JP2010500905A - 組織再生に有用な医療インプラントシート - Google Patents
組織再生に有用な医療インプラントシート Download PDFInfo
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- JP2010500905A JP2010500905A JP2009524735A JP2009524735A JP2010500905A JP 2010500905 A JP2010500905 A JP 2010500905A JP 2009524735 A JP2009524735 A JP 2009524735A JP 2009524735 A JP2009524735 A JP 2009524735A JP 2010500905 A JP2010500905 A JP 2010500905A
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- Prior art keywords
- medical implant
- implant device
- granules
- bone
- implant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
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- A61C8/0004—Consolidating natural teeth
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0019—Angular shapes rectangular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0091—Three-dimensional shapes helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
- A61F2310/00982—Coating made of collagen
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Abstract
【解決手段】上記装置は第一の面と第二の面とを含み、少なくとも第一の面には、下方に位置する顆粒により提供されるカルシウム含有の骨伝導性材料の露出した領域を提供する突出物が多数分布している。かかる装置を形成し且つ使用する方法も記載されており、荷重支承の整形外科用インプラントの骨の内部成長面に適合させた極めて薄い重合系シートを使用する工程を含む方法及び装置として説明されている。
【選択図】図1
Description
Claims (20)
- 組織再生に有用な医療インプラント装置において、
カルシウム含有の骨伝導性材料の顆粒であって、0.05mmより大きく約5mm未満の平均最大粒子直径を有する顆粒と、
前記顆粒同士を相互に接続する生分解性の重合系材料の薄い織布であって、第一の面と第二の面とを有する一体的な可撓性膜として前記顆粒及び当該生分解性の重合系材料を提供し、当該膜は2mm以下の平均厚さを有する、織布と
を備え、
前記可撓性膜の前記第一の面は不均一な突出面を有し、
前記不均一な突出面には、前記顆粒の下方に位置する顆粒により提供されるカルシウム含有の骨伝導性材料の露出した領域を提供する突出物が多数分布し、
カルシウム含有の骨伝導性材料の前記露出した領域は、前記織布の前記生分解性の重合系材料の領域により分離される、医療インプラント装置。 - 請求項1に記載の医療インプラント装置において、
前記顆粒の少なくとも10%は、前記膜の前記平均厚さの少なくとも70%の最大粒子直径を有する、医療インプラント装置。 - 請求項2に記載の医療インプラント装置において、
前記顆粒の少なくとも幾つかは、前記膜の前記平均厚さと等しく又はより大きい最大粒子直径を有する、医療インプラント装置。 - 請求項3に記載の医療インプラント装置において、
前記顆粒の少なくとも80%は、前記織布の前記厚さよりも大きい最大直径を有する、医療インプラント装置。 - 請求項1に記載の医療インプラント装置において、
前記膜の前記第二の面は実質的に平滑である、医療インプラント装置。 - 請求項1に記載の医療インプラント装置において、
前記膜の前記第二の面はまた、不均一な突出面を有し、
前記第二の面の前記不均一な突出面には、前記顆粒の下方に位置する顆粒により提供されるカルシウム含有の骨伝導性材料の露出した領域を提供する突出物が多数分布し、
カルシウム含有の骨伝導性材料の前記露出した領域は、前記織布の前記生分解性の重合系材料の領域により分離される、医療インプラント装置。 - カルシウム含有の骨伝導性材料の顆粒と、
前記顆粒同士を相互に接続する生分解性材料の薄い織布と
を備える医療インプラント装置において、
前記医療インプラント装置は、前記顆粒の表面輪郭により画成された突出物が多数分布する面を有する第一の面を含み、
前記医療インプラント装置は2mm未満の平均厚さを有する、医療インプラント装置。 - 請求項7に記載の医療インプラント装置において、
前記突出物は、前記カルシウム含有の骨伝導性材料の露出した領域を提供する、医療インプラント装置。 - 請求項8に記載の医療インプラント装置において、
前記第一の面に対向する第二の面を更に備え、
該第二の面は、全体的に平滑である、医療インプラント装置。 - 請求項8に記載の医療インプラント装置において、
前記第一の面に対向する第二の面を更に備え、
該第二の面には、更に、突出物が多数分布する、医療インプラント装置。 - 請求項10に記載の医療インプラント装置において、
前記第二の面の前記突出物は、前記カルシウム含有の骨伝導性材料の露出した領域を提供する、医療インプラント装置。 - 請求項8に記載の医療インプラント装置において、
前記生分解性ポリマーは天然ポリマーである、医療インプラント装置。 - 請求項12に記載の医療インプラント装置において、
前記天然ポリマーはコラーゲンである、医療インプラント装置。 - 請求項13に記載の医療インプラント装置において、
前記顆粒は、約0.1mmから約2mmの範囲にある平均最大粒子直径を有する、医療インプラント装置。 - 請求項14に記載の医療インプラント装置において、
前記顆粒は合成の生体機能性セラミックである、医療インプラント装置。 - 請求項7に記載の医療インプラント装置において、
前記織布内に少なくとも部分的に埋め込んだ補強メッシュを更に備える、医療インプラント装置。 - 患者を治療する方法において、請求項1に記載の医療インプラント装置を患者に植え込む工程を備える、患者を治療する方法。
- 骨の内部成長及び装着が可能な形態とされた外面を有し、荷重を支承する整形外科用インプラントと、
前記外面に対して適合させた2mm以下の厚さを有する順応性の重合系シートと
を備える、医療インプラント。 - 請求項18に記載の医療インプラントにおいて、
前記順応性の重合系シートは骨形成タンパク質を有する、医療インプラント。 - カルシウム含有の骨伝導性材料の顆粒と、
補強メッシュと、
前記顆粒同士を相互に接続し、且つ、前記補強メッシュを少なくとも部分的に埋め込む生分解性材料の薄い織布と
を備える医療インプラント装置において、
前記医療インプラント装置は、前記顆粒の表面輪郭により画成された突出物が多数分布する面を有する第一の面を備える、医療インプラント装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US11/506,078 US8524265B2 (en) | 2006-08-17 | 2006-08-17 | Medical implant sheets useful for tissue regeneration |
PCT/US2007/075538 WO2008021921A2 (en) | 2006-08-17 | 2007-08-09 | Medical implant sheets useful for tissue regeneration |
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Publication Number | Publication Date |
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JP2010500905A true JP2010500905A (ja) | 2010-01-14 |
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JP2009524735A Pending JP2010500905A (ja) | 2006-08-17 | 2007-08-09 | 組織再生に有用な医療インプラントシート |
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US (1) | US8524265B2 (ja) |
EP (2) | EP2428233B1 (ja) |
JP (1) | JP2010500905A (ja) |
WO (1) | WO2008021921A2 (ja) |
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EP2068951A2 (en) | 2009-06-17 |
US20080044449A1 (en) | 2008-02-21 |
US8524265B2 (en) | 2013-09-03 |
WO2008021921B1 (en) | 2008-07-17 |
EP2428233B1 (en) | 2015-10-07 |
WO2008021921A3 (en) | 2008-05-22 |
EP2428233A1 (en) | 2012-03-14 |
WO2008021921A2 (en) | 2008-02-21 |
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