JP2009536961A5

JP2009536961A5 -

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Publication number: JP2009536961A5
Authority: JP; Japan
Prior art keywords: ylamino; methyl; phenyl; acid compound; propanoic acid
Prior art date: 2007-05-14
Legal status : Pending

Application number

JP2009510340A

Other languages

English (en)

Japanese (ja)

Other versions

JP2009536961A (ja

Filing date

2007-05-14

Publication date

2010-07-01

2007-05-14 Application filed filed Critical

2007-05-14 Priority claimed from PCT/EP2007/004283 external-priority patent/WO2007131764A2/en

2009-10-22 Publication of JP2009536961A publication Critical patent/JP2009536961A/ja

2010-07-01 Publication of JP2009536961A5 publication Critical patent/JP2009536961A5/ja

Status Pending legal-status Critical Current

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150000001875 compounds Chemical class 0.000 claims 480
-1 O— (C═O) Inorganic materials 0.000 claims 310
XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 65
DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 54
235000019260 propionic acid Nutrition 0.000 claims 54
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 46
239000002253 acid Substances 0.000 claims 46
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 45
201000010099 disease Diseases 0.000 claims 39
125000003118 aryl group Chemical group 0.000 claims 28
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 25
125000006413 ring segment Chemical group 0.000 claims 18
229910052739 hydrogen Inorganic materials 0.000 claims 15
239000001257 hydrogen Substances 0.000 claims 15
125000004435 hydrogen atom Chemical class [H]* 0.000 claims 15
125000001424 substituent group Chemical group 0.000 claims 15
125000000217 alkyl group Chemical group 0.000 claims 13
102000006495 integrins Human genes 0.000 claims 12
108010044426 integrins Proteins 0.000 claims 12
206010016654 Fibrosis Diseases 0.000 claims 11
229910052757 nitrogen Inorganic materials 0.000 claims 11
229910052760 oxygen Inorganic materials 0.000 claims 11
125000003710 aryl alkyl group Chemical group 0.000 claims 10
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 10
230000004761 fibrosis Effects 0.000 claims 10
125000001072 heteroaryl group Chemical group 0.000 claims 10
125000005842 heteroatom Chemical group 0.000 claims 10
125000004433 nitrogen atom Chemical group N* 0.000 claims 10
229910052717 sulfur Inorganic materials 0.000 claims 10
229910052736 halogen Inorganic materials 0.000 claims 8
150000002367 halogens Chemical class 0.000 claims 8
239000008194 pharmaceutical composition Substances 0.000 claims 8
125000003545 alkoxy group Chemical group 0.000 claims 7
125000004076 pyridyl group Chemical group 0.000 claims 7
125000003107 substituted aryl group Chemical group 0.000 claims 7
125000001544 thienyl group Chemical group 0.000 claims 7
206010028980 Neoplasm Diseases 0.000 claims 6
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 6
125000004432 carbon atom Chemical group C* 0.000 claims 6
125000004122 cyclic group Chemical group 0.000 claims 6
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 6
125000000753 cycloalkyl group Chemical group 0.000 claims 6
208000035475 disorder Diseases 0.000 claims 6
125000004446 heteroarylalkyl group Chemical group 0.000 claims 6
125000000623 heterocyclic group Chemical group 0.000 claims 6
238000000034 method Methods 0.000 claims 6
125000000168 pyrrolyl group Chemical group 0.000 claims 6
125000000547 substituted alkyl group Chemical group 0.000 claims 6
238000011282 treatment Methods 0.000 claims 6
125000004093 cyano group Chemical group *C#N 0.000 claims 5
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
125000001153 fluoro group Chemical group F* 0.000 claims 5
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
125000002883 imidazolyl group Chemical group 0.000 claims 5
125000001786 isothiazolyl group Chemical group 0.000 claims 5
125000000842 isoxazolyl group Chemical group 0.000 claims 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
125000002971 oxazolyl group Chemical group 0.000 claims 5
125000003226 pyrazolyl group Chemical group 0.000 claims 5
125000000335 thiazolyl group Chemical group 0.000 claims 5
102000004190 Enzymes Human genes 0.000 claims 4
108090000790 Enzymes Proteins 0.000 claims 4
125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
125000006350 alkyl thio alkyl group Chemical group 0.000 claims 4
201000011510 cancer Diseases 0.000 claims 4
210000004027 cell Anatomy 0.000 claims 4
239000003814 drug Substances 0.000 claims 4
230000003176 fibrotic effect Effects 0.000 claims 4
125000002541 furyl group Chemical group 0.000 claims 4
125000004415 heterocyclylalkyl group Chemical group 0.000 claims 4
239000003446 ligand Substances 0.000 claims 4
125000001715 oxadiazolyl group Chemical group 0.000 claims 4
239000000126 substance Substances 0.000 claims 4
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
125000001113 thiadiazolyl group Chemical group 0.000 claims 4
125000001425 triazolyl group Chemical group 0.000 claims 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 3
108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 3
206010018364 Glomerulonephritis Diseases 0.000 claims 3
206010034277 Pemphigoid Diseases 0.000 claims 3
201000004681 Psoriasis Diseases 0.000 claims 3
206010063837 Reperfusion injury Diseases 0.000 claims 3
125000003277 amino group Chemical group 0.000 claims 3
125000004429 atom Chemical group 0.000 claims 3
229910052799 carbon Inorganic materials 0.000 claims 3
238000001514 detection method Methods 0.000 claims 3
