JP2010500331A5 - - Google Patents

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Publication number
JP2010500331A5
JP2010500331A5 JP2009523312A JP2009523312A JP2010500331A5 JP 2010500331 A5 JP2010500331 A5 JP 2010500331A5 JP 2009523312 A JP2009523312 A JP 2009523312A JP 2009523312 A JP2009523312 A JP 2009523312A JP 2010500331 A5 JP2010500331 A5 JP 2010500331A5
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JP
Japan
Prior art keywords
octapeptins
residues
polymyxins
acid
natural
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009523312A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010500331A (ja
JP5226685B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/FI2007/050441 external-priority patent/WO2008017734A1/en
Publication of JP2010500331A publication Critical patent/JP2010500331A/ja
Publication of JP2010500331A5 publication Critical patent/JP2010500331A5/ja
Application granted granted Critical
Publication of JP5226685B2 publication Critical patent/JP5226685B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009523312A 2006-08-11 2007-08-10 ポリミキシン誘導体およびその使用 Expired - Fee Related JP5226685B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83742606P 2006-08-11 2006-08-11
DKPA200601055 2006-08-11
DKPA200601055 2006-08-11
US60/837,426 2006-08-11
PCT/FI2007/050441 WO2008017734A1 (en) 2006-08-11 2007-08-10 Polymyxin derivatives and uses thereof

Publications (3)

Publication Number Publication Date
JP2010500331A JP2010500331A (ja) 2010-01-07
JP2010500331A5 true JP2010500331A5 (https=) 2010-08-12
JP5226685B2 JP5226685B2 (ja) 2013-07-03

Family

ID=39032653

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009523312A Expired - Fee Related JP5226685B2 (ja) 2006-08-11 2007-08-10 ポリミキシン誘導体およびその使用

Country Status (21)

Country Link
EP (2) EP3078672A1 (https=)
JP (1) JP5226685B2 (https=)
KR (2) KR20150008198A (https=)
CN (2) CN103059106B (https=)
AU (1) AU2007283514B2 (https=)
BR (1) BRPI0715095B8 (https=)
CA (1) CA2694289C (https=)
CY (1) CY1117848T1 (https=)
DK (1) DK2057185T3 (https=)
ES (1) ES2575521T3 (https=)
HR (1) HRP20160552T1 (https=)
HU (1) HUE028271T2 (https=)
IL (2) IL196693B (https=)
MX (1) MX2009001398A (https=)
NO (1) NO341982B1 (https=)
NZ (1) NZ575421A (https=)
PL (1) PL2057185T3 (https=)
PT (1) PT2057185E (https=)
RU (1) RU2455311C2 (https=)
SI (1) SI2057185T1 (https=)
WO (1) WO2008017734A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
FI20085469A0 (fi) * 2008-02-08 2008-05-16 Northern Antibiotics Oy Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä
CA2747995A1 (en) 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
CA2855916A1 (en) * 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
KR102354902B1 (ko) * 2013-05-22 2022-01-24 에버레스트 메디신즈 (싱가포르) 피티이. 리미티드 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
MX359104B (es) * 2014-03-11 2018-09-14 New Pharma Licence Holdings Ltd Derivados de polimixina y su uso en terapia de combinacion junto con diferentes antibioticos.
KR101664106B1 (ko) 2014-09-11 2016-10-10 한국화학연구원 폴리믹신 b 화합물을 포함하는 심혈관 질환의 예방 및 치료용 약학적 조성물
US12146004B2 (en) 2014-11-26 2024-11-19 Spero Therapeutics, Inc. Polymyxin compounds and uses thereof
WO2016100578A2 (en) 2014-12-16 2016-06-23 Micurx Pharmaceuticals, Inc. Antimicrobial polymyxins for treatment of bacterial infections
HUE052575T2 (hu) * 2014-12-18 2021-05-28 Helperby Therapeutics Ltd Új kombináció és alkalmazás
FI126143B (en) * 2015-01-15 2016-07-15 Northern Antibiotics Oy Polymyxine derivative and its uses
US9763996B2 (en) 2015-01-16 2017-09-19 Northern Antibiotics, Ltd. Polymyxin derivative and uses thereof
CN104672307B (zh) * 2015-03-23 2017-09-29 吉林大学 一种提高阳离子短肽抗菌性和稳定性的方法
EP3072956A1 (en) * 2015-03-25 2016-09-28 Université de Fribourg Selective culture medium for polymyxin-resistant, gram-negative bacteria
FR3036406B1 (fr) 2015-05-20 2019-07-19 Biomerieux Identification des bacteries resistantes aux carbapenemes par impermeabilite membranaire
JP2018534303A (ja) * 2015-11-12 2018-11-22 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク ポリミキシン系抗生物質に対する耐性グラム陰性細菌感染を標的にする合理的薬物設計
WO2017189868A1 (en) * 2016-04-27 2017-11-02 Spero Opco Serine replacement polymyxin analogues useful as antibiotic potentiators
WO2017189866A1 (en) * 2016-04-27 2017-11-02 Spero Opco Polymyxin analogs useful as antibiotic potentiators
GB201703898D0 (en) 2017-03-10 2017-04-26 Helperby Therapeautics Ltd Method
GB201704620D0 (en) 2017-03-23 2017-05-10 Helperby Therapeautics Ltd Combinations
CN111527100A (zh) * 2017-11-02 2020-08-11 昆士兰大学 肽类抗生素
EP3560489A1 (en) * 2018-04-27 2019-10-30 European Molecular Biology Laboratory Pharmaceutical compositions for prevention and/or treatment of infections and antibacterial-induced dysfunctions
RS65128B1 (sr) 2018-06-25 2024-02-29 Spero Therapeutics Inc Jedinjenja
JP7469812B2 (ja) * 2018-07-19 2024-04-17 ノースイースタン ユニバーシティ 抗微生物特性を有する化合物
CN110179967A (zh) * 2019-05-28 2019-08-30 中国医药集团总公司四川抗菌素工业研究所 多粘菌素母核和一种抗生素的组合物及其应用
IT201900025414A1 (it) * 2019-12-23 2021-06-23 Univ Bologna Alma Mater Studiorum Composto per il trattamento della sindrome emolitico uremica
WO2021150792A1 (en) 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
CN118028501B (zh) * 2022-08-30 2024-08-02 四川大学华西医院 一类phoQ基因突变体、应用及其验证方法
WO2024123712A1 (en) * 2022-12-04 2024-06-13 Genentech, Inc. Analysis of candidate cytotoxic compositions
CN120399010B (zh) * 2025-07-01 2025-09-12 杭州肽佳生物科技有限公司 抗生素多粘菌素的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450687A (en) 1966-02-24 1969-06-17 Pfizer & Co C Lower alkanoyl esters of polymyxin antibiotics
JPS4915537B1 (https=) 1970-03-25 1974-04-16
BE754411A (fr) 1969-08-05 1971-02-04 Rhone Poulenc Sa Cyclopeptides derives des polymyxines et leur
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
EP1336611B1 (en) * 2000-11-20 2007-09-05 Daiichi Pharmaceutical Co., Ltd. Dehalogeno compounds
IL156942A0 (en) 2001-01-16 2004-02-08 Univ Ramot Compounds, pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia
ATE349223T1 (de) * 2002-03-01 2007-01-15 Chiesi Farma Spa Pharmazeutische zubereitungen mit verbesserten oberflächeneigenschaften welche ein lungen surfactant und ein polymyxin enthalten
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion

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