CN101282984B - A型脑膜炎疫苗的免疫原 - Google Patents

A型脑膜炎疫苗的免疫原 Download PDF

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Publication number
CN101282984B
CN101282984B CN2006800243581A CN200680024358A CN101282984B CN 101282984 B CN101282984 B CN 101282984B CN 2006800243581 A CN2006800243581 A CN 2006800243581A CN 200680024358 A CN200680024358 A CN 200680024358A CN 101282984 B CN101282984 B CN 101282984B
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China
Prior art keywords
oligosaccharides
unit
protein
seminose
seminose unit
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CN2006800243581A
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Chinese (zh)
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CN101282984A (zh
Inventor
S·奥斯卡松
P·特奥多罗维奇
P·科斯坦蒂诺
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Costantino Paolo
Oscarson Stefan
Novartis AG
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Novartis Vaccines and Diagnostics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2006800243581A 2005-05-06 2006-05-08 A型脑膜炎疫苗的免疫原 Active CN101282984B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67828905P 2005-05-06 2005-05-06
US60/678,289 2005-05-06
PCT/IB2006/001703 WO2006120576A2 (en) 2005-05-06 2006-05-08 Immunogens for meningitidis-a vaccines

Publications (2)

Publication Number Publication Date
CN101282984A CN101282984A (zh) 2008-10-08
CN101282984B true CN101282984B (zh) 2013-05-08

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ID=36942242

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CN2006800243581A Active CN101282984B (zh) 2005-05-06 2006-05-08 A型脑膜炎疫苗的免疫原

Country Status (15)

Country Link
US (1) US8062641B2 (enExample)
EP (1) EP1885734B1 (enExample)
JP (2) JP2008540398A (enExample)
CN (1) CN101282984B (enExample)
AU (1) AU2006245440B2 (enExample)
BR (1) BRPI0611447A2 (enExample)
CA (1) CA2606890C (enExample)
ES (1) ES2533248T3 (enExample)
MX (1) MX2007013881A (enExample)
NZ (1) NZ563940A (enExample)
PL (1) PL1885734T3 (enExample)
PT (1) PT1885734E (enExample)
RU (1) RU2412944C2 (enExample)
WO (1) WO2006120576A2 (enExample)
ZA (1) ZA200710558B (enExample)

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MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
WO2007000341A2 (en) 2005-06-27 2007-01-04 Glaxosmithkline Biologicals S.A. Immunogenic composition
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
AU2014200640B2 (en) * 2007-01-11 2016-06-16 Glaxosmithkline Biologicals Sa Modified saccharides
GB0700562D0 (en) * 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
ES2584927T7 (es) * 2007-10-16 2020-11-05 Progen Pg500 Series Pty Ltd Derivados de oligosacáridos sulfatados novedosos
SI2608805T2 (sl) 2010-08-23 2025-09-30 Wyeth Llc Stabilne formulacije antigenov rLP2086 neisserie meningitidis
US9057716B2 (en) 2010-09-04 2015-06-16 Novartis Ag Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines
BR112013005329A2 (pt) 2010-09-10 2017-05-02 Wyeth Llc variantes não lipidadas de antígenos orf2086 de neisseria meningitidis
CN102417521B (zh) * 2010-09-28 2014-05-07 中国医学科学院医药生物技术研究所 一种非环核苷类抗病毒药物磷酸单酯化合物的制备方法
WO2012103444A2 (en) * 2011-01-28 2012-08-02 Purdue Research Foundation Immunogenic compositions and reagents for preparing
US9616139B2 (en) 2011-07-12 2017-04-11 The General Hospital Corporation Conjugating amines
RU2476444C1 (ru) * 2011-07-15 2013-02-27 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) СПОСОБ ПОЛУЧЕНИЯ КОНЪЮГАТА НОНА-β-(1→3)-ГЛЮКОЗИДА С БЫЧЬИМ СЫВОРОТОЧНЫМ АЛЬБУМИНОМ СКВАРАТНЫМ МЕТОДОМ
MX2018011291A (es) 2012-03-09 2023-01-31 Pfizer Composiciones de neisseria meningitidis y metodos de las mismas.
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
EP2958905B1 (en) 2013-02-22 2017-03-29 Amgen Inc. Carbohydrate phosphonate derivatives as modulators of glycosylation
WO2014136064A2 (en) 2013-03-08 2014-09-12 Pfizer Inc. Immunogenic fusion polypeptides
RU2016103771A (ru) * 2013-07-07 2017-08-11 Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. Синтетические вакцины против streptococcus pneumoniae 1-го типа
BR112016004463A2 (pt) 2013-09-08 2017-10-17 Pfizer composições de neisseria meningitidis e métodos das mesmas
EP3110825B1 (en) * 2014-02-25 2020-12-09 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. Novel synthetic oligomers of neisseria meningitis serogroup x and process of preparing them
CU20170046A7 (es) * 2014-10-09 2017-06-05 Msd Wellcome Trust Hilleman Laboratories Pvt Ltd Proceso mejorado para la conjugación y conjugados sintéticos de oligosacarido-proteina novedosos obtenidos del mismo
WO2016132294A1 (en) 2015-02-19 2016-08-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
AU2017321863B2 (en) 2016-09-02 2024-07-11 Sanofi Pasteur, Inc. Neisseria meningitidis vaccine
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2018173068A1 (en) * 2017-03-21 2018-09-27 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. A novel synthetic neisseria meningitidis serogroup a oligomer and process for synthesizing thereof
WO2020104697A1 (en) 2018-11-22 2020-05-28 Vaxxilon Ag Stable vaccine against clostridium difficile
MX2022003682A (es) 2019-09-27 2022-04-25 Pfizer Composiciones de neisseria meningitidis y metodos de las mismas.
CN118178643B (zh) * 2024-04-28 2024-11-29 亚培烯科技(上海)有限公司 饱和α烯烃低聚物作为佐剂在动物疫苗中的应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2004067030A2 (en) * 2003-01-30 2004-08-12 Chiron Srl Injectable vaccines against multiple meningococcal serogroups