210000002744 extracellular matrix Anatomy 0.000 claims 3
208000015181 infectious disease Diseases 0.000 claims 3
230000003993 interaction Effects 0.000 claims 3
208000002780 macular degeneration Diseases 0.000 claims 3
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
125000004043 oxo group Chemical group O=* 0.000 claims 3
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
206010039073 rheumatoid arthritis Diseases 0.000 claims 3
125000005415 substituted alkoxy group Chemical group 0.000 claims 3
125000005346 substituted cycloalkyl group Chemical group 0.000 claims 3
238000001356 surgical procedure Methods 0.000 claims 3
210000001519 tissue Anatomy 0.000 claims 3
238000002054 transplantation Methods 0.000 claims 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
QZKZYBXYJFCIAM-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[(1h-imidazol-2-ylamino)methyl]-1,3,4-oxadiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3NC=CN=3)=NN=2)C=C1 QZKZYBXYJFCIAM-UHFFFAOYSA-N 0.000 claims 2
VHGWTSKSCOCNJT-UHFFFAOYSA-N 2-ethyl-4-fluoro-6-methylbenzamide Chemical compound CCC1=CC(F)=CC(C)=C1C(N)=O VHGWTSKSCOCNJT-UHFFFAOYSA-N 0.000 claims 2
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
FNNZFWKITTVLLJ-UHFFFAOYSA-N 3-[4-[3-[(1h-benzimidazol-2-ylamino)methyl]-1,2,4-thiadiazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SN=C(CNC=3NC4=CC=CC=C4N=3)N=2)C=C1 FNNZFWKITTVLLJ-UHFFFAOYSA-N 0.000 claims 2
MZWWGXAZLSDWQX-UHFFFAOYSA-N 3-[4-[3-[[(4-methoxypyridin-2-yl)amino]methyl]-1,2,4-thiadiazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2N=C(SN=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 MZWWGXAZLSDWQX-UHFFFAOYSA-N 0.000 claims 2
QHGMJKULBVCOQG-UHFFFAOYSA-N 3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2,4-thiadiazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2N=C(SN=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 QHGMJKULBVCOQG-UHFFFAOYSA-N 0.000 claims 2
FYYUFQCXVFKYSI-UHFFFAOYSA-N 3-[4-[5-[(1h-benzimidazol-2-ylamino)methyl]-1,2,4-thiadiazol-3-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3NC4=CC=CC=C4N=3)SN=2)C=C1 FYYUFQCXVFKYSI-UHFFFAOYSA-N 0.000 claims 2
DWSRXQCHCCZBGS-UHFFFAOYSA-N 3-[4-[5-[(1h-benzimidazol-2-ylamino)methyl]-1,2,4-thiadiazol-3-yl]phenyl]-2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3NC4=CC=CC=C4N=3)SN=2)C=C1 DWSRXQCHCCZBGS-UHFFFAOYSA-N 0.000 claims 2
MXLUCHXRIQHKGW-UHFFFAOYSA-N 3-[4-[5-[(1h-benzimidazol-2-ylamino)methyl]-1,3,4-oxadiazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3NC4=CC=CC=C4N=3)=NN=2)C=C1 MXLUCHXRIQHKGW-UHFFFAOYSA-N 0.000 claims 2
QZHPAEVAIUMSBA-UHFFFAOYSA-N 3-[4-[5-[(1h-benzimidazol-2-ylamino)methyl]-1,3,4-thiadiazol-2-yl]phenyl]-2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3NC4=CC=CC=C4N=3)=NN=2)C=C1 QZHPAEVAIUMSBA-UHFFFAOYSA-N 0.000 claims 2
SVVBXOJTEDDMOT-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]-1,3,4-oxadiazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3NC=CN=3)=NN=2)C=C1 SVVBXOJTEDDMOT-UHFFFAOYSA-N 0.000 claims 2
ZRDNWGCQLVFDIM-UHFFFAOYSA-N 3-[4-[5-[[(4-methoxypyridin-2-yl)amino]methyl]-1,2,4-thiadiazol-3-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2SN=C(N=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 ZRDNWGCQLVFDIM-UHFFFAOYSA-N 0.000 claims 2
XBPPWCIXLWPQCG-UHFFFAOYSA-N 3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,2,4-thiadiazol-3-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2SN=C(N=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 XBPPWCIXLWPQCG-UHFFFAOYSA-N 0.000 claims 2
YGPNNYSSAOOPGT-UHFFFAOYSA-N 3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3,4-oxadiazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2OC(=NN=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 YGPNNYSSAOOPGT-UHFFFAOYSA-N 0.000 claims 2
206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
208000035473 Communicable disease Diseases 0.000 claims 2
208000011231 Crohn disease Diseases 0.000 claims 2
206010012689 Diabetic retinopathy Diseases 0.000 claims 2
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical class C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 2
239000005977 Ethylene Substances 0.000 claims 2
208000010159 IgA glomerulonephritis Diseases 0.000 claims 2
206010021263 IgA nephropathy Diseases 0.000 claims 2
201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
206010039710 Scleroderma Diseases 0.000 claims 2
206010053648 Vascular occlusion Diseases 0.000 claims 2
208000009956 adenocarcinoma Diseases 0.000 claims 2
206010064930 age-related macular degeneration Diseases 0.000 claims 2
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 2
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
208000006673 asthma Diseases 0.000 claims 2
230000015572 biosynthetic process Effects 0.000 claims 2
208000035269 cancer or benign tumor Diseases 0.000 claims 2
230000001684 chronic effect Effects 0.000 claims 2
230000000779 depleting effect Effects 0.000 claims 2
229940079593 drug Drugs 0.000 claims 2
125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 2
239000007850 fluorescent dye Substances 0.000 claims 2
125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
201000011066 hemangioma Diseases 0.000 claims 2
125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
238000003384 imaging method Methods 0.000 claims 2
150000002466 imines Chemical class 0.000 claims 2
208000027866 inflammatory disease Diseases 0.000 claims 2
239000003112 inhibitor Substances 0.000 claims 2
150000003951 lactams Chemical group 0.000 claims 2
210000004185 liver Anatomy 0.000 claims 2
238000004519 manufacturing process Methods 0.000 claims 2
