JP2008540398A5 - - Google Patents
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- Publication number
- JP2008540398A5 JP2008540398A5 JP2008509538A JP2008509538A JP2008540398A5 JP 2008540398 A5 JP2008540398 A5 JP 2008540398A5 JP 2008509538 A JP2008509538 A JP 2008509538A JP 2008509538 A JP2008509538 A JP 2008509538A JP 2008540398 A5 JP2008540398 A5 JP 2008540398A5
- Authority
- JP
- Japan
- Prior art keywords
- oligosaccharide
- unit
- mannose
- formula
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920001542 oligosaccharide Polymers 0.000 claims 24
- 150000002482 oligosaccharides Chemical class 0.000 claims 24
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 17
- 238000000034 method Methods 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 150000001720 carbohydrates Chemical group 0.000 claims 8
- 125000006850 spacer group Chemical group 0.000 claims 8
- 150000002703 mannose derivatives Chemical class 0.000 claims 7
- 125000006239 protecting group Chemical group 0.000 claims 7
- 241000588724 Escherichia coli Species 0.000 claims 4
- 201000009906 Meningitis Diseases 0.000 claims 4
- 150000001768 cations Chemical class 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 238000006751 Mitsunobu reaction Methods 0.000 claims 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 3
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 239000011574 phosphorus Substances 0.000 claims 3
- 231100000699 Bacterial toxin Toxicity 0.000 claims 2
- 201000005702 Pertussis Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 239000000688 bacterial toxin Substances 0.000 claims 2
- 229960003983 diphtheria toxoid Drugs 0.000 claims 2
- 239000012039 electrophile Substances 0.000 claims 2
- 229960000814 tetanus toxoid Drugs 0.000 claims 2
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 2
- URARQBMUQIRZQO-CBPJZXOFSA-N (3S,4R,5S,6R)-3-azido-6-(hydroxymethyl)oxane-2,4,5-triol Chemical compound OC[C@H]1OC(O)[C@@H](N=[N+]=[N-])[C@@H](O)[C@@H]1O URARQBMUQIRZQO-CBPJZXOFSA-N 0.000 claims 1
- 125000006823 (C1-C6) acyl group Chemical group 0.000 claims 1
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- -1 heteroacyl Chemical group 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 230000009851 immunogenic response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 239000012038 nucleophile Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 125000002743 phosphorus functional group Chemical group 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 230000001012 protector Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 229940124856 vaccine component Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67828905P | 2005-05-06 | 2005-05-06 | |
| PCT/IB2006/001703 WO2006120576A2 (en) | 2005-05-06 | 2006-05-08 | Immunogens for meningitidis-a vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013079295A Division JP5699174B2 (ja) | 2005-05-06 | 2013-04-05 | 髄膜炎ａ型ワクチンのための免疫原 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008540398A JP2008540398A (ja) | 2008-11-20 |
| JP2008540398A5 true JP2008540398A5 (enExample) | 2009-06-25 |
Family
ID=36942242
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008509538A Withdrawn JP2008540398A (ja) | 2005-05-06 | 2006-05-08 | 髄膜炎ａ型ワクチンのための免疫原 |
| JP2013079295A Expired - Fee Related JP5699174B2 (ja) | 2005-05-06 | 2013-04-05 | 髄膜炎ａ型ワクチンのための免疫原 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013079295A Expired - Fee Related JP5699174B2 (ja) | 2005-05-06 | 2013-04-05 | 髄膜炎ａ型ワクチンのための免疫原 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8062641B2 (enExample) |
| EP (1) | EP1885734B1 (enExample) |
| JP (2) | JP2008540398A (enExample) |
| CN (1) | CN101282984B (enExample) |
| AU (1) | AU2006245440B2 (enExample) |
| BR (1) | BRPI0611447A2 (enExample) |
| CA (1) | CA2606890C (enExample) |
| ES (1) | ES2533248T3 (enExample) |
| MX (1) | MX2007013881A (enExample) |
| NZ (1) | NZ563940A (enExample) |
| PL (1) | PL1885734T3 (enExample) |
| PT (1) | PT1885734E (enExample) |
| RU (1) | RU2412944C2 (enExample) |
| WO (1) | WO2006120576A2 (enExample) |
| ZA (1) | ZA200710558B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| WO2007000341A2 (en) | 2005-06-27 | 2007-01-04 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| ES2584927T7 (es) * | 2007-10-16 | 2020-11-05 | Progen Pg500 Series Pty Ltd | Derivados de oligosacáridos sulfatados novedosos |
| SI2608805T2 (sl) | 2010-08-23 | 2025-09-30 | Wyeth Llc | Stabilne formulacije antigenov rLP2086 neisserie meningitidis |
