BRPI0711659A2 - compostos heterocìclicos para a inibição de integrinas e uso dos mesmos - Google Patents

Info

Publication number

BRPI0711659A2

BRPI0711659A2 BRPI0711659-4A BRPI0711659A BRPI0711659A2 BR PI0711659 A2 BRPI0711659 A2 BR PI0711659A2 BR PI0711659 A BRPI0711659 A BR PI0711659A BR PI0711659 A2 BRPI0711659 A2 BR PI0711659A2

Authority

BR

Brazil

Prior art keywords

ylamino

methyl

phenyl

compound

ethyl

Prior art date

2006-05-12

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• UNRAGJHYTLZVGX-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC(CNC=3N=CC=C(C)C=3)=CN=2)C=C1 UNRAGJHYTLZVGX-UHFFFAOYSA-N 0.000 description 1
• QBCLRGIXESABDF-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(C)C=3)=CN=2)C=C1 QBCLRGIXESABDF-UHFFFAOYSA-N 0.000 description 1
• QNGJKRRQSALHPI-UHFFFAOYSA-N 2-[(4-cyano-2-ethyl-6-methylbenzoyl)amino]-3-[4-[5-[[(4-methylpyridin-2-yl)amino]methyl]thiophen-2-yl]phenyl]propanoic acid Chemical compound CCC1=CC(C#N)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC(CNC=3N=CC=C(C)C=3)=CC=2)C=C1 QNGJKRRQSALHPI-UHFFFAOYSA-N 0.000 description 1
• XESMERCPCQXGAI-UHFFFAOYSA-N 2-hydroxyiminoacetonitrile Chemical compound ON=CC#N XESMERCPCQXGAI-UHFFFAOYSA-N 0.000 description 1
• BQKDJIGYSSTTPL-UHFFFAOYSA-N 3-[4-[2-[(1h-benzimidazol-2-ylamino)methyl]-1,3-oxazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3NC4=CC=CC=C4N=3)OC=2)C=C1 BQKDJIGYSSTTPL-UHFFFAOYSA-N 0.000 description 1
• PZNOUKGDBVBQOO-UHFFFAOYSA-N 3-[4-[2-[(1h-benzimidazol-2-ylamino)methyl]-1,3-thiazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3NC4=CC=CC=C4N=3)SC=2)C=C1 PZNOUKGDBVBQOO-UHFFFAOYSA-N 0.000 description 1
• ZZGHWYIEKZDGFX-UHFFFAOYSA-N 3-[4-[2-[(1h-imidazol-2-ylamino)methyl]-1,3-oxazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3NC=CN=3)OC=2)C=C1 ZZGHWYIEKZDGFX-UHFFFAOYSA-N 0.000 description 1
• LOZSZXVYTNHOKC-UHFFFAOYSA-N 3-[4-[2-[(1h-imidazol-2-ylamino)methyl]-1,3-thiazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2N=C(CNC=3NC=CN=3)SC=2)C=C1 LOZSZXVYTNHOKC-UHFFFAOYSA-N 0.000 description 1
• AZGNFAFIGSHOOD-UHFFFAOYSA-N 3-[4-[2-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-oxazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2OC=C(N=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 AZGNFAFIGSHOOD-UHFFFAOYSA-N 0.000 description 1
• HKIWULZYOJPPKK-UHFFFAOYSA-N 3-[4-[2-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-thiazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2SC=C(N=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 HKIWULZYOJPPKK-UHFFFAOYSA-N 0.000 description 1
• JAZRVZBIIFBWBK-UHFFFAOYSA-N 3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-oxazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2OC=C(N=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 JAZRVZBIIFBWBK-UHFFFAOYSA-N 0.000 description 1
• DJWGWKWBCVSVPK-UHFFFAOYSA-N 3-[4-[2-[[(4-methylpyridin-2-yl)amino]methyl]-1,3-thiazol-4-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC=2SC=C(N=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 DJWGWKWBCVSVPK-UHFFFAOYSA-N 0.000 description 1
• NBICOZJQTRKKLI-UHFFFAOYSA-N 3-[4-[3-[(1h-imidazol-2-ylamino)methyl]pyrazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2N=C(CNC=3NC=CN=3)C=C2)C=C1 NBICOZJQTRKKLI-UHFFFAOYSA-N 0.000 description 1
• WARMQTLGTALKBE-UHFFFAOYSA-N 3-[4-[3-[(1h-imidazol-2-ylamino)methyl]pyrrol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(N2C=C(CNC=3NC=CN=3)C=C2)C=C1 WARMQTLGTALKBE-UHFFFAOYSA-N 0.000 description 1
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• DOBKHRCIBGKBLU-UHFFFAOYSA-N 3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]pyrazol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC2=NN(C=C2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 DOBKHRCIBGKBLU-UHFFFAOYSA-N 0.000 description 1
• CIKGTKGQLSRDOB-UHFFFAOYSA-N 3-[4-[3-[[(4-methylpyridin-2-yl)amino]methyl]pyrrol-1-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC=NC(NCC2=CN(C=C2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 CIKGTKGQLSRDOB-UHFFFAOYSA-N 0.000 description 1
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• UZKGPKUUKHXLMA-UHFFFAOYSA-N 3-[4-[4-[(1h-benzimidazol-2-ylamino)methyl]thiophen-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2SC=C(CNC=3NC4=CC=CC=C4N=3)C=2)C=C1 UZKGPKUUKHXLMA-UHFFFAOYSA-N 0.000 description 1
• YFWUVUYSPUGDEW-UHFFFAOYSA-N 3-[4-[4-[(1h-imidazol-2-ylamino)methyl]-1,3-oxazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3NC=CN=3)N=2)C=C1 YFWUVUYSPUGDEW-UHFFFAOYSA-N 0.000 description 1
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• HOTOKJWMPJEUHF-UHFFFAOYSA-N 3-[4-[4-[(1h-imidazol-2-ylamino)methyl]furan-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound CC1=CC(C)=CC(C)=C1C(=O)NC(C(O)=O)CC1=CC=C(C=2OC=C(CNC=3NC=CN=3)C=2)C=C1 HOTOKJWMPJEUHF-UHFFFAOYSA-N 0.000 description 1
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• RWWOVLHCBSMPSV-UHFFFAOYSA-N 3-[4-[4-[[(4-methoxypyridin-2-yl)amino]methyl]-1,3-thiazol-2-yl]phenyl]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid Chemical compound COC1=CC=NC(NCC=2N=C(SC=2)C=2C=CC(CC(NC(=O)C=3C(=CC(C)=CC=3C)C)C(O)=O)=CC=2)=C1 RWWOVLHCBSMPSV-UHFFFAOYSA-N 0.000 description 1
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