230000001404 mediated effect Effects 0.000 claims 2
RIFHJAODNHLCBH-UHFFFAOYSA-N methanethione Chemical group S=[CH] RIFHJAODNHLCBH-UHFFFAOYSA-N 0.000 claims 2
125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 claims 2
210000005170 neoplastic cell Anatomy 0.000 claims 2
125000006574 non-aromatic ring group Chemical group 0.000 claims 2
201000008482 osteoarthritis Diseases 0.000 claims 2
230000005298 paramagnetic effect Effects 0.000 claims 2
XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical compound O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 claims 2
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 2
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 2
201000000306 sarcoidosis Diseases 0.000 claims 2
239000000758 substrate Substances 0.000 claims 2
125000000446 sulfanediyl group Chemical group *S* 0.000 claims 2
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
230000008685 targeting Effects 0.000 claims 2
238000002560 therapeutic procedure Methods 0.000 claims 2
230000007838 tissue remodeling Effects 0.000 claims 2
208000021331 vascular occlusion disease Diseases 0.000 claims 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 1
125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 1
MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 claims 1
CYKKKUOHKZGCLP-UHFFFAOYSA-N 2-[(1-methylcyclohexanecarbonyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]pyrrol-1-yl]phenyl]propanoic acid Chemical compound CC1=CC=NC(NCC2=CN(C=C2)C=2C=CC(CC(NC(=O)C3(C)CCCCC3)C(O)=O)=CC=2)=C1 CYKKKUOHKZGCLP-UHFFFAOYSA-N 0.000 claims 1
GPJXMSKOVHYPGV-UHFFFAOYSA-N 2-[(1-methylcyclohexanecarbonyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]propanoic acid Chemical compound CC1=CC=NC(NCC=2SC(=NC=2)C=2C=CC(CC(NC(=O)C3(C)CCCCC3)C(O)=O)=CC=2)=C1 GPJXMSKOVHYPGV-UHFFFAOYSA-N 0.000 claims 1
CVFHTVODGJKBRE-UHFFFAOYSA-N 2-[(2,6-dimethylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]furan-2-yl]phenyl]propanoic acid Chemical compound CC1=CC=NC(NCC=2C=C(OC=2)C=2C=CC(CC(NC(=O)C=3C(=CC=CC=3C)C)C(O)=O)=CC=2)=C1 CVFHTVODGJKBRE-UHFFFAOYSA-N 0.000 claims 1
POCSJOPFIYTNCZ-UHFFFAOYSA-N 2-[(2,6-dimethylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]triazol-1-yl]phenyl]propanoic acid Chemical compound CC1=CC=NC(NCC=2N=NN(C=2)C=2C=CC(CC(NC(=O)C=3C(=CC=CC=3C)C)C(O)=O)=CC=2)=C1 POCSJOPFIYTNCZ-UHFFFAOYSA-N 0.000 claims 1
DSBRVCRRGPAMJC-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[2-[[(4-methoxypyridin-2-yl)amino]methyl]-1h-imidazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3N=CC=C(OC)C=3)NC=2)C=C1 DSBRVCRRGPAMJC-UHFFFAOYSA-N 0.000 claims 1
MYBYFQDBBWDPFN-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[3-[(1h-imidazol-2-ylamino)methyl]-1,2,4-triazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3NC=CN=3)N=C2)C=C1 MYBYFQDBBWDPFN-UHFFFAOYSA-N 0.000 claims 1
CKRUKEHQIWEEIT-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methoxypyridin-2-yl)amino]methyl]-1,2-oxazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2ON=C(CNC=3N=CC=C(OC)C=3)C=2)C=C1 CKRUKEHQIWEEIT-UHFFFAOYSA-N 0.000 claims 1
YFJAOUTXYMTPBL-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methoxypyridin-2-yl)amino]methyl]pyrazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3N=CC=C(OC)C=3)C=C2)C=C1 YFJAOUTXYMTPBL-UHFFFAOYSA-N 0.000 claims 1
VFCRZWKVLRWCJE-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-thiazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SN=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 VFCRZWKVLRWCJE-UHFFFAOYSA-N 0.000 claims 1
KVOQVZDIDJXCMW-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]pyrazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3N=CC=C(C)C=3)C=C2)C=C1 KVOQVZDIDJXCMW-UHFFFAOYSA-N 0.000 claims 1
YWSIWWQDNLJYRQ-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[(1h-imidazol-2-ylamino)methyl]triazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=NC(CNC=3NC=CN=3)=C2)C=C1 YWSIWWQDNLJYRQ-UHFFFAOYSA-N 0.000 claims 1
WWDDVNSMIUYCPM-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-oxazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3N=CC=C(OC)C=3)N=2)C=C1 WWDDVNSMIUYCPM-UHFFFAOYSA-N 0.000 claims 1
PYRKYTADJSMOSC-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methoxypyridin-2-yl)amino]methyl]pyrazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=CC(CNC=3N=CC=C(OC)C=3)=C2)C=C1 PYRKYTADJSMOSC-UHFFFAOYSA-N 0.000 claims 1
JZNVXTFMWASSPL-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methoxypyridin-2-yl)amino]methyl]thiophen-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC=C(CNC=3N=CC=C(OC)C=3)C=2)C=C1 JZNVXTFMWASSPL-UHFFFAOYSA-N 0.000 claims 1
AMSRRIUKCBIGFW-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC=C(CNC=3N=CC=C(C)C=3)N=2)C=C1 AMSRRIUKCBIGFW-UHFFFAOYSA-N 0.000 claims 1
KUHFEKXVUCBSAJ-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]-1h-pyrrol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 KUHFEKXVUCBSAJ-UHFFFAOYSA-N 0.000 claims 1
UTMAWTBTTWPULL-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]furan-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 UTMAWTBTTWPULL-UHFFFAOYSA-N 0.000 claims 1
WVLPMFPARVLOOF-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]thiophen-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 WVLPMFPARVLOOF-UHFFFAOYSA-N 0.000 claims 1
WRJCYTWDQSPKJG-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[(1h-imidazol-2-ylamino)methyl]-1h-1,2,4-triazol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3NC=CN=3)=NN=2)C=C1 WRJCYTWDQSPKJG-UHFFFAOYSA-N 0.000 claims 1
