JP2009541747A - 改善された方法 - Google Patents
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- G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4742—Keratin; Cytokeratin
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Abstract
a)ケラチンサンプルを膨潤物質に曝し、当該ケラチンサンプルに浸透させることにより誘導化学材料を得る工程、
b)誘導化学材料からデータを得る工程、
c)誘導化学材料から得たデータを参照データベースに含まれている第2のデータ群と比較し、ケラチンサンプル中の異常成分を特定する工程
を含み、異常成分の検出と被検体の病的状態の存在とが一致する方法。
Description
1.「含有する」という用語(及びその文法的な変形語)は本明細書では「有する」又は「含む」という包括的な意味で用いられ、「のみから成る」という排他的な意味では用いられない。
2.本発明の背景技術における従来技術の説明は、本明細書において説明されているすべての情報が引用可能な従来技術であること、又はいずれの国の当業者の共通の一般知識の一部であることを認めるものではない。
本発明の1つの広範な形態では、病的状態にある被検体から採取したケラチンサンプル中の異常成分を検出する方法であって、
a)ケラチンサンプルを膨潤物質に曝し、ケラチンサンプルに浸透させることにより誘導化学材料を得る工程と、
b)誘導化学材料からデータを得る工程と、
c)誘導化学材料から得たデータを参照データベースに含まれている第2のデータ群と比較し、ケラチンサンプル中の異常成分を特定する工程を含み、
異常成分の検出と被検体の病的状態の存在とが一致する方法が提供される。
次に、本発明の実施形態を添付の図面を参照しながら説明する。
「動物」とは、随意運動、感覚、及び植物並びに他の動物等の食物を摂取する能力を特徴とする、非セルロース細胞壁を有する生体と定義される。
「哺乳動物種」は、本明細書中に見られるような種のタイプを含む。これにはヒト、イヌ若しくはネコ等のペット、又は体毛を有する様々な他の動物が含まれる。
「ケラチンサンプル」又は「ケラチン物質」は実質的にケラチンから成るサンプルである。ケラチンサンプル16には、一般に、ヒトの毛髪若しくは体毛、及び特に陰毛、ペットの体毛、動物の体毛、又は哺乳動物種の体毛、或いは爪の切り屑又は睫等の他のケラチン系材料が含まれる。
「被検体」には哺乳動物種が含まれる。哺乳動物種にはヒト、イヌ若しくはネコ等のペット、又は様々な他の動物が含まれる。
あるか否かを判定することができ、例えば、問題となる結果が、参照データベース25において病的状態と相関し、その原因と関連している場合、有意義な検討が可能となる。さらに、ケラチンサンプル16中に含まれているかどうか分らない金属又は他の化合物などの成分(それにより、包含物が、誘導化学材料18中から洗い流されない)をさらに含有する場合とは対照的に、誘導化学材料18中に存在する異常成分との関連がない場合に、相関がゼロであるか情報が提供されない場合は、いくつかの例において、タンパク質のフォールディングの欠陥、すなわちケラチンサンプル16の構造的な欠陥である異常と一致する。
図5は使用時の本発明の一つの実施形態を示す。図5では、ケラチンサンプル16が、薬局26で被検体から採取される。次いで、図1に見られるように、ケラチンサンプル16中の異常成分を検出する方法を行うために、ケラチンサンプル16を試験室34に移される。
毛髪繊維の有機酸処理
毛髪繊維を蟻酸及び酢酸といった有機酸中に浸漬することにより、毛髪繊維の直径が50%ほど膨潤し、この作用が水中で濯ぐことによって元に戻ることが知られている。Blackburn及びLowther(Blackburn S and Lowther AG., The action of organic acids on some fibrous proteins: the oxidation of wool keratin., Biochem J., 1951; 49 : 554-9)によって、室温で蟻酸又は酢酸中のいずれかで処理することによって少量のタンパク質が毛繊維から抽出されることが報告されている。この方法を既知の病的状態を有する個体から得たいくつかの毛髪繊維に適用して、毛髪のシンクロトロン小角X線散乱(SAXS)によって観察される乳癌の存在に特異的なリングを、かかる処置によって取り除くことができるかどうかを判定した。乳癌に罹患した被検体からの毛髪繊維を室温で3分間、85%(体積/体積)の蟻酸溶液又は氷酢酸中に浸漬した。次いで、酸をデカントし、ミリQ水を複数回交換して置換した。繊維を乾燥させ、次いでX線源に曝露するためにサンプルホルダ内に取り付けた。これらの毛髪についてSAXS画像データを得た。
Claims (11)
- 病的状態にある被検体から採取したケラチンサンプル中の異常成分を検出する方法であって、
a)前記ケラチンサンプルを膨潤物質に曝し、当該ケラチンサンプルに浸透させることにより誘導化学材料を得る工程、
b)前記誘導化学材料からデータを得る工程、
c)誘導化学材料から得た前記データを参照データベースに含まれる第2のデータ群と比較し、ケラチンサンプル中の異常成分を特定する工程
を含み、異常成分の検出と被検体の病的状態の存在とが一致する方法。 - 前記膨潤物質が蟻酸を含む、請求項1に記載の方法。
- 前記第2のデータ群が、被検体の病的状態の存在と相関する、請求項1又は2に記載の方法。
- 前記第2のデータ群が、被検体の病的状態の存在と原因的に関連する、請求項1〜3のいずれか一項に記載の方法。
- 前記膨潤物質が複数の異なる膨潤物質から選択される、請求項1〜4のいずれか一項に記載の方法。
- 前記ケラチンサンプルが複数の異なるケラチンサンプルから選択される、請求項1〜5のいずれか一項に記載の方法。
- 前記第2のデータ群が、複数の異なるデータ群のデータから選択される、請求項1〜6のいずれか一項に記載の方法。
