JP2009531059A5 - - Google Patents
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- JP2009531059A5 JP2009531059A5 JP2009502327A JP2009502327A JP2009531059A5 JP 2009531059 A5 JP2009531059 A5 JP 2009531059A5 JP 2009502327 A JP2009502327 A JP 2009502327A JP 2009502327 A JP2009502327 A JP 2009502327A JP 2009531059 A5 JP2009531059 A5 JP 2009531059A5
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- Prior art keywords
- adherent cells
- culture
- placental
- group
- adipose tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 41
- 230000001464 adherent effect Effects 0.000 claims 30
- 210000000577 adipose tissue Anatomy 0.000 claims 15
- 210000005059 placental tissue Anatomy 0.000 claims 15
- 238000000034 method Methods 0.000 claims 9
- 230000003169 placental effect Effects 0.000 claims 9
- 230000001506 immunosuppresive effect Effects 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 6
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102100022464 5'-nucleotidase Human genes 0.000 claims 3
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 3
- 102100037241 Endoglin Human genes 0.000 claims 3
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 3
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 3
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 3
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 3
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 3
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 3
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 3
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 3
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 3
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 3
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 3
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 3
- 102100022338 Integrin alpha-M Human genes 0.000 claims 3
- 102100025304 Integrin beta-1 Human genes 0.000 claims 3
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 3
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 3
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 3
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 3
- 239000003636 conditioned culture medium Substances 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- IRLPACMLTUPBCL-KQYNXXCUSA-N 5'-adenylyl sulfate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](O)[C@H]1O IRLPACMLTUPBCL-KQYNXXCUSA-N 0.000 claims 2
- 102100036630 60S ribosomal protein L7a Human genes 0.000 claims 2
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 2
- 102300038161 CD44 antigen isoform 2 Human genes 0.000 claims 2
- 102000005701 Calcium-Binding Proteins Human genes 0.000 claims 2
- 108010045403 Calcium-Binding Proteins Proteins 0.000 claims 2
- 102100033620 Calponin-1 Human genes 0.000 claims 2
- 101710092112 Calponin-1 Proteins 0.000 claims 2
- 102100031334 Elongation factor 2 Human genes 0.000 claims 2
- 101710139370 Eukaryotic translation elongation factor 2 Proteins 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 2
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 2
- 108010033040 Histones Proteins 0.000 claims 2
- 101150067143 Hnrnph1 gene Proteins 0.000 claims 2
- 101000853243 Homo sapiens 60S ribosomal protein L7a Proteins 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 101710177504 Kit ligand Proteins 0.000 claims 2
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 2
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 102000004389 Ribonucleoproteins Human genes 0.000 claims 2
- 108010081734 Ribonucleoproteins Proteins 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- AGQFLEFSRLZALV-KQYNXXCUSA-N [9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-iminopurin-3-yl]phosphonic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(N(C=NC2=N)P(O)(O)=O)=C2N=C1 AGQFLEFSRLZALV-KQYNXXCUSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 201000002491 encephalomyelitis Diseases 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 230000003248 secreting effect Effects 0.000 claims 2
- 210000002460 smooth muscle Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 230000006052 T cell proliferation Effects 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78476906P | 2006-03-23 | 2006-03-23 | |
| US60/784,769 | 2006-03-23 | ||
| US84708806P | 2006-09-26 | 2006-09-26 | |
| US60/847,088 | 2006-09-26 | ||
| PCT/IL2007/000380 WO2007108003A2 (en) | 2006-03-23 | 2007-03-22 | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011133774A Division JP5766041B2 (ja) | 2006-03-23 | 2011-06-16 | 対象の造血系を増強させるための医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531059A JP2009531059A (ja) | 2009-09-03 |
| JP2009531059A5 true JP2009531059A5 (https=) | 2010-04-08 |
| JP5733894B2 JP5733894B2 (ja) | 2015-06-10 |
