JP2009535356A5 - - Google Patents
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- Publication number
- JP2009535356A5 JP2009535356A5 JP2009507926A JP2009507926A JP2009535356A5 JP 2009535356 A5 JP2009535356 A5 JP 2009535356A5 JP 2009507926 A JP2009507926 A JP 2009507926A JP 2009507926 A JP2009507926 A JP 2009507926A JP 2009535356 A5 JP2009535356 A5 JP 2009535356A5
- Authority
- JP
- Japan
- Prior art keywords
- dichloro
- alkyl
- ylmethyl
- pyrrolidin
- biphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052736 halogen Inorganic materials 0.000 claims 26
- 150000002367 halogens Chemical class 0.000 claims 26
- 239000001257 hydrogen Substances 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 239000011780 sodium chloride Substances 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- PUOAETJYKQITMO-FYJGNVAPSA-N (3E)-1-[1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one Chemical compound C=1C=C(N2C=C(C)N=C2)C(OC)=CC=1\C=C(C1=O)/CCCN1C(C)C1=CC=C(F)C=C1 PUOAETJYKQITMO-FYJGNVAPSA-N 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- -1 3-cyclohexyl-1- {3,5-dichloro-4 '- [4- (2-Fluoro-ethyl) - - piperazine-l-carbonyl] - biphenyl-4-ylmethyl} - pyrrolidine Chemical compound 0.000 claims 2
- BAVYNXYHQISMBS-AREMUKBSSA-N (3R)-1-[[2,6-dichloro-4-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]phenyl]phenyl]methyl]-3-piperidin-1-ylpyrrolidin-2-one Chemical compound C1CC(C(F)(F)F)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(CN3C([C@H](N4CCCCC4)CC3)=O)=C(Cl)C=2)C=C1 BAVYNXYHQISMBS-AREMUKBSSA-N 0.000 claims 1
- KJVASKCAYRHBFP-RUZDIDTESA-N (3R)-3-cyclohexyl-1-[[2,6-dichloro-4-[4-[4-(2-fluoroethyl)piperazine-1-carbonyl]phenyl]phenyl]methyl]pyrrolidin-2-one Chemical compound C1CN(CCF)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(CN3C([C@@H](C4CCCCC4)CC3)=O)=C(Cl)C=2)C=C1 KJVASKCAYRHBFP-RUZDIDTESA-N 0.000 claims 1
- BAVYNXYHQISMBS-SANMLTNESA-N (3S)-1-[[2,6-dichloro-4-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]phenyl]phenyl]methyl]-3-piperidin-1-ylpyrrolidin-2-one Chemical compound C1CC(C(F)(F)F)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(CN3C([C@@H](N4CCCCC4)CC3)=O)=C(Cl)C=2)C=C1 BAVYNXYHQISMBS-SANMLTNESA-N 0.000 claims 1
- KJVASKCAYRHBFP-VWLOTQADSA-N (3S)-3-cyclohexyl-1-[[2,6-dichloro-4-[4-[4-(2-fluoroethyl)piperazine-1-carbonyl]phenyl]phenyl]methyl]pyrrolidin-2-one Chemical compound C1CN(CCF)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(CN3C([C@H](C4CCCCC4)CC3)=O)=C(Cl)C=2)C=C1 KJVASKCAYRHBFP-VWLOTQADSA-N 0.000 claims 1
- FRSHQQKXLGZQOZ-UHFFFAOYSA-N 1-[[2,6-dichloro-4-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]phenyl]phenyl]methyl]-3-(4,4-difluoropiperidin-1-yl)pyrrolidin-2-one Chemical compound C1CC(C(F)(F)F)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(CN3C(C(N4CCC(F)(F)CC4)CC3)=O)=C(Cl)C=2)C=C1 FRSHQQKXLGZQOZ-UHFFFAOYSA-N 0.000 claims 1
- KNNBQKGTSIDXMY-UHFFFAOYSA-N 1-[[2,6-dichloro-4-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]phenyl]phenyl]methyl]-3-(4-fluoropiperidin-1-yl)pyrrolidin-2-one Chemical compound C1CC(F)CCN1C1C(=O)N(CC=2C(=CC(=CC=2Cl)C=2C=CC(=CC=2)C(=O)N2CCC(CC2)C(F)(F)F)Cl)CC1 KNNBQKGTSIDXMY-UHFFFAOYSA-N 0.000 claims 1
