JP2009540012A5 - - Google Patents

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Publication number
JP2009540012A5
JP2009540012A5 JP2009515619A JP2009515619A JP2009540012A5 JP 2009540012 A5 JP2009540012 A5 JP 2009540012A5 JP 2009515619 A JP2009515619 A JP 2009515619A JP 2009515619 A JP2009515619 A JP 2009515619A JP 2009540012 A5 JP2009540012 A5 JP 2009540012A5
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JP
Japan
Prior art keywords
diamine
pyrimidine
dimethylamino
propyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009515619A
Other languages
English (en)
Japanese (ja)
Other versions
JP5306190B2 (ja
JP2009540012A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/071073 external-priority patent/WO2007146977A1/en
Publication of JP2009540012A publication Critical patent/JP2009540012A/ja
Publication of JP2009540012A5 publication Critical patent/JP2009540012A5/ja
Application granted granted Critical
Publication of JP5306190B2 publication Critical patent/JP5306190B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009515619A 2006-06-15 2007-06-13 ２−アニリノ−４−アミノアルキレンアミノピリミジン Expired - Fee Related JP5306190B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81387506P 2006-06-15 2006-06-15
US60/813,875 2006-06-15
PCT/US2007/071073 WO2007146977A1 (en) 2006-06-15 2007-06-13 2-anilino-4-aminoalkyleneaminopyrimidines

Publications (3)

Publication Number Publication Date
JP2009540012A JP2009540012A (ja) 2009-11-19
JP2009540012A5 true JP2009540012A5 (https=) 2010-07-29
JP5306190B2 JP5306190B2 (ja) 2013-10-02

Family

ID=38611102

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009515619A Expired - Fee Related JP5306190B2 (ja) 2006-06-15 2007-06-13 ２−アニリノ−４−アミノアルキレンアミノピリミジン

Country Status (15)

Country Link
US (2) US20070293525A1 (https=)
EP (1) EP2032543A1 (https=)
JP (1) JP5306190B2 (https=)
KR (1) KR20090023698A (https=)
CN (1) CN101506176A (https=)
AR (1) AR062822A1 (https=)
AU (1) AU2007257701A1 (https=)
CA (1) CA2655315A1 (https=)
CL (1) CL2007001748A1 (https=)
IL (1) IL195865A0 (https=)
MX (1) MX2008016007A (https=)
RU (1) RU2008152193A (https=)
TW (1) TW200815368A (https=)
WO (1) WO2007146977A1 (https=)
ZA (1) ZA200809945B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2008152195A (ru) 2006-06-15 2010-07-20 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) 2-анилино-4-(гетероциклил)аминопиримидины, как ингибиторы протеинкиназы с-альфа
MX2010009159A (es) 2008-02-22 2010-09-14 Rigel Pharmaceuticals Inc Uso de 2,4-pirimidindiaminas para el tratamiento de aterosclerosis.
US20120301463A1 (en) 2009-09-30 2012-11-29 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
EP2512246B1 (en) * 2009-12-17 2015-09-30 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
ES2577829T3 (es) 2010-06-04 2016-07-19 F. Hoffmann-La Roche Ag Derivados de aminopirimidina como moduladores de la LRRK2
NO2638031T3 (https=) 2010-11-10 2018-03-10
KR101664106B1 (ko) * 2014-09-11 2016-10-10 한국화학연구원 폴리믹신 b 화합물을 포함하는 심혈관 질환의 예방 및 치료용 약학적 조성물
EP3313993A4 (en) 2015-06-29 2019-06-19 Regents of the University of Minnesota ANTI-APOBEC3 ANTIBODIES AND METHOD OF PREPARATION AND USE
KR101876514B1 (ko) * 2016-11-08 2018-07-10 한국화학연구원 신규한 피리미딘화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암 및 염증질환의 예방 또는 치료용 약학적 조성물
CN109516959A (zh) * 2018-12-03 2019-03-26 陕西师范大学 2-芳氨基-4-取代嘧啶类衍生物及其在制备抗肿瘤药物中的应用

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GB592928A (en) 1943-06-11 1947-10-03 Francis Henry Swinden Curd New pyrimidine compounds
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DE833651C (de) 1943-11-02 1952-03-10 Ici Ltd Verfahren zur Herstellung von neuen Pyrimidinabkoemmlingen
GB587550A (en) 1944-09-25 1947-04-29 Francis Henry Swinden Curd New pyrimidine compounds
US3445467A (en) * 1964-05-25 1969-05-20 Ciba Geigy Corp Biphenyl diphenylalkane and diphenylether compounds,amino - substituted on the phenyl rings
FR2244520B1 (https=) 1973-07-06 1977-02-04 Ugine Kuhlmann
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
EP0945442A1 (en) 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituted pyrimidine derivatives
EA002973B1 (ru) 1998-03-27 2002-12-26 Янссен Фармацевтика Н.В. Производные пиримидина в качестве ингибиторов репликации вируса иммунодефицита человека
ATE342892T1 (de) * 1998-08-29 2006-11-15 Astrazeneca Ab Pyrimidine verbindungen
BR0009338A (pt) 1999-03-26 2001-12-26 Astrazeneca Ab Composto, processo para a preparação do mesmo,composição farmacêutica, processo para apreparação da mesma, uso de um composto, e,método de tratamento de uma doençainflamatória em um paciente sofrendo ou em riscode dita doença
GB0016877D0 (en) * 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
BR0209774A (pt) * 2001-05-29 2004-06-01 Schering Ag Pirimidinas inibidoras de cdk, sua preparação e aplicação como medicamento
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
WO2003026664A1 (en) 2001-09-26 2003-04-03 Bayer Corporation 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors
ATE407678T1 (de) 2001-10-17 2008-09-15 Boehringer Ingelheim Pharma Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung
WO2003032994A2 (de) 2001-10-17 2003-04-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren
HUP0402106A3 (en) 2001-11-01 2009-07-28 Janssen Pharmaceutica Nv Heteroaryl amines as glycogen synthase kinase 3 beta inhibitors, process for their preparation and pharmaceutical compositions containing them
SE0104140D0 (sv) * 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
AR039540A1 (es) 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
JP2006508997A (ja) * 2002-11-28 2006-03-16 シエーリング アクチエンゲゼルシャフト Ｃｈｋ−、Ｐｄｋ−およびＡｋｔ−阻害性ピリミジン、それらの製造および薬剤としての使用
EP1571146A4 (en) * 2002-12-10 2010-09-01 Ono Pharmaceutical Co NITROGENIC HETEROCYCLIC COMPOUNDS AND THEIR MEDICAL USE
WO2005003103A2 (en) 2003-06-30 2005-01-13 Astrazeneca Ab 2, 4, 6-tri-substituted 6-membered heterocycles and their use in the treatment of neurodegenerative diseases
WO2005012294A1 (en) 2003-07-30 2005-02-10 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
ATE506953T1 (de) 2003-08-07 2011-05-15 Rigel Pharmaceuticals Inc 2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel
BRPI0506839A (pt) * 2004-01-16 2007-06-12 Novartis Ag composições e métodos para induzir a cardiomiogênese
ATE519759T1 (de) 2004-12-30 2011-08-15 Exelixis Inc Pyrimidinderivate als kinasemodulatoren und anwendungsverfahren
DE102005016634A1 (de) 2005-04-12 2006-10-19 Merck Patent Gmbh Neuartige Aza-Hetercyclen als Kinase-Inhibitoren
RU2008152195A (ru) * 2006-06-15 2010-07-20 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) 2-анилино-4-(гетероциклил)аминопиримидины, как ингибиторы протеинкиназы с-альфа

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