JP2009529544A5 - - Google Patents
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- Publication number
- JP2009529544A5 JP2009529544A5 JP2008558611A JP2008558611A JP2009529544A5 JP 2009529544 A5 JP2009529544 A5 JP 2009529544A5 JP 2008558611 A JP2008558611 A JP 2008558611A JP 2008558611 A JP2008558611 A JP 2008558611A JP 2009529544 A5 JP2009529544 A5 JP 2009529544A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- optionally substituted
- substituents
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 51
- 150000001875 compounds Chemical class 0.000 claims 48
- 125000000753 cycloalkyl group Chemical group 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
- 239000000126 substance Substances 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- 125000001188 haloalkyl group Chemical group 0.000 claims 7
- 239000000018 receptor agonist Substances 0.000 claims 6
- 102000009058 Death Domain Receptors Human genes 0.000 claims 4
- 108010049207 Death Domain Receptors Proteins 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 210000001519 tissues Anatomy 0.000 claims 4
- 108010008478 TNF-Related Apoptosis-Inducing Ligand Proteins 0.000 claims 3
- 102100002198 TNFSF10 Human genes 0.000 claims 3
- 235000010290 biphenyl Nutrition 0.000 claims 3
- 239000004305 biphenyl Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drugs Drugs 0.000 claims 3
- 230000000051 modifying Effects 0.000 claims 3
- 108091006958 BIRCs Proteins 0.000 claims 2
- 102000036581 BIRCs Human genes 0.000 claims 2
- 229960000190 Bacillus Calmette–Guérin vaccine Drugs 0.000 claims 2
- 241001467552 Mycobacterium bovis BCG Species 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000000543 intermediate Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000002062 proliferating Effects 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000007502 Anemia Diseases 0.000 claims 1
- 206010059512 Apoptosis Diseases 0.000 claims 1
- 102100007324 BIRC2 Human genes 0.000 claims 1
- 101700082851 BIRC2 Proteins 0.000 claims 1
- 102100007325 BIRC3 Human genes 0.000 claims 1
- 108010037417 Baculoviral IAP Repeat-Containing 3 Protein Proteins 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 claims 1
- 210000000777 Hematopoietic System Anatomy 0.000 claims 1
- 210000000987 Immune System Anatomy 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000004235 Neutropenia Diseases 0.000 claims 1
- 108010015181 PPAR delta Proteins 0.000 claims 1
- 108010016731 PPAR gamma Proteins 0.000 claims 1
- 102100003648 PPARD Human genes 0.000 claims 1
- 102100000077 PPARG Human genes 0.000 claims 1
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 claims 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 claims 1
- 229910005965 SO 2 Inorganic materials 0.000 claims 1
- 102000002259 TNF-Related Apoptosis-Inducing Ligand Receptors Human genes 0.000 claims 1
- 108010000449 TNF-Related Apoptosis-Inducing Ligand Receptors Proteins 0.000 claims 1
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 claims 1
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 claims 1
- 108010085257 X-Linked Inhibitor of Apoptosis Protein Proteins 0.000 claims 1
- 102100010212 XIAP Human genes 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 125000004946 alkenylalkyl group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 1
- 125000005038 alkynylalkyl group Chemical group 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitors Drugs 0.000 claims 1
