JP2010132925A5 - - Google Patents
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- Publication number
- JP2010132925A5 JP2010132925A5 JP2010044780A JP2010044780A JP2010132925A5 JP 2010132925 A5 JP2010132925 A5 JP 2010132925A5 JP 2010044780 A JP2010044780 A JP 2010044780A JP 2010044780 A JP2010044780 A JP 2010044780A JP 2010132925 A5 JP2010132925 A5 JP 2010132925A5
- Authority
- JP
- Japan
- Prior art keywords
- capsular saccharide
- modified
- saccharide
- group
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001720 carbohydrates Chemical class 0.000 claims 39
- 238000000034 method Methods 0.000 claims 17
- 125000006239 protecting group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 150000004676 glycans Chemical class 0.000 claims 9
- 229920001282 polysaccharide Polymers 0.000 claims 9
- 239000005017 polysaccharide Substances 0.000 claims 9
- 241000588650 Neisseria meningitidis Species 0.000 claims 7
- 150000002772 monosaccharides Chemical group 0.000 claims 7
- 229920001542 oligosaccharide Polymers 0.000 claims 7
- 150000002482 oligosaccharides Chemical class 0.000 claims 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 5
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 4
- 102000014914 Carrier Proteins Human genes 0.000 claims 4
- 108010078791 Carrier Proteins Proteins 0.000 claims 4
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 claims 4
- 238000004513 sizing Methods 0.000 claims 4
- PFKFTWBEEFSNDU-UHFFFAOYSA-N 1,1'-Carbonyldiimidazole Substances C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims 3
- 231100000699 Bacterial toxin Toxicity 0.000 claims 3
- 239000000010 aprotic solvent Substances 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 239000000688 bacterial toxin Substances 0.000 claims 3
- 230000001588 bifunctional effect Effects 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 2
- 241000921898 Neisseria meningitidis serogroup A Species 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- GUVUOGQBMYCBQP-UHFFFAOYSA-N dmpu Chemical compound CN1CCCN(C)C1=O GUVUOGQBMYCBQP-UHFFFAOYSA-N 0.000 claims 2
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010027202 Meningitis bacterial Diseases 0.000 claims 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- -1 amino compound Chemical class 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000009904 bacterial meningitis Diseases 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 125000006267 biphenyl group Chemical group 0.000 claims 1
- VRAVWQUXPCWGSU-UHFFFAOYSA-N bis(1h-1,2,4-triazol-5-yl)methanone Chemical compound N1=CNN=C1C(=O)C=1N=CNN=1 VRAVWQUXPCWGSU-UHFFFAOYSA-N 0.000 claims 1
- XYCAAOUPBWVNPF-UHFFFAOYSA-N bis(2h-benzotriazol-4-yl)methanone Chemical compound C=1C=CC=2NN=NC=2C=1C(=O)C1=CC=CC2=C1N=NN2 XYCAAOUPBWVNPF-UHFFFAOYSA-N 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
- 0 CC1(*)[C@@](*)(OC)OC(*)(*)C(*)(*)C1(N)I Chemical compound CC1(*)[C@@](*)(OC)OC(*)(*)C(*)(*)C1(N)I 0.000 description 2
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0207117A GB0207117D0 (en) | 2002-03-26 | 2002-03-26 | Modified saccharides having improved stability in water |
| GB0207117.3 | 2002-03-26 | ||
| GB0220195A GB0220195D0 (en) | 2002-08-30 | 2002-08-30 | Modified saccharides having improved stability in water |
| GB0220195.2 | 2002-08-30 | ||
| GB0229494A GB0229494D0 (en) | 2002-12-18 | 2002-12-18 | Modified saccharides having improved stability in water |
| GB0229494.0 | 2002-12-18 | ||
| GB0230163A GB0230163D0 (en) | 2002-12-24 | 2002-12-24 | Modified saccharides having improved stability in water |
| GB0230163.8 | 2002-12-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578430A Division JP2005526153A (ja) | 2002-03-26 | 2003-03-26 | 水中において改善された安定性を持つ修飾糖 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010132925A JP2010132925A (ja) | 2010-06-17 |
| JP2010132925A5 true JP2010132925A5 (enExample) | 2011-04-21 |
| JP5361767B2 JP5361767B2 (ja) | 2013-12-04 |
Family
ID=28457825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578430A Ceased JP2005526153A (ja) | 2002-03-26 | 2003-03-26 | 水中において改善された安定性を持つ修飾糖 |
| JP2010044780A Expired - Fee Related JP5361767B2 (ja) | 2002-03-26 | 2010-03-01 | 水中において改善された安定性を持つ修飾糖 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578430A Ceased JP2005526153A (ja) | 2002-03-26 | 2003-03-26 | 水中において改善された安定性を持つ修飾糖 |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP1777236B8 (enExample) |
| JP (2) | JP2005526153A (enExample) |
