WO2003025007A3 - Purified polypeptides involved in membrane biosynthesis - Google Patents

Purified polypeptides involved in membrane biosynthesis Download PDF

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Publication number
WO2003025007A3
WO2003025007A3 PCT/CA2002/001428 CA0201428W WO03025007A3 WO 2003025007 A3 WO2003025007 A3 WO 2003025007A3 CA 0201428 W CA0201428 W CA 0201428W WO 03025007 A3 WO03025007 A3 WO 03025007A3
Authority
WO
WIPO (PCT)
Prior art keywords
purified polypeptides
polypeptides involved
membrane biosynthesis
biosynthesis
membrane
Prior art date
Application number
PCT/CA2002/001428
Other languages
French (fr)
Other versions
WO2003025007A2 (en
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Donald Awrey
Bryan Beattie
Megan Domagala
Simon Houston
Dhushy Kanagarajah
Kathleen Nethery
Ivy Ng
Kamran Mansoury
Merry-Lynn Mcdonald
Benjamin Pinder
Cristina Viola
Olga Wrezel
Original Assignee
Affinium Pharm Inc
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Donald Awrey
Bryan Beattie
Megan Domagala
Simon Houston
Dhushy Kanagarajah
Kathleen Nethery
Ivy Ng
Kamran Mansoury
Merry-Lynn Mcdonald
Benjamin Pinder
Cristina Viola
Olga Wrezel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Aled Edwards, Akil Dharamsi, Masoud Vedadi, Muhammad Zahoor Alam, Donald Awrey, Bryan Beattie, Megan Domagala, Simon Houston, Dhushy Kanagarajah, Kathleen Nethery, Ivy Ng, Kamran Mansoury, Merry-Lynn Mcdonald, Benjamin Pinder, Cristina Viola, Olga Wrezel filed Critical Affinium Pharm Inc
Priority to AU2002328224A priority Critical patent/AU2002328224A1/en
Publication of WO2003025007A2 publication Critical patent/WO2003025007A2/en
Publication of WO2003025007A3 publication Critical patent/WO2003025007A3/en
Priority to US10/806,062 priority patent/US20050214773A1/en
Priority to US10/922,802 priority patent/US20050187718A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.
PCT/CA2002/001428 2001-09-21 2002-09-20 Purified polypeptides involved in membrane biosynthesis WO2003025007A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002328224A AU2002328224A1 (en) 2001-09-21 2002-09-20 Purified polypeptides involved in membrane biosynthesis
US10/806,062 US20050214773A1 (en) 2001-09-21 2004-03-22 Novel purified polypeptides from bacteria
US10/922,802 US20050187718A1 (en) 2001-09-21 2004-08-20 Novel purified polypeptides from Streptococcus pneumoniae

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US32415201P 2001-09-21 2001-09-21
US32399201P 2001-09-21 2001-09-21
US60/324,152 2001-09-21
US60/323,992 2001-09-21
US32469201P 2001-09-25 2001-09-25
US60/324,692 2001-09-25
US33992401P 2001-10-26 2001-10-26
US60/339,924 2001-10-26
US35097301P 2001-10-29 2001-10-29
US60/350,973 2001-10-29
US34092401P 2001-10-30 2001-10-30
US60/340,924 2001-10-30
US33366601P 2001-11-27 2001-11-27
US60/333,666 2001-11-27
US34177601P 2001-12-18 2001-12-18
US34173201P 2001-12-18 2001-12-18
US60/341,776 2001-12-18
US60/341,732 2001-12-18
US34194901P 2001-12-19 2001-12-19
US60/341,949 2001-12-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/806,062 Continuation-In-Part US20050214773A1 (en) 2001-09-21 2004-03-22 Novel purified polypeptides from bacteria

Publications (2)

Publication Number Publication Date
WO2003025007A2 WO2003025007A2 (en) 2003-03-27
WO2003025007A3 true WO2003025007A3 (en) 2004-03-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001428 WO2003025007A2 (en) 2001-09-21 2002-09-20 Purified polypeptides involved in membrane biosynthesis

Country Status (2)

Country Link
AU (1) AU2002328224A1 (en)
WO (1) WO2003025007A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108611344A (en) * 2016-12-10 2018-10-02 中国科学院大连化学物理研究所 The preparation and application of AtAGM2 and AtAGM3 encoding genes and enzyme

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999017794A1 (en) * 1997-10-03 1999-04-15 Smithkline Beecham Corporation UDP-N-ACETYLMURAMOYL-L-AIANINE:D-GLUTAMATE LIGASE (murD) OF STAPHYLOCOCCUS AUREUS
WO1999023241A1 (en) * 1997-11-04 1999-05-14 Merck & Co., Inc. MURD PROTEIN AND GENE $i(OF STAPHYLOCOCCUS AUREUS)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999017794A1 (en) * 1997-10-03 1999-04-15 Smithkline Beecham Corporation UDP-N-ACETYLMURAMOYL-L-AIANINE:D-GLUTAMATE LIGASE (murD) OF STAPHYLOCOCCUS AUREUS
WO1999023241A1 (en) * 1997-11-04 1999-05-14 Merck & Co., Inc. MURD PROTEIN AND GENE $i(OF STAPHYLOCOCCUS AUREUS)

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERTRAND JAY A ET AL: ""Open" structures of MurD: Domain movements and structural similarities with folylpolyglutamate synthetase.", JOURNAL OF MOLECULAR BIOLOGY, vol. 301, no. 5, 2000, pages 1257 - 1266, XP002249296, ISSN: 0022-2836 *
BERTRAND JAY A ET AL: "Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 16, no. 12, 1997, pages 3416 - 3425, XP002249311, ISSN: 0261-4189 *
BERTRAND JAY A ET AL: "Determination of the MurD mechanism through crystallographic analysis of enzyme complexes.", JOURNAL OF MOLECULAR BIOLOGY, vol. 289, no. 3, 11 June 1999 (1999-06-11), pages 579 - 590, XP002249297, ISSN: 0022-2836 *
EL-SHERBEINI MOHAMED ET AL: "Cloning and expression of Staphylococcus aureus and Streptococcus pyogenes murD genes encoding uridine diphosphate N-acetylmuramoyl-L-alanine: D-glutamate ligases.", GENE (AMSTERDAM), vol. 210, no. 1, 27 March 1998 (1998-03-27), pages 117 - 125, XP002249294, ISSN: 0378-1119 *
WALSH ANN W ET AL: "Comparison of the D-glutamate-adding enzymes from selected gram-positive and gram-negative bacteria.", JOURNAL OF BACTERIOLOGY, vol. 181, no. 17, 1999, pages 5395 - 5401, XP002249293, ISSN: 0021-9193 *

Also Published As

Publication number Publication date
WO2003025007A2 (en) 2003-03-27
AU2002328224A1 (en) 2003-04-01

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