- 230000003474 anti-emetic Effects 0.000 claims 1
- 230000001028 anti-proliferant Effects 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 239000002111 antiemetic agent Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 125000005418 aryl aryl group Chemical group 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000001808 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000000841 delta opiate receptor agonist Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000002834 estrogen receptor modulator Substances 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 239000004030 hiv protease inhibitor Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 230000000091 immunopotentiator Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000000436 ligase inhibitor Substances 0.000 claims 1
- 230000036457 multidrug resistance Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 150000002829 nitrogen Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000003207 proteasome inhibitor Substances 0.000 claims 1
- 102000027730 retinoid hormone receptors Human genes 0.000 claims 1
- 108091008001 retinoid hormone receptors Proteins 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 230000002195 synergetic Effects 0.000 claims 1
- 239000003558 transferase inhibitor Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78252306P | 2006-03-16 | 2006-03-16 | |
| US60/782,523 | 2006-03-16 | ||
| US87699406P | 2006-12-26 | 2006-12-26 | |
| US60/876,994 | 2006-12-26 | ||
| PCT/CA2007/000428 WO2007104162A1 (en) | 2006-03-16 | 2007-03-16 | Iap bir domain binding compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009529544A JP2009529544A (ja) | 2009-08-20 |
| JP2009529544A5 true JP2009529544A5 (US08039623-20111018-C00020.png) | 2010-04-30 |
| JP5419468B2 JP5419468B2 (ja) | 2014-02-19 |
Family
ID=38509005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008558611A Expired - Fee Related JP5419468B2 (ja) | 2006-03-16 | 2007-03-16 | Ｉａｐのｂｉｒドメインに結合する化合物 |
Country Status (15)
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005274937B2 (en) | 2004-07-15 | 2011-08-18 | Medivir Ab | IAP binding compounds |
| NZ589670A (en) | 2004-12-20 | 2013-01-25 | Genentech Inc | Pyrrolidine inhibitors of iap |
| AU2006216450C1 (en) | 2005-02-25 | 2013-01-10 | Medivir Ab | Dimeric IAP inhibitors |
| EP1883627B1 (en) | 2005-05-18 | 2018-04-18 | Pharmascience Inc. | Bir domain binding compounds |
| US20100256046A1 (en) * | 2009-04-03 | 2010-10-07 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
| EP1951698A4 (en) | 2005-10-25 | 2010-04-28 | Aegera Therapeutics Inc | BINDING COMPOUNDS TO THE IAP BIR DOMAIN |
| CN101374829A (zh) | 2005-12-19 | 2009-02-25 | 健泰科生物技术公司 | Iap的抑制剂 |
| TWI543988B (zh) | 2006-03-16 | 2016-08-01 | 科學製藥股份有限公司 | 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物 |
| WO2007136921A2 (en) * | 2006-03-21 | 2007-11-29 | Joyant Pharmaceuticals, Inc. | Small molecule apoptosis promoters |
| CN101535300B (zh) * | 2006-05-16 | 2014-05-28 | 埃格拉医疗公司 | Iap bir域结合化合物 |
| CL2007002166A1 (es) * | 2006-07-24 | 2008-01-25 | Tetralogic Pharm Corp | Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer. |
| US20100144650A1 (en) * | 2006-07-24 | 2010-06-10 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| EP2409984A1 (en) * | 2006-07-24 | 2012-01-25 | Tetralogic Pharmaceuticals Corporation | Dimeric IAP Antagonists |
| CN101668426B (zh) * | 2007-04-12 | 2014-01-15 | 焦阳特制药股份有限公司 | 可用作抗癌药的smac模拟二聚体和三聚体 |