| US9057716B2 (en) | 2010-09-04 | 2015-06-16 | Novartis Ag | Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines |
| BR112013005329A2 (pt) | 2010-09-10 | 2017-05-02 | Wyeth Llc | variantes não lipidadas de antígenos orf2086 de neisseria meningitidis |
| CN102417521B (zh) * | 2010-09-28 | 2014-05-07 | 中国医学科学院医药生物技术研究所 | 一种非环核苷类抗病毒药物磷酸单酯化合物的制备方法 |
| WO2012103444A2 (en) * | 2011-01-28 | 2012-08-02 | Purdue Research Foundation | Immunogenic compositions and reagents for preparing |
| US9616139B2 (en) | 2011-07-12 | 2017-04-11 | The General Hospital Corporation | Conjugating amines |
| RU2476444C1 (ru) * | 2011-07-15 | 2013-02-27 | Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) | СПОСОБ ПОЛУЧЕНИЯ КОНЪЮГАТА НОНА-β-(1→3)-ГЛЮКОЗИДА С БЫЧЬИМ СЫВОРОТОЧНЫМ АЛЬБУМИНОМ СКВАРАТНЫМ МЕТОДОМ |
| MX2018011291A (es) | 2012-03-09 | 2023-01-31 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| EP2958905B1 (en) | 2013-02-22 | 2017-03-29 | Amgen Inc. | Carbohydrate phosphonate derivatives as modulators of glycosylation |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| RU2016103771A (ru) * | 2013-07-07 | 2017-08-11 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Синтетические вакцины против streptococcus pneumoniae 1-го типа |
| BR112016004463A2 (pt) | 2013-09-08 | 2017-10-17 | Pfizer | composições de neisseria meningitidis e métodos das mesmas |
| EP3110825B1 (en) * | 2014-02-25 | 2020-12-09 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Novel synthetic oligomers of neisseria meningitis serogroup x and process of preparing them |
| CU20170046A7 (es) * | 2014-10-09 | 2017-06-05 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | Proceso mejorado para la conjugación y conjugados sintéticos de oligosacarido-proteina novedosos obtenidos del mismo |
| WO2016132294A1 (en) | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| AU2017321863B2 (en) | 2016-09-02 | 2024-07-11 | Sanofi Pasteur, Inc. | Neisseria meningitidis vaccine |
| AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| WO2018173068A1 (en) * | 2017-03-21 | 2018-09-27 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | A novel synthetic neisseria meningitidis serogroup a oligomer and process for synthesizing thereof |
| WO2020104697A1 (en) | 2018-11-22 | 2020-05-28 | Vaxxilon Ag | Stable vaccine against clostridium difficile |
| MX2022003682A (es) | 2019-09-27 | 2022-04-25 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| CN118178643B (zh) * | 2024-04-28 | 2024-11-29 | 亚培烯科技(上海)有限公司 | 饱和α烯烃低聚物作为佐剂在动物疫苗中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US6114309A (en) * | 1997-11-21 | 2000-09-05 | Incara Research Laboratories | Combinatorial library of moenomycin analogs and methods of producing same |
| JP4774496B2 (ja) * | 2001-06-14 | 2011-09-14 | 独立行政法人産業技術総合研究所 | α−マンノシダーゼ |
| BR0308768A (pt) * | 2002-03-26 | 2005-02-15 | Chiron Srl | Sacarìdeos modificados possuindo estabilidade melhorada em água |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| PT2191844E (pt) * | 2003-01-30 | 2014-06-04 | Novartis Ag | Vacinas injetáveis contra múltiplos serogrupos meningocócicos |
| RU2250113C2 (ru) * | 2003-06-04 | 2005-04-20 | Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова Российской академии наук | Способ приготовления бивалентной вакцины для профилактики менингококковой инфекции |
-
2006
- 2006-05-08 EP EP06765581.1A patent/EP1885734B1/en active Active
- 2006-05-08 PT PT06765581T patent/PT1885734E/pt unknown
- 2006-05-08 RU RU2007145219/05A patent/RU2412944C2/ru active
- 2006-05-08 WO PCT/IB2006/001703 patent/WO2006120576A2/en not_active Ceased
- 2006-05-08 US US11/913,765 patent/US8062641B2/en active Active
- 2006-05-08 JP JP2008509538A patent/JP2008540398A/ja not_active Withdrawn
- 2006-05-08 BR BRPI0611447-4A patent/BRPI0611447A2/pt not_active Application Discontinuation
- 2006-05-08 MX MX2007013881A patent/MX2007013881A/es active IP Right Grant
- 2006-05-08 NZ NZ563940A patent/NZ563940A/en not_active IP Right Cessation
- 2006-05-08 ES ES06765581.1T patent/ES2533248T3/es active Active
- 2006-05-08 CA CA2606890A patent/CA2606890C/en active Active
- 2006-05-08 PL PL06765581T patent/PL1885734T3/pl unknown
- 2006-05-08 AU AU2006245440A patent/AU2006245440B2/en not_active Ceased
- 2006-05-08 CN CN2006800243581A patent/CN101282984B/zh active Active
-
2007
- 2007-12-04 ZA ZA200710558A patent/ZA200710558B/xx unknown
-
2013
- 2013-04-05 JP JP2013079295A patent/JP5699174B2/ja not_active Expired - Fee Related
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