JP2008540398A - 髄膜炎ａ型ワクチンのための免疫原 - Google Patents
髄膜炎ａ型ワクチンのための免疫原 Download PDFInfo
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- JP2008540398A JP2008540398A JP2008509538A JP2008509538A JP2008540398A JP 2008540398 A JP2008540398 A JP 2008540398A JP 2008509538 A JP2008509538 A JP 2008509538A JP 2008509538 A JP2008509538 A JP 2008509538A JP 2008540398 A JP2008540398 A JP 2008540398A
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- Prior art keywords
- oligosaccharide
- mannose
- protein
- unit
- composition
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- 201000009906 Meningitis Diseases 0.000 title claims abstract description 27
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- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 163
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims abstract description 161
- 238000000034 method Methods 0.000 claims abstract description 122
- 150000001875 compounds Chemical class 0.000 claims abstract description 114
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 99
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 99
- 125000006850 spacer group Chemical group 0.000 claims abstract description 57
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims abstract description 39
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 21
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000011574 phosphorus Substances 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims description 103
- -1 heteroacyl Chemical group 0.000 claims description 51
- 125000006239 protecting group Chemical group 0.000 claims description 51
- 150000004676 glycans Chemical class 0.000 claims description 40
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- 239000005017 polysaccharide Substances 0.000 claims description 37
- 150000001540 azides Chemical class 0.000 claims description 36
- 150000001412 amines Chemical class 0.000 claims description 35
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- 150000001720 carbohydrates Chemical group 0.000 claims description 33
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- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical group OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 18
- 229910019142 PO4 Inorganic materials 0.000 claims description 18
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- 125000001424 substituent group Chemical group 0.000 claims description 14
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- 125000003118 aryl group Chemical group 0.000 claims description 8
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
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- 229940124856 vaccine component Drugs 0.000 claims description 4
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- 241000588650 Neisseria meningitidis Species 0.000 description 21
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- 210000002966 serum Anatomy 0.000 description 16
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- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 15
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- C—CHEMISTRY; METALLURGY
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
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| JP2017512203A (ja) * | 2014-02-25 | 2017-05-18 | エムエスディー ウェルカム トラスト ヒルマン ラボラトリーズ プライベート リミテッドＭｓｄ Ｗｅｌｌｃｏｍｅ Ｔｒｕｓｔ Ｈｉｌｌｅｍａｎ Ｌａｂｏｒａｔｏｒｉｅｓ Ｐｖｔ．Ｌｔｄ． | 髄膜炎菌（Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ）血清型Ｘの新規の合成オリゴマー及びその調製方法 |
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| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| WO2007000341A2 (en) | 2005-06-27 | 2007-01-04 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| AU2014200640B2 (en) * | 2007-01-11 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Modified saccharides |
| GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| ES2584927T7 (es) * | 2007-10-16 | 2020-11-05 | Progen Pg500 Series Pty Ltd | Derivados de oligosacáridos sulfatados novedosos |
| SI2608805T2 (sl) | 2010-08-23 | 2025-09-30 | Wyeth Llc | Stabilne formulacije antigenov rLP2086 neisserie meningitidis |
| US9057716B2 (en) | 2010-09-04 | 2015-06-16 | Novartis Ag | Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines |
| BR112013005329A2 (pt) | 2010-09-10 | 2017-05-02 | Wyeth Llc | variantes não lipidadas de antígenos orf2086 de neisseria meningitidis |
| CN102417521B (zh) * | 2010-09-28 | 2014-05-07 | 中国医学科学院医药生物技术研究所 | 一种非环核苷类抗病毒药物磷酸单酯化合物的制备方法 |
| WO2012103444A2 (en) * | 2011-01-28 | 2012-08-02 | Purdue Research Foundation | Immunogenic compositions and reagents for preparing |
| US9616139B2 (en) | 2011-07-12 | 2017-04-11 | The General Hospital Corporation | Conjugating amines |
| RU2476444C1 (ru) * | 2011-07-15 | 2013-02-27 | Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) | СПОСОБ ПОЛУЧЕНИЯ КОНЪЮГАТА НОНА-β-(1→3)-ГЛЮКОЗИДА С БЫЧЬИМ СЫВОРОТОЧНЫМ АЛЬБУМИНОМ СКВАРАТНЫМ МЕТОДОМ |
| MX2018011291A (es) | 2012-03-09 | 2023-01-31 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| EP2958905B1 (en) | 2013-02-22 | 2017-03-29 | Amgen Inc. | Carbohydrate phosphonate derivatives as modulators of glycosylation |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| RU2016103771A (ru) * | 2013-07-07 | 2017-08-11 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Синтетические вакцины против streptococcus pneumoniae 1-го типа |
| BR112016004463A2 (pt) | 2013-09-08 | 2017-10-17 | Pfizer | composições de neisseria meningitidis e métodos das mesmas |
| CU20170046A7 (es) * | 2014-10-09 | 2017-06-05 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | Proceso mejorado para la conjugación y conjugados sintéticos de oligosacarido-proteina novedosos obtenidos del mismo |
| WO2016132294A1 (en) | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| AU2017321863B2 (en) | 2016-09-02 | 2024-07-11 | Sanofi Pasteur, Inc. | Neisseria meningitidis vaccine |
| AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| WO2018173068A1 (en) * | 2017-03-21 | 2018-09-27 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | A novel synthetic neisseria meningitidis serogroup a oligomer and process for synthesizing thereof |
| WO2020104697A1 (en) | 2018-11-22 | 2020-05-28 | Vaxxilon Ag | Stable vaccine against clostridium difficile |
| MX2022003682A (es) | 2019-09-27 | 2022-04-25 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| CN118178643B (zh) * | 2024-04-28 | 2024-11-29 | 亚培烯科技(上海)有限公司 | 饱和α烯烃低聚物作为佐剂在动物疫苗中的应用 |
Citations (4)
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|---|---|---|---|---|
| JP2002369679A (ja) * | 2001-06-14 | 2002-12-24 | National Institute Of Advanced Industrial & Technology | α−マンノシダーゼ |
| WO2003080678A1 (en) * | 2002-03-26 | 2003-10-02 | Chiron Srl | Modified saccharides having improved stability in water |
| WO2004019992A1 (en) * | 2002-08-30 | 2004-03-11 | Chiron Srl | Modified saccharides, conjugates thereof, and their manufacture |
| WO2004067030A2 (en) * | 2003-01-30 | 2004-08-12 | Chiron Srl | Injectable vaccines against multiple meningococcal serogroups |
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|---|---|---|---|---|
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US6114309A (en) * | 1997-11-21 | 2000-09-05 | Incara Research Laboratories | Combinatorial library of moenomycin analogs and methods of producing same |