VVXFYGQPHXLZDC-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methoxypyridin-2-yl)amino]methyl]-1,2-oxazol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C2=NOC(CNC=3N=CC=C(OC)C=3)=C2)C=C1 VVXFYGQPHXLZDC-UHFFFAOYSA-N 0.000 claims 1
WGDNIYXUVJQPRB-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methoxypyridin-2-yl)amino]methyl]-1,2-thiazol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C2=NSC(CNC=3N=CC=C(OC)C=3)=C2)C=C1 WGDNIYXUVJQPRB-UHFFFAOYSA-N 0.000 claims 1
FVCDRFGBCGZZFA-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-oxazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(OC)C=3)=CN=2)C=C1 FVCDRFGBCGZZFA-UHFFFAOYSA-N 0.000 claims 1
TZVULEHCCNRPCQ-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(OC)C=3)=CN=2)C=C1 TZVULEHCCNRPCQ-UHFFFAOYSA-N 0.000 claims 1
HEUYKMXYICJFDJ-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methoxypyridin-2-yl)amino]methyl]-1h-imidazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3N=CC=C(OC)C=3)=CN=2)C=C1 HEUYKMXYICJFDJ-UHFFFAOYSA-N 0.000 claims 1
WLBZCCJZXRMNCH-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methoxypyridin-2-yl)amino]methyl]-1h-pyrrol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3N=CC=C(OC)C=3)=CC=2)C=C1 WLBZCCJZXRMNCH-UHFFFAOYSA-N 0.000 claims 1
LRANVQFNNGKOCH-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methoxypyridin-2-yl)amino]methyl]-1h-pyrrol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3N=CC=C(OC)C=3)NC=2)C=C1 LRANVQFNNGKOCH-UHFFFAOYSA-N 0.000 claims 1
AFGOAZXSYHIPJD-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methoxypyridin-2-yl)amino]methyl]furan-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(OC)C=3)=CC=2)C=C1 AFGOAZXSYHIPJD-UHFFFAOYSA-N 0.000 claims 1
TWXBNYPIWJRXFU-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methoxypyridin-2-yl)amino]methyl]thiophen-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(OC)C=3)=CC=2)C=C1 TWXBNYPIWJRXFU-UHFFFAOYSA-N 0.000 claims 1
INKXATIYWCYYEY-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-thiazol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C2=NSC(CNC=3N=CC=C(C)C=3)=C2)C=C1 INKXATIYWCYYEY-UHFFFAOYSA-N 0.000 claims 1
OIGYWZJNJPLBMV-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3,4-oxadiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=NN=2)C=C1 OIGYWZJNJPLBMV-UHFFFAOYSA-N 0.000 claims 1
ACRSWTWNNAPOND-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=CN=2)C=C1 ACRSWTWNNAPOND-UHFFFAOYSA-N 0.000 claims 1
DBPMFFNJNPTJNH-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1h-imidazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3N=CC=C(C)C=3)=CN=2)C=C1 DBPMFFNJNPTJNH-UHFFFAOYSA-N 0.000 claims 1
QLPNKBHRLDXQAU-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1h-pyrrol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3N=CC=C(C)C=3)=CC=2)C=C1 QLPNKBHRLDXQAU-UHFFFAOYSA-N 0.000 claims 1
KTNCUWWKODNRMY-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1h-pyrrol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3N=CC=C(C)C=3)NC=2)C=C1 KTNCUWWKODNRMY-UHFFFAOYSA-N 0.000 claims 1
FEERBSCTBCFGLM-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]furan-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=CC=2)C=C1 FEERBSCTBCFGLM-UHFFFAOYSA-N 0.000 claims 1
MWBWJZHXKWCUKR-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]furan-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3N=CC=C(C)C=3)OC=2)C=C1 MWBWJZHXKWCUKR-UHFFFAOYSA-N 0.000 claims 1
XYFOAGAUEZPRIO-UHFFFAOYSA-N 2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]thiophen-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(C)C=3)=CC=2)C=C1 XYFOAGAUEZPRIO-UHFFFAOYSA-N 0.000 claims 1
PPKIJWMXOIQIAO-UHFFFAOYSA-N 2-[(2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]furan-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 PPKIJWMXOIQIAO-UHFFFAOYSA-N 0.000 claims 1
XYAPQCFDZCQNLY-UHFFFAOYSA-N 2-[(2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]triazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=NC(CNC=3N=CC=C(C)C=3)=C2)C=C1 XYAPQCFDZCQNLY-UHFFFAOYSA-N 0.000 claims 1
JLAVTDCZFBCJOM-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-4-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3N=CC=C(C)C=3)OC=2)C=C1 JLAVTDCZFBCJOM-UHFFFAOYSA-N 0.000 claims 1
NDMGMQOVXNUJFI-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=NC=2)C=C1 NDMGMQOVXNUJFI-UHFFFAOYSA-N 0.000 claims 1
XDBMWIGJQOGOKW-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-4-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3N=CC=C(C)C=3)SC=2)C=C1 XDBMWIGJQOGOKW-UHFFFAOYSA-N 0.000 claims 1
BURRDVLGSYFZTI-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(C)C=3)=NC=2)C=C1 BURRDVLGSYFZTI-UHFFFAOYSA-N 0.000 claims 1
FKQWISITIQMWQR-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2,4-thiadiazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SN=C(CNC=3N=CC=C(C)C=3)N=2)C=C1 FKQWISITIQMWQR-UHFFFAOYSA-N 0.000 claims 1
FQQIVRVGUZQGQT-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2,4-triazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3N=CC=C(C)C=3)N=C2)C=C1 FQQIVRVGUZQGQT-UHFFFAOYSA-N 0.000 claims 1
ZGGNMBDKCKEYDY-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-oxazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2ON=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 ZGGNMBDKCKEYDY-UHFFFAOYSA-N 0.000 claims 1
UGWBONLGKFXAEW-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-thiazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SN=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 UGWBONLGKFXAEW-UHFFFAOYSA-N 0.000 claims 1
QRBPXWGKFWZDJU-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]pyrazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3N=CC=C(C)C=3)C=C2)C=C1 QRBPXWGKFWZDJU-UHFFFAOYSA-N 0.000 claims 1