Family
ID=38522837
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009502327A Active JP5733894B2 (ja) | 2006-03-23 | 2007-03-22 | 細胞を拡大培養するための方法ならびに該方法によって作製される細胞および馴化培地の治療のための使用 |
| JP2011133774A Active JP5766041B2 (ja) | 2006-03-23 | 2011-06-16 | 対象の造血系を増強させるための医薬組成物 |
| JP2013263148A Active JP5941454B2 (ja) | 2006-03-23 | 2013-12-20 | 対象の造血系を増強させるための医薬組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011133774A Active JP5766041B2 (ja) | 2006-03-23 | 2011-06-16 | 対象の造血系を増強させるための医薬組成物 |
| JP2013263148A Active JP5941454B2 (ja) | 2006-03-23 | 2013-12-20 | 対象の造血系を増強させるための医薬組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20110129447A1 (https=) |
| EP (5) | EP2366775B1 (https=) |
| JP (3) | JP5733894B2 (https=) |
| KR (2) | KR101557256B1 (https=) |
| CN (1) | CN105296415A (https=) |
| AU (1) | AU2007228341B2 (https=) |
| BR (1) | BRPI0709349A2 (https=) |
| CA (1) | CA2646384C (https=) |
| DK (2) | DK2626417T3 (https=) |
| ES (3) | ES2537641T3 (https=) |
| HK (1) | HK1217513A1 (https=) |
| HR (1) | HRP20160538T1 (https=) |
| HU (1) | HUE028796T2 (https=) |
| IL (1) | IL236213A (https=) |
| MX (1) | MX2008012085A (https=) |
| PL (2) | PL2366775T3 (https=) |
| PT (3) | PT2548951E (https=) |
| RU (1) | RU2433177C2 (https=) |
| SG (1) | SG170761A1 (https=) |
| SI (1) | SI2548951T1 (https=) |
| WO (1) | WO2007108003A2 (https=) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005001080A2 (en) | 2003-06-27 | 2005-01-06 | Ethicon, Incorporated | Postpartum-derived cells for use in treatment of disease of the heart and circulatory system |
| US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| WO2007070870A1 (en) | 2005-12-16 | 2007-06-21 | Ethicon, Inc. | Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| EP2366775B1 (en) * | 2006-03-23 | 2015-04-22 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
| PL2089511T3 (pl) | 2006-11-13 | 2015-02-27 | Depuy Synthes Products Llc | Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki |
| EP3763376A1 (en) * | 2007-02-12 | 2021-01-13 | Celularity, Inc. | Treatment of inflammatory diseases using placental stem cells |
| JP5162784B2 (ja) * | 2007-07-11 | 2013-03-13 | 日東電工株式会社 | 細胞培養基材及びその製造方法並びに細胞培養方法 |
| MX2010003019A (es) * | 2007-09-19 | 2010-04-30 | Pluristem Ltd | Celulas adherentes de los tejidos adiposo y de placenta y uso de las mismas en la terapia. |
| AU2013267050B2 (en) * | 2007-09-19 | 2016-01-07 | Pluristem Ltd. | Adherent cells from adipose or placenta tissues and use thereof in therapy |
| BRPI0909541A2 (pt) | 2008-05-27 | 2016-10-11 | Pluristem Ltd | ''método para tratamento de doenças inflamatórias do cólon'' |
| KR20240052847A (ko) | 2008-08-20 | 2024-04-23 | 셀룰래리티 인코포레이티드 | 개선된 세포 조성물 및 그의 제조 방법 |
| EP2331957B1 (en) * | 2008-09-02 | 2016-11-02 | Pluristem Ltd. | Methods of selection of cells for transplantation |
| CN105708862B (zh) | 2008-09-02 | 2020-11-06 | 普拉里斯坦有限公司 | 来自胎盘组织的粘附细胞及其在治疗中的用途 |
| WO2010026574A2 (en) * | 2008-09-02 | 2010-03-11 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
| CN102387807A (zh) | 2008-12-19 | 2012-03-21 | 先进科技及再生医学有限责任公司 | 肺部疾病和病症的治疗 |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| SG174551A1 (en) | 2009-03-26 | 2011-10-28 | Ethicon Inc | Human umbilical cord tissue cells as therapy for alzheimer' s disease |
| EP2977445B1 (en) | 2009-11-30 | 2018-07-25 | Pluristem Ltd. | Adherent cells from placenta and use of same in disease treatment |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| EP2575831B1 (en) | 2010-05-27 | 2016-04-20 | Pluristem Ltd. | Skeletal muscle regeneration using mesenchymal stem cells |
| PT2611906T (pt) * | 2010-08-31 | 2024-04-16 | Gallant Pet Inc | Terapias sistémicas com células estaminais alogénicas para tratamento de doenças em gatos e cães |
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| RU2539750C2 (ru) * | 2013-04-09 | 2015-01-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ оценки иммуносупрессивных свойств мезенхимальных стромальных клеток человека |
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| WO2015025059A1 (en) * | 2013-08-23 | 2015-02-26 | Fundacion Pública Andaluza Progreso Y Salud | Cd105-negative multipotent mesenchymal stromal cells |
| WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| EP3114206B1 (en) | 2014-03-04 | 2020-07-29 | Pluristem Ltd. | Systems and methods for growing and harvesting cells |
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| US20240082313A1 (en) * | 2021-01-26 | 2024-03-14 | The Trustees Of Indiana University | Pharmaceutical compositions and their methods of use |
| CN112813002B (zh) * | 2021-02-07 | 2022-11-08 | 天津科技大学 | 一株耐热短乳杆菌及其后生素制剂的应用 |
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