NZ575727A - Novel genes related to glutaminyl cyclase - Google Patents

Novel genes related to glutaminyl cyclase

Info

Publication number
NZ575727A
NZ575727A NZ575727A NZ57572707A NZ575727A NZ 575727 A NZ575727 A NZ 575727A NZ 575727 A NZ575727 A NZ 575727A NZ 57572707 A NZ57572707 A NZ 57572707A NZ 575727 A NZ575727 A NZ 575727A
Authority
NZ
New Zealand
Prior art keywords
seq
qpctl
human
isoqc
expression
Prior art date
Application number
NZ575727A
Other languages
English (en)
Inventor
Stefan Schilling
Hans-Ulrich Demuth
Holger Cynis
Jens-Ulrich Rahfeld
Original Assignee
Probiodrug Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probiodrug Ag filed Critical Probiodrug Ag
Publication of NZ575727A publication Critical patent/NZ575727A/en

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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NZ575727A 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase NZ575727A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84624406P 2006-09-21 2006-09-21
US94778007P 2007-07-03 2007-07-03
PCT/EP2007/060013 WO2008034891A2 (en) 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase

Publications (1)

Publication Number Publication Date
NZ575727A true NZ575727A (en) 2011-12-22

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ID=38779576

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ590631A NZ590631A (en) 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase
NZ575727A NZ575727A (en) 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase

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Application Number Title Priority Date Filing Date
NZ590631A NZ590631A (en) 2006-09-21 2007-09-21 Novel genes related to glutaminyl cyclase

Country Status (12)

Country Link
US (3) US20080249083A1 (OSRAM)
EP (2) EP2581449B1 (OSRAM)
JP (1) JP2010504088A (OSRAM)
KR (1) KR101432848B1 (OSRAM)
AU (1) AU2007298929B2 (OSRAM)
BR (1) BRPI0718507A2 (OSRAM)
CA (1) CA2663635A1 (OSRAM)
EA (1) EA016584B1 (OSRAM)
IL (2) IL197090A (OSRAM)
MX (1) MX2009003090A (OSRAM)
NZ (2) NZ590631A (OSRAM)
WO (1) WO2008034891A2 (OSRAM)

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DK2206496T3 (da) * 2003-05-05 2014-12-15 Probiodrug Ag Screening af inhibitorer af pyroglutaminsyredannelse i amyloid beta-peptid
US9277737B2 (en) 2006-09-21 2016-03-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
US8889709B2 (en) 2006-09-21 2014-11-18 Probiodrug Ag Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
BRPI0718507A2 (pt) * 2006-09-21 2013-11-12 Probiodrug Ag Genes relacionados à glutaminil ciclase
WO2008055950A1 (en) * 2006-11-09 2008-05-15 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
US8420684B2 (en) * 2006-11-09 2013-04-16 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5379692B2 (ja) * 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
WO2008065141A1 (en) * 2006-11-30 2008-06-05 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
US20080200567A1 (en) * 2007-01-19 2008-08-21 Probiodrug Ag In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders
DK2118101T3 (da) * 2007-03-09 2013-01-02 Probiodrug Ag IMIDAZO (1,5-A)-PYRIDinderivater som glutaminylcyclaseinhibitorer
US9656991B2 (en) * 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
US9512082B2 (en) * 2007-04-18 2016-12-06 Probiodrug Ag Inhibitors of glutaminyl cyclase
US9034907B2 (en) * 2007-04-18 2015-05-19 Probiodrug Ag Inhibitors of glutaminyl cyclase
ES2474693T3 (es) * 2007-04-18 2014-07-09 Probiodrug Ag Derivados de ciano-guanidina como inhibidores de glutaminil ciclasa
DK2142515T3 (da) * 2007-04-18 2014-06-23 Probiodrug Ag Nitrovinyl-diaminderivater som glutaminyl-cyclase-inhibitorer
WO2008128981A1 (en) * 2007-04-18 2008-10-30 Probiodrug Ag Nitrovinyl-diamine derivatives as glutaminyl cyclase inhibitors
JP5676249B2 (ja) * 2007-04-20 2015-02-25 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体
NZ583799A (en) * 2007-09-12 2011-12-22 Probiodrug Ag Transgenic mice comprising a DNA transgene encoding ABeta peptide
WO2009090190A1 (en) * 2008-01-14 2009-07-23 Probiodrug Ag Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene
EP2329274B1 (en) * 2008-07-31 2015-12-02 Probiodrug AG Glutaminyl cyclase as a diagnostic / prognostic indicator for neurodegenerative diseases
ES2599621T3 (es) * 2008-09-04 2017-02-02 Probiodrug Ag Nuevos inhibidores
WO2010026209A1 (en) * 2008-09-04 2010-03-11 Probiodrug Ag Use of isoQC inhibitors
EP2432314B1 (en) * 2009-05-19 2017-12-20 Probiodrug AG Mouse models carrying a knock-out mutation of the qpctl-gene
JP2013519891A (ja) * 2010-02-18 2013-05-30 プロビオドルグ エージー ピログルタミン酸修飾ｍｃｐ−１を決定することにより炎症性疾患を診断する方法及びグルタミニルシクラーゼの阻害剤のスクリーニング方法
EP2606129B1 (en) 2010-08-19 2015-03-25 Probiodrug AG Crystal structure of glutaminyl cyclase
JP2013541938A (ja) 2010-09-02 2013-11-21 プロビオドルグ エージー アイソｑｃ関連障害の治療のためのインビボスクリーニングモデル
US8741614B2 (en) 2010-11-02 2014-06-03 Probiodrug Ag Crystal structure of isoglutaminyl cyclase
WO2014015157A2 (en) 2012-07-19 2014-01-23 Philadelphia Health & Education Corporation Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same
US20180318260A1 (en) * 2015-11-04 2018-11-08 The Scripps Research Institute Compositions and methods for treating cystic fibrosis
EP3747438A1 (en) * 2017-07-24 2020-12-09 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Treating pathological conditions by direct and indirect targeting of sirpa - cd47 interaction
WO2019089902A1 (en) 2017-11-01 2019-05-09 Drexel University Compounds, compositions, and methods for treating diseases
GB201918108D0 (en) * 2019-12-10 2020-01-22 Vib Vzw Improved aminopeptiadases for single molecule peptide sequencing
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WO2025224179A1 (en) 2024-04-23 2025-10-30 Vivoryon Therapeutics N.V. Glutaminyl cyclase inhbitors for use in the treatment of kidney disease

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EP2082041A2 (en) 2009-07-29
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US8647834B2 (en) 2014-02-11
US20100009337A1 (en) 2010-01-14
EA016584B1 (ru) 2012-06-29
KR101432848B1 (ko) 2014-08-27
JP2010504088A (ja) 2010-02-12
CA2663635A1 (en) 2008-03-27
EP2581449B1 (en) 2016-09-14
NZ590631A (en) 2011-12-22
HK1136603A1 (zh) 2010-07-02
US20120183974A1 (en) 2012-07-19
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IL214820A0 (en) 2011-09-27
IL214820A (en) 2016-06-30
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US20080249083A1 (en) 2008-10-09
MX2009003090A (es) 2009-04-02
EP2581449A3 (en) 2013-07-31
IL197090A (en) 2016-03-31
WO2008034891A3 (en) 2008-05-08
AU2007298929A1 (en) 2008-03-27
US8129160B2 (en) 2012-03-06
AU2007298929B2 (en) 2012-09-27

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