ZAYFXXSLSNKSAW-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]pyrrol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2C=C(CNC=3N=CC=C(C)C=3)C=C2)C=C1 ZAYFXXSLSNKSAW-UHFFFAOYSA-N 0.000 claims 1
AKGKZXKIWQIYBG-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3N=CC=C(C)C=3)N=2)C=C1 AKGKZXKIWQIYBG-UHFFFAOYSA-N 0.000 claims 1
QQTBCAABZXMBJE-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC=C(CNC=3N=CC=C(C)C=3)N=2)C=C1 QQTBCAABZXMBJE-UHFFFAOYSA-N 0.000 claims 1
RUJUMVCCCKDCOZ-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]-1h-pyrrol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 RUJUMVCCCKDCOZ-UHFFFAOYSA-N 0.000 claims 1
FJHPVYGJXVHDDO-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]furan-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 FJHPVYGJXVHDDO-UHFFFAOYSA-N 0.000 claims 1
YFAMQXFXLAXMMT-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]imidazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2C=C(CNC=3N=CC=C(C)C=3)N=C2)C=C1 YFAMQXFXLAXMMT-UHFFFAOYSA-N 0.000 claims 1
MTJGFXMSBVOPNL-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]thiophen-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 MTJGFXMSBVOPNL-UHFFFAOYSA-N 0.000 claims 1
PQIZTGGBHVCXES-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,2,4-thiadiazol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3N=CC=C(C)C=3)SN=2)C=C1 PQIZTGGBHVCXES-UHFFFAOYSA-N 0.000 claims 1
AQVGJWXQQXBRGR-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-oxazol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C2=NOC(CNC=3N=CC=C(C)C=3)=C2)C=C1 AQVGJWXQQXBRGR-UHFFFAOYSA-N 0.000 claims 1
LKKWEJSJAZHEIG-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-thiazol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C2=NSC(CNC=3N=CC=C(C)C=3)=C2)C=C1 LKKWEJSJAZHEIG-UHFFFAOYSA-N 0.000 claims 1
KBZJAEZRTBJYFK-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3,4-oxadiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=NN=2)C=C1 KBZJAEZRTBJYFK-UHFFFAOYSA-N 0.000 claims 1
LQJWLDDPWSIXJV-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=CN=2)C=C1 LQJWLDDPWSIXJV-UHFFFAOYSA-N 0.000 claims 1
JUJDYTLWNQGSPQ-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(C)C=3)=CN=2)C=C1 JUJDYTLWNQGSPQ-UHFFFAOYSA-N 0.000 claims 1
SJUPXZJEKUDOSR-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1h-pyrrol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3N=CC=C(C)C=3)=CC=2)C=C1 SJUPXZJEKUDOSR-UHFFFAOYSA-N 0.000 claims 1
ZKIJUVUGMSOHAS-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1h-pyrrol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3N=CC=C(C)C=3)NC=2)C=C1 ZKIJUVUGMSOHAS-UHFFFAOYSA-N 0.000 claims 1
NOIVJJYDQSUNLF-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]furan-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=CC=2)C=C1 NOIVJJYDQSUNLF-UHFFFAOYSA-N 0.000 claims 1
VFWLORRYQURCMS-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]furan-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3N=CC=C(C)C=3)OC=2)C=C1 VFWLORRYQURCMS-UHFFFAOYSA-N 0.000 claims 1
NEJAGXCFZNKOPH-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]thiophen-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(C)C=3)=CC=2)C=C1 NEJAGXCFZNKOPH-UHFFFAOYSA-N 0.000 claims 1
LGLMYOHMUBFNMV-UHFFFAOYSA-N 2-[(4-chloro-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]thiophen-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(Cl)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3N=CC=C(C)C=3)SC=2)C=C1 LGLMYOHMUBFNMV-UHFFFAOYSA-N 0.000 claims 1
LZHHAZCKXRTBCG-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-4-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3N=CC=C(C)C=3)OC=2)C=C1 LZHHAZCKXRTBCG-UHFFFAOYSA-N 0.000 claims 1
GEABKGZBQJVTEM-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=NC=2)C=C1 GEABKGZBQJVTEM-UHFFFAOYSA-N 0.000 claims 1
OFSJNGKAQSZZHR-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-4-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3N=CC=C(C)C=3)SC=2)C=C1 OFSJNGKAQSZZHR-UHFFFAOYSA-N 0.000 claims 1
FXCJUOFBNVVMIF-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(C)C=3)=NC=2)C=C1 FXCJUOFBNVVMIF-UHFFFAOYSA-N 0.000 claims 1
KCQXGPNBQBSAIX-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2,4-thiadiazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SN=C(CNC=3N=CC=C(C)C=3)N=2)C=C1 KCQXGPNBQBSAIX-UHFFFAOYSA-N 0.000 claims 1
AWAOIMZJVYQVFR-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2,4-triazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3N=CC=C(C)C=3)N=C2)C=C1 AWAOIMZJVYQVFR-UHFFFAOYSA-N 0.000 claims 1
CLTQLGXBNLALEZ-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-oxazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2ON=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 CLTQLGXBNLALEZ-UHFFFAOYSA-N 0.000 claims 1
QJCBHWZMXZGHPX-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-thiazol-5-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SN=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 QJCBHWZMXZGHPX-UHFFFAOYSA-N 0.000 claims 1
CBUJFZWUTQSPIH-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]pyrazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3N=CC=C(C)C=3)C=C2)C=C1 CBUJFZWUTQSPIH-UHFFFAOYSA-N 0.000 claims 1
XUIOOTBGFKMRAZ-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3N=CC=C(C)C=3)N=2)C=C1 XUIOOTBGFKMRAZ-UHFFFAOYSA-N 0.000 claims 1
NGUUJGDFILFGFW-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC=C(CNC=3N=CC=C(C)C=3)N=2)C=C1 NGUUJGDFILFGFW-UHFFFAOYSA-N 0.000 claims 1
