JP2009529920A5 - - Google Patents
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- JP2009529920A5 JP2009529920A5 JP2009501725A JP2009501725A JP2009529920A5 JP 2009529920 A5 JP2009529920 A5 JP 2009529920A5 JP 2009501725 A JP2009501725 A JP 2009501725A JP 2009501725 A JP2009501725 A JP 2009501725A JP 2009529920 A5 JP2009529920 A5 JP 2009529920A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- rage
- variable region
- chain variable
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- 239000012634 fragment Substances 0.000 claims 25
- 239000000203 mixture Substances 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 206010024641 Listeriosis Diseases 0.000 claims 3
- 206010040047 Sepsis Diseases 0.000 claims 3
- 206010040070 Septic Shock Diseases 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 230000036303 septic shock Effects 0.000 claims 3
- 241000282693 Cercopithecidae Species 0.000 claims 2
- 101001014223 Homo sapiens MAPK/MAK/MRK overlapping kinase Proteins 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 241001504519 Papio ursinus Species 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 102000049409 human MOK Human genes 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000002249 Diabetes Complications Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 108010008177 Fd immunoglobulins Proteins 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000003524 antilipemic agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 229940127218 antiplatelet drug Drugs 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 102000056530 human sRAGE Human genes 0.000 claims 1
- 108700022230 human sRAGE Proteins 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78457506P | 2006-03-21 | 2006-03-21 | |
| US89530307P | 2007-03-16 | 2007-03-16 | |
| PCT/US2007/064568 WO2007109747A2 (en) | 2006-03-21 | 2007-03-21 | Methods and compositions for antagonism of rage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009529920A JP2009529920A (ja) | 2009-08-27 |
| JP2009529920A5 true JP2009529920A5 (https=) | 2011-05-06 |
Family
ID=38523302
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501727A Withdrawn JP2009530423A (ja) | 2006-03-21 | 2007-03-21 | アミロイド生成性疾患を予防および処置するための方法 |
| JP2009501725A Pending JP2009529920A (ja) | 2006-03-21 | 2007-03-21 | Ｒａｇｅの拮抗作用のための方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501727A Withdrawn JP2009530423A (ja) | 2006-03-21 | 2007-03-21 | アミロイド生成性疾患を予防および処置するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070253950A1 (https=) |
| EP (2) | EP2004694A2 (https=) |
| JP (2) | JP2009530423A (https=) |
| KR (2) | KR20080110833A (https=) |
| AU (2) | AU2007226861A1 (https=) |
| BR (2) | BRPI0708998A2 (https=) |
| CA (2) | CA2638755A1 (https=) |
| CR (2) | CR10298A (https=) |
| EC (1) | ECSP088750A (https=) |
| MX (2) | MX2008012023A (https=) |
| NO (2) | NO20083720L (https=) |
| RU (2) | RU2008134135A (https=) |
| WO (2) | WO2007109747A2 (https=) |
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| EP1660186B1 (en) * | 2003-08-18 | 2013-12-25 | MedImmune, LLC | Humanization of antibodies |
| CA2536512A1 (en) * | 2003-09-05 | 2005-03-17 | The Trustees Of Columbia University In The City Of New York | Rage-related methods and compositions for treating glomerular injury |
| KR100570422B1 (ko) * | 2003-10-16 | 2006-04-11 | 한미약품 주식회사 | 대장균 분비서열을 이용하여 항체 단편을 분비·생산하는 발현벡터 및 이를 이용하여 항체 단편을 대량 생산하는 방법 |
| MX2008012023A (es) * | 2006-03-21 | 2008-10-01 | Wyeth Corp | Metodos para prevenir y tratar enfermedades amiloidogenicas. |
-
2007
- 2007-03-21 MX MX2008012023A patent/MX2008012023A/es not_active Application Discontinuation
- 2007-03-21 CA CA002638755A patent/CA2638755A1/en not_active Abandoned
- 2007-03-21 KR KR1020087025473A patent/KR20080110833A/ko not_active Withdrawn
- 2007-03-21 AU AU2007226861A patent/AU2007226861A1/en not_active Abandoned
- 2007-03-21 US US11/689,501 patent/US20070253950A1/en not_active Abandoned
- 2007-03-21 WO PCT/US2007/064568 patent/WO2007109747A2/en not_active Ceased
- 2007-03-21 JP JP2009501727A patent/JP2009530423A/ja not_active Withdrawn
- 2007-03-21 BR BRPI0708998-8A patent/BRPI0708998A2/pt not_active IP Right Cessation
- 2007-03-21 EP EP07759060A patent/EP2004694A2/en not_active Withdrawn
- 2007-03-21 RU RU2008134135/13A patent/RU2008134135A/ru not_active Application Discontinuation
- 2007-03-21 JP JP2009501725A patent/JP2009529920A/ja active Pending
- 2007-03-21 CA CA002646643A patent/CA2646643A1/en not_active Abandoned
- 2007-03-21 RU RU2008137764/13A patent/RU2008137764A/ru not_active Application Discontinuation
- 2007-03-21 WO PCT/US2007/064571 patent/WO2007109749A2/en not_active Ceased
- 2007-03-21 EP EP07759057A patent/EP2001907A2/en not_active Withdrawn
- 2007-03-21 BR BRPI0708970-8A patent/BRPI0708970A2/pt not_active IP Right Cessation
- 2007-03-21 US US11/689,480 patent/US20070286858A1/en not_active Abandoned
- 2007-03-21 MX MX2008011933A patent/MX2008011933A/es unknown
- 2007-03-21 AU AU2007226863A patent/AU2007226863A1/en not_active Abandoned
- 2007-03-21 KR KR1020087025056A patent/KR20080113236A/ko not_active Withdrawn
-
2008
- 2008-08-29 NO NO20083720A patent/NO20083720L/no not_active Application Discontinuation
- 2008-09-19 CR CR10298A patent/CR10298A/es not_active Application Discontinuation
- 2008-09-19 CR CR10297A patent/CR10297A/es not_active Application Discontinuation
- 2008-09-19 EC EC2008008750A patent/ECSP088750A/es unknown
- 2008-09-23 NO NO20084039A patent/NO20084039L/no not_active Application Discontinuation
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