JP2010132925A5 - - Google Patents
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- Publication number
- JP2010132925A5 JP2010132925A5 JP2010044780A JP2010044780A JP2010132925A5 JP 2010132925 A5 JP2010132925 A5 JP 2010132925A5 JP 2010044780 A JP2010044780 A JP 2010044780A JP 2010044780 A JP2010044780 A JP 2010044780A JP 2010132925 A5 JP2010132925 A5 JP 2010132925A5
- Authority
- JP
- Japan
- Prior art keywords
- capsular saccharide
- modified
- saccharide
- group
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001720 carbohydrates Chemical class 0.000 claims 39
- 238000000034 method Methods 0.000 claims 17
- 125000006239 protecting group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 150000004676 glycans Chemical class 0.000 claims 9
- 229920001282 polysaccharide Polymers 0.000 claims 9
- 239000005017 polysaccharide Substances 0.000 claims 9
- 241000588650 Neisseria meningitidis Species 0.000 claims 7
- 150000002772 monosaccharides Chemical group 0.000 claims 7
- 229920001542 oligosaccharide Polymers 0.000 claims 7
- 150000002482 oligosaccharides Chemical class 0.000 claims 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 5
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 4
- 102000014914 Carrier Proteins Human genes 0.000 claims 4
- 108010078791 Carrier Proteins Proteins 0.000 claims 4
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 claims 4
- 238000004513 sizing Methods 0.000 claims 4
- PFKFTWBEEFSNDU-UHFFFAOYSA-N 1,1'-Carbonyldiimidazole Substances C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims 3
- 231100000699 Bacterial toxin Toxicity 0.000 claims 3
- 239000000010 aprotic solvent Substances 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 239000000688 bacterial toxin Substances 0.000 claims 3
- 230000001588 bifunctional effect Effects 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 2
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- GUVUOGQBMYCBQP-UHFFFAOYSA-N dmpu Chemical compound CN1CCCN(C)C1=O GUVUOGQBMYCBQP-UHFFFAOYSA-N 0.000 claims 2
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010027202 Meningitis bacterial Diseases 0.000 claims 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- -1 amino compound Chemical class 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000009904 bacterial meningitis Diseases 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 125000006267 biphenyl group Chemical group 0.000 claims 1
- VRAVWQUXPCWGSU-UHFFFAOYSA-N bis(1h-1,2,4-triazol-5-yl)methanone Chemical compound N1=CNN=C1C(=O)C=1N=CNN=1 VRAVWQUXPCWGSU-UHFFFAOYSA-N 0.000 claims 1
- XYCAAOUPBWVNPF-UHFFFAOYSA-N bis(2h-benzotriazol-4-yl)methanone Chemical compound C=1C=CC=2NN=NC=2C=1C(=O)C1=CC=CC2=C1N=NN2 XYCAAOUPBWVNPF-UHFFFAOYSA-N 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
- 0 CC1(*)[C@@](*)(OC)OC(*)(*)C(*)(*)C1(N)I Chemical compound CC1(*)[C@@](*)(OC)OC(*)(*)C(*)(*)C1(N)I 0.000 description 2
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0207117A GB0207117D0 (en) | 2002-03-26 | 2002-03-26 | Modified saccharides having improved stability in water |
| GB0207117.3 | 2002-03-26 | ||
| GB0220195A GB0220195D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides having improved stability in water |
| GB0220195.2 | 2002-08-30 | ||
| GB0229494A GB0229494D0 (en) | 2002-12-18 | 2002-12-18 | Modified saccharides having improved stability in water |
| GB0229494.0 | 2002-12-18 | ||
| GB0230163A GB0230163D0 (en) | 2002-12-24 | 2002-12-24 | Modified saccharides having improved stability in water |
| GB0230163.8 | 2002-12-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578430A Division JP2005526153A (ja) | 2002-03-26 | 2003-03-26 | 水中において改善された安定性を持つ修飾糖 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010132925A JP2010132925A (ja) | 2010-06-17 |
| JP2010132925A5 true JP2010132925A5 (enExample) | 2011-04-21 |
| JP5361767B2 JP5361767B2 (ja) | 2013-12-04 |
Family
ID=28457825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578430A Ceased JP2005526153A (ja) | 2002-03-26 | 2003-03-26 | 水中において改善された安定性を持つ修飾糖 |
| JP2010044780A Expired - Fee Related JP5361767B2 (ja) | 2002-03-26 | 2010-03-01 | 水中において改善された安定性を持つ修飾糖 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578430A Ceased JP2005526153A (ja) | 2002-03-26 | 2003-03-26 | 水中において改善された安定性を持つ修飾糖 |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP1490409B1 (enExample) |