VQVVMGLRRXRVQA-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]furan-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 VQVVMGLRRXRVQA-UHFFFAOYSA-N 0.000 claims 1
SFEJFXZBMKQSDB-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]imidazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2C=C(CNC=3N=CC=C(C)C=3)N=C2)C=C1 SFEJFXZBMKQSDB-UHFFFAOYSA-N 0.000 claims 1
MNAXKDKLDMYLMD-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]thiophen-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC=C(CNC=3N=CC=C(C)C=3)C=2)C=C1 MNAXKDKLDMYLMD-UHFFFAOYSA-N 0.000 claims 1
UKSWIWFPQRTVCH-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]triazol-1-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=NC(CNC=3N=CC=C(C)C=3)=C2)C=C1 UKSWIWFPQRTVCH-UHFFFAOYSA-N 0.000 claims 1
PNYBZXSSPKURIS-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,2,4-thiadiazol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3N=CC=C(C)C=3)SN=2)C=C1 PNYBZXSSPKURIS-UHFFFAOYSA-N 0.000 claims 1
MUPJJYRPMYDSQC-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-oxazol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C2=NOC(CNC=3N=CC=C(C)C=3)=C2)C=C1 MUPJJYRPMYDSQC-UHFFFAOYSA-N 0.000 claims 1
SVHMIPRZUQAHSA-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-thiazol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C2=NSC(CNC=3N=CC=C(C)C=3)=C2)C=C1 SVHMIPRZUQAHSA-UHFFFAOYSA-N 0.000 claims 1
HMAOKQJUNFBBEL-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3,4-oxadiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=NN=2)C=C1 HMAOKQJUNFBBEL-UHFFFAOYSA-N 0.000 claims 1
HTGXIEVJYGNTAJ-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3,4-thiadiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(C)C=3)=NN=2)C=C1 HTGXIEVJYGNTAJ-UHFFFAOYSA-N 0.000 claims 1
UNRAGJHYTLZVGX-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=CN=2)C=C1 UNRAGJHYTLZVGX-UHFFFAOYSA-N 0.000 claims 1
QBCLRGIXESABDF-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(C)C=3)=CN=2)C=C1 QBCLRGIXESABDF-UHFFFAOYSA-N 0.000 claims 1
ZNIQZHBGLINOLE-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1h-pyrrol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3N=CC=C(C)C=3)=CC=2)C=C1 ZNIQZHBGLINOLE-UHFFFAOYSA-N 0.000 claims 1
VRWURWVAHABBPR-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1h-pyrrol-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3N=CC=C(C)C=3)NC=2)C=C1 VRWURWVAHABBPR-UHFFFAOYSA-N 0.000 claims 1
PEZXIDNZPFIQNE-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]furan-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=CC=2)C=C1 PEZXIDNZPFIQNE-UHFFFAOYSA-N 0.000 claims 1
NZFMBKCFRLPHIX-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]furan-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3N=CC=C(C)C=3)OC=2)C=C1 NZFMBKCFRLPHIX-UHFFFAOYSA-N 0.000 claims 1
QNGJKRRQSALHPI-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]thiophen-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(C)C=3)=CC=2)C=C1 QNGJKRRQSALHPI-UHFFFAOYSA-N 0.000 claims 1
KESGQBXBYDBBAE-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]thiophen-3-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3N=CC=C(C)C=3)SC=2)C=C1 KESGQBXBYDBBAE-UHFFFAOYSA-N 0.000 claims 1
GMCJIDOHCIKPRJ-UHFFFAOYSA-N 2-[(4-fluoro-2,6-dimethylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]furan-2-yl]phenyl]propanoic acid Chemical compound CC1=CC=NC(NCC=2C=C(OC=2)C=2C=CC(CC(NC(=O)C=3C(=CC(F)=CC=3C)C)C(O)=O)=CC=2)=C1 GMCJIDOHCIKPRJ-UHFFFAOYSA-N 0.000 claims 1
RXGKXEXMRNEZHO-UHFFFAOYSA-N 2-[(4-fluoro-2,6-dimethylbenzoyl)amino]-3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]triazol-1-yl]phenyl]propanoic acid Chemical compound CC1=CC=NC(NCC=2N=NN(C=2)C=2C=CC(CC(NC(=O)C=3C(=CC(F)=CC=3C)C)C(O)=O)=CC=2)=C1 RXGKXEXMRNEZHO-UHFFFAOYSA-N 0.000 claims 1
ZZGHWYIEKZDGFX-UHFFFAOYSA-N 3-[4-[2-[(1h-imidazol-2-ylamino)methyl]-1,3-oxazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3NC=CN=3)OC=2)C=C1 ZZGHWYIEKZDGFX-UHFFFAOYSA-N 0.000 claims 1
BBOZWJWPSUOIGG-UHFFFAOYSA-N 3-[4-[2-[(1h-imidazol-2-ylamino)methyl]-1,3-oxazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3NC=CN=3)=NC=2)C=C1 BBOZWJWPSUOIGG-UHFFFAOYSA-N 0.000 claims 1
LOZSZXVYTNHOKC-UHFFFAOYSA-N 3-[4-[2-[(1h-imidazol-2-ylamino)methyl]-1,3-thiazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3NC=CN=3)SC=2)C=C1 LOZSZXVYTNHOKC-UHFFFAOYSA-N 0.000 claims 1
LXZIIGOLDAIMKG-UHFFFAOYSA-N 3-[4-[2-[(1h-imidazol-2-ylamino)methyl]-1,3-thiazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3NC=CN=3)=NC=2)C=C1 LXZIIGOLDAIMKG-UHFFFAOYSA-N 0.000 claims 1
AQHDVVNPKIHQEE-UHFFFAOYSA-N 3-[4-[2-[(1h-imidazol-2-ylamino)methyl]-1h-imidazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3NC=CN=3)NC=2)C=C1 AQHDVVNPKIHQEE-UHFFFAOYSA-N 0.000 claims 1
AZGNFAFIGSHOOD-UHFFFAOYSA-N 3-[4-[2-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-oxazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2OC=C(N=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 AZGNFAFIGSHOOD-UHFFFAOYSA-N 0.000 claims 1
SYMNEXZFDXMTAX-UHFFFAOYSA-N 3-[4-[2-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-oxazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2OC(=CN=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 SYMNEXZFDXMTAX-UHFFFAOYSA-N 0.000 claims 1
HKIWULZYOJPPKK-UHFFFAOYSA-N 3-[4-[2-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-thiazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2SC=C(N=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 HKIWULZYOJPPKK-UHFFFAOYSA-N 0.000 claims 1
SJPJMRFEQBLQSA-UHFFFAOYSA-N 3-[4-[2-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-thiazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2SC(=CN=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 SJPJMRFEQBLQSA-UHFFFAOYSA-N 0.000 claims 1