| WO2008134679A1 (en) | 2007-04-30 | 2008-11-06 | Genentech, Inc. | Inhibitors of iap |
| JP2010528587A (ja) * | 2007-05-07 | 2010-08-26 | テトラロジック ファーマシューティカルズ コーポレーション | アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてＴＮＦα遺伝子の発現を用いる方法 |
| US20100203012A1 (en) * | 2007-05-30 | 2010-08-12 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| US8314107B2 (en) | 2008-04-23 | 2012-11-20 | Rigel Pharmaceuticals, Inc. | Carboxamide compounds and methods for using the same |
| US20110117081A1 (en) * | 2008-05-05 | 2011-05-19 | Aegera Therapeutics, Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
| AU2009261919A1 (en) * | 2008-06-27 | 2009-12-30 | Pharmascience Inc. | Bridged secondary amines and use thereof as IAP BIR domain binding compounds |
| EP2318395A4 (en) * | 2008-08-02 | 2011-10-26 | Genentech Inc | IPA INHIBITORS |
| WO2010015090A1 (en) * | 2008-08-07 | 2010-02-11 | Aegera Therapeutics Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
| WO2010031171A1 (en) * | 2008-09-19 | 2010-03-25 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
| CA2789879A1 (en) | 2009-10-28 | 2011-05-19 | Joyant Pharmaceuticals, Inc. | Dimeric smac mimetics |
| NZ602368A (en) | 2010-02-12 | 2014-10-31 | Pharmascience Inc | Iap bir domain binding compounds |
| UY33236A (es) | 2010-02-25 | 2011-09-30 | Novartis Ag | Inhibidores dimericos de las iap |
| WO2012052758A1 (en) * | 2010-10-22 | 2012-04-26 | Astrazeneca Ab | Response biomarkers for iap antagonists in human cancers |
| UY33794A (es) | 2010-12-13 | 2012-07-31 | Novartis Ag | Inhibidores diméricos de las iap |
| US20160074515A1 (en) | 2014-06-20 | 2016-03-17 | Reform Biologics, Llc | Viscosity-reducing excipient compounds for protein formulations |
| US11357857B2 (en) | 2014-06-20 | 2022-06-14 | Comera Life Sciences, Inc. | Excipient compounds for protein processing |
| US10478498B2 (en) | 2014-06-20 | 2019-11-19 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
| CA2916970A1 (en) * | 2016-01-08 | 2017-07-08 | Pharmascience Inc. | A smac mimetic compound for use in the treatment of proliferative diseases |
| CA3070992A1 (en) * | 2017-07-25 | 2019-01-31 | Hepagene Therapeutics, Inc. | Dimeric peptide inhibitors of apoptosis proteins |
| CN117130035A (zh) * | 2017-08-18 | 2023-11-28 | 南京中硼联康医疗科技有限公司 | 生物剂量计及具有其的中子捕获治疗系统 |
| JP2021523092A (ja) * | 2018-03-21 | 2021-09-02 | ピラマル・ファーマ・リミテッドＰｉｒａｍａｌ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ | アルファ−（ジアリールメチル）アルキルアミンの改良された不斉合成 |
| EP3831811A4 (en) | 2018-07-31 | 2022-04-20 | Fimecs, Inc. | HETEROCYCLIC COMPOUND |
| CA3120023A1 (en) * | 2018-11-29 | 2020-06-04 | Reform Biologics, Llc | Excipient compounds for protein processing |
| EP3946607A1 (en) | 2019-04-05 | 2022-02-09 | Hepagene Therapeutics (HK) Limited | Bivalent antagonists of inhibitors of apoptosis proteins |
| WO2020223403A1 (en) * | 2019-04-29 | 2020-11-05 | The Regents Of The University Of California | Anticancer smac derivatives |
| JPWO2021020585A1 (US08039623-20111018-C00020.png) | 2019-07-31 | 2021-02-04 | ||
| CA3166980A1 (en) | 2020-01-20 | 2021-07-29 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| IL305835A (en) | 2021-03-15 | 2023-11-01 | Maze Therapeutics Inc | Glycogen synthase 1 (GYS1) inhibitors and methods of using them |
| JP7260725B1 (ja) * | 2021-12-27 | 2023-04-18 | 株式会社トクヤマ | ペプチド製造方法、保護基の除去方法、及び除去剤 |
| WO2023127331A1 (ja) * | 2021-12-27 | 2023-07-06 | 株式会社トクヤマ | ペプチド製造方法、保護基の除去方法、除去剤、及びベンジル化合物 |