- OOTHGGMVKQNVIB-UHFFFAOYSA-N 1-[[2,6-dichloro-4-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]phenyl]phenyl]methyl]-3-(4-hydroxycyclohexyl)pyrrolidin-2-one Chemical compound C1CC(O)CCC1C1C(=O)N(CC=2C(=CC(=CC=2Cl)C=2C=CC(=CC=2)C(=O)N2CCC(CC2)C(F)(F)F)Cl)CC1 OOTHGGMVKQNVIB-UHFFFAOYSA-N 0.000 claims 1
- BAVYNXYHQISMBS-UHFFFAOYSA-N 1-[[2,6-dichloro-4-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]phenyl]phenyl]methyl]-3-piperidin-1-ylpyrrolidin-2-one Chemical compound C1CC(C(F)(F)F)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(CN3C(C(N4CCCCC4)CC3)=O)=C(Cl)C=2)C=C1 BAVYNXYHQISMBS-UHFFFAOYSA-N 0.000 claims 1
- ZANGMGCYGFJMDH-UHFFFAOYSA-N 3-(4-bromocyclohexyl)-1-[[2,6-dichloro-4-(4-fluorophenyl)phenyl]methyl]pyrrolidin-2-one Chemical compound C1=CC(F)=CC=C1C(C=C1Cl)=CC(Cl)=C1CN1C(=O)C(C2CCC(Br)CC2)CC1 ZANGMGCYGFJMDH-UHFFFAOYSA-N 0.000 claims 1
- GMLCUSFTGGZYMS-UHFFFAOYSA-N 3-cyclohexyl-1-[(2,6-dichloro-4-hydroxyphenyl)methyl]pyrrolidin-2-one Chemical compound ClC1=CC(O)=CC(Cl)=C1CN1C(=O)C(C2CCCCC2)CC1 GMLCUSFTGGZYMS-UHFFFAOYSA-N 0.000 claims 1
- DSLWEEYIOQRKKS-UHFFFAOYSA-N 3-cyclohexyl-1-[(2,6-dichloro-4-methoxyphenyl)methyl]pyrrolidin-2-one Chemical compound ClC1=CC(OC)=CC(Cl)=C1CN1C(=O)C(C2CCCCC2)CC1 DSLWEEYIOQRKKS-UHFFFAOYSA-N 0.000 claims 1
- IDUJQCPMSZQIMO-UHFFFAOYSA-N 3-cyclohexyl-1-[[2,6-dichloro-4-[4-(4-propan-2-ylpiperazine-1-carbonyl)phenyl]phenyl]methyl]pyrrolidin-2-one Chemical compound C1CN(C(C)C)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(CN3C(C(C4CCCCC4)CC3)=O)=C(Cl)C=2)C=C1 IDUJQCPMSZQIMO-UHFFFAOYSA-N 0.000 claims 1
- OGQDTGSKKZAXES-UHFFFAOYSA-N 3-cyclohexyl-1-[[2,6-dichloro-4-[4-(morpholine-4-carbonyl)phenyl]phenyl]methyl]pyrrolidin-2-one Chemical compound ClC1=CC(C=2C=CC(=CC=2)C(=O)N2CCOCC2)=CC(Cl)=C1CN(C1=O)CCC1C1CCCCC1 OGQDTGSKKZAXES-UHFFFAOYSA-N 0.000 claims 1
- KJVASKCAYRHBFP-UHFFFAOYSA-N 3-cyclohexyl-1-[[2,6-dichloro-4-[4-[4-(2-fluoroethyl)piperazine-1-carbonyl]phenyl]phenyl]methyl]pyrrolidin-2-one Chemical compound C1CN(CCF)CCN1C(=O)C1=CC=C(C=2C=C(Cl)C(CN3C(C(C4CCCCC4)CC3)=O)=C(Cl)C=2)C=C1 KJVASKCAYRHBFP-UHFFFAOYSA-N 0.000 claims 1
- RSUXLMGUVNUOEV-UHFFFAOYSA-N 4-[3,5-dichloro-4-[(3-cyclohexyl-2-oxopyrrolidin-1-yl)methyl]phenyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C(C=C1Cl)=CC(Cl)=C1CN1C(=O)C(C2CCCCC2)CC1 RSUXLMGUVNUOEV-UHFFFAOYSA-N 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- KOALDWXZPCXUTC-UHFFFAOYSA-N methyl 4-[3,5-dichloro-4-[(2-oxo-3-piperidin-1-ylpyrrolidin-1-yl)methyl]phenyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C(C=C1Cl)=CC(Cl)=C1CN1C(=O)C(N2CCCCC2)CC1 KOALDWXZPCXUTC-UHFFFAOYSA-N 0.000 claims 1
- AWNNNMJRIAYYTD-UHFFFAOYSA-N methyl 4-[3,5-dichloro-4-[(3-cyclohexyl-2-oxopyrrolidin-1-yl)methyl]phenyl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C(C=C1Cl)=CC(Cl)=C1CN1C(=O)C(C2CCCCC2)CC1 AWNNNMJRIAYYTD-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 150000002829 nitrogen Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 0 CC1(*)C(*)=CC(*)=C(CN(CCC2*)C2=O)C(*)=C1 Chemical compound CC1(*)C(*)=CC(*)=C(CN(CCC2*)C2=O)C(*)=C1 0.000 description 19