- 得られたデータ及び前記第2のデータ群が複数の異なる比較方法を用いて分析される、請求項1〜7のいずれか一項に記載の方法。
- 使用時に、薬局、試験キット、被検体の自宅、医療施設及び試験室の少なくとも1つにおいて前記ケラチンサンプルの入手及び分析がされる、請求項1〜8のいずれか一項に記載の方法。
- 実質的に明細書の本文に示され、記載された工程を含む、ケラチンサンプル中の異常成分を検出する方法。
- 前記被検体がヒト及び動物から成る群から選択される、請求項1〜9のいずれか一項に記載の方法。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006903508A AU2006903508A0 (en) | 2006-06-29 | Improved Process | |
AU2007900272A AU2007900272A0 (en) | 2007-01-19 | Improved Process | |
AU2007900308A AU2007900308A0 (en) | 2007-01-22 | Improved Process | |
PCT/AU2007/000879 WO2008000020A1 (en) | 2006-06-29 | 2007-06-27 | Improved process |
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JP2009541747A true JP2009541747A (ja) | 2009-11-26 |
JP2009541747A5 JP2009541747A5 (ja) | 2010-08-12 |
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JP2009516820A Ceased JP2009541747A (ja) | 2006-06-29 | 2007-06-27 | 改善された方法 |
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US (1) | US20090325303A1 (ja) |
EP (1) | EP2032031B1 (ja) |
JP (1) | JP2009541747A (ja) |
KR (1) | KR101087576B1 (ja) |
CN (1) | CN101478916A (ja) |
AR (1) | AR061732A1 (ja) |
AT (1) | ATE520345T1 (ja) |
AU (1) | AU2007264394B2 (ja) |
BR (1) | BRPI0713885A2 (ja) |
CA (1) | CA2652955A1 (ja) |
ES (1) | ES2371368T3 (ja) |
TW (1) | TW200801513A (ja) |
WO (1) | WO2008000020A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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JP2010515886A (ja) * | 2007-01-12 | 2010-05-13 | ヴェロニカ ジェームズ, | バイオメトリック診断 |
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US6627215B1 (en) | 1998-12-30 | 2003-09-30 | Oligos Etc. Inc. | Devices for improved wound management |
CA2408011A1 (en) | 2000-05-04 | 2001-11-08 | Avi Biopharma, Inc. | Splice-region antisense composition and method |
US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
US8449908B2 (en) | 2000-12-22 | 2013-05-28 | Alltranz, Llc | Transdermal delivery of cannabidiol |
US7812227B2 (en) | 2001-11-13 | 2010-10-12 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
US8435459B2 (en) | 2003-01-07 | 2013-05-07 | Micropyretics Heaters International, Inc. | Heating and sterilizing apparatus and method of using same |
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EP2032031A1 (en) | 2009-03-11 |
EP2032031A4 (en) | 2010-03-24 |
CA2652955A1 (en) | 2008-01-03 |
TW200801513A (en) | 2008-01-01 |
AU2007264394B2 (en) | 2012-08-16 |
US20090325303A1 (en) | 2009-12-31 |
ATE520345T1 (de) | 2011-09-15 |
AR061732A1 (es) | 2008-09-17 |
KR101087576B1 (ko) | 2011-11-29 |
WO2008000020A1 (en) | 2008-01-03 |
EP2032031B1 (en) | 2011-08-17 |
BRPI0713885A2 (pt) | 2012-11-06 |
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