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US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US6114309A (en) * 1997-11-21 2000-09-05 Incara Research Laboratories Combinatorial library of moenomycin analogs and methods of producing same
JP4774496B2 (ja) * 2001-06-14 2011-09-14 独立行政法人産業技術総合研究所 α−マンノシダーゼ
BR0308768A (pt) * 2002-03-26 2005-02-15 Chiron Srl Sacarìdeos modificados possuindo estabilidade melhorada em água
GB0220198D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Modified saccharides,conjugates thereof and their manufacture
RU2250113C2 (ru) * 2003-06-04 2005-04-20 Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова Российской академии наук Способ приготовления бивалентной вакцины для профилактики менингококковой инфекции

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067030A2 (en) * 2003-01-30 2004-08-12 Chiron Srl Injectable vaccines against multiple meningococcal serogroups

Non-Patent Citations (2)

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Title
Ali Berkin et al.Towards a synthetic glycoconjugate vaccine against neisseria meningitidis A.《chem.Eur.J》.2002,第8卷(第19期),4424-4433. *
M.I.Torres et al.synthesis of the phosphono analogue of the dimeric subunit of neisseria meningitidis type a capsular polysaccharide.《SYNLETT》.2005,(第7期),1147-1151页. *

Also Published As

Publication number Publication date
EP1885734A2 (en) 2008-02-13
NZ563940A (en) 2010-11-26
JP2013136639A (ja) 2013-07-11
JP2008540398A (ja) 2008-11-20
ZA200710558B (en) 2010-04-28
ES2533248T3 (es) 2015-04-08
WO2006120576A3 (en) 2007-07-12
CA2606890C (en) 2014-02-04
EP1885734B1 (en) 2015-01-14
CA2606890A1 (en) 2006-11-16
US8062641B2 (en) 2011-11-22
RU2007145219A (ru) 2009-06-20
AU2006245440A1 (en) 2006-11-16
US20090304734A1 (en) 2009-12-10
MX2007013881A (es) 2008-10-22
PT1885734E (pt) 2015-03-04
AU2006245440B2 (en) 2012-04-19
JP5699174B2 (ja) 2015-04-08
PL1885734T3 (pl) 2015-08-31
WO2006120576A2 (en) 2006-11-16
BRPI0611447A2 (pt) 2010-09-08
CN101282984A (zh) 2008-10-08
RU2412944C2 (ru) 2011-02-27

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SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: STEFAN OSCARSON PETER TEODOROVIC

Free format text: FORMER OWNER: STOCKHOLM UNIVERSITY

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20100825

Address after: Siena city of Italy

Applicant after: Novartis AG

Co-applicant after: Costantino Paolo

Co-applicant after: Oscarson Stefan

Address before: Siena city of Italy

Applicant before: Novartis AG

Co-applicant before: Novartis Vaccines And Diagnostics Srl

C14 Grant of patent or utility model
GR01 Patent grant