JAZRVZBIIFBWBK-UHFFFAOYSA-N 3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2OC=C(N=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 JAZRVZBIIFBWBK-UHFFFAOYSA-N 0.000 claims 1
IMQOIMKCENQJPI-UHFFFAOYSA-N 3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2OC(=CN=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 IMQOIMKCENQJPI-UHFFFAOYSA-N 0.000 claims 1
DJWGWKWBCVSVPK-UHFFFAOYSA-N 3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2SC=C(N=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 DJWGWKWBCVSVPK-UHFFFAOYSA-N 0.000 claims 1
KOEIHNQIADMVQW-UHFFFAOYSA-N 3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2SC(=CN=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 KOEIHNQIADMVQW-UHFFFAOYSA-N 0.000 claims 1
YWWFKFLJKKUHLA-UHFFFAOYSA-N 3-[4-[3-[(1h-benzimidazol-2-ylamino)methyl]-1,2,4-triazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3NC4=CC=CC=C4N=3)N=C2)C=C1 YWWFKFLJKKUHLA-UHFFFAOYSA-N 0.000 claims 1
CUVYCHLYIJVYBF-UHFFFAOYSA-N 3-[4-[3-[(1h-benzimidazol-2-ylamino)methyl]-1,2,4-triazol-1-yl]phenyl]-2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3NC4=CC=CC=C4N=3)N=C2)C=C1 CUVYCHLYIJVYBF-UHFFFAOYSA-N 0.000 claims 1
IPCLVKCIMWPHSI-UHFFFAOYSA-N 3-[4-[3-[(1h-imidazol-2-ylamino)methyl]-1,2,4-triazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3NC=CN=3)N=C2)C=C1 IPCLVKCIMWPHSI-UHFFFAOYSA-N 0.000 claims 1
FMCQYUNUYUNWIV-UHFFFAOYSA-N 3-[4-[3-[(1h-imidazol-2-ylamino)methyl]-1,2-oxazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2ON=C(CNC=3NC=CN=3)C=2)C=C1 FMCQYUNUYUNWIV-UHFFFAOYSA-N 0.000 claims 1
JMQODZNTMNQLAT-UHFFFAOYSA-N 3-[4-[3-[(1h-imidazol-2-ylamino)methyl]-1,2-thiazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SN=C(CNC=3NC=CN=3)C=2)C=C1 JMQODZNTMNQLAT-UHFFFAOYSA-N 0.000 claims 1
NBICOZJQTRKKLI-UHFFFAOYSA-N 3-[4-[3-[(1h-imidazol-2-ylamino)methyl]pyrazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3NC=CN=3)C=C2)C=C1 NBICOZJQTRKKLI-UHFFFAOYSA-N 0.000 claims 1
VLBFQDOUULQTBZ-UHFFFAOYSA-N 3-[4-[3-[[(4-methoxypyridin-2-yl)amino]methyl]-1,2-oxazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC2=NOC(=C2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 VLBFQDOUULQTBZ-UHFFFAOYSA-N 0.000 claims 1
PYEUFTUGRVIFNF-UHFFFAOYSA-N 3-[4-[3-[[(4-methoxypyridin-2-yl)amino]methyl]-1,2-thiazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC2=NSC(=C2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 PYEUFTUGRVIFNF-UHFFFAOYSA-N 0.000 claims 1
XRIHUZYLIIDSBZ-UHFFFAOYSA-N 3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-oxazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC2=NOC(=C2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 XRIHUZYLIIDSBZ-UHFFFAOYSA-N 0.000 claims 1
PEIFIJHWDMOEFY-UHFFFAOYSA-N 3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]-1,2-thiazol-5-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC2=NSC(=C2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 PEIFIJHWDMOEFY-UHFFFAOYSA-N 0.000 claims 1
HXKJQECTXPNISX-UHFFFAOYSA-N 3-[4-[4-[(1,2-oxazol-3-ylamino)methyl]triazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=NC(CNC3=NOC=C3)=C2)C=C1 HXKJQECTXPNISX-UHFFFAOYSA-N 0.000 claims 1
WFZKROQHHVPSNR-UHFFFAOYSA-N 3-[4-[4-[(1,3-thiazol-2-ylamino)methyl]triazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=NC(CNC=3SC=CN=3)=C2)C=C1 WFZKROQHHVPSNR-UHFFFAOYSA-N 0.000 claims 1
JMNXIBOAEXSEQX-UHFFFAOYSA-N 3-[4-[4-[(1h-benzimidazol-2-ylamino)methyl]triazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=NC(CNC=3NC4=CC=CC=C4N=3)=C2)C=C1 JMNXIBOAEXSEQX-UHFFFAOYSA-N 0.000 claims 1
JMMWBNMECNXTQS-UHFFFAOYSA-N 3-[4-[4-[(1h-benzimidazol-2-ylamino)methyl]triazol-1-yl]phenyl]-2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=NC(CNC=3NC4=CC=CC=C4N=3)=C2)C=C1 JMMWBNMECNXTQS-UHFFFAOYSA-N 0.000 claims 1
YFWUVUYSPUGDEW-UHFFFAOYSA-N 3-[4-[4-[(1h-imidazol-2-ylamino)methyl]-1,3-oxazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3NC=CN=3)N=2)C=C1 YFWUVUYSPUGDEW-UHFFFAOYSA-N 0.000 claims 1
ZCGARPVOUXQJBC-UHFFFAOYSA-N 3-[4-[4-[(1h-imidazol-2-ylamino)methyl]-1,3-thiazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC=C(CNC=3NC=CN=3)N=2)C=C1 ZCGARPVOUXQJBC-UHFFFAOYSA-N 0.000 claims 1
KVUOYTFIUFODLR-UHFFFAOYSA-N 3-[4-[4-[(1h-imidazol-2-ylamino)methyl]-1h-pyrrol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC=C(CNC=3NC=CN=3)C=2)C=C1 KVUOYTFIUFODLR-UHFFFAOYSA-N 0.000 claims 1
HOTOKJWMPJEUHF-UHFFFAOYSA-N 3-[4-[4-[(1h-imidazol-2-ylamino)methyl]furan-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3NC=CN=3)C=2)C=C1 HOTOKJWMPJEUHF-UHFFFAOYSA-N 0.000 claims 1
HEOQRFSBGFYRBL-UHFFFAOYSA-N 3-[4-[4-[(1h-imidazol-2-ylamino)methyl]imidazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2C=C(CNC=3NC=CN=3)N=C2)C=C1 HEOQRFSBGFYRBL-UHFFFAOYSA-N 0.000 claims 1
QCFMPJYVRBILKS-UHFFFAOYSA-N 3-[4-[4-[(1h-imidazol-2-ylamino)methyl]pyrazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=CC(CNC=3NC=CN=3)=C2)C=C1 QCFMPJYVRBILKS-UHFFFAOYSA-N 0.000 claims 1
IXFGACAXUIYRJN-UHFFFAOYSA-N 3-[4-[4-[(1h-imidazol-2-ylamino)methyl]thiophen-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC=C(CNC=3NC=CN=3)C=2)C=C1 IXFGACAXUIYRJN-UHFFFAOYSA-N 0.000 claims 1
CDGDJMLJPNGCEI-UHFFFAOYSA-N 3-[4-[4-[(1h-imidazol-2-ylamino)methyl]triazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=NC(CNC=3NC=CN=3)=C2)C=C1 CDGDJMLJPNGCEI-UHFFFAOYSA-N 0.000 claims 1
VJZQVBCJWQXXRI-UHFFFAOYSA-N 3-[4-[4-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-oxazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2N=C(OC=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 VJZQVBCJWQXXRI-UHFFFAOYSA-N 0.000 claims 1