| JP (2) | JP2005526153A (enExample) |
| AT (1) | ATE419278T1 (enExample) |
| BR (1) | BR0308768A (enExample) |
| CA (1) | CA2480389C (enExample) |
| CY (2) | CY1108911T1 (enExample) |
| DE (1) | DE60325565D1 (enExample) |
| DK (2) | DK1490409T3 (enExample) |
| ES (2) | ES2616180T3 (enExample) |
| HU (1) | HUE030532T2 (enExample) |
| MX (1) | MXPA04009339A (enExample) |
| NZ (1) | NZ535968A (enExample) |
| PT (2) | PT1490409E (enExample) |
| WO (1) | WO2003080678A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| DE60328481D1 (de) | 2002-05-14 | 2009-09-03 | Novartis Vaccines & Diagnostic | Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| EP2351579B1 (en) | 2002-10-11 | 2016-09-21 | Novartis Vaccines and Diagnostics S.r.l. | Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| DK1587537T3 (da) | 2003-01-30 | 2012-07-16 | Novartis Ag | Injicerbare vacciner mod multiple meningococ-serogrupper |
| ES2397923T3 (es) | 2003-10-02 | 2013-03-12 | Novartis Ag | Vacunas líquidas para múltiples serogrupos meningocócicos |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| RU2379052C2 (ru) | 2004-04-30 | 2010-01-20 | Чирон С.Р.Л. | Вакцинация менингококковыми конъюгатами |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| WO2005114171A2 (en) * | 2004-05-20 | 2005-12-01 | Chiron Srl | Analysis of liquid chromatography eluates |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| CA2577920A1 (en) * | 2004-08-30 | 2006-03-09 | Sanofi Pasteur, Inc. | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
| AU2005286798A1 (en) * | 2004-09-21 | 2006-03-30 | Sanofi Pasteur, Inc. | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
| PL1885734T3 (pl) * | 2005-05-06 | 2015-08-31 | Novartis Ag | Immunogeny dla szczepionek przeciwko Meningitidis-A |
| GB0513071D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| HUE045482T2 (hu) * | 2005-06-27 | 2019-12-30 | Glaxosmithkline Biologicals Sa | Immunogén készítmény |
| WO2007023386A2 (en) * | 2005-08-24 | 2007-03-01 | Novartis Vaccines And Diagnostics Srl | Zwitterionization of capsular saccharides |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| NZ572054A (en) | 2006-03-22 | 2011-12-22 | Novartis Ag | Regimens for immunisation with meningococcal conjugates |
| GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| GB0612854D0 (en) | 2006-06-28 | 2006-08-09 | Novartis Ag | Saccharide analysis |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| IN2009KN04098A (enExample) | 2007-06-04 | 2015-08-28 | Novartis Ag | |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| HRP20120433T1 (en) | 2007-10-19 | 2012-07-31 | Novartis@Ag | Meningococcal vaccine formulations |
| AU2009215364B2 (en) | 2008-02-21 | 2014-09-18 | Glaxosmithkline Biologicals S.A. | Meningococcal fHBP polypeptides |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| AU2009329193A1 (en) | 2008-12-17 | 2011-07-14 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
| EP3017826A1 (en) | 2009-03-24 | 2016-05-11 | Novartis AG | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
| CN104548082A (zh) | 2009-03-24 | 2015-04-29 | 诺华股份有限公司 | 为脑膜炎球菌因子h结合蛋白添加佐剂 |
| AU2010264538B2 (en) | 2009-06-22 | 2013-10-03 | Wyeth Llc | Immunogenic compositions of Staphylococcus aureus antigens |
| WO2011041003A2 (en) * | 2009-06-22 | 2011-04-07 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| WO2011024072A2 (en) | 2009-08-27 | 2011-03-03 | Novartis Ag | Hybrid polypeptides including meningococcal fhbp sequences |
| CN102724988B (zh) | 2009-09-30 | 2014-09-10 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽的表达 |
| CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| WO2011161653A1 (en) | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
| CA2808975C (en) | 2010-08-23 | 2018-10-30 | Wyeth Llc | Stable formulations of neisseria meningitidis rlp2086 antigens |
| EP2612148B1 (en) | 2010-09-04 | 2019-06-12 | GlaxoSmithKline Biologicals SA | Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines |
| KR101584871B1 (ko) | 2010-09-10 | 2016-01-22 | 와이어쓰 엘엘씨 | 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체 |
| CN103533954B (zh) | 2011-03-02 | 2015-09-09 | 诺华股份有限公司 | 含较低剂量的抗原和/或佐剂的联合疫苗 |
| CN103764171B (zh) | 2011-07-08 | 2016-08-17 | 诺华股份有限公司 | 酪氨酸连接方法 |