| RU2250113C2 (ru) * | 2003-06-04 | 2005-04-20 | Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова Российской академии наук | Способ приготовления бивалентной вакцины для профилактики менингококковой инфекции |
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2006
- 2006-05-08 EP EP06765581.1A patent/EP1885734B1/en active Active
- 2006-05-08 PT PT06765581T patent/PT1885734E/pt unknown
- 2006-05-08 RU RU2007145219/05A patent/RU2412944C2/ru active
- 2006-05-08 WO PCT/IB2006/001703 patent/WO2006120576A2/en not_active Ceased
- 2006-05-08 US US11/913,765 patent/US8062641B2/en active Active
- 2006-05-08 JP JP2008509538A patent/JP2008540398A/ja not_active Withdrawn
- 2006-05-08 BR BRPI0611447-4A patent/BRPI0611447A2/pt not_active Application Discontinuation
- 2006-05-08 MX MX2007013881A patent/MX2007013881A/es active IP Right Grant
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- 2006-05-08 ES ES06765581.1T patent/ES2533248T3/es active Active
- 2006-05-08 CA CA2606890A patent/CA2606890C/en active Active
- 2006-05-08 PL PL06765581T patent/PL1885734T3/pl unknown
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- 2006-05-08 CN CN2006800243581A patent/CN101282984B/zh active Active
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| JP2002369679A (ja) * | 2001-06-14 | 2002-12-24 | National Institute Of Advanced Industrial & Technology | α−マンノシダーゼ |
| WO2003080678A1 (en) * | 2002-03-26 | 2003-10-02 | Chiron Srl | Modified saccharides having improved stability in water |
| WO2004019992A1 (en) * | 2002-08-30 | 2004-03-11 | Chiron Srl | Modified saccharides, conjugates thereof, and their manufacture |
| WO2004067030A2 (en) * | 2003-01-30 | 2004-08-12 | Chiron Srl | Injectable vaccines against multiple meningococcal serogroups |
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| JPN6012025850; ＢＥＲＫＩＮ，Ａ． ｅｔ ａｌ: 'Ｔｏｗａｒｄｓ ａ ｓｙｎｔｈｅｔｉｃ ｇｌｙｃｏｃｏｎｊｕｇａｔｅ ｖａｃｃｉｎｅ ａｇａｉｎｓｔ Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ Ａ' Ｃｈｅｍｉｓｔｒｙ--Ａ Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ Ｖｏｌ．８， Ｎｏ．１９, 2002, ｐｐ．４４２４-４４３３ * |
| JPN6012025851; ＮＩＫＯＬＡＥＶ，Ａ．Ｖ． ｅｔ ａｌ: 'Ｔｈｅ ｓｔｅｐｗｉｓｅ ｓｙｎｔｈｅｓｉｓ ｏｆ ｏｌｉｇｏ（ｇｌｙｃｏｓｙｌ ｐｈｏｓｐｈａｔｅｓ） ｖｉａ ｇｌｙｃｏｓｙｌ ｈｙｄｒｏｇｅｎｐｈｏｓｐｈｏｎａｔｅｓ． Ｔｈｅ ｃｈｅｍｉｃａｌ' Ｃａｒｂｏｈｙｄｒａｔｅ Ｒｅｓｅａｒｃｈ Ｖｏｌ．２４２, 1993, ｐｐ．９１-１０７ * |
| JPN6012025853; 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ｔｈｅ ｐｈｏｓｐｈｏｎｏ ａｎａｌｏｇｕｅ ｏｆ ｔｈｅ ｄｉｍｅｒｉｃ ｓｕｂｕｎｉｔ ｏｆ Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ ｔｙｐｅ Ａ ｃａｐｓｕｌａｒ' Ｓｙｎｌｅｔｔ Ｎｏ．７, 2005, ｐｐ．１１４７-１１５１ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017512203A (ja) * | 2014-02-25 | 2017-05-18 | エムエスディー ウェルカム トラスト ヒルマン ラボラトリーズ プライベート リミテッドＭｓｄ Ｗｅｌｌｃｏｍｅ Ｔｒｕｓｔ Ｈｉｌｌｅｍａｎ Ｌａｂｏｒａｔｏｒｉｅｓ Ｐｖｔ．Ｌｔｄ． | 髄膜炎菌（Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ）血清型Ｘの新規の合成オリゴマー及びその調製方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1885734A2 (en) | 2008-02-13 |
| NZ563940A (en) | 2010-11-26 |
| JP2013136639A (ja) | 2013-07-11 |
| ZA200710558B (en) | 2010-04-28 |
| ES2533248T3 (es) | 2015-04-08 |
| WO2006120576A3 (en) | 2007-07-12 |
| CN101282984B (zh) | 2013-05-08 |
| CA2606890C (en) | 2014-02-04 |
| EP1885734B1 (en) | 2015-01-14 |
| CA2606890A1 (en) | 2006-11-16 |
| US8062641B2 (en) | 2011-11-22 |
| RU2007145219A (ru) | 2009-06-20 |
| AU2006245440A1 (en) | 2006-11-16 |
| US20090304734A1 (en) | 2009-12-10 |
| MX2007013881A (es) | 2008-10-22 |
| PT1885734E (pt) | 2015-03-04 |
| AU2006245440B2 (en) | 2012-04-19 |
| JP5699174B2 (ja) | 2015-04-08 |
| PL1885734T3 (pl) | 2015-08-31 |
| WO2006120576A2 (en) | 2006-11-16 |
| BRPI0611447A2 (pt) | 2010-09-08 |
| CN101282984A (zh) | 2008-10-08 |
| RU2412944C2 (ru) | 2011-02-27 |
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