MXPA03010762A - Peptidos enlazantes de iap y ensayos para identificar los compuestos que enlazan el iap. - Google Patents
Peptidos enlazantes de iap y ensayos para identificar los compuestos que enlazan el iap.Info
- Publication number
- MXPA03010762A MXPA03010762A MXPA03010762A MXPA03010762A MXPA03010762A MX PA03010762 A MXPA03010762 A MX PA03010762A MX PA03010762 A MXPA03010762 A MX PA03010762A MX PA03010762 A MXPA03010762 A MX PA03010762A MX PA03010762 A MXPA03010762 A MX PA03010762A
- Authority
- MX
- Mexico
- Prior art keywords
- iap
- assays
- binding peptides
- bind
- identifying compounds
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Se revelan ensayos para identificar pepticos y peptidomimeticos para promover la apoptosis en celulas, a traves de una trayectoria que incluye Inhibidor de Proteinas de Apoptosis (IAPs), ejemplificado por XIAP, y la proteina mitocondrial Smac/DIABOLO (en lo sucesivo Smac) y sus homologos. Tambien se revelan peptidomimeticos y peptidos enlazantes de IAP identificados a traves del uso del ensayo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29468201P | 2001-05-31 | 2001-05-31 | |
US34563002P | 2002-01-03 | 2002-01-03 | |
PCT/US2002/017342 WO2002096930A2 (en) | 2001-05-31 | 2002-05-31 | Iap binding peptides and assays for identifying compounds that bind iap |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03010762A true MXPA03010762A (es) | 2005-03-07 |
Family
ID=26968661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03010762A MXPA03010762A (es) | 2001-05-31 | 2002-05-31 | Peptidos enlazantes de iap y ensayos para identificar los compuestos que enlazan el iap. |
Country Status (6)
Country | Link |
---|---|
US (1) | US20050176649A1 (es) |
EP (1) | EP1421204A4 (es) |
JP (1) | JP2004531731A (es) |
CA (1) | CA2449168A1 (es) |
MX (1) | MXPA03010762A (es) |
WO (1) | WO2002096930A2 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003040172A2 (en) * | 2001-11-09 | 2003-05-15 | Aegera Therapeutics, Inc. | Methods and reagents for peptide-bir interaction screens |
DE60322120D1 (de) * | 2003-02-07 | 2008-08-21 | Genentech Inc | Zusammensetzungen und verfahren für verstärkte apoptose |
US20080199439A1 (en) * | 2003-02-12 | 2008-08-21 | Mclendon George L | IAP-binding cargo molecules and peptidomimetics for use in diagnostic and therapeutic methods |
WO2005069888A2 (en) * | 2004-01-16 | 2005-08-04 | The Regents Of The University Of Michigan | Smac peptidomimetics and the uses thereof |
WO2005084317A2 (en) * | 2004-03-01 | 2005-09-15 | Board Of Regents, The University Of Texas System | Dimeric small molecule potentiators of apoptosis |
AU2005228950B2 (en) | 2004-03-23 | 2012-02-02 | Genentech, Inc. | Azabicyclo-octane inhibitors of IAP |
KR100984459B1 (ko) | 2004-07-02 | 2010-09-29 | 제넨테크, 인크. | Iap의 억제제 |
AU2005274937B2 (en) * | 2004-07-15 | 2011-08-18 | Medivir Ab | IAP binding compounds |
JP5007235B2 (ja) | 2004-12-20 | 2012-08-22 | ジェネンテック, インコーポレイテッド | Iapのピロリジンインヒビター |
CN101128425B (zh) * | 2005-02-25 | 2012-12-26 | 泰特拉洛吉克药业公司 | Iap二聚体抑制剂 |
KR101317661B1 (ko) | 2005-02-25 | 2013-10-15 | 테트랄로직 파마슈티칼스 코포레이션 | 이량체성 iap 억제제 |
CA2607940C (en) | 2005-05-18 | 2009-12-15 | Aegera Therapeutics Inc. | Bir domain binding compounds |
US8318717B2 (en) | 2005-05-25 | 2012-11-27 | 2Curex | Compounds modifying apoptosis |
WO2006128455A2 (en) * | 2005-05-25 | 2006-12-07 | 2Curex Aps | Compounds modifying apoptosis |
WO2007038876A1 (en) | 2005-10-04 | 2007-04-12 | Inimex Pharmaceuticals Inc. | Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity |
WO2007048224A1 (en) | 2005-10-25 | 2007-05-03 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