| RU2636350C2 (ru) | 2011-11-07 | 2017-11-22 | Новартис Аг | МОЛЕКУЛА, СОДЕРЖАЩАЯ SPR0096 и SPR2021 |
| EP2797624A1 (en) | 2011-12-29 | 2014-11-05 | Novartis AG | Adjuvanted combinations of meningococcal factor h binding proteins |
| EP2822584A1 (en) | 2012-03-08 | 2015-01-14 | Novartis AG | Combination vaccines with tlr4 agonists |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| CA2865745C (en) | 2012-03-09 | 2018-01-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| BR112015005056A2 (pt) | 2012-09-06 | 2017-11-21 | Novartis Ag | vacinas de combinação com sorogrupo b meningococcus e d/t/p |
| JP2016502994A (ja) | 2012-12-18 | 2016-02-01 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ジフテリア及び／又は破傷風から防御するためのコンジュゲート |
| GB201300707D0 (en) | 2013-01-15 | 2013-02-27 | Novartis Ag | Compounds and processes |
| CA2903716C (en) | 2013-03-08 | 2019-04-09 | Pfizer Inc. | Immunogenic fusion polypeptides |
| KR20160040556A (ko) | 2013-07-11 | 2016-04-14 | 노파르티스 아게 | 미생물 트랜스글루타미나제를 사용한 리신-특이적 화학효소적 단백질 변형 |
| RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
| CN106661092B (zh) | 2014-02-28 | 2021-07-06 | 葛兰素史密丝克莱恩生物有限公司 | 修饰的脑膜炎球菌fHbp多肽 |
| US10407703B2 (en) * | 2014-04-17 | 2019-09-10 | Medizinische Hochschule Hannover | Means and methods for producing Neisseria meningitidis capsular polysaccharides of low dispersity |
| KR20190049940A (ko) | 2015-02-19 | 2019-05-09 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
| JP7104027B2 (ja) | 2016-09-02 | 2022-07-20 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 淋菌に対するワクチン |
| CN109890413B (zh) | 2016-09-02 | 2024-04-16 | 赛诺菲巴斯德股份有限公司 | 脑膜炎奈瑟氏菌疫苗 |
| SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| CA3155669A1 (en) | 2019-09-27 | 2021-04-01 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| GB202208089D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| GB202208093D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB733459A (en) * | 1952-05-21 | 1955-07-13 | Wander A G A | Process for preparing stimulating agents for clinical use from bacterial polysaccharides |
| DE2748132A1 (de) * | 1977-10-27 | 1979-05-03 | Behringwerke Ag | Stabilisator fuer polysaccharid |
| US4882317A (en) * | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| RO111416B1 (ro) * | 1989-12-14 | 1996-10-31 | Ca Nat Research Council | Polizaharide modificate de neisseria meningitidis si e coli, combinatii antigenice si metoda de imunizare |
| FR2682388B1 (fr) * | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
| DE69708318T3 (de) * | 1996-08-27 | 2006-11-16 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung |
| JP2001519817A (ja) * | 1997-03-26 | 2001-10-23 | ブリガム アンド ウイメンズ ホスピタル | 糖断片生成法 |
| JP4435413B2 (ja) * | 1997-12-23 | 2010-03-17 | バクスター・ヘルスケヤー・ソシエテ・アノニム | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
-
2003
- 2003-03-26 ES ES06076853.8T patent/ES2616180T3/es not_active Expired - Lifetime
- 2003-03-26 BR BR0308768-9A patent/BR0308768A/pt not_active IP Right Cessation
- 2003-03-26 CA CA2480389A patent/CA2480389C/en not_active Expired - Fee Related
- 2003-03-26 MX MXPA04009339A patent/MXPA04009339A/es active IP Right Grant
- 2003-03-26 EP EP03712543A patent/EP1490409B1/en not_active Expired - Lifetime
- 2003-03-26 DK DK03712543T patent/DK1490409T3/da active
- 2003-03-26 EP EP06076853.8A patent/EP1777236B8/en not_active Expired - Lifetime
- 2003-03-26 PT PT03712543T patent/PT1490409E/pt unknown
- 2003-03-26 AT AT03712543T patent/ATE419278T1/de active
- 2003-03-26 PT PT60768538T patent/PT1777236T/pt unknown
- 2003-03-26 DK DK06076853.8T patent/DK1777236T3/en active
- 2003-03-26 WO PCT/IB2003/001436 patent/WO2003080678A1/en not_active Ceased
- 2003-03-26 NZ NZ535968A patent/NZ535968A/en not_active IP Right Cessation
- 2003-03-26 ES ES03712543T patent/ES2318117T3/es not_active Expired - Lifetime
- 2003-03-26 HU HUE06076853A patent/HUE030532T2/en unknown
- 2003-03-26 JP JP2003578430A patent/JP2005526153A/ja not_active Ceased
- 2003-03-26 DE DE60325565T patent/DE60325565D1/de not_active Expired - Lifetime
-
2009
- 2009-03-23 CY CY20091100322T patent/CY1108911T1/el unknown
-
2010
- 2010-03-01 JP JP2010044780A patent/JP5361767B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-25 CY CY20171100115T patent/CY1118584T1/el unknown
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