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| US20100144650A1 (en) | 2006-07-24 | 2010-06-10 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| EP2409984A1 (en) | 2006-07-24 | 2012-01-25 | Tetralogic Pharmaceuticals Corporation | Dimeric IAP Antagonists |
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| CL2007002166A1 (es) | 2006-07-24 | 2008-01-25 | Tetralogic Pharm Corp | Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer. |
| PE20110218A1 (es) | 2006-08-02 | 2011-04-01 | Novartis Ag | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS |
| WO2008045905A1 (en) | 2006-10-12 | 2008-04-17 | Novartis Ag | Pyrrolydine derivatives as iap inhibitors |
| US20100316573A1 (en) | 2006-10-19 | 2010-12-16 | Larry Alexander Gaither | Organic Compounds |
| WO2008085610A1 (en) | 2006-11-28 | 2008-07-17 | Novartis Ag | Use of iap inhibitors for the treatment of acute myeloid leukemia |
| US8492429B2 (en) | 2006-11-28 | 2013-07-23 | Novartis Ag | Combination of IAP inhibitors and FLT3 inhibitors |
| RU2009125620A (ru) | 2006-12-07 | 2011-01-20 | Новартис АГ (CH) | Органические соединения |
| AU2007337104A1 (en) | 2006-12-19 | 2008-07-03 | Genentech, Inc. | Imidazopyridine inhibitors of IAP |
| CN101668426B (zh) | 2007-04-12 | 2014-01-15 | 焦阳特制药股份有限公司 | 可用作抗癌药的smac模拟二聚体和三聚体 |
| AU2008240119B2 (en) | 2007-04-13 | 2012-04-05 | The Regents Of The University Of Michigan | Diazo bicyclic Smac mimetics and the uses thereof |
| WO2008134679A1 (en) | 2007-04-30 | 2008-11-06 | Genentech, Inc. | Inhibitors of iap |
| US20100203012A1 (en) | 2007-05-30 | 2010-08-12 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| EP2058312A1 (en) | 2007-11-09 | 2009-05-13 | Universita' degli Studi di Milano | SMAC mimetic compounds as apoptosis inducers |
-
2007
- 2007-03-15 TW TW103145747A patent/TWI543988B/zh not_active IP Right Cessation
- 2007-03-15 TW TW096108935A patent/TWI504597B/zh not_active IP Right Cessation
- 2007-03-16 US US11/723,044 patent/US7579320B2/en not_active Expired - Fee Related
- 2007-03-16 SG SG201101952-8A patent/SG170739A1/en unknown
- 2007-03-16 AU AU2007224932A patent/AU2007224932B2/en not_active Ceased
- 2007-03-16 BR BRPI0709610-0A patent/BRPI0709610A2/pt not_active IP Right Cessation
- 2007-03-16 CA CA2581960A patent/CA2581960C/en not_active Expired - Fee Related
- 2007-03-16 EP EP07710756A patent/EP2004600A4/en not_active Withdrawn
- 2007-03-16 NZ NZ571577A patent/NZ571577A/en not_active IP Right Cessation
- 2007-03-16 JP JP2008558611A patent/JP5419468B2/ja not_active Expired - Fee Related
- 2007-03-16 KR KR1020087025218A patent/KR101446907B1/ko not_active IP Right Cessation
- 2007-03-16 MX MX2008011837A patent/MX2008011837A/es active IP Right Grant
- 2007-03-16 WO PCT/CA2007/000428 patent/WO2007104162A1/en active Application Filing
- 2007-11-01 US US11/979,280 patent/US7645741B2/en not_active Expired - Fee Related
-
2008
- 2008-09-07 IL IL193951A patent/IL193951A/en not_active IP Right Cessation
- 2008-09-09 NO NO20083868A patent/NO20083868L/no not_active Application Discontinuation
-
2009
- 2009-11-17 US US12/619,979 patent/US20100221261A1/en not_active Abandoned
-
2012
- 2012-11-08 US US13/672,637 patent/US8765681B2/en not_active Expired - Fee Related
-
2014
- 2014-05-23 US US14/285,841 patent/US9365614B2/en not_active Expired - Fee Related
- 2014-10-28 PH PH12014502420A patent/PH12014502420B1/en unknown
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