| AT (1) | ATE419278T1 (enExample) |
| BR (1) | BR0308768A (enExample) |
| CA (1) | CA2480389C (enExample) |
| CY (2) | CY1108911T1 (enExample) |
| DE (1) | DE60325565D1 (enExample) |
| DK (2) | DK1490409T3 (enExample) |
| ES (2) | ES2318117T3 (enExample) |
| HU (1) | HUE030532T2 (enExample) |
| MX (1) | MXPA04009339A (enExample) |
| NZ (1) | NZ535968A (enExample) |
| PT (2) | PT1490409E (enExample) |
| WO (1) | WO2003080678A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| DE60328481D1 (de) | 2002-05-14 | 2009-09-03 | Novartis Vaccines & Diagnostic | Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| HUE031886T2 (en) | 2002-10-11 | 2017-08-28 | Glaxosmithkline Biologicals Sa | Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| PT2191844E (pt) | 2003-01-30 | 2014-06-04 | Novartis Ag | Vacinas injetáveis contra múltiplos serogrupos meningocócicos |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| RU2378010C2 (ru) | 2003-10-02 | 2010-01-10 | Новартис Вэксинес Энд Дайэгностикс С.Р.Л. | Жидкие вакцины для множественных серогрупп менингококков |
| GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| DK1740217T3 (da) | 2004-04-30 | 2011-09-26 | Novartis Ag | Meningokok-konjugat-vaccination |
| EP1747457B1 (en) * | 2004-05-20 | 2011-11-30 | Novartis AG | Analysis of liquid chromatography eluates |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| KR20070101207A (ko) * | 2004-08-30 | 2007-10-16 | 사노피 파스퇴르 인크 | 다가 수막구균 유도체화된 다당류-단백질 접합체 및 백신 |
| KR20070095868A (ko) * | 2004-09-21 | 2007-10-01 | 사노피 파스퇴르 인크 | 다가 수막구균 유도체화된 다당류-단백질 접합체 및 백신 |
| EP1885734B1 (en) * | 2005-05-06 | 2015-01-14 | Novartis AG | Immunogens for meningitidis-a vaccines |
| GB0513071D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| WO2007000341A2 (en) * | 2005-06-27 | 2007-01-04 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| AU2006283302B2 (en) * | 2005-08-24 | 2012-11-15 | Novartis Vaccines And Diagnostics Srl | Zwitterionization of capsular saccharides |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| DK2004225T3 (da) | 2006-03-22 | 2012-08-06 | Novartis Ag | Programmer for vaccination med meningocockonjugater |
| GB0612854D0 (en) | 2006-06-28 | 2006-08-09 | Novartis Ag | Saccharide analysis |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| NZ581367A (en) | 2007-06-04 | 2012-05-25 | Novartis Ag | Formulation of meningitis vaccines containing haemophilus influenzae and neisseria meningitidis |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| SI2200642T1 (sl) | 2007-10-19 | 2012-06-29 | Novartis Ag | Formulacije meningokoknega cepiva |
| NZ587382A (en) | 2008-02-21 | 2012-01-12 | Novartis Ag | Meningococcal fhbp polypeptides |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| CN102300585A (zh) | 2008-12-17 | 2011-12-28 | 诺华有限公司 | 包含血红蛋白受体的脑膜炎球菌疫苗 |
| ES2797504T3 (es) | 2009-03-24 | 2020-12-02 | Glaxosmithkline Biologicals Sa | Proteína de enlace del factor H meningocócico utilizada como adyuvante |
| BRPI1009829A2 (pt) | 2009-03-24 | 2016-11-16 | Novartis Ag | combinações de proteína de ligação de fator h meningocócico e conjugados de sacarídeos pneumocócicos |
| SG177310A1 (en) | 2009-06-22 | 2012-02-28 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| PL2445522T3 (pl) | 2009-06-22 | 2018-01-31 | Wyeth Llc | Kompozycje immunogenne antygenów Staphylococcus aureus |
| AU2010288240B2 (en) | 2009-08-27 | 2014-03-27 | Novartis Ag | Hybrid polypeptides including meningococcal fHBP sequences |
| EP2483390A2 (en) | 2009-09-30 | 2012-08-08 | Novartis AG | Expression of meningococcal fhbp polypeptides |
| CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| WO2011161653A1 (en) | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
| SI2608805T2 (sl) | 2010-08-23 | 2025-09-30 | Wyeth Llc | Stabilne formulacije antigenov rLP2086 neisserie meningitidis |
| US9057716B2 (en) | 2010-09-04 | 2015-06-16 | Novartis Ag | Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines |
| BR112013005329A2 (pt) | 2010-09-10 | 2017-05-02 | Wyeth Llc | variantes não lipidadas de antígenos orf2086 de neisseria meningitidis |
| ES2681698T3 (es) | 2011-03-02 | 2018-09-14 | Glaxosmithkline Biologicals Sa | Vacunas de combinación con menores dosis de antígeno y/o adyuvante |
| JP6088507B2 (ja) | 2011-07-08 | 2017-03-01 | ノバルティス アーゲー | チロシンライゲーションの方法 |
| AU2012335208B2 (en) | 2011-11-07 | 2017-08-31 | Glaxosmithkline Biologicals S.A. | Carrier molecule comprising a spr0096 and a spr2021 antigen |