RWWOVLHCBSMPSV-UHFFFAOYSA-N 3-[4-[4-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2N=C(SC=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 RWWOVLHCBSMPSV-UHFFFAOYSA-N 0.000 claims 1
FRSYATQBQPRMQJ-UHFFFAOYSA-N 3-[4-[4-[[(4-methoxypyridin-2-yl)amino]methyl]furan-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2C=C(OC=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 FRSYATQBQPRMQJ-UHFFFAOYSA-N 0.000 claims 1
OBHYTZGMDPWUTC-UHFFFAOYSA-N 3-[4-[4-[[(4-methoxypyridin-2-yl)amino]methyl]thiophen-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2C=C(SC=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 OBHYTZGMDPWUTC-UHFFFAOYSA-N 0.000 claims 1
FCRZQGFXLZHVOF-UHFFFAOYSA-N 3-[4-[4-[[(4-methoxypyridin-2-yl)amino]methyl]triazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2N=NN(C=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 FCRZQGFXLZHVOF-UHFFFAOYSA-N 0.000 claims 1
ORQUZRUVVNEMRL-UHFFFAOYSA-N 3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2N=C(OC=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 ORQUZRUVVNEMRL-UHFFFAOYSA-N 0.000 claims 1
BXEINKWRIJRXNY-UHFFFAOYSA-N 3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2N=C(SC=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 BXEINKWRIJRXNY-UHFFFAOYSA-N 0.000 claims 1
GNNSUMADLWATJP-UHFFFAOYSA-N 3-[4-[4-[[(4-methylpyridin-2-yl)amino]methyl]triazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2N=NN(C=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 GNNSUMADLWATJP-UHFFFAOYSA-N 0.000 claims 1
IBDNZGIQWNVEMX-UHFFFAOYSA-N 3-[4-[4-[[(5-methyl-1,3-thiazol-2-yl)amino]methyl]triazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound S1C(C)=CN=C1NCC1=CN(C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)N=N1 IBDNZGIQWNVEMX-UHFFFAOYSA-N 0.000 claims 1
HNSVYCYTDHWVJJ-UHFFFAOYSA-N 3-[4-[5-[(1h-benzimidazol-2-ylamino)methyl]-1,2-thiazol-3-yl]phenyl]-2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C2=NSC(CNC=3NC4=CC=CC=C4N=3)=C2)C=C1 HNSVYCYTDHWVJJ-UHFFFAOYSA-N 0.000 claims 1
UKHCDPZDYFZJKM-UHFFFAOYSA-N 3-[4-[5-[(1h-benzimidazol-2-ylamino)methyl]-1,3,4-oxadiazol-2-yl]phenyl]-2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3NC4=CC=CC=C4N=3)=NN=2)C=C1 UKHCDPZDYFZJKM-UHFFFAOYSA-N 0.000 claims 1
UKVIJYSNQAONNJ-UHFFFAOYSA-N 3-[4-[5-[(1h-benzimidazol-2-ylamino)methyl]-1,3,4-thiadiazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3NC4=CC=CC=C4N=3)=NN=2)C=C1 UKVIJYSNQAONNJ-UHFFFAOYSA-N 0.000 claims 1
VMMKRKDDAVXUFP-UHFFFAOYSA-N 3-[4-[5-[(1h-benzimidazol-2-ylamino)methyl]-1h-1,2,4-triazol-3-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3NC4=CC=CC=C4N=3)=NN=2)C=C1 VMMKRKDDAVXUFP-UHFFFAOYSA-N 0.000 claims 1
OFWAXJVULMIKQP-UHFFFAOYSA-N 3-[4-[5-[(1h-benzimidazol-2-ylamino)methyl]-1h-1,2,4-triazol-3-yl]phenyl]-2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3NC4=CC=CC=C4N=3)=NN=2)C=C1 OFWAXJVULMIKQP-UHFFFAOYSA-N 0.000 claims 1
BALPINRAEVFSOF-UHFFFAOYSA-N 3-[4-[5-[(1h-benzimidazol-2-ylamino)methyl]furan-2-yl]phenyl]-2-[(2-ethyl-4-fluoro-6-methylbenzoyl)amino]propanoic acid Chemical compound CCC1=CC(F)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3NC4=CC=CC=C4N=3)=CC=2)C=C1 BALPINRAEVFSOF-UHFFFAOYSA-N 0.000 claims 1
DXOPIBHYXDMGFE-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]-1,2-oxazol-3-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C2=NOC(CNC=3NC=CN=3)=C2)C=C1 DXOPIBHYXDMGFE-UHFFFAOYSA-N 0.000 claims 1
RUCVLHRMUHBDGA-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]-1,2-thiazol-3-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C2=NSC(CNC=3NC=CN=3)=C2)C=C1 RUCVLHRMUHBDGA-UHFFFAOYSA-N 0.000 claims 1
CDOZKRKTEZWLIH-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]-1,3-oxazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3NC=CN=3)=CN=2)C=C1 CDOZKRKTEZWLIH-UHFFFAOYSA-N 0.000 claims 1
XMPPPLXUODHDBJ-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]-1,3-thiazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3NC=CN=3)=CN=2)C=C1 XMPPPLXUODHDBJ-UHFFFAOYSA-N 0.000 claims 1
LWYAHMJMMRICOC-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]-1h-1,2,4-triazol-3-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3NC=CN=3)=NN=2)C=C1 LWYAHMJMMRICOC-UHFFFAOYSA-N 0.000 claims 1
ZRKLLNOLGCZISI-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]-1h-pyrrol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2NC(CNC=3NC=CN=3)=CC=2)C=C1 ZRKLLNOLGCZISI-UHFFFAOYSA-N 0.000 claims 1
WDPVYSAANGPKPC-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]-1h-pyrrol-3-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3NC=CN=3)NC=2)C=C1 WDPVYSAANGPKPC-UHFFFAOYSA-N 0.000 claims 1
ZPEKRPGXTNVATH-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]furan-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3NC=CN=3)=CC=2)C=C1 ZPEKRPGXTNVATH-UHFFFAOYSA-N 0.000 claims 1
SPDALJSDUBCXSK-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]furan-3-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3NC=CN=3)OC=2)C=C1 SPDALJSDUBCXSK-UHFFFAOYSA-N 0.000 claims 1
CHMDAAGIQKRSAH-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]thiophen-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3NC=CN=3)=CC=2)C=C1 CHMDAAGIQKRSAH-UHFFFAOYSA-N 0.000 claims 1
TZPPPRZIGXJFLA-UHFFFAOYSA-N 3-[4-[5-[(1h-imidazol-2-ylamino)methyl]thiophen-3-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2C=C(CNC=3NC=CN=3)SC=2)C=C1 TZPPPRZIGXJFLA-UHFFFAOYSA-N 0.000 claims 1
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JP2009510340A 2006-05-12 2007-05-14 インテグリンを阻害する新規複素環化合物及びその使用 Pending JP2009536961A (ja)