WO2003087145A3 - Purified polypeptides involved in quorum sensing - Google Patents

Purified polypeptides involved in quorum sensing Download PDF

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Publication number
WO2003087145A3
WO2003087145A3 PCT/CA2003/000483 CA0300483W WO03087145A3 WO 2003087145 A3 WO2003087145 A3 WO 2003087145A3 CA 0300483 W CA0300483 W CA 0300483W WO 03087145 A3 WO03087145 A3 WO 03087145A3
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WO
WIPO (PCT)
Prior art keywords
quorum sensing
purified polypeptides
polypeptides involved
involved
purified
Prior art date
Application number
PCT/CA2003/000483
Other languages
French (fr)
Other versions
WO2003087145A2 (en
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Merry-Lynn Mcdonald
Qin Li
Donald Awrey
Bryan Beattie
Original Assignee
Affinium Pharm Inc
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Merry-Lynn Mcdonald
Qin Li
Donald Awrey
Bryan Beattie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Aled Edwards, Akil Dharamsi, Masoud Vedadi, Merry-Lynn Mcdonald, Qin Li, Donald Awrey, Bryan Beattie filed Critical Affinium Pharm Inc
Priority to AU2003213951A priority Critical patent/AU2003213951A1/en
Publication of WO2003087145A2 publication Critical patent/WO2003087145A2/en
Publication of WO2003087145A3 publication Critical patent/WO2003087145A3/en
Priority to US10/953,901 priority patent/US20050181464A1/en

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • C—CHEMISTRY; METALLURGY
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1288—Transferases for other substituted phosphate groups (2.7.8)
    • C—CHEMISTRY; METALLURGY
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    • C12N9/14—Hydrolases (3)
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.
PCT/CA2003/000483 2002-04-04 2003-04-08 Purified polypeptides involved in quorum sensing WO2003087145A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003213951A AU2003213951A1 (en) 2002-04-08 2003-04-08 Purified polypeptides involved in quorum sensing
US10/953,901 US20050181464A1 (en) 2002-04-04 2004-09-29 Novel purified polypeptides from bacteria

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US37080602P 2002-04-08 2002-04-08
US60/370,806 2002-04-08
US37100902P 2002-04-09 2002-04-09
US37097802P 2002-04-09 2002-04-09
US60/371,009 2002-04-09
US60/370,978 2002-04-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/953,901 Continuation-In-Part US20050181464A1 (en) 2002-04-04 2004-09-29 Novel purified polypeptides from bacteria

Publications (2)

Publication Number Publication Date
WO2003087145A2 WO2003087145A2 (en) 2003-10-23
WO2003087145A3 true WO2003087145A3 (en) 2004-06-17

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PCT/CA2003/000483 WO2003087145A2 (en) 2002-04-04 2003-04-08 Purified polypeptides involved in quorum sensing

Country Status (2)

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AU (1) AU2003213951A1 (en)
WO (1) WO2003087145A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0326192D0 (en) * 2003-11-10 2003-12-17 Univ Kent Canterbury Proteins involved in signal transduction
CN106706693A (en) * 2016-12-30 2017-05-24 南京理工大学 Metabonomics analysis method for quorum sensing inhibition mechanism

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BEAVIS R C ET AL: "Cinnamic acid derivatives as matrices for ultraviolet laser desorption mass spectrometry of proteins.", RAPID COMMUNICATIONS IN MASS SPECTROMETRY: RCM. ENGLAND DEC 1989, vol. 3, no. 12, December 1989 (1989-12-01), pages 432 - 435, XP009017328, ISSN: 0951-4198 *
DATABASE EMBL [online] 1 April 1988 (1988-04-01), XP002254404, Database accession no. p07026 *
KANAMARU KYOKO ET AL: "SdiA, an Escherichia coli homologue of quorum-sensing regulators, controls the expression of virulence factors in enterohaemorrhagic Escherichia coli O157:H7.", MOLECULAR MICROBIOLOGY, vol. 38, no. 4, November 2000 (2000-11-01), pages 805 - 816, XP002254403, ISSN: 0950-382X *
YAMAMOTO KANEYOSHI ET AL: "Novel mode of transcription regulation by SdiA, an Escherichia coli homologue of the quorum-sensing regulator.", MOLECULAR MICROBIOLOGY, vol. 41, no. 5, September 2001 (2001-09-01), pages 1187 - 1198, XP002254402, ISSN: 0950-382X *

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WO2003087145A2 (en) 2003-10-23
AU2003213951A1 (en) 2003-10-27
AU2003213951A8 (en) 2003-10-27

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