- OFQGPQISJBQVSZ-UHFFFAOYSA-N CC(C)C(N(CC1)CCC1C(F)(F)F)=O Chemical compound CC(C)C(N(CC1)CCC1C(F)(F)F)=O OFQGPQISJBQVSZ-UHFFFAOYSA-N 0.000 description 1
- MEZCQZJDXVJARQ-UHFFFAOYSA-N CC(C)OC1CCOCC1 Chemical compound CC(C)OC1CCOCC1 MEZCQZJDXVJARQ-UHFFFAOYSA-N 0.000 description 1
- HZZCSLKKNXVQSN-UHFFFAOYSA-N CC(N(CC1)CCC1(F)F)=O Chemical compound CC(N(CC1)CCC1(F)F)=O HZZCSLKKNXVQSN-UHFFFAOYSA-N 0.000 description 1
- KYWXRBNOYGGPIZ-UHFFFAOYSA-N CC(N1CCOCC1)=O Chemical compound CC(N1CCOCC1)=O KYWXRBNOYGGPIZ-UHFFFAOYSA-N 0.000 description 1
- LUHMEWXLOBDYSW-UHFFFAOYSA-O CCC(C=C)N(CC[NH3+])C(CC)=O Chemical compound CCC(C=C)N(CC[NH3+])C(CC)=O LUHMEWXLOBDYSW-UHFFFAOYSA-O 0.000 description 1
- HVCNXQOWACZAFN-UHFFFAOYSA-N CCN1CCOCC1 Chemical compound CCN1CCOCC1 HVCNXQOWACZAFN-UHFFFAOYSA-N 0.000 description 1
- BAUWRHPMUVYFOD-UHFFFAOYSA-N CN(CC1)CCC1O Chemical compound CN(CC1)CCC1O BAUWRHPMUVYFOD-UHFFFAOYSA-N 0.000 description 1
- VKDLRDAJFPYZGR-UHFFFAOYSA-N C[IH]N1CCCCC1 Chemical compound C[IH]N1CCCCC1 VKDLRDAJFPYZGR-UHFFFAOYSA-N 0.000 description 1
- ZAFOWOZVCPRPHP-UHFFFAOYSA-N C[IH]S(NCCO)(=O)=O Chemical compound C[IH]S(NCCO)(=O)=O ZAFOWOZVCPRPHP-UHFFFAOYSA-N 0.000 description 1
- AOJJJTCPKZLNCB-UHFFFAOYSA-N C[I](C)N1CCC1 Chemical compound C[I](C)N1CCC1 AOJJJTCPKZLNCB-UHFFFAOYSA-N 0.000 description 1
- GQUWUWLTHOEGLZ-UHFFFAOYSA-N C[I](C)N1CCCC1 Chemical compound C[I](C)N1CCCC1 GQUWUWLTHOEGLZ-UHFFFAOYSA-N 0.000 description 1
- JERNIPLXCBQWIQ-UHFFFAOYSA-N C[I](C)S(N1CCCCC1)(=O)=O Chemical compound C[I](C)S(N1CCCCC1)(=O)=O JERNIPLXCBQWIQ-UHFFFAOYSA-N 0.000 description 1
- YPKBCLZFIYBSHK-UHFFFAOYSA-N Cc(cc1)cc2c1[nH]cc2 Chemical compound Cc(cc1)cc2c1[nH]cc2 YPKBCLZFIYBSHK-UHFFFAOYSA-N 0.000 description 1
- KCZQNAOFWQGLCN-UHFFFAOYSA-N Cc(cc1)cc2c1[o]cc2 Chemical compound Cc(cc1)cc2c1[o]cc2 KCZQNAOFWQGLCN-UHFFFAOYSA-N 0.000 description 1
- SEBIXVUYSFOUEL-UHFFFAOYSA-N Cc(cc1)cc2c1[s]cn2 Chemical compound Cc(cc1)cc2c1[s]cn2 SEBIXVUYSFOUEL-UHFFFAOYSA-N 0.000 description 1
- MGHKWBQZEBMFOH-UHFFFAOYSA-N Cc1c(C)[o]nc1C Chemical compound Cc1c(C)[o]nc1C MGHKWBQZEBMFOH-UHFFFAOYSA-N 0.000 description 1
- RIKMMFOAQPJVMX-UHFFFAOYSA-N Cc1c[nH]nc1 Chemical compound Cc1c[nH]nc1 RIKMMFOAQPJVMX-UHFFFAOYSA-N 0.000 description 1
- RRZFDFYIDRCBCQ-UHFFFAOYSA-N Cc1cc2n[o]nc2cc1 Chemical compound Cc1cc2n[o]nc2cc1 RRZFDFYIDRCBCQ-UHFFFAOYSA-N 0.000 description 1
- DOHZWDWNQFZIKH-UHFFFAOYSA-N Cc1ccc2[s]ccc2c1 Chemical compound Cc1ccc2[s]ccc2c1 DOHZWDWNQFZIKH-UHFFFAOYSA-N 0.000 description 1
- XQQBUAPQHNYYRS-UHFFFAOYSA-N Cc1ccc[s]1 Chemical compound Cc1ccc[s]1 XQQBUAPQHNYYRS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74556906P | 2006-04-25 | 2006-04-25 | |
| US60/745,569 | 2006-04-25 | ||
| PCT/US2007/067296 WO2007127726A2 (en) | 2006-04-25 | 2007-04-24 | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009535356A JP2009535356A (ja) | 2009-10-01 |
| JP2009535356A5 true JP2009535356A5 (US07981874-20110719-C00313.png) | 2010-05-13 |
| JP5189079B2 JP5189079B2 (ja) | 2013-04-24 |
Family
ID=38564372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507926A Expired - Fee Related JP5189079B2 (ja) | 2006-04-25 | 2007-04-24 | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
Country Status (18)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2029576B1 (en) | 2006-04-21 | 2013-06-19 | Eli Lilly & Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EA014718B1 (ru) * | 2006-04-21 | 2011-02-28 | Эли Лилли Энд Компани | Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 |
| US7981918B2 (en) * | 2006-04-21 | 2011-07-19 | Eli Lilly And Company | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2007127693A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5118692B2 (ja) | 2006-04-24 | 2013-01-16 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロヘキシル置換ピロリジノン |
| EP2021336B1 (en) | 2006-04-24 | 2010-06-30 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| MX2008013656A (es) | 2006-04-25 | 2008-11-10 | Lilly Co Eli | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa. |
| WO2007127763A2 (en) | 2006-04-25 | 2007-11-08 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| KR101060016B1 (ko) | 2006-04-28 | 2011-08-29 | 일라이 릴리 앤드 캄파니 | 11-베타-히드록시스테로이드 데히드로게나제 1의 억제제로서의 피페리디닐 치환 피롤리디논 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2243479A3 (en) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Novel amide and amidine derivates and uses thereof |
| US8440710B2 (en) * | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2576600B1 (de) * | 2010-05-27 | 2018-01-24 | Pharmazell GmbH | Neuartige 7alpha-hydroxysteroid dehydrogenase-knockout-mutanten und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2013010092A1 (en) | 2011-07-13 | 2013-01-17 | Novartis Ag | 4-oxo-3,5,7,8-tetrahydro-4h-pyrano {4,3-d} pyrminidinyl compounds for use as tankyrase inhibitors |
| JP5957077B2 (ja) | 2011-07-13 | 2016-07-27 | ノバルティス アーゲー | タンキラーゼ阻害剤として使用するための４−ピペリジニル化合物 |
| WO2013012723A1 (en) | 2011-07-13 | 2013-01-24 | Novartis Ag | Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2772484B1 (en) | 2011-10-18 | 2017-06-28 | Astellas Pharma Inc. | Bicyclic heterocyclic compound |
| WO2015135461A1 (zh) * | 2014-03-10 | 2015-09-17 | 四川海思科制药有限公司 | 取代的二氢苯并呋喃-哌啶-甲酮衍生物、其制备及用途 |
| CN108046988B (zh) * | 2017-12-25 | 2021-04-16 | 云南民族大学 | 一种高效制备碘代醇的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| JP5014983B2 (ja) * | 2004-05-07 | 2012-08-29 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | １１−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのピロリジン−２−オン及びピペリジン−２−オン誘導体 |
| WO2005108361A1 (en) | 2004-05-07 | 2005-11-17 | Janssen Pharmaceutica N.V. | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| US8138342B2 (en) | 2004-10-12 | 2012-03-20 | High Point Pharmacueticals, LLC | 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds |
| ATE419848T1 (de) | 2004-10-29 | 2009-01-15 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
| EA019747B1 (ru) | 2004-11-10 | 2014-06-30 | Инсайт Корпорейшн | Лактамные соединения и их применение в качестве фармацевтических препаратов |
| ES2308602T3 (es) | 2004-12-20 | 2008-12-01 | Eli Lilly And Company | Derivados de cicloalquil lactamas como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa 1. |
| WO2006068991A1 (en) | 2004-12-21 | 2006-06-29 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EP1864971A4 (en) | 2005-03-31 | 2010-02-10 | Takeda Pharmaceutical | PROPHYLACTIC / THERAPEUTIC AGENT AGAINST DIABETES |
| WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| US7981918B2 (en) | 2006-04-21 | 2011-07-19 | Eli Lilly And Company | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EA014718B1 (ru) | 2006-04-21 | 2011-02-28 | Эли Лилли Энд Компани | Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 |
| EP2029576B1 (en) | 2006-04-21 | 2013-06-19 | Eli Lilly & Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5118692B2 (ja) | 2006-04-24 | 2013-01-16 | イーライ リリー アンド カンパニー | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロヘキシル置換ピロリジノン |
| EP2021336B1 (en) | 2006-04-24 | 2010-06-30 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2007127693A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2007127763A2 (en) | 2006-04-25 | 2007-11-08 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| MX2008013656A (es) | 2006-04-25 | 2008-11-10 | Lilly Co Eli | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa. |
| KR101060016B1 (ko) | 2006-04-28 | 2011-08-29 | 일라이 릴리 앤드 캄파니 | 11-베타-히드록시스테로이드 데히드로게나제 1의 억제제로서의 피페리디닐 치환 피롤리디논 |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
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2007
- 2007-04-24 DK DK07761186.1T patent/DK2021337T3/da active
- 2007-04-24 JP JP2009507926A patent/JP5189079B2/ja not_active Expired - Fee Related
- 2007-04-24 BR BRPI0710050-7A patent/BRPI0710050A2/pt not_active IP Right Cessation
- 2007-04-24 US US12/297,964 patent/US7994176B2/en not_active Expired - Fee Related
- 2007-04-24 WO PCT/US2007/067296 patent/WO2007127726A2/en active Application Filing
- 2007-04-24 CN CN2007800148990A patent/CN101454310B/zh not_active Expired - Fee Related
- 2007-04-24 DE DE602007004324T patent/DE602007004324D1/de active Active
- 2007-04-24 PT PT07761186T patent/PT2021337E/pt unknown
- 2007-04-24 AU AU2007244904A patent/AU2007244904B2/en not_active Ceased
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- 2007-04-24 ES ES07761186T patent/ES2336849T3/es active Active
- 2007-04-24 SI SI200730213T patent/SI2021337T1/sl unknown
- 2007-04-24 EA EA200870474A patent/EA015516B1/ru not_active IP Right Cessation
- 2007-04-24 MX MX2008013651A patent/MX2008013651A/es active IP Right Grant
- 2007-04-24 AT AT07761186T patent/ATE455110T1/de active
- 2007-04-24 PL PL07761186T patent/PL2021337T3/pl unknown
- 2007-04-24 EP EP07761186A patent/EP2021337B1/en active Active
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2010
- 2010-02-19 CY CY20101100164T patent/CY1109842T1/el unknown
