AU2007251756A1 - New heterocyclic compounds for the inhibition of integrins and use thereof - Google Patents
New heterocyclic compounds for the inhibition of integrins and use thereof Download PDFInfo
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- AU2007251756A1 AU2007251756A1 AU2007251756A AU2007251756A AU2007251756A1 AU 2007251756 A1 AU2007251756 A1 AU 2007251756A1 AU 2007251756 A AU2007251756 A AU 2007251756A AU 2007251756 A AU2007251756 A AU 2007251756A AU 2007251756 A1 AU2007251756 A1 AU 2007251756A1
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- Prior art keywords
- ylamino
- methyl
- phenyl
- propanoic acid
- acid compound
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06009872 | 2006-05-12 | ||
| EP06009872.0 | 2006-05-12 | ||
| PCT/EP2007/004283 WO2007131764A2 (en) | 2006-05-12 | 2007-05-14 | New heterocyclic compounds for the inhibition of integrins and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2007251756A1 true AU2007251756A1 (en) | 2007-11-22 |
Family
ID=38564437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007251756A Abandoned AU2007251756A1 (en) | 2006-05-12 | 2007-05-14 | New heterocyclic compounds for the inhibition of integrins and use thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8309735B2 (https=) |
| EP (1) | EP2024357A2 (https=) |
| JP (1) | JP2009536961A (https=) |
| KR (1) | KR20090017512A (https=) |
| CN (1) | CN101448818A (https=) |
| AR (1) | AR060901A1 (https=) |
| AU (1) | AU2007251756A1 (https=) |
| BR (1) | BRPI0711659A2 (https=) |
| CA (1) | CA2652101A1 (https=) |
| IL (1) | IL194946A0 (https=) |
| MX (1) | MX2008014345A (https=) |
| RU (1) | RU2008148943A (https=) |
| TW (1) | TW200811164A (https=) |
| WO (1) | WO2007131764A2 (https=) |
| ZA (1) | ZA200809074B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059224A1 (es) | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| TW200811164A (en) | 2006-05-12 | 2008-03-01 | Jerini Ag | New heterocyclic compounds for the inhibition of integrins and use thereof |
| WO2008093064A1 (en) * | 2007-01-29 | 2008-08-07 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS α5 BETA 1 ANTAGONISTS |
| WO2010062829A1 (en) * | 2008-11-28 | 2010-06-03 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for treating osteoporosis |
| UA110924C2 (uk) * | 2009-08-05 | 2016-03-10 | Е. І. Дю Пон Де Немур Енд Компані | Мезоіонні пестициди |
| AU2010315190A1 (en) * | 2009-11-05 | 2012-05-10 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of cancer |
| WO2015048819A1 (en) | 2013-09-30 | 2015-04-02 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| CN103588770B (zh) * | 2013-11-27 | 2016-08-17 | 武汉尚赛光电科技有限公司 | 1，2，4-噻二唑衍生物及其作为电致发光材料的应用 |
| CA2981371A1 (en) * | 2015-03-10 | 2016-09-15 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| CN108794496B (zh) * | 2018-04-28 | 2020-04-24 | 北京施安泰医药技术开发有限公司 | 一类cdk抑制剂、其药物组合物、制备方法及用途 |
| EP3932912A4 (en) * | 2019-02-28 | 2022-09-07 | Osaka University | PROTEIN AND/OR PEPTIDE MODIFICATION MOLECULE |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE4302051A1 (de) * | 1993-01-26 | 1994-07-28 | Thomae Gmbh Dr K | 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| EP0895475A4 (en) * | 1995-12-29 | 2000-08-23 | Smithkline Beecham Corp | VITRONECTIN RECEPTOR ANTAGONISTS |
| EP1017382B1 (en) * | 1997-05-29 | 2006-03-01 | Merck & Co., Inc. (a New Jersey corp.) | Biarylalkanoic acids as cell adhesion inhibitors |
| AU1411499A (en) * | 1997-11-20 | 1999-06-15 | Merck & Co., Inc. | Para-aminomethylaryl carboxamide derivatives |
| MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| CZ20012185A3 (cs) * | 1998-12-16 | 2001-10-17 | Bayer Aktiengesellschaft | Nové bifenylové sloučeniny a sloučeniny analogické bifenylovým sloučeninám, způsob jejich přípravy, farmaceutické prostředky a pouľití těchto sloučenin a prostředků jako antagonistů integrinu |