NZ594746A (en) | 2005-12-19 | 2013-03-28 | Genentech Inc | Inhibitors of iap |
TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白(iap)之桿狀病毒iap重複序列(bir)區域之化合物 |
EP2049524A2 (en) | 2006-07-24 | 2009-04-22 | Tetralogic Pharmaceuticals Corporation | Iap inhibitors |
EP2049563B1 (en) | 2006-07-24 | 2014-03-12 | Tetralogic Pharmaceuticals Corporation | Dimeric iap antagonists |
RU2466131C2 (ru) | 2006-12-19 | 2012-11-10 | Дженентек, Инк. | Имидазопиридиновые ингибиторы iap |
US8907092B2 (en) | 2007-04-30 | 2014-12-09 | Genentech, Inc. | Inhibitors of IAP |
CN102171209A (zh) | 2008-08-02 | 2011-08-31 | 健泰科生物技术公司 | Iap抑制剂 |
US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
MX2012009388A (es) | 2010-02-11 | 2012-10-01 | Univ Northwestern | Moduladores del receptor de n-metil-d-aspartato estabilizado de estructura secundaria y sus usos. |
KR101692275B1 (ko) * | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도 |
SG182724A1 (en) | 2010-02-12 | 2012-08-30 | Pharmascience Inc | Iap bir domain binding compounds |
EP2864528A1 (en) * | 2012-06-25 | 2015-04-29 | Silicor Materials Inc. | Lining for surfaces of a refractory crucible for purification of silicon melt and method of purification of the silicon melt using that crucible |
KR102302971B1 (ko) * | 2020-04-24 | 2021-09-15 | 성신여자대학교 연구 산학협력단 | 활성 기반 htra 검출용 테트라 펩타이드 프로브 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5698448A (en) * | 1988-12-02 | 1997-12-16 | Soldin; Steven J. | Immunosuppressive drug binding proteins and use |
US6187557B1 (en) * | 1995-08-08 | 2001-02-13 | Tularik Inc. | c-IAP1 and c-IAP2: inhibitors of apoptosis |
US5786173A (en) * | 1996-03-19 | 1998-07-28 | Idun Pharmaceuticals, Inc. | MCH4 and MCH5, apoptotic protease, nucleic acids encoding and methods of use |
ATE398459T1 (de) * | 1996-04-26 | 2008-07-15 | Univ Ottawa | Verwendung von naip oder iap für die behandlung und vorbeugung von neuronalen erkrankungen |
US5977311A (en) * | 1997-09-23 | 1999-11-02 | Curagen Corporation | 53BP2 complexes |
US6110691A (en) * | 2000-01-06 | 2000-08-29 | Board Of Regents, The University Of Texas System | Activators of caspases |
US6608026B1 (en) * | 2000-08-23 | 2003-08-19 | Board Of Regents, The University Of Texas System | Apoptotic compounds |
CA2420534A1 (en) * | 2000-08-24 | 2002-02-28 | Thomas Jefferson University | An iap binding peptide or polypeptide and methods of using the same |
US6992063B2 (en) * | 2000-09-29 | 2006-01-31 | The Trustees Of Princeton University | Compositions and method for regulating apoptosis |
AU2001293189A1 (en) * | 2000-09-29 | 2002-04-08 | Trustees Of Princeton University | Compositions and methods for regulating apoptosis |
US20020160975A1 (en) * | 2001-02-08 | 2002-10-31 | Thomas Jefferson University | Conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO for mediating apoptosis |
-
2002
- 2002-05-31 JP JP2003500109A patent/JP2004531731A/ja active Pending
- 2002-05-31 EP EP02729333A patent/EP1421204A4/en not_active Withdrawn
- 2002-05-31 CA CA002449168A patent/CA2449168A1/en not_active Abandoned
- 2002-05-31 MX MXPA03010762A patent/MXPA03010762A/es not_active Application Discontinuation
- 2002-05-31 WO PCT/US2002/017342 patent/WO2002096930A2/en not_active Application Discontinuation
- 2002-05-31 US US10/478,521 patent/US20050176649A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1421204A2 (en) | 2004-05-26 |
WO2002096930A2 (en) | 2002-12-05 |
CA2449168A1 (en) | 2002-12-05 |
EP1421204A4 (en) | 2004-12-15 |
JP2004531731A (ja) | 2004-10-14 |
US20050176649A1 (en) | 2005-08-11 |
WO2002096930A3 (en) | 2004-03-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |