JP2009532388A5 - - Google Patents
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- Publication number
- JP2009532388A5 JP2009532388A5 JP2009503378A JP2009503378A JP2009532388A5 JP 2009532388 A5 JP2009532388 A5 JP 2009532388A5 JP 2009503378 A JP2009503378 A JP 2009503378A JP 2009503378 A JP2009503378 A JP 2009503378A JP 2009532388 A5 JP2009532388 A5 JP 2009532388A5
- Authority
- JP
- Japan
- Prior art keywords
- oil
- drug delivery
- delivery composition
- composition according
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 54
- 238000012377 drug delivery Methods 0.000 claims 49
- 239000011248 coating agent Substances 0.000 claims 14
- 238000000576 coating method Methods 0.000 claims 14
- 239000003921 oil Substances 0.000 claims 11
- 235000019198 oils Nutrition 0.000 claims 11
- 239000008186 active pharmaceutical agent Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 235000010418 carrageenan Nutrition 0.000 claims 6
- 239000000679 carrageenan Substances 0.000 claims 6
- 229920001525 carrageenan Polymers 0.000 claims 6
- 229940113118 carrageenan Drugs 0.000 claims 6
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 6
- 238000001125 extrusion Methods 0.000 claims 5
- 239000000314 lubricant Substances 0.000 claims 5
- 239000004014 plasticizer Substances 0.000 claims 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 229920002472 Starch Polymers 0.000 claims 4
- 239000007884 disintegrant Substances 0.000 claims 4
- 238000005563 spheronization Methods 0.000 claims 4
- 239000008107 starch Substances 0.000 claims 4
- 229940032147 starch Drugs 0.000 claims 4
- 235000019698 starch Nutrition 0.000 claims 4
- -1 sterotex Chemical compound 0.000 claims 4
- 239000001856 Ethyl cellulose Substances 0.000 claims 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- 239000007894 caplet Substances 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 239000001913 cellulose Substances 0.000 claims 3
- 235000010980 cellulose Nutrition 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000006185 dispersion Substances 0.000 claims 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims 3
- 229920001249 ethyl cellulose Polymers 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- 239000003826 tablet Substances 0.000 claims 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 235000019486 Sunflower oil Nutrition 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 2
- 235000010443 alginic acid Nutrition 0.000 claims 2
- 239000000783 alginic acid Substances 0.000 claims 2
- 229920000615 alginic acid Polymers 0.000 claims 2
- 229960001126 alginic acid Drugs 0.000 claims 2
- 150000004781 alginic acids Chemical class 0.000 claims 2
- NPAKNKYSJIDKMW-UHFFFAOYSA-N carvedilol Chemical compound COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=NC3=CC=C[CH]C3=C12 NPAKNKYSJIDKMW-UHFFFAOYSA-N 0.000 claims 2
- 229960004195 carvedilol Drugs 0.000 claims 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims 2
- 229960000913 crospovidone Drugs 0.000 claims 2
- 229920006037 cross link polymer Polymers 0.000 claims 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
- 229940031954 dibutyl sebacate Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 229920001519 homopolymer Polymers 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 239000003456 ion exchange resin Substances 0.000 claims 2
- 229920003303 ion-exchange polymer Polymers 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 229940119170 jojoba wax Drugs 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 229960001344 methylphenidate Drugs 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000010466 nut oil Substances 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 235000008390 olive oil Nutrition 0.000 claims 2
- 239000004006 olive oil Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 235000005713 safflower oil Nutrition 0.000 claims 2
- 239000003813 safflower oil Substances 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 235000012239 silicon dioxide Nutrition 0.000 claims 2
- 239000008109 sodium starch glycolate Substances 0.000 claims 2
- 229920003109 sodium starch glycolate Polymers 0.000 claims 2
- 229940079832 sodium starch glycolate Drugs 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000002600 sunflower oil Substances 0.000 claims 2
- 230000002459 sustained effect Effects 0.000 claims 2
- 239000000454 talc Substances 0.000 claims 2
- 229910052623 talc Inorganic materials 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 2
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims 2
- 229960004688 venlafaxine Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 244000144730 Amygdalus persica Species 0.000 claims 1
- 235000007319 Avena orientalis Nutrition 0.000 claims 1
- 244000075850 Avena orientalis Species 0.000 claims 1
- 240000008067 Cucumis sativus Species 0.000 claims 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims 1
- 235000019487 Hazelnut oil Nutrition 0.000 claims 1
- 240000008415 Lactuca sativa Species 0.000 claims 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 claims 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 claims 1
- 240000000912 Macadamia tetraphylla Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims 1
- 235000019482 Palm oil Nutrition 0.000 claims 1
- 235000019483 Peanut oil Nutrition 0.000 claims 1
- 235000019495 Pecan oil Nutrition 0.000 claims 1
- 235000019497 Pistachio oil Nutrition 0.000 claims 1
- 235000006040 Prunus persica var persica Nutrition 0.000 claims 1
- 235000019774 Rice Bran oil Nutrition 0.000 claims 1
- 241000220317 Rosa Species 0.000 claims 1
- 235000019485 Safflower oil Nutrition 0.000 claims 1
- 235000003434 Sesamum indicum Nutrition 0.000 claims 1
- 244000040738 Sesamum orientale Species 0.000 claims 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 235000019498 Walnut oil Nutrition 0.000 claims 1
- 229920002494 Zein Polymers 0.000 claims 1
- 235000011037 adipic acid Nutrition 0.000 claims 1
- 239000001361 adipic acid Substances 0.000 claims 1
- 239000004964 aerogel Substances 0.000 claims 1
- 239000010477 apricot oil Substances 0.000 claims 1
- 235000021302 avocado oil Nutrition 0.000 claims 1
- 239000008163 avocado oil Substances 0.000 claims 1
- 229940094199 black currant oil Drugs 0.000 claims 1
- 235000021324 borage oil Nutrition 0.000 claims 1
- 239000000378 calcium silicate Substances 0.000 claims 1
- 229910052918 calcium silicate Inorganic materials 0.000 claims 1
- 235000012241 calcium silicate Nutrition 0.000 claims 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims 1
- 235000019519 canola oil Nutrition 0.000 claims 1
- 239000000828 canola oil Substances 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 235000013709 carrot oil Nutrition 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 235000019864 coconut oil Nutrition 0.000 claims 1
- 239000003240 coconut oil Substances 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 235000005687 corn oil Nutrition 0.000 claims 1
- 239000002285 corn oil Substances 0.000 claims 1
- 235000012343 cottonseed oil Nutrition 0.000 claims 1
- 239000002385 cottonseed oil Substances 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000000378 dietary effect Effects 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims 1
- 239000001734 eugenia caryophyllata l. bud oleoresin Substances 0.000 claims 1
- 235000008524 evening primrose extract Nutrition 0.000 claims 1
- 239000010475 evening primrose oil Substances 0.000 claims 1
- 229940089020 evening primrose oil Drugs 0.000 claims 1
- 239000010462 extra virgin olive oil Substances 0.000 claims 1
- 235000021010 extra-virgin olive oil Nutrition 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 239000008169 grapeseed oil Substances 0.000 claims 1
- 239000010468 hazelnut oil Substances 0.000 claims 1
- 239000010460 hemp oil Substances 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 235000021388 linseed oil Nutrition 0.000 claims 1
- 239000000944 linseed oil Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229940037627 magnesium lauryl sulfate Drugs 0.000 claims 1
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 235000010446 mineral oil Nutrition 0.000 claims 1
- 235000019488 nut oil Nutrition 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- 210000002741 palatine tonsil Anatomy 0.000 claims 1
- 239000002540 palm oil Substances 0.000 claims 1
- 239000000312 peanut oil Substances 0.000 claims 1
- 239000010470 pecan oil Substances 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000001885 petroselinum crispum mill. leaf oil Substances 0.000 claims 1
- 239000010471 pistachio oil Substances 0.000 claims 1
- 229940082415 pistachio oil Drugs 0.000 claims 1
- 229920006254 polymer film Polymers 0.000 claims 1
- 239000008171 pumpkin seed oil Substances 0.000 claims 1
- 239000008165 rice bran oil Substances 0.000 claims 1
- 239000010668 rosemary oil Substances 0.000 claims 1
- 229940058206 rosemary oil Drugs 0.000 claims 1
- 235000012045 salad Nutrition 0.000 claims 1
