibitors
EP2142514B1 (en) * 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
WO2008128981A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Nitrovinyl-diamine derivatives as glutaminyl cyclase inhibitors
US8188094B2 (en) * 2007-04-20 2012-05-29 Probiodrug Ag Inhibitors of glutaminyl cyclase
NZ583799A (en) * 2007-09-12 2011-12-22 Probiodrug Ag Transgenic mice comprising a DNA transgene encoding ABeta peptide
NZ586665A (en) * 2008-01-14 2011-12-22 Probiodrug Ag MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE GLUTAMINYL CYCLASE GENE (Qpct)
EP2329274B1 (en) * 2008-07-31 2015-12-02 Probiodrug AG Glutaminyl cyclase as a diagnostic / prognostic indicator for neurodegenerative diseases
US8962860B2 (en) 2008-09-04 2015-02-24 Probiodrug Ag Inhibitors of glutaminyl cyclase
WO2010026209A1 (en) * 2008-09-04 2010-03-11 Probiodrug Ag Use of isoQC inhibitors
AU2010251176A1 (en) * 2009-05-19 2011-12-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
US20110212853A1 (en) * 2010-02-18 2011-09-01 Probiodrug Ag Novel diagnostic method
JP5952816B2 (ja) 2010-08-19 2016-07-13 プロビオドルグ エージー グルタミニルシクラーゼの結晶構造
JP2013541938A (ja) 2010-09-02 2013-11-21 プロビオドルグ エージー アイソｑｃ関連障害の治療のためのインビボスクリーニングモデル
JP6026425B2 (ja) 2010-11-02 2016-11-16 プロビオドルグ エージー イソグルタミニルシクラーゼの結晶構造
JP6397407B2 (ja) 2012-07-19 2018-09-26 ドレクセル ユニバーシティ 細胞タンパク質ホメオスタシスを調節するためのシグマ受容体リガンド
WO2017079547A2 (en) * 2015-11-04 2017-05-11 The Scripps Research Institute Compositions and methods for treating cystic fibrosis
FI3658141T3 (fi) * 2017-07-24 2023-03-02 Patologisten tilojen hoitaminen suoralla tai epäsuoralla siralfa-cd47-vuorovaikutukseen kohdentamisella
US11117870B2 (en) 2017-11-01 2021-09-14 Drexel University Compounds, compositions, and methods for treating diseases
GB201918108D0 (en) * 2019-12-10 2020-01-22 Vib Vzw Improved aminopeptiadases for single molecule peptide sequencing
WO2025224179A1 (en) 2024-04-23 2025-10-30 Vivoryon Therapeutics N.V. Glutaminyl cyclase inhbitors for use in the treatment of kidney disease
WO2025224169A1 (en) 2024-04-23 2025-10-30 Vivoryon Therapeutics N.V. Dose regimens for the glutaminyl cyclase inhibitor varoglutamstat

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BRPI0410078A (pt) * 2003-05-05 2006-05-16 Probiodrug Ag uso de efetuadores de ciclases de glutaminila e glutamato
US7732162B2 (en) * 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US8338120B2 (en) * 2003-05-05 2012-12-25 Probiodrug Ag Method of treating inflammation with glutaminyl cyclase inhibitors
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JP2010504088A (ja) * 2006-09-21 2010-02-12 プロビオドルグ エージー グルタミニルシクラーゼに関連した新規遺伝子
DK2091945T3 (da) 2006-11-09 2014-04-22 Probiodrug Ag Nye inhibitorer af glutaminylcyclase
US8188094B2 (en) 2007-04-20 2012-05-29 Probiodrug Ag Inhibitors of glutaminyl cyclase

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