| CA2862247A1 (en) | 2011-12-29 | 2013-07-04 | Novartis Ag | Adjuvanted combinations of meningococcal factor h binding proteins |
| US20150125486A1 (en) | 2012-03-08 | 2015-05-07 | Novartis Ag | Adjuvanted formulations of pediatric antigens |
| MX2018011291A (es) | 2012-03-09 | 2023-01-31 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| US9526776B2 (en) | 2012-09-06 | 2016-12-27 | Glaxosmithkline Biologicals Sa | Combination vaccines with serogroup B meningococcus and D/T/P |
| WO2014095771A1 (en) | 2012-12-18 | 2014-06-26 | Novartis Ag | Conjugates for protecting against diphtheria and/or tetanus |
| GB201300707D0 (en) * | 2013-01-15 | 2013-02-27 | Novartis Ag | Compounds and processes |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| WO2015006728A2 (en) | 2013-07-11 | 2015-01-15 | Usera Aimee | Site-specific chemoenzymatic protein modifications |
| BR112016004463A2 (pt) | 2013-09-08 | 2017-10-17 | Pfizer | composições de neisseria meningitidis e métodos das mesmas |
| JP6786394B2 (ja) | 2014-02-28 | 2020-11-18 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 改変髄膜炎菌ｆＨｂｐポリペプチド |
| WO2015158898A2 (en) * | 2014-04-17 | 2015-10-22 | Medizinische Hochschule Hannover | Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity |
| WO2016132294A1 (en) | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| EP3506933A2 (en) | 2016-09-02 | 2019-07-10 | GlaxoSmithKline Biologicals SA | Vaccines for neisseria gonorrhoeae |
| AU2017321863B2 (en) | 2016-09-02 | 2024-07-11 | Sanofi Pasteur, Inc. | Neisseria meningitidis vaccine |
| AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| MX2022003682A (es) | 2019-09-27 | 2022-04-25 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| GB202208089D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| GB202208093D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB733459A (en) * | 1952-05-21 | 1955-07-13 | Wander A G A | Process for preparing stimulating agents for clinical use from bacterial polysaccharides |
| DE2748132A1 (de) * | 1977-10-27 | 1979-05-03 | Behringwerke Ag | Stabilisator fuer polysaccharid |
| US4882317A (en) * | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| ATE121947T1 (de) * | 1989-12-14 | 1995-05-15 | Ca Nat Research Council | Verbessertes meningokokkale polysaccharidkonjugatvakzin. |
| FR2682388B1 (fr) * | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
| JP4162267B2 (ja) * | 1996-08-27 | 2008-10-08 | カイロン コーポレイション | Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ複合糖質およびその使用法 |
| CA2284606A1 (en) * | 1997-03-26 | 1998-10-01 | Brigham And Women's Hospital, Inc. | Method for generating saccharide fragments |
| ES2346022T3 (es) * | 1997-12-23 | 2010-10-07 | Baxter Healthcare S.A. | Procedimiento para la extraccion y el aislamiento de polisacaridos capsulares bacterianos para su uso como vacunas o ligandos a proteinas como vacunas de conjugados. |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
-
2003
- 2003-03-26 BR BR0308768-9A patent/BR0308768A/pt not_active IP Right Cessation
- 2003-03-26 EP EP06076853.8A patent/EP1777236B8/en not_active Expired - Lifetime
- 2003-03-26 DK DK03712543T patent/DK1490409T3/da active
- 2003-03-26 PT PT03712543T patent/PT1490409E/pt unknown
- 2003-03-26 ES ES03712543T patent/ES2318117T3/es not_active Expired - Lifetime
- 2003-03-26 DE DE60325565T patent/DE60325565D1/de not_active Expired - Lifetime
- 2003-03-26 WO PCT/IB2003/001436 patent/WO2003080678A1/en not_active Ceased
- 2003-03-26 AT AT03712543T patent/ATE419278T1/de active
- 2003-03-26 HU HUE06076853A patent/HUE030532T2/en unknown
- 2003-03-26 ES ES06076853.8T patent/ES2616180T3/es not_active Expired - Lifetime
- 2003-03-26 MX MXPA04009339A patent/MXPA04009339A/es active IP Right Grant
- 2003-03-26 NZ NZ535968A patent/NZ535968A/en not_active IP Right Cessation
- 2003-03-26 JP JP2003578430A patent/JP2005526153A/ja not_active Ceased
- 2003-03-26 PT PT60768538T patent/PT1777236T/pt unknown
- 2003-03-26 CA CA2480389A patent/CA2480389C/en not_active Expired - Fee Related
- 2003-03-26 DK DK06076853.8T patent/DK1777236T3/en active
- 2003-03-26 EP EP03712543A patent/EP1490409B1/en not_active Expired - Lifetime
-
2009
- 2009-03-23 CY CY20091100322T patent/CY1108911T1/el unknown
-
2010
- 2010-03-01 JP JP2010044780A patent/JP5361767B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-25 CY CY20171100115T patent/CY1118584T1/el unknown
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