- 235000011803 sesame oil Nutrition 0.000 claims 1
- 239000008159 sesame oil Substances 0.000 claims 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 1
- 235000010234 sodium benzoate Nutrition 0.000 claims 1
- 239000004299 sodium benzoate Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 235000012222 talc Nutrition 0.000 claims 1
- 239000010677 tea tree oil Substances 0.000 claims 1
- 229940111630 tea tree oil Drugs 0.000 claims 1
- 239000008170 walnut oil Substances 0.000 claims 1
- 239000005019 zein Substances 0.000 claims 1
- 229940093612 zein Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39603106A | 2006-04-03 | 2006-04-03 | |
| US11/396,031 | 2006-04-03 | ||
| PCT/CA2007/000548 WO2007112579A1 (en) | 2006-04-03 | 2007-04-03 | Drug delivery composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013169662A Division JP5592547B2 (ja) | 2006-04-03 | 2013-08-19 | 薬物送達組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009532388A JP2009532388A (ja) | 2009-09-10 |
| JP2009532388A5 true JP2009532388A5 (enExample) | 2010-05-20 |
| JP5349290B2 JP5349290B2 (ja) | 2013-11-20 |
Family
ID=38563052
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503378A Expired - Fee Related JP5349290B2 (ja) | 2006-04-03 | 2007-04-03 | 薬物送達組成物およびそれを含む医薬品、ならびにその製造方法 |
| JP2013169662A Expired - Fee Related JP5592547B2 (ja) | 2006-04-03 | 2013-08-19 | 薬物送達組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013169662A Expired - Fee Related JP5592547B2 (ja) | 2006-04-03 | 2013-08-19 | 薬物送達組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20190083399A9 (enExample) |
| EP (1) | EP2010162A4 (enExample) |
| JP (2) | JP5349290B2 (enExample) |
| CN (1) | CN101453996B (enExample) |
| CA (1) | CA2648278C (enExample) |
| WO (1) | WO2007112579A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1912730A2 (en) * | 2005-07-28 | 2008-04-23 | Isp Investments Inc. | Method to improve characteristics of spray dried powders and granulated materials, and the products thereby produced |
| CN104825397A (zh) | 2006-04-03 | 2015-08-12 | 伊萨·奥迪迪 | 含有机溶胶涂层的受控释放递送物件 |
| US20090130220A1 (en) | 2007-11-20 | 2009-05-21 | Johnson Pamela A | Cosmetic composition having pomace olive oil |
| CN102188490B (zh) * | 2011-04-12 | 2013-05-01 | 李信金 | 一种治疗阳痿早泄的药酒 |
| KR101336411B1 (ko) * | 2011-05-27 | 2013-12-04 | 한국식품연구원 | 쌀 추출물의 수면 장애, 불안 또는 우울증의 개선, 예방 또는 치료를 위한 신규 용도 |
| US10918589B2 (en) * | 2013-03-15 | 2021-02-16 | John Robert Goepfert | Personal-lubricating material and method for lubricant manufacture |
| US9132096B1 (en) | 2014-09-12 | 2015-09-15 | Alkermes Pharma Ireland Limited | Abuse resistant pharmaceutical compositions |
| EP3256141A1 (en) * | 2015-02-09 | 2017-12-20 | Vereeken, Jose | Multiparticulate formulation comprising herbal extracts |
| US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| EP3459527B1 (en) * | 2017-09-20 | 2022-11-23 | Tillotts Pharma Ag | Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization |
| MX2019005217A (es) * | 2019-05-03 | 2020-11-04 | Eduardo Arciniega Vazquez | Proceso de obtención de membranas poliméricas a partir de componentes de origen natural. |
| CN110124580B (zh) * | 2019-05-30 | 2020-04-10 | 天津中澳嘉喜诺生物科技有限公司 | 一种茶树精油肠溶包衣小丸及其制备方法和应用 |
| WO2022072099A1 (en) * | 2020-09-30 | 2022-04-07 | Eirgen Pharma, Ltd | Immediate release dosage forms, methods of making and using |
| CN116869944A (zh) * | 2023-08-15 | 2023-10-13 | 重庆士立德医药科技有限公司 | 一种托瑞米芬组合物及其制备方法 |
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| GB1359643A (en) * | 1970-09-28 | 1974-07-10 | Controlled Medications | Controlled release medicament |
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| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4034758A (en) * | 1975-09-08 | 1977-07-12 | Alza Corporation | Osmotic therapeutic system for administering medicament |
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2007
- 2007-04-03 CN CN200780019665.5A patent/CN101453996B/zh not_active Expired - Fee Related
- 2007-04-03 JP JP2009503378A patent/JP5349290B2/ja not_active Expired - Fee Related
- 2007-04-03 US US12/225,956 patent/US20190083399A9/en not_active Abandoned
- 2007-04-03 CA CA2648278A patent/CA2648278C/en not_active Expired - Fee Related
- 2007-04-03 WO PCT/CA2007/000548 patent/WO2007112579A1/en not_active Ceased
- 2007-04-03 EP EP07719478A patent/EP2010162A4/en not_active Ceased
-
2013
- 2013-08-19 JP JP2013169662A patent/JP5592547B2/ja not_active Expired - Fee Related
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