WO2003083099A3 - Purified polypeptides involved in protein synthesis and modification - Google Patents

Purified polypeptides involved in protein synthesis and modification Download PDF

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Publication number
WO2003083099A3
WO2003083099A3 PCT/CA2003/000462 CA0300462W WO03083099A3 WO 2003083099 A3 WO2003083099 A3 WO 2003083099A3 CA 0300462 W CA0300462 W CA 0300462W WO 03083099 A3 WO03083099 A3 WO 03083099A3
Authority
WO
WIPO (PCT)
Prior art keywords
modification
protein synthesis
purified polypeptides
polypeptides involved
involved
Prior art date
Application number
PCT/CA2003/000462
Other languages
French (fr)
Other versions
WO2003083099A2 (en
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Cheryl Arrowsmith
Donald Awrey
Bryan Beattie
Dawn Richards
Veronica Canadien
Megan Domagala
Simon Houston
Kamran Mansoury
Qin Li
Kathleen Nethery
Cristina Virag
Ivy Ng
Hui Ouyang
Matthew Tai
Rosanne Thalakada
Dhushy Kanagarajah
Original Assignee
Affinium Pharm Inc
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Cheryl Arrowsmith
Donald Awrey
Bryan Beattie
Dawn Richards
Veronica Canadien
Megan Domagala
Simon Houston
Kamran Mansoury
Qin Li
Kathleen Nethery
Cristina Virag
Ivy Ng
Hui Ouyang
Matthew Tai
Rosanne Thalakada
Dhushy Kanagarajah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Aled Edwards, Akil Dharamsi, Masoud Vedadi, Muhammad Zahoor Alam, Cheryl Arrowsmith, Donald Awrey, Bryan Beattie, Dawn Richards, Veronica Canadien, Megan Domagala, Simon Houston, Kamran Mansoury, Qin Li, Kathleen Nethery, Cristina Virag, Ivy Ng, Hui Ouyang, Matthew Tai, Rosanne Thalakada, Dhushy Kanagarajah filed Critical Affinium Pharm Inc
Priority to AU2003213933A priority Critical patent/AU2003213933A1/en
Publication of WO2003083099A2 publication Critical patent/WO2003083099A2/en
Priority to US10/958,216 priority patent/US20050181388A1/en
Publication of WO2003083099A3 publication Critical patent/WO2003083099A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.
PCT/CA2003/000462 2002-04-02 2003-04-02 Purified polypeptides involved in protein synthesis and modification WO2003083099A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003213933A AU2003213933A1 (en) 2002-04-02 2003-04-02 Purified polypeptides involved in protein synthesis and modification
US10/958,216 US20050181388A1 (en) 2002-04-02 2004-10-04 Novel purified polypeptides from bacteria

Applications Claiming Priority (32)

Application Number Priority Date Filing Date Title
US36951102P 2002-04-02 2002-04-02
US60/369,511 2002-04-02
US38508902P 2002-05-31 2002-05-31
US60/385,089 2002-05-31
US38575102P 2002-06-04 2002-06-04
US60/385,751 2002-06-04
US38657702P 2002-06-05 2002-06-05
US38636702P 2002-06-05 2002-06-05
US38656602P 2002-06-05 2002-06-05
US38655302P 2002-06-05 2002-06-05
US60/386,566 2002-06-05
US60/386,553 2002-06-05
US60/386,367 2002-06-05
US60/386,577 2002-06-05
US38639002P 2002-06-06 2002-06-06
US38660102P 2002-06-06 2002-06-06
US60/386,601 2002-06-06
US60/386,390 2002-06-06
US39997202P 2002-07-31 2002-07-31
US60/399,972 2002-07-31
US42405302P 2002-11-05 2002-11-05
US60/424,053 2002-11-05
US43680402P 2002-12-27 2002-12-27
US43686102P 2002-12-27 2002-12-27
US43683402P 2002-12-27 2002-12-27
US60/436,834 2002-12-27
US60/436,861 2002-12-27
US60/436,804 2002-12-27
US43728102P 2002-12-31 2002-12-31
US43752702P 2002-12-31 2002-12-31
US60/437,281 2002-12-31
US60/437,527 2002-12-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/958,216 Continuation-In-Part US20050181388A1 (en) 2002-04-02 2004-10-04 Novel purified polypeptides from bacteria

Publications (2)

Publication Number Publication Date
WO2003083099A2 WO2003083099A2 (en) 2003-10-09
WO2003083099A3 true WO2003083099A3 (en) 2008-01-03

Family

ID=28679270

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2003/000462 WO2003083099A2 (en) 2002-04-02 2003-04-02 Purified polypeptides involved in protein synthesis and modification

Country Status (2)

Country Link
AU (1) AU2003213933A1 (en)
WO (1) WO2003083099A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0505949D0 (en) * 2005-03-23 2005-04-27 Univ Sheffield Polypeptides
WO2006116010A2 (en) * 2005-04-21 2006-11-02 Advandx, Inc. Detection of virulence markers of staphylococci

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024635A1 (en) * 1999-10-04 2001-04-12 Smithkline Beecham Corporation AsuE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024635A1 (en) * 1999-10-04 2001-04-12 Smithkline Beecham Corporation AsuE

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ABOLA E ET AL: "AUTOMATION OF X-RAY CRYSTALLOGRAPHY", NATURE STRUCTURAL BIOLOGY, NEW YORK, NY, US, vol. 7, no. SUPPL, November 2000 (2000-11-01), pages 973 - 977, XP001062873, ISSN: 1072-8368 *
BAGBY S ET AL: "Optimization of protein solubility and stability for protein nuclear magnetic resonance.", METHODS IN ENZYMOLOGY. UNITED STATES 2001, vol. 339, 2001, pages 20 - 41, XP001152932, ISSN: 0076-6879 *
KAY L E: "Nuclear magnetic resonance methods for high molecular weight proteins: a study involving a complex of maltose binding protein and beta-cyclodextrin.", METHODS IN ENZYMOLOGY. UNITED STATES 2001, vol. 339, 2001, pages 174 - 203, XP001152928, ISSN: 0076-6879 *
KRAFT P ET AL: "Infrared, surface-assisted laser desorption ionization mass spectrometry on frozen aqueous solutions of proteins and peptides using suspensions of organic solids", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, ELSEVIER SCIENCE INC., NEW YORK, NY, US, vol. 9, no. 9, September 1998 (1998-09-01), pages 912 - 924, XP004149186, ISSN: 1044-0305 *
THOMA R ET AL: "Efficient expression, purification and crystallisation of two hyperthermostable enzymes of histidine biosynthesis", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 454, no. 1-2, 2 July 1999 (1999-07-02), pages 1 - 6, XP004259914, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
WO2003083099A2 (en) 2003-10-09
AU2003213933A8 (en) 2008-02-28
AU2003213933A1 (en) 2003-10-13

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