| RU2270193C2 (ru) * | 1999-12-06 | 2006-02-20 | Ф.Хоффманн-Ля Рош Аг | 4-пиридинил-n-ацил-l-фенилаланины |
| US6388084B1 (en) * | 1999-12-06 | 2002-05-14 | Hoffmann-La Roche Inc. | 4-pyridinyl-n-acyl-l-phenylalanines |
| US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
| SK287781B6 (sk) * | 2000-08-18 | 2011-09-05 | Ajinomoto Co., Inc. | Fenylalanínové deriváty, farmaceutický prípravok s ich obsahom a ich použitie |
| JP4250423B2 (ja) * | 2001-03-19 | 2009-04-08 | 大日本住友製薬株式会社 | アリール置換脂環式化合物及びそれを含有する医薬組成物 |
| WO2003089410A1 (en) | 2002-04-19 | 2003-10-30 | Kyowa Hakko Kogyo Co., Ltd. | Phenylalanine derivative |
| AU2003278814A1 (en) * | 2002-09-13 | 2004-04-30 | Georgetown University | Ligands for the peroxisome proliferator-activated receptor, and methods of use thereof |
| GB0329584D0 (en) | 2003-12-20 | 2004-01-28 | Tanabe Seiyaku Co | Novel compounds |
| KR20070004676A (ko) * | 2004-02-10 | 2007-01-09 | 얀센 파마슈티카 엔.브이. | 알파４ 인테그린의 길항제로서의 피리다지논 |
| JP5032299B2 (ja) | 2004-03-24 | 2012-09-26 | シャイア・オーファン・セラピーズ・ゲーエムベーハー | 血管形成を阻害する新規化合物及びその使用 |
| BRPI0511099A (pt) * | 2004-05-14 | 2007-12-26 | Irm Llc | compostos e composições como moduladores de ppar |
| EP1954696B1 (en) * | 2005-01-19 | 2011-02-23 | Bristol-Myers Squibb Company | 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders |
| US8324265B2 (en) * | 2005-11-21 | 2012-12-04 | Shionogi & Co., Ltd. | Heterocyclic compounds having type I 11β hydroxysteroid dehydrogenase inhibitory activity |
| EP1957476A1 (en) | 2005-11-23 | 2008-08-20 | AstraZeneca AB | L-alanine derivatives |
| JP2009516729A (ja) * | 2005-11-23 | 2009-04-23 | アストラゼネカ アクチボラグ | Ｌ−フェニルアラニン誘導体 |
| AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| TW200811164A (en) | 2006-05-12 | 2008-03-01 | Jerini Ag | New heterocyclic compounds for the inhibition of integrins and use thereof |
-
2007
- 2007-05-11 TW TW096116863A patent/TW200811164A/zh unknown
- 2007-05-11 AR ARP070102052A patent/AR060901A1/es not_active Application Discontinuation
- 2007-05-14 MX MX2008014345A patent/MX2008014345A/es not_active Application Discontinuation
- 2007-05-14 KR KR1020087027452A patent/KR20090017512A/ko not_active Withdrawn
- 2007-05-14 RU RU2008148943/04A patent/RU2008148943A/ru not_active Application Discontinuation
- 2007-05-14 WO PCT/EP2007/004283 patent/WO2007131764A2/en not_active Ceased
- 2007-05-14 BR BRPI0711659-4A patent/BRPI0711659A2/pt not_active IP Right Cessation
- 2007-05-14 US US12/300,530 patent/US8309735B2/en not_active Expired - Fee Related
- 2007-05-14 EP EP07725202A patent/EP2024357A2/en not_active Withdrawn
- 2007-05-14 CN CNA2007800171978A patent/CN101448818A/zh active Pending
- 2007-05-14 AU AU2007251756A patent/AU2007251756A1/en not_active Abandoned
- 2007-05-14 CA CA002652101A patent/CA2652101A1/en not_active Abandoned
- 2007-05-14 JP JP2009510340A patent/JP2009536961A/ja active Pending
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2008
- 2008-10-22 ZA ZA200709074A patent/ZA200809074B/xx unknown
- 2008-10-27 IL IL194946A patent/IL194946A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR060901A1 (es) | 2008-07-23 |
| KR20090017512A (ko) | 2009-02-18 |
| ZA200809074B (en) | 2009-08-26 |
| CN101448818A (zh) | 2009-06-03 |
| US20090203745A1 (en) | 2009-08-13 |
| IL194946A0 (en) | 2009-08-03 |
| EP2024357A2 (en) | 2009-02-18 |
| BRPI0711659A2 (pt) | 2012-01-17 |
| WO2007131764A3 (en) | 2008-01-10 |
| WO2007131764A2 (en) | 2007-11-22 |
| RU2008148943A (ru) | 2010-06-20 |
| CA2652101A1 (en) | 2007-11-22 |
| MX2008014345A (es) | 2008-11-27 |
| JP2009536961A (ja) | 2009-10-22 |
| TW200811164A (en) | 2008-03-01 |
| US8309735B2 (en) | 2012-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |